Evaluation of Diagnostic Measures in Veterans With Self-Perceived Hearing Handicap Despite Normal Audiometric Thresholds: A Rapid Scoping Review.

Purpose: This rapid scoping review examined clinical test measure literature among veterans with self-perceived hearing handicap with normal audiometric threshold configurations (SPHH-NA) and those with normal audiometric thresholds and no self-perceived hearing handicap to determine which tests differentiate these groups.

Method: A rapid scoping review in the PubMed and CINAHL databases was completed. Articles included met the following criteria: experimental studies, written in English, with full online article access, participants who were U.

Content Analysis of Over-the-Counter Hearing Aid Reviews.

Hearing loss is a prevalent and impactful condition that affects millions globally. In 2022, the U.S.

Sound Advice: A Consumer's Perspective on Navigating the World of Over-the-Counter Hearing Aids.

This article describes the breadth of experiences associated with pursuing commercially available over-the-counter hearing aids (OTC-HAs). Dr. Katz behaved as a consumer pursuing various OTC-HAs.

Phosphorylation of distal C-terminal residues promotes TRPV4 channel activation in response to arachidonic acid.

Transient receptor potential vanilloid 4 (TRPV4) is a Ca-permeable channel activated by diverse physical and chemical stimuli, including mechanical stress and endogenous lipid arachidonic acid (AA) and its metabolites. Phosphorylation of TRPV4 by protein kinase A (PKA) and protein kinase C (PKC) is a predominant mechanism for channel regulation, especially in the cytoplasmic domains due to their importance in protein assembly, and channelopathies. However, studies corresponding to phosphorylation sites for these kinases remain incomplete.

Structure of human TRPV4 in complex with GTPase RhoA.

Transient receptor potential (TRP) channel TRPV4 is a polymodal cellular sensor that responds to moderate heat, cell swelling, shear stress, and small-molecule ligands. It is involved in thermogenesis, regulation of vascular tone, bone homeostasis, renal and pulmonary functions. TRPV4 is implicated in neuromuscular and skeletal disorders, pulmonary edema, and cancers, and represents an important drug target.