Regioselective construction of two isomeric BN-fused aromatic frameworks enabling the synthesis of ultralong room-temperature phosphorescence materials.

BN-fused aromatic compounds have garnered significant attention due to their unique electronic structures and exceptional photophysical properties, positioning them as highly promising candidates for applications in organic optoelectronics. However, the regioselective synthesis of BN isomers remains a formidable challenge, primarily stemming from the difficulty in precisely controlling reaction sites, limiting structural diversity and property tunability. Herein, we propose a regioselective synthetic strategy that employs 2,1-BN-naphthalene derivatives, wherein selective activation of N-H and C-H bonds is achieved in conjunction with -halogenated phenylboronic acids.

Liver response to heat and humidity stress in high fat diet fed rats: a biochemical and histological investigation.

Climate change, characterized by rising global temperatures, has resulted in increased instances of heatwaves, posing significant public health threats. Among various health risks, heat-related illnesses are prevalent, exacerbated by environmental factors like high humidity and high-fat diet (HFD), which are known to impact metabolic functions in animals. The study was conducted to evaluate the effects of heat and humidity stress on liver function markers and histological changes in rats fed a high fat diet, thereby enhancing our understanding of how environmental stressors impact liver health.

Recent Advances in Iodine-Mediated Radical Reactions.

Over the past two decades, iodine-mediated free radical reactions have been extensively explored and employed in chemical transformations that complement traditional ionic reactions. In this review, we have updated the progress of the iodine-mediated radical reactions in organic synthesis reported between 2015 and mid-2024, and organized the reactions according to their mechanistic pathways. In general, the proposed mechanisms can be divided into four categories based on the radical initiation or its preceding steps, namely, (1) formation of a covalent X-I (X=C, N, S, Se) bond, which subsequently participates in a radical reaction; (2) formation of a noncovalent N···I bond, which assists the homolysis of the I-I bond; (3) formation of the key iodine radicals by visible-light or heat induced homolysis of I or by electrochemical oxidation of iodide; (4) iodine induced peroxide decomposition single electron transfer (SET) mechanism to generate alkoxy or alkyl peroxy radicals.

Copper Ion and Tannic Acid Polyphenol-Metal Scaffold Loaded with Curcumin Promote Skin Wound Healing.

Skin wound healing is a complex physiological process that requires coordinated action of various tissue cells. Several factors, such as infection and excessive inflammation, can prolong the healing process and, in severe cases, may lead to chronic wounds, threatening people's lives and health. Therefore, effective treatment strategies are required to accelerate the healing process and improve the quality of healing.

Prediction model of heat transfer coefficient for high pressure water descaling based on water flux.

While existing mathematical formulas have provided empirical references, significant discrepancies were observed in the calculated heat transfer coefficient (HTC) values when these formulations were applied to high-pressure water descaling processes. Consequently, the analysis of the descaling temperature field was rendered inaccurate. This study undertook a systematic investigation of the impacts of various operational variables, including water flow rate, nozzle-to-billet standoff distance, nozzle geometric parameters, and installation configuration, which were subsequently converted into water flux.

Branchio-oto-renal syndrome in a young Han Chinese female: a case report and review of the literature.

Background: Branchio-oto-renal syndrome is a rare autosomal dominant disorder characterized by branchial arch anomalies, hearing loss, and renal dysplasia. Its diagnosis remains challenging due to clinical heterogeneity and overlapping features with other syndromes. This case report aims to enhance awareness of branchio-oto-renal syndrome and highlight multidisciplinary management strategies.

Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron-Mediated Lung-to-Brain Axis.

Mesenchymal stromal cells (MSC) have emerged as a promising therapeutic option for neuropathic pain (NP), but the mechanisms remain elusive. Using murine pain models, it is demonstrated that MSC effectively alleviates pain, with efficacy comparable to dexmedetomidine, a moderate analgesic. Mechanistically, peripheral delivery of MSC-activated pulmonary Npy2r-expressing vagal sensory neurons, which project to the nucleus tractus solitarius and ventral lateral periaqueductal gray area, drives analgesia via the vagal lung-to-brain pathway.

