Facet-dependent Heterogeneous Fenton Reaction Mechanisms on Hematite Nanoparticles for (Photo)catalytic Degradation of Organic Dyes.

Although heterogeneous photo-Fenton reactions on nanoparticulate iron oxides effectively degrade organic pollutants, the underlying surface mechanisms remain debated. Here, we demonstrate how these pathways are modulated by specific hematite crystal facets. To investigate the influence of particle surface structure, methylene blue (MB) adsorption and photodegradation kinetics are examined using facet-engineered hematite nanoparticles with distinct exposed facets.

Integrated network pharmacology and transcriptomics analysis elucidated the underlying mechanisms by which Pegaeophyton scapiflorum alleviated LPS-induced acute lung injury.

Ethnopharmacological Relevance: Acute lung injury is one of the most fatal lung diseases and has a significant impact on mortality and morbidity. Currently, ALI treatment options remain limited. Pegaeophyton scapiflorum (DHJ) has been documented in Dumu Materia Medica, as clearing heat from the lungs, and are clinically used for respiratory disorders.

Acoustofluidic system for targeted antibody removal in transplantation: Enabling small-volume therapeutic apheresis.

Antibody-mediated rejection is a leading cause of allograft failure and mortality in pediatric solid organ transplant recipients. Current apheresis systems require large blood volumes and are primarily designed for adults, making them unsuitable for children and small animals. These systems often indiscriminately remove both harmful and protective antibodies, increasing the risk of complications such as life-threatening infections.

Comparative Pharmacokinetics of Five Major Ingredients in Normal and Atherosclerotic Rats after Oral Administration of Shenlian Formula.

Introduction: Shenlian formula (SL) has been widely used to treat various diseases, including type 2 diabetes mellitus and atherosclerosis (AS). Pathological states can significantly alter drug pharmacokinetics (PK) compared to normal physiology, primarily by modulating biological membrane permeability and metabolic enzyme activity, thereby affecting drug absorption, distribution, metabolism, and excretion. However, the specific influence of AS on the PK profile of SL remains uncharacterized.

[Effects of combined use of active ingredients in Buyang Huanwu Decoction on oxygen-glucose deprivation/reglucose-reoxygenation-induced inflammation and oxidative stress of BV2 cells].

This study aims to explore the effects and action mechanisms of the active ingredients in Buyang Huanwu Decoction(BYHWD), namely tetramethylpyrazine(TMP) and hydroxy-safflor yellow A(HSYA), on oxygen-glucose deprivation/reglucose-reoxygenation(OGD/R)-induced inflammation and oxidative stress of microglia(MG). Network pharmacology was used to screen the effective monomer ingredients of BYHWD and determine the safe concentration range for each component. Inflammation and oxidative stress models were established to further screen the best ingredient combination and optimal concentration ratio with the most effective anti-inflammatory and antioxidant effects.

Efficacy and safety of different doses of dexmedetomidine on gastrointestinal function recovery after laparoscopic colorectal surgery.

Background: Postoperative gastrointestinal recovery affects hospital stay time and patient's quality of life. Studies suggest that the use of dexmedetomidine during the perioperative period can promote post operational recovery of gastrointestinal function.

Aim: To evaluate the efficacy and safety of different doses of dexmedetomidine on postoperative gastrointestinal function recovery after laparoscopic colorectal surgery.

Risk factors and predictors of contralateral hip fracture after surgical treatment in elderly patients.

Background: Hip fractures are common in elderly patients, with some experiencing contralateral fractures. Even so, information on predictors of hip fractures in elderly adults is lacking. In this study, we investigated risk factors for contralateral hip fractures after surgical treatment of primary fractures.

Essential Oil-Antibiotics Synergistic Delivery Strategy via Phenylboronic-Acid-Functionalized Liposomes for Targeted Treatment of MRSA Pneumonia.

Methicillin-resistant (MRSA)-induced pneumonia has become a major global public health challenge due to its high mortality and drug resistance. Essential oils, derived from plants, offer a promising solution to combat resistance owing to their low cytotoxicity and multitarget antimicrobial properties. This study designed a phenylboronic acid (PBA)-functionalized liposomal codelivery system (P-Lip@CE) to reverse MRSA resistance by synergistically delivering cefazolin sodium (Cefas) and essential oil (EOFAZ).

