Advantages of TiRobot-assisted surgery in the treatment of osteoporotic thoracolumbar compression fractures: a meta-analysis based on multiple clinical indicators.

This study aims to systematically assess the therapeutic effectiveness of TiRobot-assisted percutaneous kyphoplasty or vertebroplasty in managing osteoporotic thoracolumbar compression fractures. Previous studies have suggested that TiRobot-assisted techniques outperform conventional manual procedures in treating this condition, but relevant conclusions remain controversial. A thorough literature retrieval was carried out across 4 major databases: PubMed, Embase, the Cochrane Library, and Web of Science.

A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2.

Targeted protein degraders hold potential as therapeutic agents to target conventionally 'undruggable' proteins. Here, we develop a high-throughput screen, DEath FUSion Escaper (DEFUSE), to identify small-molecule protein degraders. By conjugating the protein of interest to a fast-acting triggerable death protein, this approach translates target protein degradation into a cell survival phenotype to illustrate the presence of degraders.

Minimally invasive versus open pancreaticoduodenectomy for periampullary tumors: a systematic review and meta-analysis of randomized controlled trials.

Background: Minimally invasive pancreaticoduodenectomy (MIPD) is used more commonly, but this surge is mostly based on observational data. This meta-analysis aimed to compare the short-term outcomes between MIPD and open pancreaticoduodenectomy (OPD) using data collected from randomized controlled trials (RCTs).

Methods: We searched PubMed, Cochrane Library, Embase, and Web of Science databases for RCTs comparing MIPD and OPD published before December 10, 2024.

Mapping multitissue regulatory variants reveals a liver-centric coexpression network associated with duck egg-laying performance.

Poultry egg production is shaped by the intertwined action of multiple physiological systems, greatly magnifying the complexity of its underlying genetic regulation. Although multitissue mapping of regulatory variants offers a powerful route to untangle this complexity, comprehensive data sets in ducks remain scarce. Meanwhile, the contributions of peripheral systems beyond neuroendocrine regulation on poultry egg production are still largely unexplored.

Neonatal Liver-Derived FTH1-Enriched Extracellular Vesicles Attenuate Ferroptosis and Ameliorate MASLD Pathogenesis.

Metabolic dysfunction-associated steatotic liver disease (MASLD), a leading cause of chronic liver pathology, lacks effective therapies. This study identifies ferroptosis-a lipid peroxidation-driven, iron-dependent form of cell death-as a central pathogenic mechanism in MASLD. Integrative proteomic and histopathological analyses of human and murine MASLD livers revealed marked ferroptosis activation, characterized by dysregulated iron metabolism (reduced FTH1 and GPX4; elevated ACSL4) and oxidative stress.

Intersecting precision fermentation for global cell-based food production innovation: Challenges and opportunities.

Precision fermentation represents an innovative cell-based production approach that employs synthetic biology and metabolic engineering tools, revolutionizing global food production by utilizing "microbial cell factories" to produce added-value ingredients. However, its global implementation is hindered by technological and scalability bottlenecks, regulatory fragmentation, regional accessibility and consumer acceptance, and nutritional trade-offs challenges. This review utilizes illustrated case studies and modeling analysis to present a detailed exploration of precision fermentation intersecting with global cell-based food production, discussing actionable research gaps and insights as well as advanced bioengineering practices and analytical techniques, to address these challenges for ongoing academic research, industrial applications and policy initiatives, thus supporting the transition of fermentation-enabled food production toward efficient and sustainable manufacturing.

Individual and collaborative solid-state fermentation by Monascus purpureus and Eurotium cristatum: Impact on metabolite profiling and hypolipidemic properties of black Tartary buckwheat.

The growing demand for healthy Tartary buckwheat-based foods has sparked interest in fermentation as a processing technique to enhance food quality and bioactivity. This study investigated the impact of solid-state fermentation of black Tartary buckwheat (BTB) with Monascus purpureus and Eurotium cristatum PW-1 on its quality, biochemical properties, and hypolipidemic potential, using metabolomics, bioinformatics, network pharmacology, and invivo zebrafish models. Fermentation significantly increased total amino acids, γ-aminobutyric acid, and aromatic volatile compounds such as alcohols, esters, terpenes, and terpenoids, enhancing the flavor profile.

