Arts in Medicine Partnerships: Interdisciplinary Collaborations to Support Behavioral Health.

The Emporia State University (ESU) /Kansas Arts Commission (KAC) Arts in Medicine Partnership exemplifies interdisciplinary collaboration and the capacity of art therapy to impact mental health and well-being. Through the partnership, art therapy services were offered to medical agencies across the state of Kansas. Participants included medical patients, families, caregivers, staff, and professionals.

Single-cell perspective on the Monocyte-to-HDL cholesterol ratio as a metastasis biomarker in papillary thyroid cancer.

Background: Papillary thyroid carcinoma (PTC) is a globally widespread inflammation-related cancer, where lymph node metastasis (LNM) poses significant challenges to the prognosis of PTC. The role of the monocyte-to-high-density lipoprotein cholesterol ratio (MHR), a novel inflammation marker attracting increasing attention, in PTC remains unclear.

Methods: Clinical data analysis was adopted to preliminarily explore the relationship between clinical features and LNM of PTC.

Adaptive Dispersal and Collaborative Clustering for Few-Shot Unsupervised Domain Adaptation.

Unsupervised domain adaptation is mainly focused on the tasks of transferring knowledge from a fully-labeled source domain to an unlabeled target domain. However, in some scenarios, the labeled data are expensive to collect, which cause an insufficient label issue in the source domain. To tackle this issue, some works have focused on few-shot unsupervised domain adaptation (FUDA), which transfers predictive models to an unlabeled target domain through a source domain that only contains a few labeled samples.

The functional near infrared spectroscopy applications in children with developmental diseases: a review.

This review provides a comprehensive synthesis of the application of functional near-infrared spectroscopy (fNIRS) in pediatric developmental disorders, with a particular emphasis on its potential for clinical translation. fNIRS is a portable and non-invasive brain imaging technique that detects the relative concentration changes of oxyhemoglobin (HbO), deoxyhemoglobin (HbR), and total hemoglobin in the cerebral cortex. These measurements effectively reflect cortical activation, making fNIRS a valuable tool in the field of pediatric neurodevelopmental research.

hUMSC-derived exosomes alleviate follicular interstitial cell autophagy by let-7a-5p/AMPK/mTOR axis in POI rats.

Background: One major factor contributing to infertility in women of childbearing age is premature ovarian insufficiency (POI). Exosomes produced from human umbilical cord mesenchymal stem cells (hUMSC-Exos) have drawn a lot of attention lately as a potential treatment for ovarian dysfunction brought on by POI. However, its therapeutic mechanism is still unclear and needs further exploration.

Flexible and Stable Ternary Organic Photodetector for Broadband Visible-NIR Applications in High-Fidelity Imaging and Optical Communication.

Organic photodetectors (OPD)have emerged as promising candidates with broadband photodetection from the visible to the near-infrared (NIR) region. However, challenges like limited response speed and environmental instability remain. Herein, we present a vis-NIR responsive OPD based on PTB7-Th:BTP-4F:COTIC-4F ternary organic system, achieving broadband detection covering up to 1200 nm.

Dendrimer-Entrapped CuPt Bimetallic Nanozymes for Tumor Microenvironment-Regulated Photothermal/Catalytic Therapy.

Noble metal nanozymes have attracted extensive attention in tumor therapy due to their multiple enzyme-like activities for catalytic therapy and unique optical properties for photothermal therapy (PTT). However, their therapeutic efficiency may be compromised by the intricate tumor microenvironment (TME). Herein, copper-platinum (CuPt) bimetallic nanozymes were synthesized and entrapped by poly(amidoamine) dendrimers, with -carboxybenzenesulfonamide (BS, a carbonic anhydrase IX (CA IX) inhibitor) modified on the surface and lonidamine (Lon) loaded inside to regulate TME for enhanced catalytic therapy and PTT.

Identification of a novel linear B-cell epitope recognized by a monoclonal antibody against the capsid protein of goose astrovirus genotypes 2.

Background: Goose astrovirus genotype 2 (GoAstV-2) is a novel and highly infectious pathogen characterized by symptoms of gout, swelling, and hemorrhage of the kidneys in 5-15-day-old goslings. The virus has caused severe economic losses for the goose husbandry industry. The capsid protein of GoAstV-2 is involved in viral packaging and immunogenicity, and it has served as a target antigen for diagnostic methods.

Focusing properties and deep learning-based efficient tuning of symmetric butterfly beams.

In this Letter, we report what we believe to be a new type of abruptly autofocusing beams, termed symmetric butterfly Gaussian beams (SBGBs). The proposed beams appear to have a high degree of tunability for their focal position, focal length, focal intensity, and propagation trajectory. In addition, we propose a deep learning-based model for quick and accurate predictions of the propagation properties of SBGBs, achieving an average relative error of no more than 2.

Coherence shaping for optical vortices: a coherence shift keying scheme enabled by deep learning for optical communication.

To meet rapidly growing communication demands, researchers have focused on structured light-based shift keying techniques. However, higher-order modes are prone to large diffraction divergence and are easily perturbed. In this study, we experimentally demonstrate what we believe to be a novel coherence shaping method for petal-like structures of optical vortices, enabling the generation of non-diffraction interference states between completely coherent and incoherent states.

Nonpolar P-type Conjugated Small Molecules Enable High-Performance Organic Photodetectors for Potential Application in Optical Wireless Communication.

