Broad learning system via adaptive maximum weighted correntropy.

Broad Learning System (BLS) is widely used in various regression problems due to its simple structure and strong generalization ability. The standard optimized method for BLS is sensitive to the noise and outliers since it uses the Minimum Mean Square Error (MMSE) criterion, which may decrease the model's accuracy. As a solution, an Adaptive Maximum Weighted Correntropy - based BLS (AMWC-BLS) is proposed in this paper.

Prognostic impact and characteristics of ROS1 fusion in patients with surgically resected lung adenocarcinoma.

Objective: We aimed to investigate the prognostic significance of ROS1 fusion in surgically resected lung adenocarcinoma (LUAD).

Materials And Methods: Consecutive patients who underwent complete resection and ROS1 testing between 2015 and 2020 were included. Propensity score matching (1:2) was applied to balance baseline characteristics.

Mechanisms of Propolis Ethanol Extracts to Alleviate Sarcopenia based on Network Pharmacology and Experimental Validation.

Introduction: Sarcopenia (Sar) is an age-related loss of muscle mass and function. Propolis, a natural product with anti-inflammatory properties, may help prevent Sar, but its active components and mechanisms remain unclear.

Methods: Network pharmacology identified intersecting targets of propolis ethanol extract (PEE) and Sar.

Analyzing the correlation between the longitudinal trajectories of blood urea nitrogen and 30-day survival in hemorrhagic stroke patients.

Background: While some studies suggest a link between blood urea nitrogen (BUN) levels and adverse outcomes in hemorrhagic stroke (HS) patients, the prognostic value of longitudinal BUN changes remains unclear.

Objective: To evaluate the association between longitudinal BUN trajectories and 30-day mortality risk in HS patients.

Methods: We analyzed HS patients from the MIMIC-IV database diagnosed within 24 hours of hospitalization.

Utilisation of AI-driven chatbots for perioperative health information seeking: a descriptive qualitative study of orthopaedic patients and family members.

Objective: This study aimed to explore orthopaedic patients' and families' experiences with artificial intelligence (AI)-driven chatbots for perioperative health information, focusing on usability, effectiveness and perceptions.

Design: A descriptive qualitative design was employed.

Setting: This study was conducted at a regional care centre for orthopaedics.

Rational Design of Purely Inorganic Self-Healing Colloidal Hydrogels To Enable "Green" 3D Printing of Bioglass-Based Bone Substitutes.

3D printing of ceramics or glass typically requires sacrificial organic plasticizers and high-temperature sintering, which is time- and cost-consuming, potentially cytotoxic, and may compromise the bioactivity and functionality of the inorganic components. We herein developed purely inorganic self-healing colloidal gels, consisting of electrostatically attractive silica-based hard nanospheres, to enable 3D printing of highly strong inorganic constructs via additive-free and low temperature sintering (LTS) processing. Through cross-scale analysis of the structural and mechanical features, we quantitatively described the constitutive relationship of attractive colloidal gels based on the integration of colloidal assembly theory with experimental characterizations.

A fully digital approach to autonomous robot-assisted immediate implant and interim restoration placement in the maxillary anterior esthetic zone: A case series.

Statement Of Problem: Immediate implant and interim restoration placement in the maxillary anterior esthetic zone presents challenges in achieving optimal implant positioning, esthetics, and peri-implant tissue stability. A more accurate and efficient clinical workflow is needed to address these demands.

Purpose: This study aimed to establish a fully digital workflow that combines autonomous robotic-assisted immediate implant placement and prefabricated interim restorations in the maxillary anterior esthetic region and to evaluate its accuracy and short-term clinical outcomes.

A non-specific lipid transfer protein gene HcnsLTP111 positively regulates drought and salt stress tolerance in kenaf (Hibiscus cannabinus L.).

Kenaf (Hibiscus cannabinus L.), an important bast fiber crop with strong abiotic stress tolerance, holds significant significance in the utilization of saline-alkali land and other marginal lands. Non-specific lipid transfer protein (nsLTPs) are key regulators of plant stress responses, yet their roles in kenaf and the underlying molecular mechanisms remain uncharacterized.

The impact of nutritional intervention and resistance training on muscle strength and mass in healthy older adults-a comparative analysis.

