Development and evaluation of the low back pain questionnaire for personnel working on islands.

Background: Low back pain (LBP) is a significant musculoskeletal disorder with multifactorial causes, affecting workforce productivity globally. Personnel working on islands face heightened LBP risk due to intensive training (e.g.

The functional near infrared spectroscopy applications in children with developmental diseases: a review.

This review provides a comprehensive synthesis of the application of functional near-infrared spectroscopy (fNIRS) in pediatric developmental disorders, with a particular emphasis on its potential for clinical translation. fNIRS is a portable and non-invasive brain imaging technique that detects the relative concentration changes of oxyhemoglobin (HbO), deoxyhemoglobin (HbR), and total hemoglobin in the cerebral cortex. These measurements effectively reflect cortical activation, making fNIRS a valuable tool in the field of pediatric neurodevelopmental research.

Identification of disulfidptosis-related genes and subgroups in spinal cord injury.

Study Design: Bioinformatics analysis and experimental validation study.

Objectives: To investigate the role and expression patterns of disulfidptosis-related genes in spinal cord injury (SCI), identify potential pivotal genes, and explore possible therapeutic targets.

Setting: Shanghai, China.

Revolutionizing the treatment of intervertebral disc degeneration: an approach based on molecular typing.

Background: Intervertebral disc degeneration (IVDD) is a significant cause of global disability, reducing labor productivity, increasing the burden on public health, and affecting socio-economic well-being. Currently, there is a lack of recognized clinical approaches for molecular classification and precision therapy.

Methods: Chondrocyte differentiation and prognosis-related genes were extracted from single-cell RNA sequencing and multi-omics data in the Gene Expression Omnibus (GEO) database through chondrocyte trajectory analysis and non-parametric tests.

Bioprinted hydrogels in bone regeneration: a bibliometric analysis.

Background: The application of bioprinted hydrogels in the field of bone regeneration is garnering increasing attention. The objective of this study is to provide a comprehensive overview of the current research status, hotspots and research directions in this field through bibliometric methods, and to predict the development trend of this field.

Methods: A search was conducted on 27 December 2024, for papers published on the Web of Science from 2010 to 2025.

The application and influence of "Small Private Online Course" based on flipped classroom teaching model in the course of fundamental operations in surgery in China.

To investigate the effect of "Small Private Online Course" (SPOC) based on flipped classroom teaching model on the students in the course of fundamental operations in surgery. A prospective study. 8-year program students (juniors) majored in clinical medicine in Navy medical university.

Reliability and validity of simplified Chinese version of Spinal Cord Injury Pain Instrument in patients with spinal cord injury in mainland China.

Purpose: To cross-culturally adapt the Spinal Cord Injury Pain Instrument (SCIPI) into a simplified Chinese version (SC-SCIPI) and verify reliability and validity in screening for neuropathic pain in SCI patients.

Methods: A preliminary validation study was conducted to screen for neuropathic pain after SCI using SCIPI. A total of 130 patients with SCI treated at Shanghai Changhai Hospital were enrolled.

Microneedle/CD-MOF-mediated transdural controlled release of methylprednisolone sodium succinate after spinal cord injury.

A new method of transdural delivering drugs to the spinal cord has been developed, involving the use of microneedles (MNs) and a β-cyclodextrin metal-organic framework (CD-MOF). This epidural microneedle array, dubbed MNs@CD-MOF@MPSS, can be utilized to deliver methylprednisolone sodium succinate (MPSS) to the site of spinal cord injury (SCI) in a controlled manner. MNs allows to generate micropores in the dura for direct drug delivery to the spinal cord, overcoming tissue barriers and targeting damaged regions.

Measurement Properties of the Simplified Chinese Version of the Lumbar Spine Instability Questionnaire for Patients With Low Back Pain in Mainland China.

Study Design: A prospective study.

Objective: To develop a simplified Chinese version of Lumbar Spine Instability Questionnaire (SC-LSIQ) and test its measurement properties.

Summary Of Background Data: The LSIQ has been translated into several languages.

Do hypokyphotic adolescent idiopathic scoliosis patients treated with Ponte osteotomy obtain a better clinical efficacy? A preliminary retrospective study.

Study Design: A retrospective case-control study.

Objective: To evaluate whether Ponte osteotomy improves thoracic kyphosis and to determine its clinical efficacy in hypokyphotic adolescent idiopathic scoliosis (AIS).

Methods: Eighty consecutive Lenke type 1 AIS patients with hypokyphotic curves who underwent posterior spinal fusion by one spine surgeon at a single institution were recruited.

RHOA inhibits chondrogenic differentiation of mesenchymal stem cells in adolescent idiopathic scoliosis.

Purpose: The etiology of adolescent idiopathic scoliosis (AIS) remains unclear. The chondrogenic differentiation of mesenchymal stem cells (MSCs) is important in AIS, and the Ras homolog gene family member A (RHOA) is associated with chondrogenesis. The purpose of this study was to explore the effect of RHOA on the chondrogenic differentiation of MSCs in AIS.

