Unconventional strong 3p-3d orbital hybridization in sulfur-doped FeSe: for tailored ultrathin electromagnetic wave absorbers.

Anion doping engineering is an effective method to regulate the electronic structure of transition metal dichalcogenides (TMDs), especially at the electron orbital level. Based on electromagnetic wave (EMW) loss theory, this study innovatively constructs dipole polarization sites S doping in FeSe. The electronic structure of these sites is systematically analyzed to reveal charge redistribution and bond hybridization induced by dopant incorporation.

A red-emitting fluoresce probe based on supramolecular acyclic cucurbit[n]urils self-assembly for dual-responsive detection of ClO and cell imaging.

Hypochlorite (ClO) is a significant reactive oxygen species, and excessive amount ClO is associated with oxidative stress and various diseases. Therefore, high sensitivity monitoring of intracellular ClO is crucial for diseases diagnosis. In this context, the supramolecular fluorescent probe (ACBs@APFG) has been successfully developed based on self-assembly between acyclic cucurbit[n]urils (ACBs, including M1 and M2) and Astrazone pink FG (APFG).

BBOX1 is a Metabolic Checkpoint that Mediates Metastatic Cancer Cell Evasion from Immunosurveillance by Natural Killer Cells.

Primary tumors constantly shed cancer cells into the circulation, yet only a fraction of these cells manages to give rise to metastatic tumors. Successful metastatic seeding and growth appears to depend on metabolic changes within cancer cells. Here, using a metabolism-focused CRISPR screen in a spontaneous metastasis model, we found that expression of the enzyme γ-butyrobetaine hydroxylase 1 (BBOX1) in a subpopulation of tumor cells in various carcinomas enables immune evasion.

Co-Production of KPC-2 and NDM-5 in a Carbapenem-Resistant Clinical Isolate: Genetic Insights and Risks.

Background:  Carbapenem-resistant  (CRKP), particularly strains co-producing KPC and NDM carbapenemases, poses a severe global health threat due to limited treatment options. Understanding the genetic drivers of resistance and transmission is critical.

Methods:  A multidrug-resistant CRKP strain, KP3T58, co-harboring   and  , was isolated from an ICU patient.

Pipeline corrosion detection via group delay accumulation effect of multi-path circumferential guided wave packets.

Circumferential Guided Waves (CGW) inspection offers a prospective approach for detecting corrosion damage in metallic pipeline structures. It could be used to identify the circumferential location of defects and provide quantitative assessments of defects. Typically, the group delay of the first wave packet passing through the corroded region is utilized to evaluate the variation in group velocity due to corrosion.

circGAPVD1 inhibits the progression of gastric cancer through miR-4424/STK4 axis and encoding GAPVD1-137aa protein.

Background: Gastric cancer (GC) is a malignant gastrointestinal tumor that originates from the epithelium of the gastric mucosa, and circular RNA (circRNA) plays an important role in its progression.

Methods: The localization of circGAPVD1 and miR-4424 was determined using cytoplasmic RNA isolation and fluorescence in situ hybridization (FISH) assay. The expression levels of circGAPVD1, miR-4424 and mRNA transcripts were determined by quantitative real-time polymerase chain reaction (qPCR).

Free Radical Polymerization of Styrene and Maleimide Derivatives: Molecular Weight Control and Application as a Heat Resistance Agent.

Poly (styrene-maleic anhydride) copolymers, due to their unique structure, are extensively functionalized and modified for preparing heat stabilizers, compatibilizers, and other functional additives. Using 4-methylpent-1-ene-2,4-diyl diphenyl (α-MSD) as a chain transfer agent, a series of molecular-weight-controlled maleic anhydride-derived styrene copolymers, poly(N-p-fluorophenylmaleimide-alt-styrene) (PFS) and poly(N-p-carboxylphenylmaleimide-alt-styrene) (PCS), were synthesized via free radical copolymerization. The molecular weights of PFS and PCS were adjusted to explore their impact on the properties of PFS/PA6 and PCS/PA6 blends.

Chitosan composite films with high-content technical alkali lignin.

