Artificial Peptides as Autophagy Modulators.

Autophagy is a highly conserved lysosomal degradation pathway for maintaining cellular homeostasis. Its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections, making precise modulation of autophagy a potentially promising therapeutic strategy. Artificial peptide-based autophagy modulators have emerged as a promising alternative to conventional small molecules, offering several advantages in terms of specificity, biocompatibility, and functional versatility.

Unconventional strong 3p-3d orbital hybridization in sulfur-doped FeSe: for tailored ultrathin electromagnetic wave absorbers.

Anion doping engineering is an effective method to regulate the electronic structure of transition metal dichalcogenides (TMDs), especially at the electron orbital level. Based on electromagnetic wave (EMW) loss theory, this study innovatively constructs dipole polarization sites S doping in FeSe. The electronic structure of these sites is systematically analyzed to reveal charge redistribution and bond hybridization induced by dopant incorporation.

Pocket Electronic Nose Integrating an Ultra-Compact Sensor Array Chip and Spatiotemporal Network Enables Highly Selective Gas Sensing.

Accurately distinguishing gases with nearly identical molecular structures─such as nitric oxide (NO) and nitrogen dioxide (NO)─remains challenging for conventional sensors. We report a palm-sized (5 cm × 5 cm) electronic nose that integrates an ultralow-power microelectro-mechanical systems (MEMS) sensor array with a spatiotemporal deep-learning model (STNet), for trace-level detection and quantification of NO and NO. The array contains nine carbon-based nanocomposite sensors monolithically fabricated on a 3 mm × 3 mm chip; each sensor operates at room temperature, consumes <2 mW, and achieves detection limits below 0.

Epidemiology and Pathogenicity Analysis Based on Partial Recombinant PRRSV Strains in China.

Currently, multiple recombinant variants of porcine reproductive and respiratory syndrome virus (PRRSV) are circulating in China. These variants exhibit differences in pathogenicity. To comprehensively understand the current status of the virus and its recombination patterns, a total of 677 PRRSV strains were used for evolutionary analysis, of which 673 strains were isolated from mainland China.

VrMYB90 negatively regulates proanthocyanidin biosynthesis by repressing VrANR in mung bean (Vigna radiata L.).

VrANR and VrMYB90 were identified by transcriptome between 'Sulv1' and 'M0313'. VrMYB90 acted upstream of VrANR by binding to the promoter of VrANR and inhibiting the expression of VrANR, thus regulating negatively the biosynthesis of proanthocyanins. Anthocyanin reductase (ANR), the enzyme responsible for converting anthocyanidins to their corresponding 2,3-cis-flavan-3-ols, which is crucial to balance the anthocyanins and proanthocyanidins (PAs) level.

[Acupuncture at combined with auricular point sticking in the treatment of primary dysmenorrhea: a randomized controlled trial].

Objective: To observe the clinical effect of acupuncture at combined with auricular point sticking on primary dysmenorrhea (PDM).

Methods: Sixty patients with PDM were randomly divided into an observation group and a control group, with 30 cases in each group. Patients in the observation group were treated with acupuncture at combined with auricular point sticking.

Implementation of RT-RAA and CRISPR/Cas13a for an NiV Point-of-Care Test: A Promising Tool for Disease Control.

Nipah virus (NiV) is a severe zoonotic pathogen that substantially threatens public health. Pigs are the natural hosts of NiV and can potentially transmit this disease to humans. Establishing a rapid, sensitive, and accurate point-of-care detection method is critical in the timely identification of infected pig herds.

Bacterial extracellular vesicles in osteoarthritis: a new bridge of the gut-joint axis.

Osteoarthritis (OA) is a degenerative joint disease primarily characterized by cartilage degeneration. Increasing evidence suggests that there is an interplay between the gut microbiota (GM) and joint health, known as the gut-joint axis. In recent years, with the advancement of bacterial extracellular vesicles (BEVs) research, its role in the gut-joint axis has attracted increasing attention.

A novel classification for aseptic femoral shaft nonunion after intramedullary nailing: a retrospective study.