Objective: A growing body of evidence confirms that nutritional supplementation strategies combined with resistance training can enhance muscle strength and mass in older adults. However, the optimal supplementation approach remains unclear. This study aimed to evaluate the comparative efficacy of different nutritional interventions combined with resistance training on muscle strength and mass in healthy older adults and determine the optimal strategy.

Functional characterization of NLG14 provides novel insights into the synergistic improvement of grain length, grain quality and salt tolerance in rice.

Rice, as a vital food crop, faces persistent challenges in breeding programs aimed at achieving stable high yield under environmental stresses due to intrinsic trade-off mechanisms. This study functionally characterizes NARROW AND LONGER GRAIN 14 (NLG14), which encodes a spermine synthase. Loss-of-function nlg14 mutants exhibit slender grains due to enhanced cell expansion and proliferation, alongside significantly improved grain quality-manifested as reduced chalkiness, lower amylose/protein content, higher gel consistency, and superior taste value.

Development of cardiovascular clinical research data warehouse and real-world research.

Background: Medical informatics accumulated vast amounts of data for clinical diagnosis and treatment. However, limited access to follow-up data and the difficulty in integrating data across diverse platforms continue to pose significant barriers to clinical research progress. In response, our research team has embarked on the development of a specialized clinical research database for cardiology, thereby establishing a comprehensive digital platform that facilitates both clinical decision-making and research endeavors.

Impact of body composition on prognostic stratification and survival in periampullary carcinoma after pancreatoduodenectomy.

Objectives: To evaluate the prognostic impact of preoperative body composition parameters and their changes at three months post-pancreatoduodenectomy (PD) on overall survival (OS) and recurrence-free survival (RFS) in periampullary carcinoma patients.

Materials And Methods: This retrospective study analyzed 505 patients (294 males, mean age 62.58 ± 9.

Development and validation of an interpretable machine learning model for predicting venous thromboembolism in ICU patients with traumatic brain injury: a multicenter study.

Objective: To develop and validate a machine learning (ML) model predicting venous thromboembolism (VTE) risk in ICU patients with traumatic brain injury (TBI).

Methods: Utilizing data from 1,564 TBI patients in MIMIC-IV (2008-2021), models were trained (80%) and tested (20%). We used 304 TBI patients from the 904th Hospital of the Joint Support Force of the Chinese People's Liberation Army's ICU (2021-2024) as an external validation cohort.

TRIM2 inhibits apoptosis by ubiquitinating BNIP3 to protect the intestine against ischemia-reperfusion injury in mice.

Intestinal damage following interrupted blood flow and its return (intestinal ischemia/reperfusion injury) is a serious medical problem occurring in various clinical situations. While the death of intestinal epithelial cells is a key factor, the precise reasons behind this cell death are not fully known. In this study, we identified significant downregulation of an E3 ubiquitin ligase TRIM2 in mouse models of this injury and in cells mimicking the condition.

YOLO-PTHD: A UAV-Based Deep Learning Model for Detecting Visible Phenotypic Signs of Pine Decline Induced by the Invasive Woodwasp (Hymenoptera, Siricidae).

is an invasive pest that contributes to pine tree decline, leading to visual symptoms such as needle discoloration, crown thinning, and eventual tree death. Detecting these visible phenotypic signs from drone imagery is challenging due to elongated or irregular crown shapes, weak color differences, and occlusion within dense forests. This study introduces YOLO-PTHD, a lightweight deep learning model designed for detecting visible signs of pine decline in UAV images.

Vertebral Fracture Prediction From MRI-based Vertebral Bone Quality Scores in Postmenopausal Women: A Longitudinal Cohort Study.

Study Design: A longitudinal cohort study.

Objective: The study aims to assess the lumbar MRI-based vertebral bone quality (VBQ) score and dual energy x-ray absorptiometry (DXA) T score in a longitudinal cohort of postmenopausal women and to evaluate the performance of these scores in predicting VF over 5 years of follow-up.

Summary Of Background Data: VBQ scores can be used for osteoporosis screening and identification of vertebral fractures (VFs).

Water Film-Mediated Hydrolysis of Pyrophosphate on a Nanosized Mn Oxide.

