Analyzing the toxicological effects of PET-MPs on male infertility: Insights from network toxicology, mendelian randomization, and transcriptomics.

Current research indicates that polyethylene terephthalate microplastics (PET-MPs) may significantly impair male reproductive function. This study aimed to investigate the potential molecular mechanisms underlying this impairment. Potential gene targets of PET-MPs were predicted via the SwissTargetPrediction database.

Comparison of Navier-Stokes and lattice Boltzmann solvers for subject-specific modelling of intracranial aneurysms.

Modelling cardiovascular disease is at the forefront of efforts to use computational tools to assist in the analysis and forecasting of an individual's state of health. To build trust in such tools, it is crucial to understand how different approaches perform when applied to a nominally identical scenario, both singularly and across a population. To examine such differences, we have studied the flow in aneurysms located on the internal carotid artery and middle cerebral artery using the commercial solver Ansys CFX and the open-source code HemeLB.

Performance evaluation of a p-type co-axial HPGe detector: Long-term analysis of key parameters for gamma spectroscopy.

Accurate determination of the parameters of each high purity germanium, HPGe detectors ensure the precision of quantitative results obtained from spectrum analysis. This study presents a comprehensive performance evaluation and long-term quality control assessment of a high-purity germanium (HPGe) gamma spectrometry system that has been operational for over 15 years. Key spectrometric measures were recorded, including energy resolution, peak shape ratios, asymmetry, peak-to-Compton ratio, relative efficiency, electronic noise, minimum detectable activity (MDA), and repeatability and reproducibility of the system.

CRISPR/Cas9-mediated editing of COQ4 in induced pluripotent stem cells: A model for investigating COQ4-associated human coenzyme Q deficiency.

Pathogenic variants in the gene COQ4 cause primary coenzyme Q deficiency, which is associated with symptoms ranging from early epileptic encephalopathy up to adult-onset ataxia-spasticity spectrum disease. We genetically modified commercially available wild-type iPS cells by using a CRISPR/Cas9 approach to create heterozygous and homozygous isogenic cell lines carrying the disease-causing COQ4 variants c.458C > T, p.

A novel multimodal framework combining habitat radiomics, deep learning, and conventional radiomics for predicting MGMT gene promoter methylation in Glioma: Superior performance of integrated models.

Purpose: The present study aimed to develop a noninvasive predictive framework that integrates clinical data, conventional radiomics, habitat imaging, and deep learning for the preoperative stratification of MGMT gene promoter methylation in glioma.

Materials And Methods: This retrospective study included 410 patients from the University of California, San Francisco, USA, and 102 patients from our hospital. Seven models were constructed using preoperative contrast-enhanced T1-weighted MRI with gadobenate dimeglumine as the contrast agent.

Mechanistic roles of long non-coding RNAs in DNA damage response and genome stability.

To maintain genomic stability, cells have evolved complex mechanisms collectively known as the DNA damage response (DDR), which includes DNA repair, cell cycle checkpoints, apoptosis, and gene expression regulation. Recent studies have revealed that long non-coding RNAs (lncRNAs) are pivotal regulators of the DDR. Beyond their established roles in recruiting repair proteins and modulating gene expression, emerging evidence highlights two particularly intriguing functions.

Vanadium shows no effect in stress-induced hyperthermia and the tail suspension test in healthy mice.

Vanadium (V) is a trace element in the environment; it is detected in soil, water, air, dust, and food products. V-containing compounds have shown therapeutic potential in the treatment of diabetes. However, studies on the effects of V on animal behavior remain limited and sporadic.

Associations between element mixtures and biomarkers of pathophysiologic pathways related to autism spectrum disorder.

Objective: We previously documented that exposure to a spectrum of elements is associated with autism spectrum disorder (ASD). However, there is a lack of mechanistic understanding as to how elemental mixtures contribute to the ASD development.

Materials And Methods: Serum and urinary concentrations of 26 elements and six biomarkers of ASD-relevant pathophysiologic pathways including serum HIPK 2, serum p53 protein, urine malondialdehyde (MDA), urine 8-OHdG, serum melatonin, and urine carnitine, were measured in 21 ASD cases and 21 age-matched healthy controls of children aged 6-12 years.

Clinicopathological features of dermal clear cell sarcoma: A series of 13 cases.

Background: Dermal clear cell sarcoma (DCCS) is a rare malignant mesenchymal neoplasm. Owing to the overlaps in its morphological and immunophenotypic profiles with a broad spectrum of tumors exhibiting melanocytic differentiation, it is frequently misdiagnosed as other tumor entities in clinical practice. By systematically analyzing the clinicopathological characteristics, immunophenotypic features, and molecular biological properties of DCCS, this study intends to further enhance pathologists' understanding of this disease and provide a valuable reference for its accurate diagnosis.

Not all type of lepidic pattern is useful for distinguishing whether metachronous multiple lung adenocarcinomas are separate primary lung cancers.

Our research aims to ascertain the value of precursor and outgrowth lepidic in aiding the confirmation of multiple lung adenocarcinomas as separate primary lung cancers (SPLC). A total of 151 patients with metachronous multiple invasive adenocarcinomas were included in this study. Driver mutation tests（at least five genes: EGFR, ALK, KRAS, BRAF, and ROS1） were conducted on 302 tumors collected from 151 patients.

