Epidemiological characteristics of influenza after COVID-19 pandemic in Zhejiang province, China.

Background: To analyse the epidemiological characteristics and variation trend of influenza in Zhejiang Province from 2018 to 2023, so as to provide reference for the prevention and control of influenza after COVID-19 pandemic.

Methods: Throat swab samples of influenza-like illness (ILI) cases from 16 local sentinel hospitals were collected every week, and real-time reverse transcription-polymerase chain reaction (RT-PCR) was used to detect and identify the specific types of influenza viruses. Descriptive epidemiological method was used to analyse the surveillance data from sentinel hospitals and network laboratories.

Genetic influences on the association between DNA methylation and obesity measures: insights from a twin study design.

Background: Both obesity and DNA methylation (DNAm) are influenced by genetic factors. Despite more than a thousand of obesity-related DNAm sites (CpGs) being identified, studies that account for genetic influences in these associations are limited.

Results: Using data from 1,074 twins in the Chinese National Twin Registry and bivariate structural equation models (SEMs), we investigated the phenotypic (Rph), genetic (Ra), and environmental (Re) correlations between genome-wide DNAm and three obesity indices: BMI, waist circumference (WC), and waist-to-hip ratio (WHR).

The Evolving Industrial Landscape in Occupational Chronic Benzene Poisoning - 6 PLADs, China, 2020-2023.

Introduction: As a major producer and consumer of benzene, China has long confronted the challenge of occupational chronic benzene poisoning (OCBP). Between 2005 and 2019, OCBP in China primarily occurred in private enterprises, small- and medium-sized enterprises, and the general/special-purpose equipment manufacturing industry. However, with the continuous strengthening of national supervision and restrictions on the use of benzene-containing materials, the industrial distribution of OCBP may have changed from 2020 to 2023.

[Distribution characteristics of smoking behavior among adult twins in China].

This study aims to describe the population and regional distribution characteristics of smoking behavior among adult twins in the China Twin Registry (CNTR), as well as the concordance rates for smoking behavior in monozygotic and dizygotic twins, and estimate the heritability. The study population included adult twins in CNTR who had smoking questionnaire data. A random-effects regression model was used to describe the distribution of smoking behavior among different subgroups based on various characteristics.

[Association between DNA methylation clock and obesity-related indicators: A longitudinal twin study].

Objective: To explore the relationship between obesity indicators and DNA methylation clocks acceleration, and to analyze their temporal sequence.

Methods: Data were obtained from two surveys conducted in 2013 and 2017-2018 by the Chinese National Twin Registry. Peripheral blood DNA methylation data were measured using the Illumina Infinium Human Methylation 450K BeadChip and EPIC BeadChip.

Multiple Transmission Pathways of Coxsackievirus A10 Leading to its Global Spread: A Phylogenetic and Spatiotemporal Analysis Based on Virological Surveillance.

Coxsackievirus A10 (CVA10) has been reported frequently in many infectious diseases and cases associated with hand, foot, and mouth disease (HFMD) emerging increasingly in recent years. Based on the National HFMD System Surveillance, 180 CVA10 strains were isolated from the mainland of China between 2008 and 2023. These strains were analyzed alongside 103 representative full VP1 sequences obtained from GenBank, with a focus on global-scale phylogenetic analysis and spatiotemporal dynamics of CVA10.

Adverse Events Following Type b (Hib) Monovalent Vaccines in Zhejiang Province, China, from 2017 to 2023.

Background: The type b (Hib) vaccination has well-established safety and efficacy in preventing Hib and reducing related morbidity and mortality worldwide. China has a high disease burden of Hib yet a low coverage rate of Hib vaccines and remains the only WHO member country not including the Hib vaccine in its National Immunization Program (NIP), partly due to insufficient surveillance data on its safety. This study analyzed all adverse events following immunization (AEFIs) after Hib monovalent vaccination in Zhejiang Province from 2017 to 2023 to provide evidence for formulating relevant immunization strategies.