Caspase-9 activates β-catenin signaling to promote pulmonary fibrosis.

Background: Pulmonary fibrosis (PF) is a progressive interstitial lung disease marked by extracellular matrix accumulation and epithelial damage, with limited therapeutic options. Alveolar epithelial cell apoptosis is a key pathological hallmark of PF, but the upstream regulators driving this process remain unclear. Caspase-9, a central initiator of the intrinsic apoptotic pathway, has been implicated in fibrotic diseases across multiple organs.

Investigating the role of transposable elements in shaping abdominal fat and egg production phenotypic traits in geese.

While transposable elements (TE) are critical drivers of genomic diversity, their influence on phenotypic traits in geese remain largely unexplored, primarily because most research has focused on single nucleotide polymorphisms (SNP). In this study, we identified 157,044 TE absence polymorphisms (TAP) in the genome of 566 Sichuan White geese through whole-genome resequencing (with an average coverage depth of 12.44 ×) to evaluate their influence across different populations, and we extended our investigation to include a TE genome-wide association study (TE-GWAS) encompassing 48 traits, with a particular focus on abdominal fat weight.

Trends and Characteristics of Pertussis Epidemic in Pediatric Patients During and After the COVID-19 Pandemic in East China.

Background: Pertussis is a highly contagious respiratory disease caused by Bordetella pertussis, posing a significant health threat to children. Despite vaccination efforts, a resurgence of pertussis has been observed globally, especially during and after the COVID-19 pandemic. This study aims to investigate the epidemiological trends and characteristics of pertussis among pediatric patients during and after the COVID-19 pandemic in East China.

Global and regional molecular epidemiology of HIV-1 among men who have sex with men: a systematic review and meta-analysis.

Objectives: The diversity of HIV-1 genotypes among Men who have sex with men (MSM) globally has changed considerably. The purpose of this study to assess the global prevalence of HIV-1 genotypes among MSM.

Methods: PubMed, Embase, Scopus, and Web of Science were systematically searched to identify the articles.

Strategies of overcoming osimertinib resistance in EGFR-mutated non-small cell lung cancer.

Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has significantly advanced the treatment of non-small cell lung cancer (NSCLC), particularly in patients who develop resistance to first- and second-generation EGFR-TKIs. However, most patients inevitably develop resistance to the treatment, which presents a major challenge for long-term disease control. The molecular mechanisms underlying osimertinib resistance are complex and are generally categorised into EGFR-dependent and EGFR-independent pathways.

Do Family Physicians' Recommendations for Influenza and Pneumococcal Vaccines Impact the Elderly Aged ≥60 Years? A Cross-Sectional Study in Six Chinese Cities.

: Influenza vaccine and pneumococcal vaccine are essential to protect the health of older adults. This study focuses on the impact of family physicians' recommendations on influenza and pneumococcal vaccine uptake among urban Chinese older adults and makes recommendations for improving vaccination rates. : A cross-sectional survey on influenza vaccination and pneumonia vaccination was conducted in December 2024 in six cities in China among adults aged ≥60 years.

New insights into soil bacteria communities in Beijing urban greenspace based on urbanization gradient.

Research on urban soils has traditionally neglected two significant dimensions: the spatial heterogeneity emerging within megacity resulting from varying urbanization rates, and the dynamic responses of soil microbial communities to ongoing urban expansion processes. To address these research gaps, we propose a new approach to study soil bacterial communities based on urbanization gradients. Beijing is divided into three regions according to urbanization gradient by machine learning method.

Spatiotemporal patterns and propagation of meteorological and hydrological drought in a humid basin of Southeast China.

Droughts have caused great damage due to climate change and intensified human activities. Quantifying the propagation law of meteorological drought (MD) to hydrological drought (HD) is essential for drought warning, defense and adaption. In this study, based on the standardized precipitation evapotranspiration index (SPEI) and standardized runoff index (SRI), we analyzed the spatiotemporal characteristics and propagation patterns of MD and HD 1975-2020 in Minjiang River Basin (MRB) located in Southeast China.

Effects of Combined Salt and Heat Stress on Agronomic Traits, Photosynthetic Parameters, and Physiological Biochemistry in Six Alfalfa ( L.) Cultivars.

