[Association of cadmium internal exposure levels with blood lipid in adults aged 18 to 79 years in China].

To explore the association of blood and urinary cadmium levels with lipid profile levels and dyslipidemia in Chinese adults aged 18 to 79 years. Based on the China National Human Biomonitoring (CNHBM) program, a cross-sectional survey was conducted from 2017 to 2018 using a multi-stage stratified random sampling method, including a total of 10 713 adults aged 18 to 79 years. Data was obtained through questionnaires, physical examinations, biological sample collection, and laboratory testing.

Ce(III)-Doped Mixed-Valence Metal-Organic Frameworks Boosting Ligand-To-Metal Charge Transfer for Photooxidation of a Mustard-Gas Simulant.

Due to the high toxicity and potential threats to society, extensive efforts are devoted to developing catalysts for efficient photodegradation of mustard gas. Metal-organic frameworks (MOFs) are considered as promising candidates for photooxidation, but the limited charge separation efficiency of the pristine MOFs restricts their further applications. Herein, through a one-pot synthesis strategy, Ce(III) ions are incorporated in a Ti-based porphyrin MOF (DGIST-1), leading to a mixed-valence MOF with enhanced charge transfer efficiency.

Freely-Rotatable Multidentate Molecular Anchor Enables Self-Adaptive Aqueous Binders for Lithium-Ion Batteries.

The rational design and synthesis of reliable binders is a big challenge to efficiently mitigate the severe volume change of silicon-based anodes for lithium ion batteries. Herein, we report a multidentate molecular anchoring strategy to construct a novel self-adaptive aqueous binder. This binder composes of robust 3D dynamic networks derived from the crosslinking of the freely-rotatable multidentate molecular anchor (2,2-bis(hydroxymethyl)butyric acid, BHB) and polyacrylic acid (PAA) via dynamic hydrogen-mediated self-assembly, which effectively imparts the fabrication of high-strength Si/C anodes and achieves high areal capacities (6.

Cabozantinib overcomes ROS1 L2086F NSCLC resistance to lorlatinib: A case report.

Rationale: ROS1 rearrangement a distinct molecular subtype of non-small cell lung cancer that is amenable to targeted therapeutic interventions. Despite the availability of effective targeted therapies, the development of acquired resistance to later-line inhibitors, particularly lorlatinib, remains an inevitable, and clinically significant challenge. The emergence of the ROS1 L2086F mutation as a mechanism of lorlatinib resistance further complicates treatment, with limited therapeutic options available post-resistance.

Nanobubble-infused electrolytes for enhanced mass transfer in liquid-fed CO electroreduction.

Electrochemical carbon dioxide reduction (CORR) in aqueous systems provides a sustainable pathway to convert CO into valuable chemicals and fuels. However, the limited solubility and slow diffusion of CO in aqueous electrolyte impose significant mass transfer barriers, particularly at high current densities. This study introduces a nanobubble-infused electrolyte strategy that leverages the unique properties of nanobubbles, including localized CO enrichment, enhanced diffusion, and micro-convection to overcome these limitations.

Transposable element expression and sub-cellular dynamics during hPSC differentiation to endoderm, mesoderm, and ectoderm lineages.

Transposable elements (TEs) are genomic elements present in multiple copies in mammalian genomes. TEs were thought to have little functional relevance but recent studies report roles in biological processes, including embryonic development. To investigate the expression dynamics of TEs during human early development, we generated long-read sequence data from human pluripotent stem cells (hPSCs) in vitro differentiated to endoderm, mesoderm, and ectoderm lineages to construct lineage-specific transcriptome assemblies and accurately place TE sequences.

Sliding Ferroelectric Control of Unconventional Magnetism in Stacked Bilayers.

