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Objective: This study aimed to compare the efficacy and safety of two tip-flexible suctioning ureteral access sheaths (TFS-UAS), 12/14Fr (Group A) and 10/12Fr (Group B), combined with a 7.5Fr flexible ureteroscope (f-URS) for treating upper ureteral and renal stones.
Methods: A retrospective analysis of 168 patients undergoing retrograde intrarenal surgery (RIRS) was conducted. Group A ( = 76) used a 12/14Fr TFS-UAS, while Group B ( = 92) used a 10/12Fr TFS-UAS. Primary outcomes included stone-free rates (SFR) (Grade I: ≤2 mm; Grade II: ≤4 mm fragments), operative times, and complications.
Results: Baseline characteristics were comparable between groups. Group A demonstrated significantly shorter operation (72.5 vs. 78.5 min, < 0.05) and lithotripsy durations (57.5 vs. 64.5 min, < 0.05). Immediate SFR (Grade I) was higher in Group A (86.8% vs. 71.7%, = 0.018), but 1-month SFR showed no difference (90.8% vs. 84.4%, = 0.242). Grade II SFR and complication rates (ureteric injury, fever, sepsis) were similar ( > 0.05).
Conclusion: The 12/14Fr TFS-UAS combined with a 7.5Fr f-URS offers superior lithotripsy efficiency and immediate SFR compared to the 10/12Fr variant, while maintaining comparable long-term outcomes and safety. These findings support its clinical preference for RIRS in upper tract calculi.
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http://dx.doi.org/10.3389/fsurg.2025.1628264 | DOI Listing |
FEMS Microbiol Rev
September 2025
CIISA - Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
African Swine Fever (ASF), caused by the highly contagious African swine fever virus (ASFV), poses a significant threat to domestic and wild pigs worldwide. Despite its limited host range and lack of zoonotic potential, ASF has severe socio-economic and environmental consequences. Current control strategies primarily rely on early detection and culling of infected animals, but these measures are insufficient given the rapid spread of the disease.
View Article and Find Full Text PDFJAMA Intern Med
September 2025
Bayer CC AG, Basel, Switzerland.
Importance: There is an unmet need for long-term, safe, effective, and hormone-free treatments for menopausal symptoms, including vasomotor symptoms (VMS) and sleep disturbances.
Objective: To evaluate the 52-week efficacy and safety of elinzanetant, a dual neurokinin-targeted therapy, for treating moderate to severe VMS associated with menopause.
Design, Setting, And Participants: OASIS-3 was a double-blind, placebo-controlled, randomized phase 3 clinical trial that was conducted at 83 sites in North America and Europe from August 27, 2021, to February 12, 2024, and included postmenopausal women aged 40 to 65 years who were seeking treatment for moderate to severe VMS (no requirement for a minimum number of VMS events per week).
Oncologist
September 2025
Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Background: Belzutifan is a HIF-2ɑ inhibitor approved for the treatment of tumors in von Hippel-Lindau (VHL) syndrome and sporadic metastatic clear cell renal cell carcinoma (spRCC) in the refractory setting. The efficacy and side effects of belzutifan are well-documented from clinical trials, however, real-world data examining the incidence and management of adverse events (AEs) are lacking. Our study aims to describe the AE profiles of belzutifan in spRCC and VHL populations.
View Article and Find Full Text PDFBioDrugs
September 2025
Department of Nephrology, Instituto de Investigación Hospital "12 de Octubre" (imas12), Avda. De Córdoba s/n, 28041, Madrid, Spain.
Anti-CD20 monoclonal antibodies are gaining clinical relevance in the nephrology community due to their demonstrated efficacy and favorable safety profiles across short-, medium-, and long-term use. Initially developed for hematologic malignancies and multiple sclerosis, B-cell depletion therapies are now being investigated across a broader spectrum of autoimmune diseases, including glomerulopathies, both with and without associated podocytopathy. Recent advances have led to the development of novel anti-CD20 agents that are being used not only as potential alternatives to corticosteroids but also as adjunctive therapies in complex clinical settings.
View Article and Find Full Text PDFAdv Ther
September 2025
Bristol Myers Squibb, Princeton, NJ, 08540, USA.
Background And Objectives: Deucravacitinib, a first-in-class, oral, selective, allosteric tyrosine kinase 2 inhibitor, demonstrated efficacy across the primary endpoint and all key secondary endpoints in the phase 2 PAISLEY SLE trial in patients with active systemic lupus erythematosus (SLE). Here, we describe 2 phase 3 trials [POETYK SLE-1 (NCT05617677), POETYK SLE-2 (NCT05620407)] which will assess the efficacy and safety of deucravacitinib in patients with active SLE. These phase 3 trials have been designed to replicate the successful elements of the phase 2 trial, including its glucocorticoid-tapering strategy and disease activity adjudication.
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