Climate change due to global warming increases the susceptibility of plants to multiple combined stresses. Soil salinization and high temperature stresses that co-occur in arid/semiarid regions severely restrict the growth and development of plants. Although alfalfa ( L.

Personalized Federated Learning Based on Dynamic Parameter Fusion and Prototype Alignment.

To address the limitation of generalization of federated learning under non-independent and identically distributed (Non-IID) data, we propose FedDFPA, a personalized federated learning framework that integrates dynamic parameter fusion and prototype alignment. We design a class-wise dynamic parameter fusion mechanism that adaptively fuses global and local classifier parameters at the class level. It enables each client to preserve its reliable local knowledge while selectively incorporating beneficial global information for personalized classification.

Preparation and characterization of a iRGD-modified recombinant spider silk particles for antitumor polypeptide drug delivery into cancer cells.

Spider silk is highly attractive material because of its superior mechanical properties and excellent biocompatibility, enabling it to self-assemble into a wide range of morphological structures for drug delivery system. However, most spider silk particles developed as drug carriers are based on complex repetitive domains of spider silk proteins and exhibit relatively large particle sizes (> 300 nm), which limits their biomedical applications. In this study, we engineered a novel recombinant spider silk protein (NC-iRGD) by integrating terminal domains derived from major ampullate silk and the tumor-penetrating peptide iRGD.

Bioactive Spirocyclic C-Arylglycosides From the Fungal-Fungal Co-Culture of Pestalotiopsis sp. and Nigrospora sp.

Introduction: In this study, two new papulacandin analogs (1-2), together with 12 known compounds (3-14), were identified from the co-culture of two endophytic fungi, Pestalotiopsis sp. J025 and Nigrospora sp. Wn-2-2, which were isolated from Wikstroemia nutans Champ.

[A reporter gene assay for determining antibody-dependent cell-mediated phagocytosis activity of HER2-targeted antibody drug conjugate].

To develop a method for determining the antibody-dependent cell-mediated phagocytosis (ADCP) activity of human epidermal growth factor receptor 2 (HER2)-targeted antibody drug conjugate (ADC) based on the reporter gene assay, we established an ADCP activity assay with Jurkat/NFAT/FcγRIIa cells as the effector cells and BT474 as the target cells. Then, the target cell density, the ratio of effector to target cells, the target cell adhesion time, the incubation time for drug administration, and the induction time after adding effector cells were optimized by the method of design of experiment (DOE). The method showed a significant dose-response relationship, which was complied with the four-parameter equation: =(A-D)/[1+(/C)]+D.

The effects of permissive hypercapnia on regional cerebral oxygen saturation and postoperative delirium in obese patients undergoing laparoscopic bariatric surgery: a randomized controlled trial.

Background: The aim of the study was to investigate the effect of permissive hypercapnia on regional cerebral oxygen saturation (rScO2) in obese patients undergoing sleeve gastrectomy and its association with the development of delirium.

Methods: In this randomized controlled trial, 83 patients undergoing elective laparoscopic sleeve gastrectomy were randomly divided into two groups. Respiratory parameters were adjusted to achieve the target PaCO2 in each group by pressure-controlled ventilation-volume guaranteed (PCV-VG) mode.

Liquiritigenin Restores Declined Oocyte Quality and Improves Embryo Development in Aged Mice.

Ovarian aging leads to a decline in oocyte quality and reduced reproductive potential, which is one of the main challenges faced by assisted reproductive technology (ART). Oxidative stress (OS) is a major contributor to this decline. In this study, we investigated the protective effects of natural flavonoid compound liquiritigenin (LQ) on oocyte maturation and embryo development in aged mice.

The impact of psychological nursing interventions on occupational burnout in sterilization supply center personnel: A retrospective analysis.

This study investigates the prevalence of occupational burnout among hospital sterilization supply center staff and evaluates the effectiveness of psychological interventions in mitigating burnout and associated mental health concerns, such as anxiety and depression. A retrospective analysis was conducted on 120 sterilization supply center employees, categorized into an intervention group (n = 40) receiving structured psychological support-including stress management, emotional regulation training, and mindfulness practices-and a nonintervention group (n = 80). Burnout levels were assessed using the Maslach Burnout Inventory (MBI), while the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) measured anxiety and depression, respectively.