Comparing the outcomes of three UU surgical methods for the treatment of complete duplex kidney: Changes to continually improve surgical success and reduce operative time and operative difficulty.

Introduction: Duplex kidney is a common malformation of the urinary system among children. There are various treatment options for this malformation.

Objective: This study aimed to compare the therapeutic effects of three minimally invasive urinary tract reconstruction surgery methods for complete duplex kidney among children and to compare demographic characteristics, perioperative data, surgical techniques, complications, and outcomes between these three methods.

Associations of urinary biomarkers of exposure to drinking-water disinfection by-products with haematological parameters and systemic inflammation indices among women undergoing assisted reproductive technology treatment.

Experimental research has shown that disinfection by-products (DBPs) exhibit haematological toxicity and trigger inflammatory responses, but epidemiological evidence remains underexplored. Among 1201 women undergoing assisted reproductive technology treatment from the Tongji Reproductive and Environmental (TREE) cohort, we investigated the relationships of drinking-water DBP exposures measured by urinary levels of dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA) with haematological parameters and systemic inflammation indices. No statistically significant associations of DCAA and TCAA concentrations in urine with leukocyte-related parameters or systemic inflammation indices were found.

RST-YOLOv8: An Improved Chip Surface Defect Detection Model Based on YOLOv8.

Surface defect detection in chips is crucial for ensuring product quality and reliability. This paper addresses the challenge of low identification accuracy in chip surface defect detection, which arises from the similarity of defect characteristics, small sizes, and significant scale differences. We propose an enhanced chip surface defect detection algorithm based on an improved version of YOLOv8, termed RST-YOLOv8.

Full-Length Transcriptome Sequencing of Under Simulated Feeding Highlights bHLH Transcription Factor Involved in Defense Response.

Background: is a significant lipid-producing tree species in China and a susceptible host for both the pine wood nematode and its insect vector, . The basic helix-loop-helix (bHLH) family of transcription factors play a crucial role in responding to both biotic and abiotic stresses. However, the role of bHLH in terpene-induced defense in remains poorly studied.

Modifying the Structural and Functional Properties of Walnut Glutenin Through Atmospheric Cold Plasma Treatment: Evaluation of Treatment Times Effects.

Walnut gluten (WGLU) is a plant-based protein rich in essential amino acids for the human body. Due to its poor water solubility and functional properties, its application in the food industry is limited. For the first time, this study looks into how different durations (0, 30, 60, 90, and 120 s) of atmospheric cold plasma (ACP) treatment affect the structure and functional properties of WGLU.

Impacts of Captive Domestication and Geographical Divergence on the Gut Microbiome of Endangered Forest Musk Deer.

Forest musk deer ( Flerov), a critically endangered ruminant species, faces extinction risks, with captive populations further threatened by prevalent digestive and immune disorders. This study utilized comparative metagenomic sequencing to assess intestinal microbiota structure and functional profiles between wild populations in Chongqing and Hunan and captive individuals. Wild populations exhibited a Pseudomonadota-dominated gut microbiota (significantly more abundant than in captive counterparts), enriched with lignin-degrading genera and .

A virulent phage vB_VpaP_R28Z infecting Vibrio parahaemolyticus with potential for therapeutic application.

Background: Vibrio parahaemolyticus, a major foodborne pathogen, contaminates aquatic products and causes significant economic losses in aquaculture while threatening food security and public health. Given the rising prevalence of multidrug-resistant V. parahaemolyticus strains, phage therapy has emerged as an effective and environmentally sustainable alternative for controlling vibriosis in aquaculture.

Safety, feasibility, and effectiveness of exercise interventions in patients with hematologic malignancy during chemotherapy: a systematic review and meta-analysis.

Purpose: To evaluate the safety, feasibility, and effectiveness of exercise interventions aimed at improving the physical and/or mental health of patients with hematologic malignancies (HM) during chemotherapy.

Methods: We systematically searched nine electronic databases for studies from their inception up to February 2024. The review process strictly adhered to the Cochrane guidelines and followed the PRISMA checklist for reporting systematic reviews.

Beta sitosterol inhibits the proliferation and migration of synoviocytes in rheumatoid arthritis via lactylation of GPI.

Fibroblast-like synoviocytes (FLSs) are critical for promoting joint and surrounding soft tissue damage in Rheumatoid arthritis (RA). β-Sitosterol has the potential to attenuate RA; however, the underlying mechanism remains largely unknown. This study aimed to investigate the effect of β-Sitosterol on the biological functions of FLSs.

Spatial variability of methane fluxes driven by lacustrine groundwater discharge and its influence on lake methane emissions.

Methane (CH) input into lakes via groundwater discharge (LGD-derived CH) has recently been identified as a significant contributor to the lake methane budget. The high spatial variability of LGD-derived CH can substantially influence the delineation of methane emission hotspots and thus cause failure to accurately estimate and mitigate aquatic methane emissions. However, systematic studies on the spatial variability of LGD-derived CH, its controlling factors, and its influence on lake methane emissions remain limited.

Discretizing Cobalt Spin-Orbitals through Tuning the Crystal Symmetry for Zinc-Air Batteries.

Regulating the electron-spin state of metal active sites is a rarely cultivated topic for oxygen electrocatalysis. Here, a dual-ligand metal-organic framework (DM) is developed to endow Co sites with crystal symmetry, reconfiguring their orbital degeneracy and electron spin state. The discretized spin-orbital configuration offers the accelerated transformation of the O-related intermediate by accepting electrons via partial d-orbital occupation and mediation of the hydroxyl adsorption strength through electron donation to O p-orbitals.

