A facile and stable single-system fluorescent sensor array for the quantification and discrimination of nitrofuran antibiotics.

The misuse of nitrofuran antibiotics (NFAs) poses serious risks to food safety and human health. Thus, it is urgent to establish a rapid and sensitive method for detecting NFAs. In this work, a dual-emission fluorescent material (TbUDPA) was developed by embedding Tb in a Zr-MOF for rapid and sensitive detection of four NFAs, and it successfully detected nitrofurazone (NFZ) residues in real food samples with high recovery rates.

Effectiveness of thulium versus diode lasers in oral soft tissue surgery: a randomized clinical study.

Objectives: To comprehensively compare and evaluate the relative effectiveness of thulium laser and diode laser in oral soft tissue surgery procedures.

Methods: Thirty-three participants who needed oral soft tissue surgery, encompassing frenectomy and gingivectomy, were recruited and subsequently randomized into two groups including 14 in the experimental group and 19 in the control group. The experimental group was treated with thulium fiber laser, while the control group was treated with the diode laser (980 nm).

Joint Optimization and Performance Analysis of Analog Shannon-Kotel'nikov Mapping for OFDM with Carrier Frequency Offset.

An analog joint source-channel coding (AJSCC) based on Shannon-Kotel'nikov (S-K) mapping transmitting discrete-time encoded samples in orthogonal frequency division multiplexing (OFDM) systems over wireless channel has exhibited excellent performance. However, the phenomenon of carrier frequency offset (CFO) caused by the frequency mismatch between the transmitter's and receiver's local oscillators often exists in actual scenarios; thus, in this paper the performance of AJSCC-OFDM with CFO is analyzed and the S-K mapping is optimized. A joint optimization strategy is developed to maximize the signal-to-distortion ratio (SDR) subject to CFO constraints.

Wafer-Scale Growth of Monolayer MoSe via Salt-Assisted Chemical Vapor Deposition.

2D transition metal dichalcogenide (TMDs) of monolayer molybdenum diselenide (MoSe) is an emerging semiconductor for next-generation electronics, owing to its remarkable physical and electronic properties. The realization of diverse device applications depends critically on the scalable synthesis of high-quality monolayer MoSe crystals, which remains challenging. In this study, the successful epitaxy of monolayer MoSe films is demonstrated on sapphire substrates at a maximum wafer size of 2 inches via a salt-assisted chemical vapor deposition (SA-CVD) technique.

Alterations of plasma neural-derived extracellular vesicles microRNAs in patients with bipolar disorder.

Background: MicroRNAs (miRNAs) alterations in patients with bipolar disorder (BD) are pivotal to the disease's pathogenesis. Since obtaining brain tissue is challenging, most research has shifted to analyzing miRNAs in peripheral blood. One innovative solution is sequencing miRNAs in plasma extracellular vesicles (EVs), particularly those neural-derived EVs emanating from the brain.

Mechanisms of traditional Chinese medicine regulating polycystic ovary syndrome through gut microbiota: a review.

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that adversely affects women's reproductive and metabolic health conditions. Recent studies have highlighted the significant contributory role of gut microbiota in the pathogenesis of PCOS, indicating a complex interplay between the microbiome and the syndrome's clinical manifestations. Given this connection, Traditional Chinese Medicine (TCM), a well-established therapeutic approach, has demonstrated potential efficacy in modulating gut microbiota and alleviating symptoms associated with PCOS.

Bifacial Defect Management of Buried Interface for Enhanced Photovoltaic Performance of Inverted-Perovskite Devices with Precise Regulation of Charge Transport.

The intrinsic aggregation behavior of self-assembled molecules (SAMs) leads to severe heterogeneity or even blankness in the perovskite substrate layer. The direct contact between the bottom surface of perovskite and nickel oxide undergoes a redox reaction, which inevitably leads to perovskite degradation and strengthens the charge transport barrier. Herein, a 1-propenyl-2,3-dimethylimidazole hexafluorophosphate (PDMIMPF) molecule with bidirectional defect regulation has been developed.

Combination Therapy Against Mood and Anxiety Disorders: Association Between Efficacy and White Blood Cell Count.

Background: Numerous studies suggest that hyperactivation of the immuno-inflammatory system, as reflected in cytokine levels, is associated with more severe symptoms in mood and anxiety disorders and weaker response to treatment. Here we examined whether the efficacy of a combination of bright light therapy, repetitive transcranial magnetic stimulation and medication is associated with another immuno-inflammatory index, white blood cell count, before and/or after treatment, in a retrospective observational study.

