Correction: Dual drug-loaded metal-phenolic networks for targeted magnetic resonance imaging and synergistic chemo-chemodynamic therapy of breast cancer.

Correction for 'Dual drug-loaded metal-phenolic networks for targeted magnetic resonance imaging and synergistic chemo-chemodynamic therapy of breast cancer' by Li Xia , , 2024, , 6480-6491, https://doi.org/10.1039/D4TB00462K.

Heparin-loaded silk fibroin microparticles/bacterial nanocellulose (Hep@SFMPs/BNC) conduits for application as small-caliber artificial blood vessels.

Small-caliber artificial blood vessels are highly demanded and face challenges, including thrombosis and intimal hyperplasia. The excellent properties of bacterial nanocellulose (BNC) make it an excellent material for preparing artificial blood vessels. Heparin (Hep)-loaded silk fibroin microparticles (SFMPs) were synthesized in situ within the conduit wall via liquid pressure injection and phase separation, aiming to improve BNC's anticoagulant properties.

Impact of Stimuli-Responsiveness on the mRNA Delivery Efficiency of Low-Generation Dendrimer Nanogels.

Development of efficient and stimuli-responsive gene delivery systems for therapeutic protein expression and immunomodulation remains challenging. Here, we report the synthesis of three types of pH-, reactive oxygen species (ROS)- and glutathione (GSH)-responsive dendrimer nanogels (for short, DNGs-pH, DNGs-ROS, and DNGs-GSH, respectively) a microemulsion method for delivery of messenger RNA (mRNA) and plasmid DNA (pDNA), both encoding enhanced green fluorescent protein (for short, mEGFP and pEGFP), to dendritic cells (DCs). The synthesized DNGs exhibit a nanoscale dimension, high monodispersity, desired colloidal stability, low cytotoxicity, and efficient gene delivery efficiency.

Hierarchically Reinforcing Hydrogel for Multidimensional Bone Homeostasis Modulation to Regenerate Osteoporotic Defect.

To balance the requirement of high mechanical properties and convenient injectability for the hydrogel design of osteoporotic bone defects (OBD) repair, a hierarchical hydrogel stiffening strategy is proposed through the synergetic utilizing of rapidly formed dynamic hydrazone crosslinking, high-strength double-bond chemical crosslinking, and contraction of activated shape-memory short fibers (SMSFs). In detail, the Schiff Base reaction mediated first network enabled stable precursor retention at the injection site without compromising injectability. Subsequent radical polymerization by photocrosslinking enhanced the hydrogel stiffness from 9.

Engineering Motile Coacervate Droplets via Nanomotor Stabilization.

Coacervate-based artificial cells have gained significant attraction in synthetic biology for their ability to mimic life-like functions such as compartmentalization, selective molecular uptake, and the hosting of biochemical reactions. However, the incorporation of motility, a key feature of natural cells, remains underexplored. This is mainly caused by the dynamic character of coacervates, which hampers their stability and limits control over functional motile components within the structure.

Engineering a placenta-inspired biomimicking fibrous patch for chondrogenesis through immunomodulation.

The frequent onset of hyper-inflammatory responses after implantation impairs the availability of tissue transplants, impedes cellular renewal, and ultimately leads to the failure of scaffold-based cartilage regeneration. Existing scaffold modification strategies show limited efficacy in controlling immune cell infiltration and modulating inflammatory responses. Inspired by the placenta's dual protective and immunomodulatory attributes-through its physical barrier and biofactors release-this study develops a biomimetic surface-engineered aligned poly (L-lactic acid) (PLLA) fibrous patch barrier with pH-responsive drug release capabilities to shield implanted grafts, control post-implantation immunomodulatory processes, and foster chondrogenesis.

Strontium and Tannic Acid-Modified Eggshell-Derived Nanoparticles Promote Wound Healing in Poly(Lactic Acid)/Gelatin-Based Nanofibrous Dressings.

Wound healing may be impaired by excessive bleeding, bacterial colonization, slower angiogenesis, and poor cell proliferation, which necessitate the advent of innovative hemostatic, antibacterial, and pro-angiogenic dressings. The objective of this research is to synthesize strontium-substituted tannic acid-modified eggshell-based nanoparticles (ECa-TA-Sr NPs) and exploit them to endow multifunctionality to poly(lactic acid)/gelatin (PG) fibers. Physical and chemical properties of unmodified and modified NPs, as well as dressings, are evaluated with different types of assays in vitro.

