Development and validation of an interpretable machine learning model for predicting venous thromboembolism in ICU patients with traumatic brain injury: a multicenter study.

Objective: To develop and validate a machine learning (ML) model predicting venous thromboembolism (VTE) risk in ICU patients with traumatic brain injury (TBI).

Methods: Utilizing data from 1,564 TBI patients in MIMIC-IV (2008-2021), models were trained (80%) and tested (20%). We used 304 TBI patients from the 904th Hospital of the Joint Support Force of the Chinese People's Liberation Army's ICU (2021-2024) as an external validation cohort.

Interplay of social integration, well-being, and fairness in older migrant workers: a four -year longitudinal analysis.

In China, older migrant workers represent an especially vulnerable group, facing challenges to their quality of life as they grow older and move away from their hometowns. This study aimed to investigate the relationship between social integration, subjective well-being, and subjective fairness over a four-year period in a cohort of 1,394 older Chinese migrant workers aged 50 and older. Latent growth modeling showed a significant positive change over time in all three psychosocial constructs.

Clinical and genomic insights into Acinetobacter parvus: A rare pathogen with low antibiotic resistance and potential clinical implications.

Research Background: Traditionally seen as an environmental bacterium, Acinetobacter parvus has rarely been studied in clinical settings. Its role in human infections remains unclear, particularly in vulnerable populations. This study explores its biological traits, antibiotic resistance, and genomic features through the first systematic analysis of strain ZDL0830, isolated from an immunocompromised patient with an abscess.

Development of an End-Effector-Based System for Arm Support and Swing During Rehabilitation of Walking.

The theory of interlimb neural coupling suggests that arm swing should be integrated into gait training to promote neural control of walking. We previously developed a mobile gait trainer which followed the user during free overground walking. However, it did not provide assistance in the synchronised arm and leg movements.

Mechanical Development and Preliminary Control Results of a Cable-Driven Robotic Platform for Whole-Body Rehabilitation.

To promote whole-body rehabilitation in the early post-injury phase, a system is desirable to provide user transfer, automatic posture change and therapy for various arm-leg movements. This work aimed to present a cable-driven robotic platform that can provide whole-body rehabilitation for the user in a lying position and to demonstrate preliminary results for generation of 3D leg movements. Seventeen compact cable-driven actuators (CDAs) were designed and mounted on a robotic frame.

Dynamic changes in network structure of depressive symptoms: a two-year naturalistic follow-up study.

Background: Depression is a complex mental disorder, with much unknown about its dynamic symptom network. Investigating the topology and temporal dynamics of this network can uncover pathological mechanisms.

Methods: This is a longitudinal study with a 2-year follow up.

Knockdown of PARM1 Alleviates Aortic Valve Calcification via the PRKCH-MAPK Signaling Pathway.

With the aging of the population, the prevalence of calcific aortic valve disease (CAVD) has increased yearly. However, effective means to delay or even reverse the progression of CAVD are still lacking. This study revealed that prostate androgen-regulated mucin-like protein 1 (PARM1) expression was significantly up-regulated in calcified aortic valve tissues.

The mediating role of family functioning between childhood adversity and adult Health- related risk behaviors: a moderated mediation analysis of generational gap in Chinese migrant workers.

Background: Adverse Childhood Experiences have been implicated in a range of health-related risk behaviors in adulthood, but there is limited research on how these patterns manifest among internal migrant workers in China. This study aims to elucidate the mediating role of family functioning and explore generational differences in this relationship.

Methods: A cross-sectional study was conducted among two groups of migrant workers in China: first-generation migrant workers (FGWs) and new-generation migrant workers (NGMWs).

Risk discrepancies in COVID-19-related community environments based on spatiotemporal monitoring.

The geo-inequality of COVID-19 risk has attracted a great deal of research attention. In this study, the spatial correlation between community environment and the incidence of COVID-19 cases in 30 Chinese cities is discussed. The spread of the disease is analyzed based on timing and spatial monitoring at the km2-grid level, with the use of publicly available data relating to housing prices, Gross Deomestic Product (GDP), medical facilities, consumer sites, public green spaces, and industrial sites.

Development and validation of the medical students' self-reported selfishness questionnaire (MSSSQ): a context-specific design for assessing selfish tendencies in medical education.

Background: Selfishness, defined as the prioritization of one's own interests at the expense of others, can significantly influence the career choices and professional behavior of medical students. Understanding the levels of selfish tendency and preemptively detecting possible manifestations of selfish intents among medical students is essential for developing educational strategies that foster ethical and responsible conduct within the medical profession. This study aimed to develop and validate the Medical Students' Self-Reported Selfishness Questionnaire (MSSSQ), specifically designed to assess selfish tendencies amongst medical students.

Epidemiological characteristics and clinical treatment of melioidosis: a 11-year retrospective cohort study in Hainan.

Background: Melioidosis is a tropical infectious disease caused by , characterised by a high case fatality rate.

Objectives: We summarized the cases of melioidosis at Sanya People's Hospital in Hainan over the past eleven years. This information served as a reference for the epidemiological study, diagnosis, treatment, and prevention of melioidosis in China.

Contributions of Dietary Patterns and Factors to Regulation of Rheumatoid Disease.