Methods: We retrospectively analyzed 467 inpatients with major depressive, bipolar, or generalized anxiety disorder who were treated with combination therapy for at least one week at Hangzhou Seventh People's Hospital between April 2022 and April 2024.

Unraveling the Excellent High-Temperature Oxidation Behavior of FeNiCuAl-Based Alloy.

This study synthesized FeNiCuAlX high-entropy alloys (HEAs) (where X = Cr, Co, Mn) using arc melting and investigated their high-temperature oxidation behavior in air at 900 °C. The oxidation kinetics of all alloys followed a parabolic rate, with the oxidation rate constants (kp) of FeNiCuAlCr, FeNiCuAlCo, and FeNiCuAlMn being approximately two to three orders of magnitude lower than that of the FeNiCu alloy. Specifically, FeNiCuAlCr exhibited the lowest kp value of 1.

Conjugated linoleic acid regulation of fatty acid metabolism by mTOR signaling pathway in grass carp (Ctenopharyngodon idella) adipocytes.

The purpose of this study was to investigate the effects of conjugated linoleic acid (CLA) on fatty acid metabolism through the mammalian target of rapamycin (mTOR) signaling pathway in grass carp (Ctenopharyngodon idella) adipocytes. Grass carp preadipocytes were cultured and treated with various concentrations of CLA (0, 50, 100, 150 and 200 μmol/L). Lipid accumulation was assessed using Oil Red O staining.

Humic-metal complexes as dominant anaerobic digestion inhibitor: Multidimensional diagnostic framework for 16,200-tonne full-scale sludge treatment plant.

This study investigates a 16,200-tonne full-scale anaerobic digestion (AD) plant facing poor organic reduction and limited biogas recovery. Biochemical methane potential tests using active exogenous sludge confirmed that the inefficiency was due to intrinsic properties of the sludge rather than insufficient microbial activity. Alkaline thermal hydrolysis increased methane yield by 69 %, whereas the maximum output remained low (76 mL CH/g VS), suggesting heightened inhibition.

JAK2/STAT3 Signaling in Myeloid Cells Contributes to Obesity-Induced Inflammation and Insulin Resistance.

Adipose tissue inflammation contributes to obesity-induced insulin resistance. However, increasing evidence shows that high BMI (obesity) is not an accurate predictor of poor metabolic health in individuals. The molecular mechanisms regulating the metabolically activated M1 macrophage phenotype in the adipose tissues leading to insulin resistance remain largely unknown.

High efficiency and ultra-broadband suspended grating coupler on ultra-thin lithium niobate on insulator.

We propose and demonstrate a high-performance suspended grating coupler on ultra-thin X-cut lithium niobate on insulator (LNOI) for fully-etched photonic devices. The optimized design achieves exceptional coupling efficiency (-3.5 dB at 1546.

Prediction models after hepatectomy for hepatocellular carcinoma-based ultrasonic radiomics: an observational study.

Background: This study aims to develop and validate predictive models for postoperative complications and early recurrence in hepatocellular carcinoma (HCC) patients.

Methods: In a 7:3 ratio, 633 post-hepatectomy HCC patients were modeled and validated. Using 1561 radiomic features from two-dimensional shear wave elastography (2D-SWE), predictive models for the Comprehensive Complication Index (CCI) and recurrence were constructed, refined by LASSO regression, and integrated with clinical and pathologic data.

High level of carbapenem resistance and transmission ability of in multidrug-resistant isolates from China.

The emergence of metallo-beta-lactamase gene variants, such as , has posed a significant challenge to bacterial infection treatment, drawing considerable attention in public health. This study aims to investigate the resistance mechanism of -carrying clinical in China. -harboring carbapenem-resistant (CRE) isolates were collected from a multicenter study across China.

E3RC: A step-by-step computational protocol for exploring enhancer RNA expression and regulation using conventional RNA-seq data.

Here, we present a computational framework, E3RC, for exploring enhancer RNA (eRNA) expression and regulation using conventional RNA sequencing (RNA-seq) data. Using a public dataset as an example, we describe step-by-step guidelines for identifying eRNAs and characterizing their expressional changes and transcriptional regulation across multiple developmental stages of mouse preimplantation embryos. For complete details on the use and execution of this protocol, please refer to Yu et al.

An optimal conversion cascading of distinct lignocelluloses to maximize bioethanol productivity and bio-adsorption capacities of Cd/Cr(VI) and red/blue dyes selective for complete biomass recycling.