The control of unconventional magnetism, which displays ferromagnetismlike properties with compensated magnetization, has drawn intense attention for advancing antiferromagnetic spintronics. Here, through symmetry analysis, we propose a general stacking rule, characterized by a connection operator linking two stacked bilayers, for controlling unconventional magnetism via sliding ferroelectricity. Such a rule enables the simultaneous switching of both electric polarization and nonrelativistic spin splitting or anomalous Hall effect in altermagnets, a class of collinear unconventional magnets.

Microbes Under Climate Refugia: Equable Subcommunity Rank Dynamics in Large-River Deltaic Estuaries.

Microorganisms, similar to macroorganisms, can be sheltered by climate refugia-a property overlooked due to their speciose nature. Using the latent Dirichlet allocation model to categorize microbial communities into ecologically distinct subcommunities, we conducted a 2-year survey of large-river deltaic estuaries (LDEs), recognized as refugial hotspots, and established rank hierarchies with the continuous time dynamic model to monitor temporal changes. We found that, consistent with macroecology, LDEs harbor distinct microbial community structures, with the abundance distribution of subcommunities exhibiting resilience against environmental perturbations, persisting on an annual cycle.

Phosphorus-induced interfacial chemistry electrolyte design for dense and highly stable potassium metal anodes.

Potassium (K) metal anodes have attracted widespread attention in the realm of energy storage due to their cost-effectiveness, abundance, and high theoretical capacity. However, the undesirable K-dendrite growth accompanied by void formation upon prolonged cycling presents formidable obstacles to their real-world applications. Herein, phosphorus-based electrolytes are developed based on the electrolyte additive design criteria of steric hindrance, polar ability, and decomposition preference to enhance the anode/electrolyte interface stability.

Evaluating treatment options for symptomatic uterine fibroids: a systematic review and meta-analysis of effectiveness, recovery, and long-term outcomes (MARIE WP1).

Background: Uterine fibroids can significantly impair the quality of life of women. While most fibroids remain asymptomatic, 25% of women diagnosed with uterine fibroids require medical intervention.

Methods: A systematic review and meta-analysis protocol was developed and published in PROSPERO (CRD42022346251) to explore surgical treatment outcomes linked to uterine fibroids.

Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease.

Background: Inflammatory bowel disease (IBD) presents unpredictable therapeutic responses and complex immune dysregulation. Current precision medicine approaches lack robust molecular tools integrating transcriptomic signatures with immune dynamics for personalized treatment guidance.

Methods: We performed multi-omics analyses of GEO datasets using machine learning algorithms (LASSO/Random Forest) to derive a four-gene signature.

Sodium Alginate/Erythritol/d‑Mannitol Phase Change Materials for Long-Term Thermal Energy Storage and Controllable Release.

As renewable energy technologies continue to advance, supercooled phase change materials (PCMs) are emerging as a promising solution for long-term thermal energy storage (TES), gaining significant attention from both researchers and industry for their potential to enhance energy efficiency. In our previous study, a supercooled PCMs system that blended erythritol (ET) and d-mannitol (DM) was shown to exhibit high latent heat but could not achieve long-term thermal storage stability. To extend the thermal storage duration of the previous DM/ET (DE) material, it served as a foundation that was integrated with sodium alginate (SA) to produce novel SA/DE PCMs.

Identification of human pathogens in soil by virulence gene-based machine learning method.

Soils are important reservoirs of human pathogenic bacteria that can spread to humans through various pathways. Metagenomics enables high-throughput pathogen identification by mapping sequencing reads to known pathogen genomes. However, this approach has several limitations, e.

AGAPIR: A Novel PIWI-Interacting RNA Enhancing Post-Decompression Angiogenesis in Degenerative Cervical Myelopathy.

Degenerative cervical myelopathy (DCM) is the most common cause of spinal cord dysfunction worldwide. Although surgical decompression can halt disease progression and improve neurological function in most patients, there remains a subset for whom functional improvement is limited. Impaired spinal cord perfusion is a pathological hallmark of DCM, which highlights the importance of restoring blood flow to enhance neurological outcomes.