Background: Although intramedullary nailing has been established as the gold standard for treating femoral shaft fractures, nonunion following intramedullary nailing remains a major concern for clinicians, severely affecting patients' walking ability and quality of life. Presently, there are certain controversies and deficiencies in nonunion classification and treatment. Herein, we propose a novel classification system for aseptic femoral shaft nonunion after intramedullary nailing based on X-ray-assessed nailing morphology and stability.

The NADC30-like PRRSV activates the integrin αV subunit to facilitate its entry into Marc-145 cells.

Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious virus that poses a significant threat to the global pig farming industry, resulting in substantial economic losses. However, owing to the high variability of PRRSV and unclear mechanisms of infection, there are currently no effective vaccines or drugs available for its prevention and control. Our previous report revealed that highly pathogenic PRRSV (HP-PRRSV) requires the FAK-PI3K-AKT signaling pathway to facilitate its entry into cells.

Research advances in replication-deficient viral vector vaccines.

In recent years, replication-deficient viral vector vaccines have attracted much attention in the field of vaccine research and development due to their high safety and immunogenicity. These vaccines use genetic modifications to engineer viral vectors that make them unable to replicate but effective in expressing recombinant proteins and induce immune responses. Currently, replication-deficient adenovirus vectors and poxvirus vectors are widely used in vaccine R&D for a variety of infectious diseases in humans and animals, including AIDS, hepatitis B, pseudorabies, avian influenza, infectious bronchitis in poultry, and foot-and-mouth disease.

Epidemiology, genetic diversity and evolution of pigeon circovirus.

With the global prevalence of pigeon racing, pigeon infections with Pigeon circovirus (PiCV) have been reported across the world. PiCV-infected pigeons are susceptible to subsequent infections and exhibit a range of symptoms including weight loss, lethargy, anorexia, respiratory distress and diarrhea, which exerts a huge impact on the pigeon industry. However, there is currently a lack of epidemiological data on PiCV infection in pigeons.

FLRT3 Overexpression Attenuates Ischemia-Reperfusion Induced Vascular Hyperpermeability and Lung Injury Through RND3.

Purpose: Pulmonary ischemia/reperfusion injury (IRI) causes endothelial barrier dysfunction and increased vascular permeability. Fibronectin leucine-rich transmembrane protein-3 (FLRT3) is known to regulate endothelial cell function, but its role in pulmonary IRI remains unexplored.

Methods: We established both a mouse lung I/R model and a hypoxia/reoxygenation (H/R) cell culture model using human pulmonary microvascular endothelial cells (HPMECs).

The role of advanced glycation end products between thyroid function and diabetic nephropathy and metabolic disorders.

Unlabelled: purpose of this study was to investigate the relationship between AGEs, TSH, metabolic metrics and DN, and to provide evidence for future intervention.

Method: This study selected community health service centers which had signed medical alliance agreement with the First Affiliated Hospital of Anhui Medical University and outpatints and inpatients in Anhui province. From March 2018 to July 2022, the multi-stage cluster sampling.

A Cross-Machine Intelligent Fault Diagnosis Method with Small and Imbalanced Data Based on the ResFCN Deep Transfer Learning Model.

Intelligent fault diagnosis (IFD) for mechanical equipment based on small and imbalanced datasets has been widely studied in recent years, with transfer learning emerging as one of the most promising approaches. Existing transfer learning-based IFD methods typically use data from different operating conditions of the same equipment as the source and target domains for the transfer learning process. However, in practice, it is often challenging to find identical equipment to obtain source domain data when diagnosing faults in the target equipment.

Radiofrequency ablation for peribiliary hepatocellular carcinoma: propensity score matching analysis.

Objectives: At present, there are no established clinical guidelines for radiofrequency ablation (RFA) of peribiliary hepatocellular carcinoma (HCC). Therefore, the aim of this study was to compare the long-term outcomes of RFA for peribiliary vs. non-peribiliary HCC.

Mitsunobu reaction: assembling C-N bonds in chiral traditional Chinese medicine.

The synthesis of chiral molecules has long been a central focus and challenge in medicinal chemistry research. The Mitsunobu reaction, developed by Japanese chemist Mitsunobu in 1967, is a widely utilized bimolecular nucleophilic substitution reaction that plays a vital role in synthesizing chiral natural products. In this reaction, alcohols react with nucleophilic reagents in the presence of a phosphine ligand to form an intermediate phosphonium salt.