Correction: Phosphorus core-shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters.

Correction for 'Phosphorus core-shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters' by Mengsi Zhan , , 2023, , 7387-7396.

Photocrosslinkable hydrogel of kartogenin functionalized chitosan methacrylate preserves chondrogenesis.

Cartilage damage- and degeneration-related osteoarthritis (OA) causes inconvenience and pain to patients. Hydrogels loaded with therapeutics are receiving increasing attention. Kartogenin (KGN), a small molecule drug, has been proven to be effective in protecting cartilage regeneration.

Chitosan and ibuprofen functionalized electrospun nanofiber membrane modulates inflammatory response and promotes full-thickness abdominal wall repair.

Electrospun nanofiber membranes are promising for abdominal wall repair. Our previous studies have shown that while electrospun nanofiber-bundle membranes promote cellular and tissue infiltration through their porous architecture, they also induce an elevated foreign body response (FBR) that impedes tissue integration and remodeling. In this study, we functionalized electrospun polylactic acid (PLA)/gelatin (Gel) nanofiber-bundle membrane with chitosan (CS) and ibuprofen (IBU) to improve its biological performance for abdominal wall repair.

A costal-cartilage derived stem cell-laden prominin-1-derived peptide collagen hydrogel for angiogenesis and bone regeneration.

Addressing bone injury repair remains a significant challenge in clinical settings, as effective regeneration of healthy bone tissue requires simultaneous promotion of both osteogenesis and angiogenesis. Costal cartilage, being the most abundant cartilage tissue in the human body, shares structural similarities and prolonged cartilaginous properties with long bone growth plates. Its potential as a seed cell source for bone repair, however, remains unexplored.

A Multifaceted Nanodrug Disrupts the Copper-Iron Homeostasis to Enhance Cancer Radiotherapeutic Effect.

Radiation therapy (RT) is a core modality in cancer treatment; however, its efficacy is often limited by tumor resistance. Studies have shown that RT induces abnormal copper ion accumulation and iron reduction, thereby inhibiting ferroptosis and exacerbating therapeutic resistance. In this study, multiomics database analysis revealed that various RT-resistant cancer cell lines and patient-derived tumor models exhibit characteristics of disrupted copper homeostasis and enhanced copper ion-binding capacity.

Review on electrical stimulation combined with electroactive biomaterials to promote peripheral nerve regeneration.

Peripheral nerve injury results in sensory and motor dysfunction, which is an enormous economic burden for patients and society. Complete recovery of peripheral nerve function after injury is complicated. Utilizing the electrophysiological properties of natural nerves for neuronal regulation and axon regeneration has attracted considerable interest.

High-Temperature Enhancing Triboelectric Nanogenerator Based on Antioxidant Liquid Crystalline Polyarylate.

Triboelectric nanogenerator (TENG) is a prospective energy harvesting technology, especially polymer-based TENG has achieved remarkable achievements. However, most polymer-based triboelectric layers suffer serious structural degradation and rapid decrease of charge density at high temperatures, which severely lowers the power supply capacity of TENG and definitely limits their applications in extreme environments. Herein, the antioxidants are introduced into liquid crystalline polyarylate (LCP) to fabricate thermally stable TENG and enhance its thermal oxidation resistance.

Three-dimensional composite aerogel scaffolds based on electrospun poly(lactic acid)/gelatin and silica-strontium oxide short fibers promote bone defect healing.

Background: Bone defect regeneration is a dynamic healing process that relies on the body's innate repair mechanisms, yet natural healing capacity remains limited. To address this challenge, advanced biomaterials combining bioactive inorganic components with biocompatible polymers have emerged as a promising strategy to enhance osteogenesis and angiogenesis.

Methods: In this study, a novel three-dimensional composite scaffold material was successfully fabricated using a combined electrospinning-freeze drying technique.

Functionally graded scaffold with M2 macrophage-derived LncRNA-Encoded peptide: Mechanistic and therapeutic evaluation for rotator cuff repair.