The high responsivity and broad spectral sensitivity of organic photodetectors (OPDs) present a bright future of commercialization. However, the relatively high dark current density still limits its development. Herein, two novel nonpolar p-type conjugated small molecules, NSN and NSSN, are synthesized as interface layers to enhance the performance of the OPDs, which not only can tune energy alignments and increase the reverse charge injection barrier but also can reduce the interfacial trap density.

Effects of repetitive transcranial magnetic stimulation on prefrontal cortical activation in children with attention deficit hyperactivity disorder: a functional near-infrared spectroscopy study.

Background: Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder characterized by inattention, impulsivity, and hyperactivity. With the continuous development of neuromodulation technology, Repetitive Transcranial Magnetic Stimulation (rTMS) has emerged as a potential non-invasive treatment for ADHD. However, there is a lack of research on the mechanism of rTMS for ADHD.

Goose astrovirus induces apoptosis and endoplasmic reticulum stress in gosling hepatocytes.

The ongoing Goose astrovirus (GoAstV) epidemic, which primarily infects goslings causing severe liver damage, has inflicted considerable damage on the poultry industry. Endoplasmic reticulum stress (ERS) is a significant modulator of several viral infections, while severe ERS may result in apoptosis. This study examined the roles and possible mechanisms of ERS and apoptosis in GoAstV-induced liver injury in goslings.

RBD-EVIO: optimized event-based visual-inertial odometry for a large field of view with a rotated binary DART descriptor.

Event-based cameras offer unique advantages over traditional cameras, such as high dynamic range, absence of motion blur, and microsecond-level latency. This paper introduces an innovative approach to visual odometry, to our knowledge, by integrating the newly proposed Rotated Binary DART (RBD) descriptor within a Visual-Inertial Navigation System (VINS)-based event visual odometry framework. Our method leverages event optical flow and RBD for precise feature selection and matching, ensuring robust performance in dynamic environments.

Transcranial Direct Current Stimulation for Cognitive Impairment Rehabilitation: A Bibliometric Analysis.

Background And Aims: As global demographics shift toward an older population, cognitive impairment is becoming increasingly critical. Transcranial Direct Current Stimulation (tDCS), an innovative brain stimulation technique, has the potential to significantly improve cognitive function. Our main aim is to comprehensively analyze the existing literature, identify key aspects of tDCS research in the rehabilitation of cognitive impairment, and predict future trends in this field.

Comparative efficacy of non-invasive brain stimulation on cognition function in patients with mild cognitive impairment: A systematic review and network meta-analysis.

Background: Mild cognitive impairment (MCI) is a critical time window for implementing prevention strategies to attenuate or delay cognitive decline. Non-invasive brain stimulation (NIBS) techniques are promising non-pharmacological therapies for improving the cognitive function of MCI, but it is unclear which type of NIBS protocol is most effective. This study aimed to compare and rank the beneficial effect of different NIBS methods/protocols on cognitive function and examine the acceptability of NIBS in patients with MCI.

Development and Experiment of Semi-Physical Simulation Platform for Space Manipulator.

To address the extended development cycle, high costs, and maintenance difficulties associated with existing microgravity simulation methods, this study has developed a semi-physical simulation platform for robotic arms tailored to different gravity environments and loading conditions. The platform represents difficult-to-model joints as physical objects, while the easily modeled components are simulated based on principles of similarity. In response to the strong coupling, nonlinearity, and excess force disturbance issues in the electric variable load loading system, a fractional-order linear active disturbance rejection control algorithm was employed.

The role of EMG1 in lung adenocarcinoma progression: Implications for prognosis and immune cell infiltration.

Background And Aims: Lung adenocarcinoma (LUAD) is the most common and aggressive cancer with a high incidence. N1-specific pseudouridine methyltransferase (EMG1), a highly conserved nucleolus protein, plays an important role in the biological development of ribosomes. However, the role of EMG1 in the progression of LUAD is still unclear.

Alteration of gut microbiome in goslings infected with goose astrovirus.

Goose astrovirus (GoAstV) is an emerging avian pathogen that induces gout in goslings with a mortality of up to 50%. Organ damage caused by GoAstV infection was considered the cause of gout, but it is still unclear whether other factors are involved. Human and murine studies have linked the gut microbiome-derived urate and gout, thus we hypothesized that gut microbiome may also play an important role in gout induced by GoAstV infection.

Dual drug-loaded metal-phenolic networks for targeted magnetic resonance imaging and synergistic chemo-chemodynamic therapy of breast cancer.

The development of nanomedicines with simplified compositions and synergistic theranostic functionalities remains a great challenge. Herein, we develop a simple method to integrate both atovaquone (ATO, a mitochondrial inhibitor) and cisplatin within tannic acid (TA)-iron (Fe) networks coated with hyaluronic acid (HA) for targeted magnetic resonance (MR) imaging-guided chemo-chemodynamic synergistic therapy. The formed TFP@ATO-HA displayed good colloidal stability with a mean size of 95.

Targeting SOX13 inhibits assembly of respiratory chain supercomplexes to overcome ferroptosis resistance in gastric cancer.

Therapeutic resistance represents a bottleneck to treatment in advanced gastric cancer (GC). Ferroptosis is an iron-dependent form of non-apoptotic cell death and is associated with anti-cancer therapeutic efficacy. Further investigations are required to clarify the underlying mechanisms.