Effectiveness of gua sha with Masanggoubang oil in rats with chronic soft tissue injury.

Background: Chronic soft tissue injury is characterized by sterile inflammation and pain. Gua sha with Masanggoubang oil (GSMO) treatment has been found to possess anti-inflammatory and analgesic effects.

Objectives: To explore the mechanism of GSMO in chronic soft tissue injuries.

Recent progress in C-S bond formation electron donor-acceptor photoactivation.

Recent advancements in C-S bond formation electron donor-acceptor (EDA) complex photoactivation have been remarkable. EDA complexes, which are composed of electron donors and acceptors, facilitate C-S bond construction under mild conditions through single-electron transfer events upon visible light irradiation. This review highlights the utilization of various sulfur-containing substrates, including diacetoxybenzenesulfonyl (DABSO), sulfonic acids, sodium sulfinates, sulfonyl chlorides, and thiophenols, in EDA-promoted sulfonylation and thiolation reactions, covering the works published since 2017 to date.

FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models.

Background: We developed the FORCE platform to overcome limitations of oligonucleotide delivery to muscle and enable their applicability to neuromuscular disorders. The platform consists of an antigen-binding fragment, highly specific for the human transferrin receptor 1 (TfR1), conjugated to an oligonucleotide via a cleavable valine-citrulline linker. Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by expanded CUG triplets in the DMPK RNA, which sequester splicing proteins in the nucleus, lead to spliceopathy, and drive disease progression.

Adenosine signaling: a potential therapeutic target for psychogenic erectile dysfunction.

Therapeutic modalities for psychogenic erectile dysfunction (PED) are poorly targeted because of the lack of specific pathological features. The common symptoms of PED include psychological stress-related negative emotions and erectile dysfunction. Exploring their common therapeutic targets is helpful in the development of effective PED treatment strategies.

[Acupuncture combined with bamboo-based medicinal moxibustion for chronic insomnia complicated with mild depressive state: a randomized controlled trial].

Objective: To observe the clinical efficacy of acupuncture combined with bamboo-based medicinal moxibustion in the treatment of chronic insomnia complicated with mild depressive state.

Methods: A total of 60 patients with chronic insomnia complicated with mild depressive state were randomly divided into an observation group and a control group, 30 cases in each group. The control group was treated with acupuncture at bilateral Zhaohai (KI6), Shenmen (HT7), Sanyinjiao (SP6), Anmian (Extra) and Sishencong (EX-HN1), Baihui (GV20), etc.

Peritumoral vessel characteristics on magnetic resonance venography reflect the sinus invasion status of para-sinus meningioma.

Background: Early recognition of sinus invasion for meningiomas matters the clinical intervention. Therefore, we retrospectively investigated the relationship between peritumoral vessel features on magnetic resonance venography (MRV) and sinus invasion status.

Methods: Images of phase contrast MRV (PC-MRV, n=46) and contrast-enhanced MRV (CE-MRV, n=39) were independently assessed by four experienced neuroradiologists, including the adjacent sinus status, the peritumoral vessel count and diameter-associated parameters.

Immunotherapy beyond progression following first‑line chemotherapy plus immunotherapy in advanced non‑small cell lung cancer: A retrospective study.

Immunotherapy has paved the way for new treatment options for advanced non-small cell lung cancer (NSCLC). However, for patients who have progressed following first-line immunotherapy combined with chemotherapy, little is known about the benefits of the continuation of immunotherapy. Thus, the current study aimed to evaluate the efficacy of immunotherapy beyond progression (IBP) in patients with advanced NSCLC.

A cross-tissue transcriptome-wide association study identifies WDPCP as a potential susceptibility gene for coronary atherosclerosis.

Background: Coronary atherosclerosis (CAS) is a complex chronic inflammatory disease with significant genetic and environmental contributions. While genome-wide association studies (GWAS) have pinpointed many risk loci, over 75 % are in non-coding regions, complicating functional analysis and understanding gene-disease mechanisms.

Methods: We conducted a cross-tissue transcriptome-wide association study (TWAS) using data from the GWAS Catalog (16,041 cases, 440,307 controls) and the Genotype-Tissue Expression (GTEx) v8 eQTL dataset.