The rotator cuff is prone to tear under degenerative changes or mechanical injury, leading to excessive inflammation, extracellular matrix degradation, and unsatisfactory prognosis. Interleukin-4 (IL-4) was used to induce macrophages polarization toward M2 phenotype. By mapping IL 4-activated pathways and applying peptidome profiling, macrophage-derived peptide 1 (MDP1) was identified and shown to promote the phosphorylation of STAT3 and STAT6, thereby inducing the polarization of M0 macrophages toward the anti-inflammatory M2 phenotype.

Ibuprofen Conjugated Epsilon-poly-l-lysine Methacrylate Hydrogel Modulates Macrophage Polarization and Mitigates Inflammation .

Epsilon-poly-l-lysine (EPL) is widely used in many biomedical applications due to its excellent antibacterial activity and good biocompatibility. In this study, we report an approach of carbodiimide chemistry to graft water-soluble EPL with hydrophobic drug ibuprofen (IBU) and then modify the obtained IBU-EPL conjugate with methacrylic anhydride (MA) to prepare IBU-EPL-MA. The IBU-EPL-MA was of good photo-cross-linkability to form hydrogel with sustained drug release and good blood compatibility.

An Advanced Nanomedicine Based on Dual Drug-Encapsulated Layered Double Hydroxides for Synergistic Photothermo-Chemotherapy.

Developing highly effective nanomedicines for precision therapeutics of nasopharyngeal carcinoma still remains a challenging task. We report here a layered double hydroxide (LDH)-based therapeutic platform for synergistic photothermo-chemotherapy of nasopharyngeal carcinoma. In our approach, we first optimized the synthesis approach and selected a microfluidic method to create homogeneously distributed LDH nanodisks.

NIR-Activatable Antibacterial 3D-Printed Hydrogel Scaffold with Controllable Drug Release for Enhanced Vascularized Bone Regeneration.

Three-dimensional (3D)-printed scaffolds have been extensively researched in the field of tissue engineering for their exceptional biocompatibility as well as precise regenerative capabilities. However, developing photothermal-responsive scaffolds that exhibit near-infrared (NIR)-activatable mechanical shrinkage for controlled and highly sensitive drug release remains a significant challenge in achieving efficient and rapid bone repair. In this article, we designed a 3D-printed hydrogel scaffold (DFO-Au@GN) composed of deferoxamine (DFO)-loaded gold nanoparticles (AuNPs), gelatin methacrylate (GelMA), and -isopropylacrylamide (NIPAM) to promote superior vascularized osteogenesis.

A photothermally triggered cascade bioreactor for cuproptosis and ferroptosis-driven cancer immunotherapy.

Excessive intracellular accumulation of metal ions results in metal-dependent programmed cell death, including ferroptosis and cuproptosis. However, cancer cells have defences against these processes, which allow them to resist therapy. Therefore, this work reports a laser-controlled cascade bioreactor based on gold and silica-coated Cu- and Mn-doped iron oxide nanocrystals (IONCs) loaded with the drug disulfiram (DSF).

Biomimetic Chitosan Nanogels Codeliver Drug/Small Activating RNA for Metastasis-Inhibited Necroptosis Therapy of Ovarian Cancer.

Ovarian cancer remains the leading cause of gynecologic malignancy-related deaths. Developing novel nanoplatforms to overcome the low efficacy of chemotherapy and advanced metastasis in ovarian cancer is crucial. Here, we report biomimetic chitosan nanogels (CH NGs) designed to codeliver gambogic acid (GA) and MAS1 small activating RNA (saMAS1).

Near-Infrared Light-Triggered Construction of 3D "Fishing Net" Polymer Networks Using Upconversion Nanoparticles for Tumor Therapy.

construction of three-dimensional (3D) polymer networks for tumor cell capture, localization, and killing provides a different option for precision tumor therapy. Current approaches, however, face limitations due to insufficient and heterogeneous endogenous polymerization stimuli and the phototoxicity and limited tissue penetration of ultraviolet (UV)/visible light-triggered exogenous polymerization, constraining effective network assembly. We present a near-infrared (NIR) light-driven strategy utilizing the upconversion properties of thulium-doped core-shell nanoparticles (UCNPs) to enable precise, localized polymerization within tumor cells.