Technical alkali lignin (TAL) has been widely studied as the regulator in forming materials. When composited with non-thermoplastic polymers, its content was generally below 10 wt%, which is utterly inadequate in dealing with a difficult situation for the large-scale production of TAL. Here, we adjusted the solvent to form a series of high-strength chitosan-based composite films with high-content TAL.

The Association of Age and Liver Transplant Outcomes in Patients With Acute-On-Chronic Liver Failure.

Introduction: To explore the role of age at listing on outcomes for patients with acute-on-chronic liver failure (ACLF) awaiting liver transplantation (LT).

Materials And Methods: We assessed adult candidates listed for LT in the Scientific Registry of Transplant Recipients database from January 1, 2007 to June 30, 2018. Patients were divided into four groups based on age at listing: I (≤34), II (35-49), III (50-64), and IV (≥65).

USP10 stabilizes BAZ1A to drive tumor stemness via an epigenetic mechanism in head and neck squamous cell carcinoma.

Aberrant epigenetic remodeling events occurred in head and neck squamous cell carcinoma (HNSCC) contribute to tumor stemness and chemotherapy resistance, yet little is known. In this study, we identified that ubiquitin-specific peptidase 10 (USP10) is up-regulated in HNSCC tissues, and high USP10 is associated with poor prognosis of patients. Functionally, USP10 serving as an oncogene potentiates the proliferation and metastasis of HNSCC cells in vitro and in vivo.

Lignin: Dissolution, modification, and derived materials.

Global environmental issues and energy dilemmas have made renewable and sustainable technologies become on the cutting edge. Lignin, the most abundant non-petroleum polyhydroxy aromatic macromolecule, has been widely studied to convert to platform chemicals via violent cleavage. This makes good use of lignin, which can effectively remit environmental and energy problems.

Characterization of a multidrug-resistant hypovirulent ST1859-KL35 klebsiella quasipneumoniae subsp. similipneumoniae strain co-harboring tmexCD2-toprJ2 and bla.

Objectives: The rise of multidrug-resistant (MDR) Klebsiella pneumoniae is a significant public health threat. Klebsiella quasipneumoniae is often misidentified as K. pneumoniae, and its genetic and virulence traits remain underexplored.

Custom-Primed Rolling Circle Amplicons for Highly Accurate Nanopore Sequencing.

Tandem repeats of a certain DNA sequence can be generated using rolling circle amplification (RCA), where a circular template is continuously amplified by a polymerase with strand displacement activity. In leveraging the linear repetition of the target sequence, enhanced accuracy is achievable by consensus calling in nanopore sequencing. However, traditional multiply-primed RCA produces branched products with limited length, which may not be optimal for nanopore sequencing.

Trophic-transferred hierarchical fragmentation of microplastics inducing distinct bio-adaptations via a microalgae-mussel-crab food chain.

Microplastics (MPs) are alarming social issues owing to their detrimental influences on both ecology and human health. Although MPs retained in low-trophic organisms are assumed to be transferred to high-trophic organisms via the food chain, concrete knowledge about the physical-chemical alterations of MPs via trophic transfer and the impact of trophic-transferred MPs on organisms remains scarce. Here, we established a three-tiered (microalgae-mussel-crab) trophic-transfer model to systematically investigate the bio-accumulation and distribution of polyethylene MPs (PE-MPs, 10-45 μm), and subsequent induction of antioxidant defenses in marine organisms with pivotal ecological and economic status at each trophic level.

Facile fabrication of high-strength whole cotton-based cellulose film and its freshness preservation.

Current studies have shown the potential of cellulose-based films in freshness preservation but are restricted by shrinkage due to the intramolecular and intermolecular hydrogen bonds in the regeneration process. The route that can consume hydroxyl groups is proper for fabricating cellulose-based film with flat appearances, such as the Schiff reaction that was the further crosslinking with polyamines. However, dynamic Schiff reaction undoubtedly releases amine components under acidic or alkaline conditions, as well as the presence of the microorganisms.

JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer.

Ferroptosis inducers have shown therapeutic potential in prostate cancer, but tumor heterogeneity poses a barrier to their efficacy. Distinguishing the regulators orchestrating metabolic cross-talk between cancer cells could shed light on therapeutic strategies to more robustly activate ferroptosis. In this study, we found that aberrant accumulation of Jumonji domain-containing 6 (JMJD6) proteins correlated with poorer prognosis of patients with prostate cancer.