Intracellular Galectin-3 as a Crucial Regulator of Foam Cell Formation and Apoptosis Progression through the Modulation of Membrane Lipid Rafts.

Background: Atherosclerosis, a leading cause of cardiovascular disease (CVD) mortality worldwide, is characterized by dysregulated lipid metabolism and unresolved inflammation. Macrophage-derived foam cell formation and apoptosis contribute to plaque formation and vulnerability. Elevated serum galectin-3 (Gal-3) levels are associated with increased CVD risk, and Gal-3 in plaques is strongly associated with macrophages.

Effects of multi-component interventions on the lifestyle in pre-frail or frail older adults: A systematic review and meta-analysis.

Background: Frailty is defined as a biological syndrome characterized by a decreased reserve and resistance to stressors. Frailty is closely related to lifestyle, and improving lifestyle can effectively reduce the incidence of frailty and related adverse events. Multi-component interventions were an effective mean of improving lifestyle, which has been validated in studies of other populations.

Amphiphilic Poly(SBMA--EGDEA) Coatings for Marine Antifouling: Insights into Design Criteria for Hydrophobic Monomers.

Marine biofouling poses significant economic and environmental challenges, highlighting the need for effective antifouling coatings. We report amphiphilic poly(SBMA--EGDEA) copolymer coatings that resist both marine diatom adhesion and sediment adsorption. The coatings were synthesized via surface-initiated ATRP and RAFT polymerization using hydrophilic sulfobetaine methacrylate (SBMA) and hydrophobic ethylene glycol dicyclopentenyl ether acrylate (EGDEA).

In Vivo Electrochemical Aptasensors Reveal Reversible Dopamine Dysregulation from Adolescent Malnutrition.

Dopamine (DA) signaling is essential for neurodevelopment and is particularly sensitive to disruption during adolescence. Protein restriction (PR) can impair DA dynamics, yet mechanistic insights remain limited due to challenges in real-time neurochemical sensing. Here, we present aptCFE, a robust implantable aptamer-based sensor fabricated via a reagent-free, 3 min electrochemical conjugation (E-conjugation) using amine-quinone chemistry.

Combined SHR and SIRI biomarkers predict increased coronary heart disease risk in type 2 diabetes.

Coronary heart disease (CHD) is a leading cause of morbidity and mortality; patients with type 2 diabetes mellitus (T2DM) are at particularly high risk, highlighting the need for reliable biomarkers for early detection and risk stratification. We investigated whether combining the stress hyperglycemia ratio (SHR) and systemic inflammation response index (SIRI) improves CHD detection in T2DM. In this retrospective cohort of 943 T2DM patients undergoing coronary angiography, associations of SHR and SIRI with CHD were evaluated using multivariable logistic regression and restricted cubic splines; robustness was examined with subgroup and sensitivity analyses.

Perovskite Nanozyme-Mediated Sonocatalytic Therapy: A Mitochondrion-Targeted Strategy for Enhanced Cancer Therapy.

The generation of reactive oxygen species (ROS) through nanozyme-mediated sonocatalytic therapy has demonstrated remarkable therapeutic efficacy in the field of cancer. Nevertheless, it remains a significant challenge for nanozymes with a single catalytic active center to generate sufficient ROS via Fenton or Fenton-like reactions to effectively induce tumor cell death. In order to enhance the catalytic efficacy, we devised and synthesized a multiple active centre and mitochondrial-targeted perovskite nanozyme (NCFP), doped with cobalt (Co) element, and incorporated 4-carboxybutyltriphenylphosphonium bromide (TPP) as a mitochondrial targeting marker for ultrasound (US)-assisted enzyme-like catalytic treatment of tumors.

Microwave Spectroscopy and Structure of the 1-Fluoronaphthalene···HO Complex: Two Hydrogen Bonds Make the Complex a Rigid Rotor.

The microwave spectrum of the complex formed between 1-fluoronaphthalene and HO has been recorded using a chirped pulse Fourier transform microwave spectrometer within the frequency range of 2.0 to 8.0 GHz, with neon as the carrier gas.

Ultra-High Zinc Utilization Enabled by MXene Anode for Flexible Dual-Plating Zn-Br Microbatteries.

Aqueous zinc-ion microbatteries exhibit promising prospects for wearable devices due to their high safety and cost-effectiveness but face challenges such as low energy density and short cycle life. To address these challenges, a dual-plating flexible Zn-Br microbattery was developed using freestanding MXene films as a zinc metal free anode. The MXene anode retains no redundant Zn, as Zn from the electrolyte undergoes deposition/stripping reactions on its substrate, thereby eliminating the necessity for excess zinc.

Synergistic Dual-Carbon Networks Bridged Mn-Doped TiNbO Anode for Fast-Charging Lithium-Ion Batteries.

The development of anode materials for lithium-ion batteries must meet the demands for high safety, high energy density, and fast-charging performance. TiNbO is notable for its high theoretical specific capacity, low structural strain, and exceptional fast-charging capability, attributed to its Wadsley-Roth crystal structure. However, its inherently poor conductivity has hindered its practical application.