Frailty and the short-term prognosis of patients with intracranial hemorrhage: A meta-analysis.

Background: Frailty is increasingly recognized as a predictor of poor outcomes in acute neurological conditions. However, its impact on the short-term prognosis of patients with intracranial hemorrhage (ICrH) remains unclear. This meta-analysis aimed to evaluate the association between frailty and short-term mortality and functional outcomes in patients with ICrH.

Alpha-linolenic acid ameliorates T2DM via reshaping gut-liver axis and inflammatory GPR120-NF-κB/NLRP3 pathway in mouse and rat models.

Background: The gut-liver axis, pivotal in managing glucose balance and insulin responsiveness, is central to the development of type 2 diabetes mellitus (T2DM). Research has highlighted the regulatory effects of dietary alpha-linolenic acid (ALA), but it remains unclear how ALA modulates gut microbiota and liver inflammation in T2DM.

Purpose: This study aimed to systematically investigate ALA's influence on liver inflammation, intestinal barrier integrity, gut microbial composition, and metabolic homeostasis in T2DM, with a focus on the underlying molecular mechanisms.

The application of manure and straw is beneficial for improving the content and stability of DOM in paddy soil.

While organic manure application effectively increases soil organic carbon (SOC) content, it may elevate greenhouse gas emissions. Crop straw, a widely available agricultural residue, enhances SOC through gradual decomposition. The effect of organic manure combined with crop straw on the organic carbon components of paddy soil is still unclear.

Internal cognitive responses to typical external inducing factors in the indoor evacuation: The regulatory model of the brain.

Individual cognitive patterns in pathfinding play a pivotal role for understanding the intricate dynamics of crowd evacuation. However, the relationship between individual cognitive responses and whose evacuation performance remains underexplored in scholarly research. To address this issue, a new evacuation experimental design of functional near-infrared spectroscopy combined with an eye tracking device was employed by manipulating various inducing factors.

Discovery of novel indazole derivatives as type Ⅰ PRMTs inhibitors for the treatment of triple-negative breast cancer.

Type I protein arginine methyltransferases (PRMTs) play significant roles in various diseases, including cancer. The inhibition of type I PRMTs significantly suppresses the growth of breast cancer, particularly triple-negative breast cancer (TNBC). The development of potent and selective type I PRMTs inhibitors has become a research hotspot in recent years.

Ultra-High Zinc Utilization Enabled by MXene Anode for Flexible Dual-Plating Zn-Br Microbatteries.

Aqueous zinc-ion microbatteries exhibit promising prospects for wearable devices due to their high safety and cost-effectiveness but face challenges such as low energy density and short cycle life. To address these challenges, a dual-plating flexible Zn-Br microbattery was developed using freestanding MXene films as a zinc metal free anode. The MXene anode retains no redundant Zn, as Zn from the electrolyte undergoes deposition/stripping reactions on its substrate, thereby eliminating the necessity for excess zinc.

Key factors underpinning neuroimmune-metabolic-oxidative (NIMETOX) major depression in outpatients: paraoxonase 1 activity, reverse cholesterol transport, increased atherogenicity, protein oxidation, and differently expressed cytokine networks.

Background: Major depressive disorder (MDD) is associated with neuro-immune - metabolic - oxidative (NIMETOX) pathways.

Aims: To examine the connections among NIMETOX pathways in outpatient MDD (OMDD) with and without metabolic syndrome (MetS); and to determine the prevalence of NIMETOX aberrations in a cohort of OMDD patients.

Methods: We included 67 healthy controls and 66 OMDD patients and we assessed various NIMETOX pathways.

The influence of lighting environment in extra-long tunnels and its psychological impact on young drivers: evidence from virtual driving simulations.

Purpose: The monotonous lighting environment in extra-long tunnels often induces mind-wandering in drivers. To address this issue, this study explores effective strategies to optimize tunnel lighting environments by configuring various background colors and special lighting zones to enhance the alertness of young drivers and ensure driving safety.

Methods: A virtual driving simulator was utilized to carry out the experiment.

Nitrogen removal efficiency and pathways of the simultaneous nitrification and denitrification process under ultra-low oxygen conditions.