A previously undescribed 3,4-secodammarane derivative from .

A new 3,4-secodammarane derivative () was obtained from the bark of . The combination of spectral analysis and the computation of electronic circular dichroism (ECD) has definitively confirmed the absolute configuration of the compound. This configuration has been identified as methyl (20S, 24 R)-epoxy-25-hydroxy-3,4-secodammar-4(28)-en-29-al-3-oate.

Global, regional, and national burdens of pancreatitis in children and adolescents aged 0-24 years from 1992 to 2021: a trend analysis based on the global burden of disease study 2021.

Background: The younger onset of pancreatitis presents a significant public health challenge. This study aims to analyze the global burden of pancreatitis in younger populations based on the Global Burden of Disease 2021.

Methods: This study uses incidence rates and Disability-Adjusted Life Years (DALYs) to assess the burden of pancreatitis.

Diagnosis and treatment of and coinfection following myocardial infarction: A case report and literature review.

Background: () is an opportunistic fungal pathogen increasingly reported among immunocompromised individuals, particularly those admitted to intensive care units (ICUs). Due to its intrinsic resistance to amphotericin B and partial resistance to azoles, treatment remains challenging. Coinfection with bacterial ( []) and viral pathogens ( [HSV-1], [CMV]) further complicates the clinical course.

Preliminary notes on (Acanthaceae) in Peru.

L. is the most species-rich genus of Acanthaceae in Peru and is here accepted in its broader traditional circumscription. The present paper marks a preliminary step towards a complete revision of the genus in Peru.

Liquid metal microparticles enabled low-cost, compact, and sensitive humidity sensors for moisture monitoring.

Moisture-sensitive materials require reliable moisture-proof packaging to maintain quality throughout manufacturing. humidity monitoring inside moisture-proof packaging is essential for an early detection of moisture barrier failures. Although moisture testing kits like humidity indicator cards are available, they are often toxic or slow, and technological advancements in developing faster, safer, and more affordable alternatives have remained stagnant for years.

Direct effects of the small molecule PD‑L1 inhibitor BMS‑202 on A375 melanoma cells: Anti‑tumor activity accompanied by increased mitochondrial function.

The aim of the present study was to investigate the direct effects of BMS‑202 on melanoma cells. The small molecule programmed cell death ligand 1 (PD‑L1) inhibitor BMS‑202 was used to treat A375 melanoma cells. The cell distribution of BMS‑202 was examined using low‑power and high‑resolution confocal microscopy, focusing on its localization in mitochondria.

The mediating role of resilience in the relationships between posttraumatic growth and depression as well as anxiety among survivors of nasopharyngeal carcinoma: a cross-sectional study.

Background: Nasopharyngeal carcinoma (NPC) survivors demonstrate heightened vulnerability to depression and anxiety, while posttraumatic growth (PTG) and resilience have been reported as important protective factors for mental health. This study examined the mediating role of resilience in the associations between PTG and both depression and anxiety among NPC survivors.

Methods: A total of 773 NPC survivors were recruited through convenience sampling at Sun Yat-sen University Cancer Center (Guangzhou, China).

Gut microbiota dysbiosis exacerbates heart failure by the LPS-TLR4/NF-κB signalling axis: mechanistic insights and therapeutic potential of TLR4 inhibition.

Objective: This study aimed to investigate the associations between gut microbiota dysbiosis and alterations in cardiac function and to elucidate the underlying molecular mechanisms involved.

Methods: Eighteen rats were divided into a control group (n = 6), a heart failure (HF) group (n = 6), and a TAK-242 intervention group (n = 6). Cardiac function was assessed using small-animal echocardiography.

MedKA: A knowledge graph-augmented approach to improve factuality in medical Large Language Models.

Large language models (LLMs) have demonstrated remarkable potential in medical applications. However, they still face critical challenges such as hallucinations, knowledge inconsistency, and insufficient integration of domain-specific medical expertise. To address these limitations, we introduce MedKA, a novel knowledge graph-augmented approach for fine-tuning and evaluating medical LLMs.

Diversified Segmental Defocus Optimization Lenses With and Without Atropine for Myopia Prevention: A Randomized Clinical Trial.

Importance: With growing myopia prevalence worldwide, effective strategies to prevent early-onset myopia are needed.

Objective: To evaluate the efficacy of diversified segmental defocus optimization (DSDO) spectacle lenses with or without 0.01% atropine for myopia prevention.

The Time Reliable Effect of Probiotic Clostridium butyricum on the Growth of Spotted Sea Bass (Lateolabrax maculatus).

Probiotic Clostridium butyricum has been demonstrated to enhance the growth of spotted sea bass (Lateolabrax maculatus). However, the time reliable effect of C. butyricum application for L.

hsa_circ_0004771-Targeted Adsorption of miR-429 Mediates ATP2A2 Expression to Attenuate Endoplasmic Reticulum Stress and Mitochondrial Dysfunction During Myocardial Infarction.

Circular RNAs (circRNAs) have emerged as key regulators of cardiovascular pathophysiology. This study intended to mechanistically dissect the role of hsa_circ_0004771 in MI pathogenesis. An in vivo MI mouse model was established, and mouse cardiomyocytes (HL-1 cells) were cultured under hypoxic conditions to construct an in vitro cardiomyocyte injury model.