Correlation between radiologic feature and spread through air space in lung solid adenocarcinoma 30.0 mm or less in maximum diameter.

Purpose: Tumor spread through air space (STAS) is recognized as an important prognostic indicator for lung cancer patients. However, few studies have focused on radiologic features for predicting STAS in patients with small solid lung adenocarcinomas 30.0 mm or less in maximum diameter.

Research on the high velocity compaction process of iron-based powder based on the DEM.

In order to further study the dynamic response of granular systems under impact loading, this paper establishes an SHPB test model of metal powder based on the discrete element method (DEM) of particles using PFC3D software. The High Velocity Compaction (HVC) process is simulated by numerical simulation. The distribution and change rules of particle movement are observed from different angles; the change rules of particle normal velocities at different positions in the particle sample are analyzed; the formation process of force chains under impact is observed; and the change rules of contact forces between particles at different positions are analyzed.

Skin-Inspired Healthcare Electronics.

With the improvement in living standards and the aging of the population, the development of thin, light, and unobtrusive electronic skin devices is accelerating. These electronic devices combine the convenience of wearable electronics with the comfort of a skin-like fit. They are used to acquire multimodal physiological signal data from the wearer and real-time transmission of signals for vital signs monitoring, health dynamics warning, and disease prevention.

Magnetic continuum robot-mediated intracranial delivery of peptide nanophotosensitizers for glioblastoma photodynamic therapy.

Effective treatment of glioblastoma (GBM) remains a significant clinical challenge. Although photodynamic therapy (PDT) is a promising anticancer treatment method, its clinical application in GBM is limited by poor light penetration through the skull and insufficient drug delivery across the blood-brain barrier (BBB). Here, an innovative magnetic continuum robot (MCR)-mediated intracranial PDT strategy is proposed.

Molecular Encoded Beads for Multiplexed Nucleic Acid Quantitative Detection.

Here, we present an improved version of our previously proposed DNA coding method, incorporating three key modifications: (1) modification of the hybridization region in the coding probe, (2) replacement bead type, and (3) introduction of a third fluorescent dye that overcomes previous limitations in quantitative nucleic acid detection. To demonstrate practical utility, we developed a trifluorophore system capable of simultaneously quantifying eight distinct nucleic acids using flow cytometry with just two excitation channels and three emission channels. This plug-and-play strategy enables concurrent encoding and target detection, significantly simplifying the workflow.

Microbiota composition-based donor selection affects FMT efficacy in a murine colitis model.

Background: Growing evidence links gut microbial dysbiosis to inflammatory bowel disease (IBD) pathogenesis, establishing fecal microbiota transplantation (FMT) as a microbiota-targeted therapy; however, variable outcomes in randomized trials highlight the need to identify compositional features of donor microbiota associated with FMT efficacy.

Objective: This study aimed to investigate how the composition of the donor gut microbiota influences the therapeutic efficacy of FMT in IBD.

Method: Fecal DNA from 39 IBD patients and 42 healthy donors was analyzed via 16S rRNA sequencing.

Non-Invasive Kupffer-CEUS Enhances the Accuracy of Focal Liver Lesions Diagnosis in Patients with Liver Cirrhosis or Fibrosis: A Prospective Multicenter Study from China.

Introduction: It is challenging to diagnose liver masses in the context of a rough liver background using computed tomography and magnetic resonance imaging. Perfluorobutane CEUS microbubble, an ultrasound (US) contrast agent, has a unique phase called the Kupffer phase. This study aimed to explore whether the diagnostic ability of Kupffer-CEUS is affected by the rough liver background.

Gene-specific ctDNA dynamics predict tumour burden and survival outcomes in ESCC: A prospective cohort study.

Background: Oesophageal squamous cell carcinoma (ESCC) remains a highly aggressive malignancy with limited biomarkers for monitoring tumour burden and prognosis. Circulating tumour DNA (ctDNA) has emerged as a promising tool for real-time disease assessment, but its clinical utility in ESCC remains underexplored.

Methods: In this prospective cohort study, we analysed preoperative and postoperative ctDNA from 54 treatment-naïve ESCC patients undergoing radical surgery using a 61-gene panel.

[Influencing factors of positive surgical margins after radical resection of prostate cancer].

