The impact of nutritional intervention and resistance training on muscle strength and mass in healthy older adults-a comparative analysis.

Objective: A growing body of evidence confirms that nutritional supplementation strategies combined with resistance training can enhance muscle strength and mass in older adults. However, the optimal supplementation approach remains unclear. This study aimed to evaluate the comparative efficacy of different nutritional interventions combined with resistance training on muscle strength and mass in healthy older adults and determine the optimal strategy.

Using WGCNA and transcriptome profiling to identify hub genes for salt stress tolerance in germinating soybean seeds.

Salinized soil can significantly hinder soybean growth, leading to a reduction in overall yield. To address this issue, identifying key genes related to salt tolerance in soybeans is essential for improving their resistance to salinity and ensuring sustainable development of soybean production. While current research predominantly focuses on salt tolerance during the seedling stage, there is still a lack of comprehensive studies on the genes involved in salt tolerance during the germination stage.

Efficacy and safety of two tip flexible suctioning ureteral access sheaths combined with a 7.5Fr flexible ureteroscope: a retrospective study.

Objective: This study aimed to compare the efficacy and safety of two tip-flexible suctioning ureteral access sheaths (TFS-UAS), 12/14Fr (Group A) and 10/12Fr (Group B), combined with a 7.5Fr flexible ureteroscope (f-URS) for treating upper ureteral and renal stones.

Methods: A retrospective analysis of 168 patients undergoing retrograde intrarenal surgery (RIRS) was conducted.

A Novel Deep Learning Radiomics Nomogram Integrating B-Mode Ultrasound and Contrast-Enhanced Ultrasound for Preoperative Prediction of Lymphovascular Invasion in Invasive Breast Cancer.

Objective: This study aimed to develop a deep learning radiomics nomogram (DLRN) that integrated B-mode ultrasound (BMUS) and contrast-enhanced ultrasound (CEUS) images for preoperative lymphovascular invasion (LVI) prediction in invasive breast cancer (IBC).

Methods: Total 981 patients with IBC from three hospitals were retrospectively enrolled. Of 834 patients recruited from Hospital I, 688 were designated as the training cohort and 146 as the internal test cohort, whereas 147 patients from Hospitals II and III were assigned to constitute the external test cohort.

HIF-independent oxygen sensing via KDM6A regulates ferroptosis.

Ferroptosis, a metabolic cell death process driven by iron-dependent phospholipid peroxidation, is implicated in various pathologies, including cancer. While metabolic factors such as glucose, lipids, and multiple amino acids have all been demonstrated to modulate ferroptosis, the role of oxygen, another fundamental metabolic component, in ferroptosis is not fully understood. Here, we show that cells acclimated to a low oxygen environment develop marked resistance to ferroptosis, and this resistance is independent of canonical oxygen-sensing pathway mediated by prolyl hydroxylases (PHDs) and HIF transcription factors.

Miniaturized optically-generated Bessel beam ultrasound for volumetric transcranial brain stimulation.

Non-invasive stimulation of small, variably shaped brain sub-regions is crucial for advancing our understanding of brain functions. Current ultrasound neuromodulation faces two significant trade-offs when targeting brain sub-regions: miniaturization versus volumetric control and spatial resolution versus transcranial capability. Here, we present an optically-generated Bessel beam ultrasound (OBUS) device designed to overcome these limitations.

Copper(II)-Catalyzed Enantioselective Friedel-Crafts Alkylation Reactions of 1-Naphthols and Electron-Rich Phenols with Trifluoropyruvates.

By fine-tuning the electronic and steric properties of the chiral ligands, chiral Cu(II) complex-catalyzed enantioselective Friedel-Crafts alkylation/lactonization of 1-naphthols and electron-rich phenols with trifluoropyruvates provided the desired products with up to 99% ee and up to 99% yield. The reactions were carried out on a gram scale with low catalyst loading. Especially, the optically pure GABA positive allosteric modulator ()-BHFF was prepared using this protocol.

Arbuscular mycorrhizal fungi confer aluminum toxicity tolerance in Ricinus communis via modulating root metabolic mechanisms and the composition and quantity of root exudates.