Surveillance of psychogenic adverse events following immunization in Zhejiang, China, 2020-2023.

Background: Adverse events following immunization (AEFIs) refer to any untoward medical occurrence that follows immunization. Despite the large number of studies reporting various types of AEFIs worldwide, information on the psychogenic AEFIs remains scarce.

Objective: To describe the frequency and characteristics of psychogenic AEFIs among vaccine recipients in Zhejiang Province, China, from 2020 to 2023.

National estimates of mortality of unintentional drowning in China from 1990 to 2021 and its predicted level in the next decade: results from the global burden of disease study 2021.

Background: It is reported that burden of unintentional drowning deaths is high in low- and middle-income countries. In recent decades, China has achieved remarkable economic growth and substantial advancements in infrastructure development; however, the understanding of the unintentional drowning burden in China has lagged behind. This article aims to provide an in-depth understanding of the current unintentional drowning situation in China.

The relationship between body appreciation and weight-related health behaviors among Chinese adolescents.

Introduction: Research on body appreciation has flourished globally in recent years. College students and adults, rather than adolescents have been mainly focused in China. Therefore, this study aims to investigate the current status of body appreciation and weight-related health behaviors among Chinese adolescents, and elucidate their multifaceted relationships.

[Cost-effectiveness analysis of community-based nutrition interventions in the context of rapid urbanization in Zhejiang Province in 2022].

Objective: Exploring the cost-effectiveness of community-based nutrition interventions in urbanizing areas.

Methods: In January, 2022, 2 communities with typical urbanization process in Hangzhou, Zhejiang Province were selected, and adults aged 18 years or older from each community were recruited as study subjects. Whole venous blood sample was collected.

[Review of epidemic trend and immunization strategy of diphtheria].

The morbidity and mortality associated with diphtheria have been effectively managed through mass immunization strategies. Nevertheless, recent outbreaks of diphtheria have been reported in various regions of Africa and Asia. In addition to infections among children, there has been a notable increase in cases among middle-aged and elderly individuals, underscoring the necessity of continued vigilance in the control of diphtheria.

Surveillance of Adverse Events Following Varicella Vaccine Immunization in Zhejiang Province, China, from 2020 to 2022.

: China has a high incidence rate of varicella yet a low coverage rate of the varicella vaccine (VarV), with safety concerns being a leading cause of the lack of vaccination willingness. This study aimed to describe VarV-related adverse events following immunization (AEFIs) and analyze their characteristics in Zhejiang, China, 2020-2022. : VarV-related AEFIs in Zhejiang Province from 1 January 2020 to 31 December 2022 were collected through the Chinese National AEFI Information System (CNAEFIS) for a descriptive epidemiological analysis.

Trends of genetic contributions on epigenetic clocks and related methylation sites with aging: A population-based adult twin study.

Several crucial acceleration periods exist during aging process. Epigenetic clocks, serving as indicators of aging, are influenced by genetic factors. Investigating how the genetic contributions on these clocks change with age may provide novel insights into the aging process.

The joint associations of ambient air pollutants and weather factors with mortality: Evidence from a national time-stratified case-crossover study in China.

Background: People in daily life are usually exposed to multiple environmental factors, but few studies have evaluated the joint health impacts of ambient air pollutants and weather factors.

Objectives: To investigate the joint associations of short-term exposures to ambient air pollutants and weather factors with mortality and estimate the mortality burden attributable to these multiple environmental exposures in China.

Methods: We collected individual death information from six provinces (Guangdong, Yunnan, Hunan, Zhejiang, Tibet and Jilin) in China during 2013 to 2018, and applied a time-stratified case-crossover study design to estimate the joint associations of air pollutants [PM (particulate matter with an aerodynamic diameter ≤2.

Toxic and essential metals: metabolic interactions with the gut microbiota and health implications.

Human exposure to heavy metals, which encompasses both essential and toxic varieties, is widespread. The intestine functions as a critical organ for absorption and metabolism of heavy metals. Gut microbiota plays a crucial role in heavy metal absorption, metabolism, and related processes.