Objective: To investigate the influencing factors of pathological positive surgical margins (PSM) after radical resection of prostate cancer.

Methods: The clinical data of 407 patients who underwent radical resection of prostate cancer in our hospital from 2011 to 2020 were retrospectively analyzed. And the patients were divided into two groups according to postoperative pathological results.

Long non-coding RNA NORAD serves as a promoter of oncogenesis and inhibits ferroptosis via miR-144-3p-mTOR-ferritinophagy axis in cancer.

Non-coding RNA activated by DNA damage (NORAD) has been found to enhance proliferation and metastasis of cancer cells. Ferroptosis is characterized by excess lipid peroxidation and has been confirmed to eliminate cancer cells. However, the specific role of NORAD in cancer and ferroptosis is not clear.

Structurally novel tryptamine-derived alkaloids from the seeds of Peganum harmala and their antiviral activities against respiratory syncytial virus.

Peganum harmala L. (P. harmala) is a significant economic and medicinal plant.

Integrative Single-Cell Analysis Reveals Iron Overload-Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis-Associated Infertility.

Endometriosis, particularly ovarian endometriosis (OE), is a major cause of infertility, often associated with reduced oocyte quality and impaired ovarian function. Iron overload plays a key role in OE progression. This study investigates the effects of iron overload on follicular function in OE-associated infertility (OEI).

Modified technique for dissection of working space in retroperitoneal laparoscopic surgery: A step-by-step guide.

Objectives: This work aims to describe with a step-by-step guide for modified dissection technique to create a retroperitoneal working space during laparoscopic surgery.

Materials And Methods: From May 2021 to December 2022, we performed a modified dissection technique to create a retroperitoneal working space prior retroperitoneal laparoscopic surgery in 47 patients. The retroperitoneum is initially accessed by puncturing the trocar through a 10-mm transverse skin incision in the midaxillary line.

Expose flexible conformations for intrinsically disordered protein.

The folding conformation of native protein has flexibility in different degrees, which may bring difficulty in presenting the structures, and also it causes complexity in understanding the relationship between structure and functions. Although many methods and databases provide information for intrinsically disordered protein (IDP), they are mainly limited to determining the intrinsically disordered regions (IDR) lacking knowledge of possible folding patterns. To overcome the barrier, the protein structure fingerprint technology has been developed, which includes PFSC (Protein Folding Shape Code) (Yang, 2008) and PFVM (Protein Folding Variation Matrix) (Yang et al.

Molecular Encoded Beads with DNA Duplex Programming Fluorophore-Quencher Distance for Multiplexed Detection.

Currently, the leading-edge bead encoding technique adopts the dye-doped strategy, which requires the construction of an encoded bead library in advance and is limited by strict material and technical barriers. Here, we report a simple, versatile, and plug-and-play bead encoding strategy, which uses bead surface DNA encoding instead of a dye-doped strategy. This is a fluorophore-quencher (F-Q) distance encoded strategy through the different Q-labeled positions at the DNA duplex, thereby changing the FRET efficiency.

Recyclable self-secreting autonomous healing dielectrics for millisecond water quality sensing.

Developing a sustainable, in-situ responsive sensing method for continuously monitoring water quality is crucial for water use and quality management globally. Conventional water quality monitoring sensors face challenges in achieving ultrafast response time and are non-recyclable. We present a self-assembly approach for a closed-loop recyclable, autonomous self-healing and transparent dielectric material with nanostructured amphiphobic surfaces (termed 'ReSURF').

Cascade Reaction of 2-Azirines and -Bromoaryl Isothiocyanates: An Access to Benzo[]imidazo[2,1-]thiazoles.

A novel CsCO-promoted method for the synthesis of benzo[]imidazo[2,1-]thiazol derivatives from 2-azirines and -bromoaryl isothiocyanates was successfully explored via C-S bond formation under transition-metal-free condition. The investigation indicated that the mild, efficient, low-cost, and low-toxic synthesis strategy could proceed smoothly without the aid of light, a metal catalyst, or an expensive photocatalyst. There is an intramolecular free-radical coupling step in a possible mechanistic pathway.

Ultrahigh-Capacity Vertical Encoded Micro-Spherical Nucleic Acids for Multiplexed Detection.