Aluminum (Al) phytotoxicity is an essential factor that severely threatens plant productivity in acidic soil with pH < 5. Nevertheless, the specific interactions and functional contributions of arbuscular mycorrhizal fungus (AMF) in the adaptability of Ricinus communis to Al stress remain poorly understood. In this study, we investigated the changes in biomass, Al accumulation, antioxidant system, sucrose metabolism, gene expression, and root exudates of R.

Aqueous Eutectic Electrolytes Design for Advanced Rechargeable Zinc-Ion Batteries.

Rechargeable aqueous zinc-ion batteries (RAZIBs) have emerged as leading candidates for next-generation large-scale energy storage systems, owing to their environmental sustainability, cost-effectiveness, and operational safety. Nevertheless, in conventional aqueous electrolytes (AEs), the rampant dendrite growth, parasitic hydrogen evolution reactions (HER), and progressive cathode dissolution in RAZIBs fundamentally constrain their practical application. Addressing these limitations through electrolyte engineering has thus become a pivotal research frontier for developing practical RAZIBs.

Characterization of two novel angiotensin converting enzyme-inhibitory peptides from yellow tuna peptides: Inhibitory mechanism, transport route and network pharmacology analysis.

Angiotensin-converting enzyme inhibitory peptides (ACEIPs) from natural food sources are effective alternatives for treating hypertension. This study aims to screen highly active ACEIPs from yellow tuna peptides, and to elucidate their inhibitory mechanism, stability, transport mechanism and potential antihypertensive mechanism by a multiple approach. Two novel ACEIPs STHPHF (IC = 30.

Enhancing prognostic accuracy in invasive breast cancer by combining contrast-enhanced ultrasound and clinical data: a multicenter retrospective study.

Background: Current predictive models for disease-free survival (DFS) in invasive breast cancer predominantly utilize clinical and pathological factors, with minimal incorporation of ultrasound (US) and contrast-enhanced ultrasound (CEUS) characteristics. This study aimed to establish a multimodal map integrating US, clinical features, and US data to enhance the prediction of DFS in invasive breast cancer.

Methods: The study utilized three retrospective datasets obtained from three academic medical centers, covering the period from March 2014 to December 2022.

Labeling of Pathogenic Tau Using Photo-Affinity Chemical Probes.

Tau aggregation plays a crucial role in the development of Alzheimer's disease (AD). Developing specific techniques that can isolate pathogenic tau from brain tissue is important for understanding tauopathies and advancing targeted therapies. Here, we develop photoaffinity small molecular probes and a novel method for tissue labeling and investigate their activity in interacting with tau in cells and AD patient brains.

Predicting Microvascular Invasion and Early Recurrence in Hepatocellular Carcinoma Using DeepLab V3+ Segmentation of Multiregional MR Habitat Images.

Rationale And Objectives: Accurate identification of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) is crucial for treatment and prognosis. Single-modality and feature fusion models using manual segmentation fail to provide insights into MVI. This study aims to develop a DeepLab V3+ model for automated segmentation of HCC magnetic resonance (MR) images and a decision fusion model to predict MVI and early recurrence (ER).

Replacing rice straw with peanut vine and silage in beef cattle feed reduced the use of soybean meal.

The present study investigated whether replacing dietary rice straw with peanut vine (PEV) and silage (BPS) reduces the use of soybean meal and explored its effects on the growth performance, blood biochemical indicators, serum metabolomics, and meat quality of fattening bulls. Forty-five Simmental crossbred bulls (initial body weight = 484.29 ± 8.

Analysis of efficacy of picosecond laser treatment for nevus of Ota.

To analyze the efficacy, safety, and influencing factors of 1064 nm picosecond Nd: YAG laser(PSAL)treatment for Nevus of Ota. From January 2018 to March 2024, 212 patients with Nevus of Ota were treated with 1064 nm picosecond Nd: YAG laser at the Guangzhou Dermatology Hospital. The study analyzed the impact of patient gender, age, Tanino classification of skin lesions, color of skin lesions, Fitzpatrick classification of skin, and number of treatments on efficacy, while also documenting any adverse reactions to the treatment.

N, P-doped graphite/LiMnO hybrid electrode for high-performance all-climate dual-ion batteries.