The geochemical behaviors of phosphate-containing species at mineral surfaces are of fundamental importance for controlling phosphorus (P) mobility, fate, and bioavailability. Understanding these interfacial behaviors in water-unsaturated environments, where minerals are covered by thin water films, is of special importance in the context of soil vadose zone geochemistry. This study resolved the transformation of pyrophosphate to orthophosphate within the confines of nanometer-thick water films condensed on nanosized birnessite (MnO).

Smart-SNPer: Automated crRNA design for ultrasensitive RPA-Cas12a SNP detection.

Single-nucleotide polymorphism (SNP) detection is critical for precision medicine but is often hindered by complex workflows in resource-limited settings. Here, we introduce Smart-SNPer (https://smart-crisprer.com), a one-click, structure-guided crRNA design tool that automates the development of highly specific RPA (Recombinase Polymerase Amplification)-Cas12a assays (CORDSv2).

Photothermally Responsive Biomimetic Composite Scaffolds Based on Polydopamine-Functionalized Nanoparticles/Polyurethane for Bone Repair.

In this study, a shape-changeable 3D scaffold with photothermal effects was developed to address the clinical challenges of complex bone defects. The multifunctional construct was fabricated via in situ polymerization combined with a gas foaming technique, creating hierarchical porous architectures that mimic the native bone extracellular matrix. By incorporating polydopamine (PDA)-modified amorphous calcium phosphate (CA) into poly(propylene glycol) (PPG)- and poly(ԑ-caprolactone) (PCL)-based polyurethane (PU).

De Novo Design of Photosensitizers Activated by Tumor Microenvironments for NIR Imaging and Photodynamic Therapy of Tumor.

Photodynamic therapy (PDT) has emerged as a commonly employed treatment for cancer patients. However, existing photosensitizers exhibit inadequate selectivity toward cancer cells and are susceptible to penetration depth. Herein, we de novo designed an activatable photosensitizer theranostic platform (), extended the excitation light to the near-infrared (NIR) region, which contained an iodinated thiohemicyanine moiety as the strong photosensitizing fluorophore and a hydroxyl as the regulated group.

Esculetin inhibits ferroptosis after ICH by promoting NUDT1-mediated m7G methylation modification of GPX4.

Intracerebral hemorrhage (ICH) is the most morbid of all stroke types with a high mortality and significant disability burden. Inhibiting ferroptosis after ICH will effectively treat ICH and improve prognosis. Esculetin is the main active ingredient of the Chinese medicine Cortex Fraxini, which has neuroprotective effects.

Interleukin-10 Mitigates Chondrocyte Ferroptosis Associated With Haemophilic Arthropathy via Modulation of the STAT3 Signalling Pathway.

Introduction: Haemophilic arthropathy (HA) is characterized by recurrent intra-articular bleeding leading to cartilage degeneration. Ferroptosis plays a critical role in this process. While IL-10 is known to inhibit apoptosis, its effect on ferroptosis remains unexplored.

Zwitterionic Binder-Engineered Interfaces Enable Anti-Pulverization and Long-Cycling Anode-Free Zn Batteries.

Anode-free zinc batteries (AFZBs) offer exceptional theoretical energy density, yet suffer from severe structural pulverization and dendritic growth during cycling, leading to rapid capacity decay and poor reversibility. To address these challenges, this work proposes a novel zwitterionic binder strategy that concurrently suppresses Zn pulverization and stabilizes the electrode-electrolyte interface. Incorporation of a rationally designed zwitterionic polymer binder (ZPB) endows the engineered Zn anode with unprecedented mechanical robustness and homogeneous ion flux distribution.

Efficacy and safety of neoadjuvant toripalimab plus chemotherapy in localized deficient mismatch repair/microsatellite instability-high gastric or esophagogastric junction adenocarcinoma (NICE): a multicentre, single-arm, exploratory phase 2 study.

Background: In locally advanced gastric or gastroesophageal junction adenocarcinoma (GC/EGJC), deficient mismatch repair/microsatellite instability-high (dMMR/MSI-H) tumors exhibit high responsiveness to immunotherapy. The synergistic efficacy of neoadjuvant immunotherapy combined with chemotherapy in dMMR/MSI-H GC/EGJC remains uncertain.

Methods: The NICE trial is a multicentre, single-arm, exploratory phase 2 study conducted at six hospitals in China, evaluating the safety and efficacy of toripalimab in combination with CapeOX as perioperative therapy for locally advanced GC/EGJC across three biomarker-defined cohorts.