Here, we report a DNA-programmable microsphere encoding platform using spatially organized fluorophores on magnetic cores with elongated DNA scaffolds. By engineering vertically stratified DNA scaffolds on paramagnetic microspheres, we achieved orthogonal spectral separation of 2-3 fluorophores through spatial confinement, generating 96 distinct two-color and 536 three-color barcodes via tunable stoichiometric control. We validated the platform's utility for nucleic acid multiplexing by demonstrating simultaneous detection of multiple targets, establishing a foundation for scalable high-order multiplexing.

Frontiers in Innovative Materials and Technologies for Oil-Water Separation.

Oil-contaminated wastewater represents a major source of industrial pollution, posing significant risks to both the environment and human health. Traditional oil-water separation methods, including gravity separation, centrifugal separation, and air flotation, are limited by their processing efficiency and scope of applicability. In recent years, innovative oil-water separation technologies have gained considerable attention, particularly those utilizing adsorption, filtration, and membrane separation, owing to their high efficiency and environmental sustainability.

Prosthesis-Patient Mismatch in Young and Low-Risk Patients After Newer Generation Balloon-Expandable Transcatheter Aortic Valve Replacement.

Background: The clinical impact of prosthesis-patient mismatch (PPM) after transcatheter aortic valve replacement (TAVR) is not well known in young and low-risk patients.

Objectives: The aim of this single-center study was to evaluate the incidence, predictors, and long-term impact of PPM in young and low-risk patients with severe native aortic stenosis (AS) following TAVR.

Methods: From August 2015 to December 2022, a total of 3,549 patients underwent TAVR with newer generation balloon-expandable valves.

Hydroperiodic dynamics of microbial-mediated nitrogen cycling and its multi-element coupling effect in the Weihe River.

The aquatic ecosystem is affected by both human activities and climate change, and the excessive input and imbalance of nitrogen (N) have become an environmental issue of global concern. In this study, based on metagenomic sequencing, network analysis, random forest and structural equation model were used to investigate the hydroperiod dynamics, driving mechanisms of N cycling and the coupling effects of N, carbon (C) and sulfur (S) cycling in the Weihe River. The results showed that the nitrogen concentration and pathways exhibited heterogeneity during the high, normal and low water periods.

Natural products in rheumatoid arthritis: Cell type-specific mechanisms and therapeutic implications.

Background: The pathogenesis of rheumatoid arthritis (RA) involves abnormal activation and interactions among various cell types. Traditional Chinese medicine (TCM) natural products show therapeutic potential with multi-target anti-inflammatory effects, but their specific impacts on RA-related cell types remain unclear.

Purpose: This review aims to provide a comprehensive overview of the effects of natural products on key cell types in RA.

Palladium-Catalyzed Regio- and Monoselective B(2)-H Alkylation of Zwitterionic -Carboranes at Room Temperature in Water.

The achievement of regio- and monoselective control is a fundamental challenge for the development of efficient B-H functionalization of polyhedral carboranes bearing multiple chemically similar B-H bonds. While -polyhedral B-H activation of zwitterionic -carboranes has witnessed remarkable progress, developing direct functionalization methods for the closed polyhedral B-H bonds remains a significant challenge. Herein, we report the development of a regioselective B(2)-H monoalkylation of -carboranes enabled by a novel pyridyl directing group containing a NH group that can form a favorable macrocyclic intramolecular H-bonding interaction with the alkyl substituent.

Hydroxysafflor yellow A ameliorates myocardial ischemia/reperfusion injury by promoting MDH1-mediated mitochondrial metabolic homeostasis.

Background: Myocardial ischemia/reperfusion injury (MIRI) is a critical complication in the management of acute myocardial infarction, substantially compromising clinical outcomes. Hydroxysafflor yellow A (HSYA), a natural compound derived from Carthamus tinctorius L., has been approved by the National Medical Products Administration for the management of cardiovascular and cerebrovascular diseases.

Patterns of sleep problems and associated factors in older people living with HIV: A latent class analysis.

BackgroundTo identify sleep subtypes and associated factors in older people living with HIV (PLWH).MethodsA cross-sectional study was conducted to recruit older PLWH in Wuxi, China. Sleep quality was assessed using the Pittsburgh Sleep Quality Index.