The association between long-term exposure to ambient formaldehyde and respiratory mortality risk: A national study in China.

Introduction: While ambient formaldehyde (HCHO) concentrations are increasing worldwide, there was limited research on its health effects.

Objectives: To assess the association of long-term exposure to ambient HCHO with the risk of respiratory (RESP) mortality and the associated mortality burden in China.

Methods: Annual and seasonal RESP death and tropospheric HCHO vertical columns data were collected in 466 counties/districts across China during 2013-2016.

Five years of change in adult twins: longitudinal changes of genetic and environmental influence on epigenetic clocks.

Background: Epigenetic clocks were known as promising biomarkers of aging, including original clocks trained by individual CpG sites and principal component (PC) clocks trained by PCs of CpG sites. The effects of genetic and environmental factors on epigenetic clocks are still unclear, especially for PC clocks.

Methods: We constructed univariate twin models in 477 same-sex twin pairs from the Chinese National Twin Registry (CNTR) to estimate the heritability of five epigenetic clocks (GrimAge, PhenoAge, DunedinPACE, PCGrimAge, and PCPhenoAge).

Coverage of the Combined DTaP-IPV/Hib Vaccine Among Children Aged 2-18 Months - 9 PLADs, China, 2019-2021.

What Is Already Known On This Topic?: In China, there is limited data available on the use and coverage of the non-program, combined diphtheria, tetanus toxoid, acellular pertussis adsorbed, inactivated poliovirus and haemophilus influenzae type b (DTaP-IPV/Hib) pentavalent vaccine, and its role as a substitute for the separately administered standalone program vaccines.

What Is Added By This Report?: We evaluated the use and coverage of the pentavalent vaccine in nine provincial-level administrative divisions (PLADs) spanning eastern, central, and western China from 2019 to 2021. Initial use and coverage were low, but demonstrated annual growth albeit with regional and urban-rural discrepancies.

Gratification and its associations with problematic internet use: A systematic review and meta-analysis using Use and Gratification theory.

Problematic Internet Use (PIU) has been a growing issue for two decades, and many researchers have sought to explain its occurrence. Use and Gratification Theory (UGT) has guided empirical studies investigating the associations between gratification and PIU. However, their results appear equivocal.

Association between epigenetic age and type 2 diabetes mellitus or glycemic traits: A longitudinal twin study.

Epigenetic clocks based on DNA methylation have been known as biomarkers of aging, including principal component (PC) clocks representing the degree of aging and DunedinPACE representing the pace of aging. Prior studies have shown the associations between epigenetic aging and T2DM, but the results vary by epigenetic age metrics and people. This study explored the associations between epigenetic age metrics and T2DM or glycemic traits, based on 1070 twins (535 twin pairs) from the Chinese National Twin Registry.

Ambient PM and cardiopulmonary mortality in the oldest-old people in China: A national time-stratified case-crossover study.

Background: Evidence on the associations of fine particulate matter (PM) with cardiopulmonary mortality in the oldest-old (aged 80+ years) people remains limited.

Methods: We conducted a time-stratified case-crossover study of 1,475,459 deaths from cardiopulmonary diseases in China to estimate the associations between short-term exposure to ambient PM and cardiopulmonary mortality among the oldest-old people.

Findings: Each 10 μg/m increase in PM concentration (6-day moving average [lag05]) was associated with higher mortality from cardiopulmonary diseases (excess risks [ERs] = 1.

Association of psychological distress and DNA methylation: A 5-year longitudinal population-based twin study.

Aim: To identify the psychological distress (PD)-associated 5'-cytosine-phosphate-guanine-3' sites (CpGs), and investigate the temporal relationship between dynamic changes in DNA methylation (DNAm) and PD.

Methods: This study included 1084 twins from the Chinese National Twin Register (CNTR). The CNTR conducted epidemiological investigations and blood withdrawal twice in 2013 and 2018.