Global research trends of adult degenerative scoliosis in this decade (2010-2019): a bibliometric study.

Objective: With the population aging, there is an associated rise in the prevalence of adult degenerative scoliosis (ADS). However, limited data were found to elaborate the trend of ADS research. Our study aims to investigate the global trend of ADS research in this decade.

Shikonin mitigates ovariectomy-induced bone loss and RANKL-induced osteoclastogenesis via TRAF6-mediated signaling pathways.

Background: Postmenopausal osteoporosis results from estrogen withdrawal and is characterized mainly by bone resorption. Shikonin is a bioactive constitute of Chinese traditional herb which plays a role in antimicrobial and antitumor activities. The study was designed to investigate the role of shikonin on postmenopausal osteoporosis and explore its underlying mechanisms.

Assessment of Sagittal Spinopelvic Balance in a Population of Normal Chinese Children.

Study Design: A retrospective study of 257 normal children at a single center from July 2016 to November 2018 was performed.

Objective: To evaluate the spinopelvic parameters in a population of normal children and adolescents in mainland China.

Summary Of Background Data: Values for sagittal parameters of the spine vary significantly by ages and different population.

Low-intensity pulsed ultrasound promotes spinal fusion by regulating macrophage polarization.

Background: Spinal fusion is considered the gold standard procedure for treating spinal degeneration, tumors, and trauma. An inflammatory response is an important part of bone repair. We investigated the polarization change of inflammatory macrophages (M1) and resident macrophages (M2) during low-intensity pulsed ultrasound (LIPUS) treatment.

Validation of Simplified Chinese Version of the Pain Self-Efficacy Questionnaire (SC-PSEQ) and SC-PSEQ-2 for Patients With Nonspecific Low Back Pain in Mainland China.

Study Design: A prospective study.

Objective: The aim of this study was to develop the simplified Chinese version of Pain Self-efficacy Questionnaire (PSEQ) (SC-PESQ) and PSEQ-2 (SC-PSEQ-2), and evaluate the psychometric properties of the two questionnaires in patients with nonspecific low back pain.

Summary Of Background Data: PSEQ has been cross-culturally adapted into many languages with excellent reliability and validity.

Cross-cultural Adaptation and Validation of the Simplified-Chinese Version of Neck Bournemouth Questionnaire for Patients in Mainland China.

Study Design: A prospective study.

Objective: The aim of this study was to develop and assess the internal reliability and structure validity of a simplified Chinese version of the Neck Bournemouth Questionnaire (SC-NBQ) for evaluation of patients with nonspecific neck pain (NP) in mainland China.

Summary Of Background Data: The NBQ has been cross-culturally translated into several languages with good internal consistency and construct validity to evaluate low back pain and NP.

Bibliometric Analysis of Global Scientific Research on lncRNA: A Swiftly Expanding Trend.

To investigate trends in long-noncoding (lnc) RNA research systematically, we compared the contribution of publications among different regions, institutions, and authors. Publications on lncRNA were retrieved from Web of Science (WoS) from 1975 to 2017. A total of 3879 papers were identified, and together they were cited 62967 times.

Low-intensity pulsed ultrasound promotes spinal fusion and enhances migration and proliferation of MG63s through sonic hedgehog signaling pathway.

Low-intensity pulsed ultrasound (LIPUS) has been found to accelerate the healing process of spinal fusion via a process closely related to osteoblast differentiation and migration. Sonic hedgehog (Shh) signaling plays an important role in development and homeostasis, including a critical function in bone formation. However, its role in spinal fusion during LIPUS treatment is still unknown.

Low-intensity pulsed ultrasound promotes endothelial cell-mediated osteogenesis in a conditioned medium coculture system with osteoblasts.

Angiogenesis plays an important role during bone regeneration. Low-intensity pulsed ultrasound (LIPUS) has been proven to accelerate the process of bone fracture healing. However, the mechanism of the effect of LIPUS on bone regeneration is still unclear.

I-BET151 inhibits expression of RANKL, OPG, MMP3 and MMP9 in ankylosing spondylitis and .

Ankylosing spondylitis (AS) is characterized by osteoclastogenesis and inflammatory bone resorption. The present study aimed to investigate the effect of bromodomain and extra-terminal domain (BET) protein inhibitor I-BET151 on AS process. A total of 38 AS Chinese patients were recruited and a further 38 sex- and age-matched healthy participants were selected as control.

Global research trends in spinal ultrasound: a systematic bibliometric analysis.

Background: In recent years, there has been increased interest in the use of ultrasound technology in the evaluation of spinal and paraspinal regions.

Objective: This study aimed to investigate trends in spinal ultrasound research from 1994 to 2015 and compare the contributions of such research from different countries and authors.

Study Design: Bibliometric analysis.

Cross-cultural validation of simplified Chinese version of spine functional index.

Background: No effective constructs were available in mainland China to assess the whole spine function. The SFI was developed to evaluate spinal function based on the concept of a single kinetic chain concept for whole spine. The SFI has been translated to Spanish and Turkish with accepted psychometric properties.