Preparation and Characterization of Small-Size and Strong Antioxidant Nanocarriers to Enhance the Stability and Bioactivity of Curcumin.

The purpose of this study was to design nanocarriers with small-size and antioxidant properties for the effective encapsulation of curcumin. Here, procyanidins, vanillin, and amino acids were used to successfully prepare nanocarriers of a controllable size in the range of 328~953 nm and to endow antioxidant ability based on a one-step self-assembly method. The reaction involved a Mannich reaction on the phenolic hydroxyl groups of procyanidins, aldehyde groups of vanillin, and amino groups of amino acids.

Cellulose nanocrystals-based Pickering emulsion with enhanced foliar adhesion and pH responsiveness for intelligent delivery of pesticides.

Pickering emulsions stabilized by functionalized natural macromolecules have emerged with promising responsiveness for pesticide encapsulation and release. This study developed Pickering emulsions using amine-modified cellulose nanocrystals (ACNCs) as stabilizers. The resultant O/W ACNCs-Pickering emulsions (ACNCs-Pickering) exhibited long-term storage stability and showed increasing emulsion stability depending on the concentration of ACNCs.

Toward Efficient Utilization of Photogenerated Charge Carriers in Photoelectrochemical Systems: Engineering Strategies from the Atomic Level to Configuration.

Photoelectrochemical (PEC) systems are essential for solar energy conversion, addressing critical energy and environmental issues. However, the low efficiency in utilizing photogenerated charge carriers significantly limits overall energy conversion. Consequently, there is a growing focus on developing strategies to enhance photoelectrode performance.

Biological aging accelerates hepatic fibrosis: Insights from the NHANES 2017-2020 and genome-wide association study analysis.

Introduction And Objectives: This study aimed to investigate the association between biological aging and liver fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

Materials And Methods: We analyzed NHANES 2017-2020 data to calculate phenotypic age. Hepatic steatosis and fibrosis were identified using controlled attenuation parameters (CAP), fatty liver index (FLI) and transient elastography (TE).

Responsive Supramolecular Nanomicelles Formed through Self-Assembly of Acyclic Cucurbit[]uril for Targeted Drug Delivery to Cancer Cells.

The supramolecular drug delivery systems (SDDSs) based on host-guest recognition through noncovalent interactions, capable of responsive behavior and dynamic switching to external stimuli, have attracted considerable attention in cancer therapy. In this study, a targeted dual-functional drug delivery system was designed and synthesized. A hydrophilic macrocyclic host molecule (acyclic cucurbit[]uril ACB) was modified with folic acid (FA) as a targeting ligand.

Sediment dynamic responses of coastal salt marsh to wind waves and swells in a semi-open tidal flat.

Coastal salt marshes provide effective protection to the coastal environments they front against coastal erosion by reducing the incoming wave energy. Understanding sediment dynamic processes in coastal salt marshes environments is of crucial importance for coastal defense. The objective of this study is to assess the impact of Spartina alterniflora (S.

The interaction between water quality and meteorological factors on chlorophyll-a concentration in Honghu Lake: based on PiecewiseSEM-generalized additive model coupling model.

In order to explore the interactive effects of environmental factors on the chlorophyll-a (Chl-a) concentration variation in Honghu Lake, this study was based on the monitoring data of Chl-a mass concentration and water quality factors (water temperature, pH, dissolved oxygen, permanganate index, total nitrogen, total phosphorus) and meteorological factors (evaporation, precipitation, sunshine hours, average wind speed) at three research sites (Dakou, Chatan Island, Lantian) in Honghu Lake from January 2010 to December 2019. Time series analysis, piecewise structural equation model (PiecewiseSEM), and generalized additive model (GAM) were used to quantitatively study the spatial and temporal changes of different environmental factors and their interaction with chlorophyll-a concentration in Honghu Lake. The results showed that the effects of TN and DO on Chl-a at Dakou and Chatan Island were more significant than other environmental meteorological factors, while the effects of DO and COD on Chl-a at Lantian were more obvious.