Broad-spectrum antiviral activity of the sigma-1 receptor antagonist PB28 against coronaviruses.

The continuous evolution of coronaviruses poses persistent and severe threats to both human and animal health. While α- and β-coronaviruses mainly infect mammals, including humans, γ-coronaviruses predominantly infect poultry, causing substantial economic losses. Their rapid mutation rates and wide host tropism underscore the urgent demand for pan-coronavirus therapeutics.

Correction: Dual roles of proteins in macrophage immune dynamics.

[This corrects the article DOI: 10.3389/fimmu.2025.

Deciphering the uncertainties in ecosystem service value: An innovative protocol focused on ecological traits.

In the growing assessment of ecosystem service value (ESV), the endeavours to unravel the uncertainties of ESV assessment have been limited, especially those arising from ecological traits (e.g., net primary productivity, precipitation and soil erosion).

Integrated pH-responsive three-phase system: Time- and solvent-efficient biorefining of waste into multifunctional saponins.

seed cake (COSC), an agricultural byproduct, offers untapped potential as a biosurfactant source but suffers from inefficient extraction. We developed a pH-responsive platform integrating ultrasound-assisted alkaline three-phase partitioning (-butanol/ammonium sulfate, pH 10) and acid-triggered precipitation (pH 4.5).

Genome-wide association study and transcriptome analysis reveal candidate genes related to drought stress in the germination stage of soybean.

Drought is the major abiotic stress threatening soybean production globally. However, the genetic basis of soybean drought resistance at the germination stage remains largely unknown. In this study, the drought-tolerance phenotypes of a diverse panel of 207 soybean accessions were examined.

Anemoside B4 mitigates endoplasmic reticulum stress-induced apoptosis post cerebral ischemia/reperfusion injury in rats.

Objectives: Anemoside B4 (AB4) exhibits neuroprotective effects on cerebral ischemia/reperfusion injury (CIRI), and endoplasmic reticulum stress (ERS) plays a crucial role in the process of CIRI. Nevertheless, it remains unknown whether AB4 acts on CIRI via ERS. This study is designed to determine whether AB4 mitigates CIRI by suppressing ERS-induced neuronal apoptosis.

Advances in Chondroitin Sulfate-Based Nanoplatforms for Biomedical Applications.

Chondroitin sulfate (CS) is a naturally sulfated glycosaminoglycan with diverse biofunctional properties, including anti-inflammatory effects, reactive oxygen species scavenging, cartilage regeneration and immune regulation. In recent years, CS has shown significant progress in biomedical applications, particularly in drug delivery, tissue engineering, and biosensing. This paper reviews the latest advancements of CS-based nanoplatforms in the biomedical field.

Prognostic value of FIB-4 and NFS for cardiovascular events in patients with and without NAFLD.

Background: The association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) is well studied. Liver fibrosis is the main histopathologic manifestations of NAFLD. However, whether concomitant NAFLD influence the association of non-invasive liver fibrosis scores with CVD remains unclear.

Laparoscopic versus open repeat liver resection for recurrent liver cancer: an updated systematic review and meta-analysis.

Background: Liver resection is still the most effective and curative treatment for recurrent liver cancer, laparoscopic repeat liver resection (LRLR) offers an option for recurrent liver cancer due to invasive advantages. However, multicenter, large-sample population-based LRLR has rarely been reported. We aimed to assess the advantages and drawbacks of LRLR compared with laparoscopic and open surgery for recurrent liver cancer by meta-analysis.

Nursing management of the neurogenic bladder: Evidence map of quality and recommendations from clinical practice guidelines.

Objectives: This study employed evidence mapping to systematically evaluate clinical practice guidelines (CPGs) for neurogenic bladder (NB) care. We aimed to identify research trends, evidence gaps, and consensus patterns to inform evidence-based nursing practices and support the formulation of high-quality CPGs.

Methods: A systematic search of electronic databases and guideline repositories was conducted, included PubMed, Web of Science, Embase, Guidelines International Network (GIN), ect.