Conventional lithium-ion batteries (LIBs) are nearing their theoretical capacity limit, and there is an urgent need to develop energy storage devices with higher energy densities and cycling stabilities. In this work, a hybrid electrode design, which combines the traditional "rocking chair" mechanism and "anion intercalation" mechanism to improve energy density is reported. The hybrid electrode is composed of LiMnO and N,P-doped graphite (NPG) to use both anion and cation storage mechanisms.

Progress in Preparation Technology and Functional Research On Marine Bioactive Peptides.

Marine bioactive peptides are a class of peptides derived from marine organisms that can optimize the body's metabolic environment and benefit the body's health. These peptides have attracted increasing amounts of attention due to their wide range of health-promoting effects. Additionally, they have the potential to ameliorate diseases such as hypertension, diabetes, influenza viruses, and inflammation and can be used as functional foods or nutritional supplements for the purpose of treating or alleviating diseases.

Assessing the Causal Effect of Circulating Protein-To-Protein Ratio on the Risk of Morbidity of Hepatocellular Carcinoma.

Objective: Several observational studies have identified an association between plasma proteins and hepatocellular carcinoma (HCC). This study aimed to explore the potential causal relationship between the circulating protein-to-protein ratio and the morbidity risk of HCC.

Methods: Genetic association data for circulating plasma proteins and 2821 protein-to-protein ratios were sourced from the UKB PPP and Suhre's study.

A Nomogram Based on MRI Visual Decision Tree to Evaluate Vascular Endothelial Growth Factor in Hepatocellular Carcinoma.

Backgrounds: Anti-vascular endothelial growth factor (VEGF) therapy has been developed and recognized as an effective treatment for hepatocellular carcinoma (HCC). However, there remains a lack of noninvasive methods in precisely evaluating VEGF expression in HCC.

Purpose: To establish a visual noninvasive model based on clinical indicators and MRI features to evaluate VEGF expression in HCC.

Copper(II)-Catalyzed Enantioselective Addition of Aryl Amines to Isatin-Derived -Boc-Ketimines for the Synthesis of Acyclic ,'-Ketals.

Here, we demonstrated a copper(II)-catalyzed enantioselective addition of aryl amines to isatin-derived -Boc-ketimines using chiral O-N-N tridentate ligands derived from BINOL and proline. Generally, the chiral acyclic ,'-ketals were obtained in high yields (up to 98%) and excellent ee values (up to 98%). Various aryl amines could be tolerated and a gram-scale reaction was also possible.

Strategies of positron emission tomography (PET) tracer development for imaging of tau and α-synuclein in neurodegenerative disorders.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by the presence of extracellular amyloid plaques consisting of β-amyloid peptides (Aβ) and intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau (pTau) protein in the brain. Genetic and animal studies strongly indicate that Aβ, tau and neuroinflammation play important roles in the pathogenesis of AD. Several staging models showed that NFTs correlated well with the disease progression.

Improving the quality of steamed bread with whole soybean pulp: Effects of ultrasonic treatment on protein structure and reduction of beany flavor.

Incorporation of whole soybean pulp (WSP) into wheat flour has been shown to improve the nutritional profile of steamed bread. However, this substitution often disrupts the protein network and introduces an undesirable beany flavor, compromising the overall quality of the steamed bread. This research explored the impacts of varying ultrasonic power levels on the quality of steamed bread containing WSP (WSPSB), with the goal of improving both the protein network structure and the flavor profile.

Regulation of the Rhizosphere Microenvironment by Arbuscular Mycorrhizal Fungi to Mitigate the Effects of Cadmium Contamination on Perennial Ryegrass ( L.).

Rhizosphere microorganisms are crucial for enhancing plant stress resistance. Current studies have shown that Arbuscular mycorrhizal fungi (AMF) can facilitate vegetation recovery in heavy metal-contaminated soils through interactions with rhizosphere microbiota. However, the mechanisms by which AMF influences rhizosphere microbiota and plant growth under cadmium (Cd) stress remain unclear.

Changes in composition and concentration of differential metabolites in root exudates are associated with aluminum-tolerance of Ricinus communis under a high CO environment.

Root exudates are the most direct performance for plants responding to adverse environments, and are also important media for materials exchange, energy transmission and information communication between the roots and rhizosphere. However, how plant roots and exudates respond to aluminum (Al) stress under elevated CO concentration (eCO) is still unclear. Ricinus communis is a famous oilseed crop throughout the world, which has strong tolerance to metal contaminated soil.