Although agriculture and forestry provide enormous lignocellulose resources, it remains to explore a novel technology for efficient biomass conversion into renewable bioethanol followed with complete recycling for valuable bioproduction with zero- waste release. As classic chemical (acid and alkali) pretreatments could cause chemical waste liberation, this study performed optimal pretreatments with hot-FeCl for sequentially enhancing biomass enzymatic saccharification in three bioenergy crops, which led to achieving hexoses yields raised by 4-7 times compared to the controls. By employing engineered yeast strain for xylose co-fermentation, the highest bioethanol yield was achieved at 18 % (% dry matter) in Miscanthus sample.

Effects of Hypoxia in Pancreatic Cancer on Immune Cell Behavior in the Tumor Microenvironment.

Hypoxia serves as a fundamental component of the tumor microenvironment, exerting a crucial influence on tumor advancement. Nonetheless, a comprehensive examination of a prognostic signature linked to hypoxia in pancreatic cancer is notably absent, presenting an urgent necessity. Therefore, our objective was to create and authenticate a robust prognostic signature capable of predicting outcomes for pancreatic cancer.

Artemisinin synergizes with CCCP in autophagic cell death induction via ER stress in uveal melanoma.

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, and it is associated with a poor prognosis due to the lack of effective targeted therapies. Artemisinin (ARS), a widely used antimalarial drug, has demonstrated anti-tumor effects in several types of cancer, including UM. However, these effects are primarily observed at high concentrations, which restricts its broader use.

Structural connectome architecture shapes cortical atrophy in major depression disorder: a Chinese DIRECT consortium study.

Background: Cortical morphological alterations are evident in major depressive disorder (MDD), yet the underlying neurobiological processes that contribute to their characteristic spatial pattern remain unclear.

Methods: Large-scale, multi-site structural MRI data from a homogeneous Chinese cohort of 1,442 MDD patients and 1,277 healthy controls were used to calculate cortical morphological measures, which were compared between groups to determine cortical morphological alterations in MDD. A connectome constraint model was then used to examine whether structural connectome shapes MDD-related cortical morphological alterations, followed by performance of a network diffusion model to identify the epicenters.

Perineural invasion as a prognostic determinant in combined hepatocellular-cholangiocarcinoma: a multicenter pathological study.

Background: The prognostic role of perineural invasion (PNI) in combined hepatocellular-cholangiocarcinoma (cHCC-CCA) remains undefined. This multicenter study assessed the incidence, patterns, and clinical significance of PNI in cHCC-CCA.

Methods: This study included 307 patients with cHCC-CCA undergoing hepatectomy with curative intent.

Potential MiRNA therapies for premature ovarian failure: new challenges and opportunities.

Premature ovarian failure (POF) is characterized by decreased ovarian function in women under 40 years of age, which leads to amenorrhea and infertility. This condition is commonly associated with diverse symptoms related to hormonal deficiency. The individuals with POF are also at an increased risk of developing several systemic conditions, including osteoporosis, neurological issues, and cardiovascular diseases.

A Multifaceted Nanodrug Disrupts the Copper-Iron Homeostasis to Enhance Cancer Radiotherapeutic Effect.

Radiation therapy (RT) is a core modality in cancer treatment; however, its efficacy is often limited by tumor resistance. Studies have shown that RT induces abnormal copper ion accumulation and iron reduction, thereby inhibiting ferroptosis and exacerbating therapeutic resistance. In this study, multiomics database analysis revealed that various RT-resistant cancer cell lines and patient-derived tumor models exhibit characteristics of disrupted copper homeostasis and enhanced copper ion-binding capacity.

Subgenual anterior cingulate cortex functional connectivity abnormalities in depression: insights from brain imaging big data and precision-guided personalized intervention via transcranial magnetic stimulation.

The subgenual anterior cingulate cortex (sgACC) plays a central role in the pathophysiology of major depressive disorder (MDD). Its functional interactive profile with the left dorsal lateral prefrontal cortex (DLPFC) is associated with transcranial magnetic stimulation (TMS) treatment outcomes. Previous research on sgACC functional connectivity (FC) in MDD has yielded inconsistent results, partly due to small sample sizes and limited statistical power.

Development, Reliability, and Validity of Comprehensive Frailty Assessment Tool for Older Adults with Cancer (FOAC) in China.

Purpose: With the accelerating ageing population, frailty has emerged as a critical concern among older cancer patients. The purpose of the study was to develop a valid and reliable Comprehensive Frailty Assessment Tool for Older Adults with Cancer (FOAC) in China.

Patients And Methods: The FOAC was developed in 4 phases.