Publications by authors named "Yong-Lin Gao"
Angiotensin-converting enzyme inhibitory peptides (ACEIPs) from natural food sources are effective alternatives for treating hypertension. This study aims to screen highly active ACEIPs from yellow tuna peptides, and to elucidate their inhibitory mechanism, stability, transport mechanism and potential antihypertensive mechanism by a multiple approach. Two novel ACEIPs STHPHF (IC = 30.
View Article and Find Full Text PDFA novel role for microtubule affinity-regulating kinases in neuropathic pain.
Br J Pharmacol
July 2024
Article Synopsis
- Neuropathic pain is a prevalent issue affecting many people, with limited effective treatment options; this study investigates the potential role of microtubule affinity-regulating kinases (MARK1 and MARK2) in this type of pain.
- Researchers used a rat model of neuropathic pain and employed genetic knockdown of MARKs and a small molecule inhibitor to assess their influence on pain, cognitive function, and anxiety.
- The findings revealed that inhibiting MARKs can reduce pain-like behaviors and improve cognitive and motor deficits, suggesting that targeting MARKs may offer a new approach for treating neuropathic pain.
Background And Purpose: Indoleamine 2, 3-dioxygenase 1 (IDO1) has been linked to neuropathic pain and IDO1 inhibitors have been shown to reduce pain in animals. Some studies have indicated that IDO1 expression increased after neuropathic pain in hippocampus and spinal cord, whether these changes existing in anterior cingulate cortex (ACC) and amygdala remains obscure and how IDO1 inhibition leads to analgesia is largely unknown. Here, we evaluated the antinociceptive effect of PCC0208009, an indirect IDO1 inhibitor, on neuropathic pain and examined the related neurobiological mechanisms.
View Article and Find Full Text PDFBackground: Sleep disturbance has been implicated in both prodromal and syndromal phases of bipolar illness.
Methods: Charts of bipolar disorder (BD) patients who had been euthymic for at least 2 months were reviewed for mood symptoms, Clinical Global Impression scores, Global Assessment of Functioning scores, and sleep.
Results: Among 116 patients, 10 never achieved a euthymic interval of 2 months' duration.
[Expression and significance of Hsp70 and PCNA during the development of forestomach carcinoma in NIH mice].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
September 2004
Article Synopsis
- The study aimed to examine how heat shock protein 70 (Hsp70) and proliferating cell nuclear antigen (PCNA) express and relate to the development of forestomach carcinoma in mice induced with a carcinogen called NSEE.
- 144 NIH mice were tested, divided into 6 groups, and assessed for Hsp70 and PCNA expression levels every two weeks after NSEE infusion through immunohistochemical staining.
- Results showed that Hsp70 levels fluctuated but consistently increased, while PCNA expression gradually increased, with both proteins being strongly correlated as cancer progressed.