Microscale Contact Electrification with Unprecedented High Intrinsic Charge Density.

Contact electrification (CE) refers to the charge generation of two materials after contact and separation, benefiting applications including electrophotography, electrostatic self-assembly, and energy harvesting. However, surface asperities lead to a low effective charging area and restrict the net CE charge density. Here, atomically flat polytetrafluoroethylene (PTFE) and graphite microflake are used to increase the contact efficiency and achieve an unprecedented intrinsic CE charge density of 2.

An Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart Failure.

Background: Endogenous retroviruses (ERVs) occupy >8% of the human genome. Aberrant resurgence of ERVs has been implicated recently in several critical pathologies. However, the possible incidence and role of ERV resurgence in heart failure (HF), a leading cause of global morbidity and mortality, remain unexplored.

Absolute Length Distribution of Human Telomeres with Single-Molecule Techniques.

Human telomeres exhibit progressive shortening with each replication cycle. This phenomenon plays a critical role in the onset of senescence and the development of cancers. The measurement of absolute telomere length (TL) is not only serving as a marker of aging, but also holds substantial medical relevance.

Oxyberberine alleviates fructose-induced hyperuricemia by modulating purine metabolism and gut microbiota.

Phellodendri Chinensis Cortex, a time-honored Chinese materia medica, has long been applied in the management of gout and other diseases. Hyperuricemia (HUA) is the vital contributor for the occurrence and progression of gout. Oxyberberine (OBB), an oxidized protoberberine alkaloid, is naturally present in Phellodendri Chinensis Cortex.

An insect β1-3-galactosyltransferase enables efficient synthesis of multi-sites T antigen glycoconjugates.

Tumor-associated carbohydrate antigens (TACAs), particularly the T antigen characterized by the Galβ1-3GalNAc structure, are commonly expressed in various human cancers. However, the in vitro enzymatic synthesis of the Galβ1-3GalNAc structure has remained a significant challenge. In this study, we report the characterization of a β1-3-galactosyltransferase, DmC1GalT1, derived from D.

Ecological functions coupled with plasmid and phage-mediated dissemination drive the global prevalence of high-risk antimicrobial resistance genes in influent.

Antibiotic resistance genes (ARGs) in wastewater treatment plant (WWTP) influent pose potential global risk to public health. However, the spatiotemporal distribution of global influent ARGs, the highly prevalent core ARGs components, and their transmission mechanisms remain unclear. The resistance risk ranking integrating abundance, mobility, and pathogenicity in actual influent samples is still undefined.

An Additive with Carbonate-Sulfate Hybrid Structure Enables High-Voltage and Long-Life Lithium-Ion Batteries.

Driving LiNiCoMnO (NCM) cathode to operate at high voltage represents an effective strategy to increase battery energy density, however, it also applies extreme electrochemical constraints on both electrode and electrolyte materials, which induce the generation of oxygen gas and formation of vacancies, transition metal ion dissolution, degradation of lattice structure and cracking of particles, as well as electrolyte oxidation. In this study, a new electrolyte molecule that combines the structures of carbonate and sulfates is designed. When used at additive level, the reactivity of this polycyclic structure ensures its early reduction at anode before any other components in the electrolyte, whose products form robust electrolyte-electrode interphases and prevent sustained electrolyte decomposition while preserving electrodes' integrity.

CD31 regulates metabolic switch in Treg migration attenuates rheumatoid arthritis.

CD31 (PECAM-1) plays a critical role in T cell migration, whilst its immunoreceptor tyrosine inhibitory motifs (ITIMs), Y663 and Y686, are recognised for their roles in endothelial function, the precise mechanism in regulating immune cell remains elusive. Here, we demonstrate that CD31 is essential for Treg migration. Upon ITIM engagement, CD31 activates and interacts with the protein tyrosine phosphatase SHP2.