To explore strategies for further reducing aeration energy consumption in the simultaneous nitrification and denitrification (SND) process, an SND reactor was constructed to treat low carbon-to-nitrogen (C/N) ratio domestic wastewater under ultra-low dissolved oxygen (DO) conditions (DO < 0.05 mg·L⁻). The effects of hydraulic retention time (HRT) and C/N ratio on nitrogen removal performance were systematically evaluated, and batch experiments were conducted to determine nitrification and denitrification rates.

Observation of Three Resonant Structures in the Cross Section of e^{+}e^{-}→π^{+}π^{-}h_{c}.

Using e^{+}e^{-} collision data collected with the BESIII detector operating at the Beijing electron positron collider, the cross section of e^{+}e^{-}→π^{+}π^{-}h_{c} is measured at 59 points with center-of-mass energy sqrt[s] ranging from 4.009 to 4.950 GeV with a total integrated luminosity of 22.

Self-activating air filtration device for aerosol control during luminal instruments drying in the sterile processing department.

Background: Luminal instruments are characterized by their slender internal lumens, which make them particularly challenging to clean and dry. A common drying method used by Sterile Processing Department (SPD) technicians involves blowing high-pressure air into one end of the lumen to expel moisture. However, this process generates a significant amount of aerosols that may contain bacteria, viruses, and other microorganisms.

Characterization of strontium-rich groundwater in a typical alpine basin on Tibetan Plateau: Implications for sustainable exploitation and development.

This study focuses on mineral groundwater in alpine regions and its sustainable exploitation. The Tongde basin on Tibetan Plateau was investigated to reveal the hydrochemistry and formation of mineral groundwater in alpine basins and its sustainable development under anthropogenic disturbances. The results show that groundwater there is characterized by enriched strontium, with concentrations in the range of 0.

EphA3/EFNA3 Reverse Signalling Promotes Epithelial-to-Mesenchymal Transition via ERK Pathway to Facilitate Colorectal Cancer Metastasis.

Background And Aims: Liver metastasis significantly contributes to poor survival in patients with colorectal cancer (CRC), posing therapeutic challenges due to limited understanding of its mechanisms. We aimed to identify a potential target critical for CRC liver metastasis.

Methods: We analyzed the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) databases and identified EphrinA3 (EFNA3) as a potential clinically relevant target.

The composition, influencing factors, and physiological functions of bifidobacteria in the infant gut: a review.

Bifidobacteria are naturally found in the human gut and quickly establish dominance shortly after birth, playing a crucial role in the development and stability of the infant gut microbiota. A growing body of research suggests that host and environmental factors shape the colonization and the relative abundance of bifidobacteria in the infant gut during early life. Understanding the factors that influence bifidobacterial colonization and maintaining normal colonization levels are keys to ensuring gut health.

Number of Examined Lymph Nodes in the Highest Quartile Enhances Staging and Prognosis for Patients with Esophageal Cancer Receiving Neoadjuvant Therapy.

Background: The optimal number of examined lymph nodes (ELN) for accurate staging and prognosis for esophageal cancer patients receiving neoadjuvant therapy remains controversial. This study aimed to evaluate the impact of ELN count on pathologic staging and survival outcomes and to develop a predictive model for lymph node positivity in this patient population.

Methods: Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and a multicenter cohort.

Development and Validation of an Individualized Prediction Model for Postoperative Late Recurrence After Hepatectomy for Hepatocellular Carcinoma (POLAR-HCC): A Multicenter Study.

Background: Postoperative late recurrence (POLAR) after 2 years from the date of surgical resection of hepatocellular carcinoma (HCC) represents a unique surveillance and management challenge. Despite identified risk factors, individualized prediction tools to guide personalized surveillance strategies for recurrence remain scarce. The current study sought to develop a predictive model for late recurrence among patients undergoing HCC resection.

Ectomycorrhizal symbiosis with Tuber spp. Enhances host performances in Pinus and Carya and induces host-specific patterns in defense-related regulation in the leaf transcriptomes.

Ectomycorrhizal fungi (EMF) colonize roots to establish symbiotic associations with plants. Sporocarps of the EMF Tuber spp. are considered as a delicacy in numerous countries and is a kind of EMF of great economic and social importance.