Rheumatoid arthritis (RA) is a systemic autoimmune disease that commonly causes pain in joints and the progressive destruction of cartilage and bone, which significantly reduces the quality of life and increases the social burden. However, there is still no cure for RA, so it is highly important to explore additional adjuvant treatment methods. Studies have indicated that malnutrition, changes in intestinal microbiota, and changes in immune status caused by dietary imbalance are directly related to the onset of RA, indicating that dietary intervention may offer a simple, economical, and practical avenue to relieve RA.

Antimicrobial strategies of lower respiratory tract infections in immunocompromised patients based on metagenomic next-generation sequencing: a retrospective study.

Background: Immunocompromised patients with Lower Respiratory Tract Infections (LRTI) frequently encounter a diverse range of pathogenic infections, characterized by rapid disease progression and significant mortality rates due to reckless or excessive utilization of antibiotics. Therefore, it is crucial to promptly and accurately identify the causative microorganisms for pathogen diagnosis and clinical decision-making. The objective of this study is to evaluate the clinical applicability of metagenomic next-generation sequencing (mNGS) in the diagnosis and management of LRTI, as well as its impact on empirical antibacterial therapy for patients with varying immune statuses.

Phosphorylation of distal C-terminal residues promotes TRPV4 channel activation in response to arachidonic acid.

Transient receptor potential vanilloid 4 (TRPV4) is a Ca-permeable channel activated by diverse physical and chemical stimuli, including mechanical stress and endogenous lipid arachidonic acid (AA) and its metabolites. Phosphorylation of TRPV4 by protein kinase A (PKA) and protein kinase C (PKC) is a predominant mechanism for channel regulation, especially in the cytoplasmic domains due to their importance in protein assembly, and channelopathies. However, studies corresponding to phosphorylation sites for these kinases remain incomplete.

Mediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults.

Background: Frailty has become a significant public health issue. The recent increase in the number of frail older adults has led to increased attention being paid to psychological care services in communities. The social isolation of pre-frail older adults can impact their psychological distress.

Decoding the mA epitranscriptomic landscape for biotechnological applications using a direct RNA sequencing approach.

Epitranscriptomic modifications, particularly N6-methyladenosine (mA), are crucial regulators of gene expression, influencing processes such as RNA stability, splicing, and translation. Traditional computational methods for detecting mA from Nanopore direct RNA sequencing (DRS) data are constrained by their reliance on experimentally validated labels, often resulting in the underestimation of modification sites. Here, we introduce pum6a, an innovative attention-based framework that integrates positive and unlabeled multi-instance learning (MIL) to address the challenges of incomplete labeling and missing read-level annotations.

The Novel Effect and Potential Mechanism of Lactoferrin on Organ Fibrosis Prevention.

Organ fibrosis is gradually becoming a human health and safety problem, and various organs of the body are likely to develop fibrosis. The ultimate pathological feature of numerous chronic diseases is fibrosis, and few interventions are currently available to specifically target the pathogenesis of fibrosis. The medical detection of organ fibrosis has gradually matured.

The mediating role of job fairness and job burnout between subjective social status and depressive symptoms in Chinese migrant workers: a generational difference analysis.

Background: In China, migrant workers (MWs) constitute a significant vulnerable group that may be highly susceptible to depression. However, there is a lack of empirical research exploring the correlation between subjective social status (SSS) and depressive symptoms among MWs. The objective of this study is to examine the mediating roles of job fairness and job burnout, as well as to investigate potential generational differences in this association.

Identification and Verification of a Novel Disulfidptosis-Related lncRNAs Prognostic Signature to Predict the Prognosis and Immune Activity of Head and Neck Squamous Carcinoma.

Background: We aimed to explore the prediction value of disulfidptosis-related long noncoding RNAs (lncRNAs) on the prognosis and immunotherapy efficiency of patients with head and neck squamous carcinoma (HNSCC).

Methods: Clinical and RNA-seq information were collected from The Cancer Genome Atlas (TCGA) and Genome Data Sharing (GDC) portal. The Pearson correlation analysis, univariate COX regression analysis, the least absolute shrinkage and selection operator (LASSO) COX regression were employed to construct the disulfidptosis-related lncRNAs (DRLs) prognostic model.

Comprehensive analysis of clinical research profiles and study characteristics of oral potentially malignant disorders: an observational study.

Objective: The study aims to present an observational study of clinical trials on Oral Potentially Malignant Disorders (OPMDs) and corresponding publications.

Study Design And Setting: We searched the OPMDs-related clinical studies registered in the ClinicalTrials.gov database before March 1, 2024.

Combining motivational and exercise intervention components to reverse pre-frailty and promote self-efficacy among community-dwelling pre-frail older adults: a randomized controlled trial.

Background: Exercise is effective in preventing frailty status in older adults, but the effect of an exercise program based on Wellness Motivation Theory (WMT) on the frailty status, self-efficacy for exercise, and quality of life for older adults with pre-frailty remains unclear. Our objective was to examine the efficacy of a multicomponent exercise program based on WMT on frailty status, self-efficacy, and quality of life among pre-frail older adults.

Methods: This was a randomized controlled trial of pre-frail older adults aged from 60 years to 85 years.

Natural medicine can substitute antibiotics in animal husbandry: protective effects and mechanisms of rosewood essential oil against Salmonella infection.

Aniba rosaeodora essential oil (RO) has been traditionally used in natural medicine as a substitute for antibiotics due to its notable antidepressant and antibacterial properties. Salmonella, a prevalent pathogen in foodborne illnesses, presents a major challenge to current antibiotic treatments. However, the antibacterial efficacy and mechanisms of action of RO against Salmonella spp.