Differentiation of Postoperative Tumor Recurrence and Pseudoprogression in Gliomas: A Comparative Study of Six Diffusion Models.

Rationale And Objectives: The purpose of this study is to investigate whether six diffusion models derived from multi-b-value diffusion-weighted imaging can enhance the differentiation between pseudoprogression (PsP) and postoperative tumor recurrence (TR) in glioma patients, with the aim of providing clinical insights.

Materials And Methods: A retrospective study was conducted on 82 patients with WHO grade 2-4 gliomas who underwent surgery at our hospital, with MRI sequences including TWI, TWI, TFLAIR, contrast-enhanced TWI, and multi-b-value DWI. Postoperative follow-up or secondary surgery pathology confirmed 46 cases of TR and 36 cases of PsP.

Small intestinal NK/T-cell lymphoma with malignant peritoneal effusion as the first symptom: a case report and literature review.

Introduction: Small intestinal NK/T-cell lymphoma (NK/T-L) is a rare condition, and cases presenting with malignant peritoneal effusion as the initial symptoms are not well-documented. We report a unique case that contributes to the understanding of this rare disease.

Case Report: A 47-year-old man was admitted to the hospital with a chief complaint of abdominal distension and weight loss persisting for over 2 months.

Short-term rainfall prediction based on radar echo using an efficient spatio-temporal recurrent unit.

Accurate short-term precipitation prediction is critical for agricultural production, transportation safety, and water resource management. In this paper, we propose an Efficient Spatio-Temporal Recurrent Unit (ESTRU) for short-term precipitation prediction based on radar echoes. The ability of the model to process spatio-temporal information is enhanced by fusing two ConvGRU units while controlling the complexity.

Nanomaterials engineered for photothermal therapy in neural tumors and neurodegenerative diseases: biomaterial design, clinical mechanisms and applications.

The rising incidence of neural tumors and neurodegenerative diseases cause significant health, emotional, and financial burdens. Conventional treatments like surgery and chemotherapy often lack effectiveness. However, advancements in nanotechnology, particularly photothermal therapy (PTT), offer new hope.

Robust Fractional Low Order Adaptive Linear Chirplet Transform and Its Application to Fault Analysis.

Time-frequency analysis (TFA) technology is an important tool for analyzing non-Gaussian mechanical fault vibration signals. In the complex background of infinite variance process noise and Gaussian colored noise, it is difficult for traditional methods to obtain the highly concentrated time-frequency representation (TFR) of fault vibration signals. Based on the insensitive property of fractional low-order statistics for infinite variance and Gaussian processes, robust fractional lower order adaptive linear chirplet transform (FLOACT) and fractional lower order adaptive scaling chirplet transform (FLOASCT) methods are proposed to suppress the mixed complex noise in this paper.

Isolation and Characterizations of Histamine- and Tyramine-Producing Strains Isolated from Fermented Soybean Food: Soy Sauce and Soybean Paste.

Histamine (HIM) and tyramine (TYM) are among the most toxic biogenic amines (BAs) commonly found in various fermented soybean foods, yet the crucial BAs-producing strains are ignored. This study discussed and compared the effectiveness of two methods based on medium pH screening and target gene amplification for identifying HIM- and TYM-producing strains from two fermented soybean foods. The crucial strains responsible for HIM and TYM formation were identified and then characterized.

The Role of Circular RNA in the Progression of Gliomas and Its Potential Clinical Applications.

Circular RNAs (circRNAs) are single-stranded noncoding RNAs with a covalently closed loop structure. They are known for their stability, abundance, and highly conserved nature. Their expression is often specific to tissues or developmental stages.

Histopathological and ultrastructural changes in different cell types during ischemic and hemorrhagic stroke.

Stroke is a disease of the central nervous system that leads to high rates of morbidity and mortality, along with limited treatment options. This condition is frequently linked to pathologic alterations at the ultrastructural level within diverse neuronal components, including cell bodies, neurites, and synapses, as well as in glial cells like astrocytes, microglia, and oligodendrocytes. These changes include alterations in the shape and size of cell bodies, disruption of neurites, and changes in the density and distribution of synapses.