Anemoside B4 mitigates endoplasmic reticulum stress-induced apoptosis post cerebral ischemia/reperfusion injury in rats.

Objectives: Anemoside B4 (AB4) exhibits neuroprotective effects on cerebral ischemia/reperfusion injury (CIRI), and endoplasmic reticulum stress (ERS) plays a crucial role in the process of CIRI. Nevertheless, it remains unknown whether AB4 acts on CIRI via ERS. This study is designed to determine whether AB4 mitigates CIRI by suppressing ERS-induced neuronal apoptosis.

Geniposide Improves Glycolysis Driven Angiogenesis in Experimentary Arthritis by Inhibiting SphK1-PI3K-Akt-PFKFB3 Signal.

Angiogenesis driven by aerobic glycolysis in endothelial cells sustains rheumatoid arthritis (RA) progression. Geniposide (GE), an iridoid ether extracted from the Rubiaceae plant Gardenia jasminoides J. Ellis, has shown anti-angiogenic potential in experimental arthritis.

IL-37 Mitigates the Inflammatory Response in Macrophages Induced by SARS-CoV-2 Omicron Infection Through the NF-κB Signaling Pathway.

The expression levels of macrophage-associated cytokines are significantly greater in COVID-19 patients than in healthy individuals. Exploring strategies to modulate pathological cytokine storms can effectively prevent the development of severe coronavirus infection-induced pneumonia. Treatment with interleukin-37 (IL-37), an anti-inflammatory factor, has unique anti-inflammatory and antiviral effects on infections caused by various pathogens.

Siphon-driven all-in-one fabric evaporators for multi-purpose treatment of hypersaline oily wastewater.

Hypersaline oily wastewater from industrial processes poses significant environmental challenges, but traditional treatment methods struggle with issues like oil contamination, membrane fouling, and incomplete oil/salt separation. In this work, we developed a siphon-driven all-in-one fabric evaporator (SAFE) that integrates siphon-driven separation with solar-driven evaporation to address these issues effectively. The photothermal fabrics are facilely fabricated by depositing polydopamine on polypropylene non-woven fabrics, imparting oil repellence, light-to-heat conversion, and hydrophilicity.

Comparison of the pathogenicity of multiple SARS-CoV-2 variants in mouse models.

Background: New variants of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continue to drive global epidemics and pose significant health risks. The pathogenicity of these variants evolves under immune pressure and host factors. Understanding these changes is crucial for epidemic control and variant research.

A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5.

The global spread of Severe Acute Respiratory Syndrome Coronavirus 2. (SARS-CoV-2) and its variant strains, including Alpha, Beta, Gamma, Delta, and now Omicron, pose a significant challenge. With the constant evolution of the virus, Omicron and its subtypes BA.

[Main active components and mechanism of Sanmiao Pills in treating rheumatoid arthritis].

UPLC-Q-TOF-MS was employed to analyze the chemical components of Sanmiao Pills(SMP) and network pharmacology and animal experiments were employed to investigate the mechanism of SMP in treating rheumatoid arthritis(RA). DisGeNET and SwissTargetPrediction were used to identify the overlapping targets between RA and SMP. Subsequently, a protein-protein interaction(PPI) network was built based on the key targets.

Application of microdialysis combined with lipidomics to analyze fatty acid metabolic changes in the disease process of rheumatoid arthritis.

Rheumatoid arthritis (RA) is a metabolically active disease, with shifts in fatty acid metabolism during disease progression profoundly affecting the systemic inflammatory response. Altered fatty acid biomarker metabolism may be a key target for the treatment of RA. To investigate the changes of fatty acid metabolism in RA, collagen-induced arthritis (CIA) model was established.

Isolation and identification of naphtalene-degrading bacteria and its application in a two-phase partitioning bioreactor.

Naphthalene is a persistent environmental pollutant for its potential teratogenic, carcinogenic and mutagenic effects. In this study, 10 strains of bacteria capable of degrading naphthalene were isolated from crude-oil contaminated soil. Among them, Pseudomonas plecoglossicida 2P exhibited prominent growth with 1000 mg/L naphthalene as the sole carbon source and degraded 94.

Infection with SARS-CoV-2 can cause pancreatic impairment.

Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction and an even higher risk of the occurrence of diabetes. Herein, we retrospectively analyzed pancreatic lesions in autopsy tissues from 67 SARS-CoV-2 infected non-human primates (NHPs) models and 121 vaccinated and infected NHPs from 2020 to 2023 and COVID-19 patients. Multi-label immunofluorescence revealed direct infection of both exocrine and endocrine pancreatic cells by the virus in NHPs and humans.

Research on a Wire Rope Breakage Detection Device for High-Speed Operation Based on the Multistage Excitation Principle.

Wire rope breakage, as damage easily produced during the service period of wire rope, is an important factor affecting the safe operation of elevators. Especially in the high-speed elevator operation process, the problem of magnetization unsaturation caused by speed effects can easily lead to deformation of the magnetic flux leakage detection signal, thereby affecting the accuracy and reliability of wire breakage quantitative detection. Therefore, this article focuses on the problem that existing wire rope detection methods cannot perform non-destructive testing on high-speed elevator wire ropes and conducts design and experimental research on a high-speed running wire rope breakage detection device based on the principle of multi-stage excitation.

Wood-based capillary enhancers for accelerated moisture capture and solar-powered release.

The pressing need to address the global water crisis has spurred research efforts toward exploring alternative sources and technologies, and harvesting atmospheric water from the humid air emerges as a promising solution. Liquid desiccants, known for their high absorption capacity, have been widely utilized for moisture capture, but their water yield is mainly restricted by sluggish adsorption and desorption dynamics. To address this limitation, we present a facile strategy to promote the absorption/desorption dynamics of moisture by virtue of capillary transport and enlarged interfaces in a photothermal wood enhancer.

Geniposide augments apoptosis in fibroblast-like synoviocytes by restoring hypoxia-enhanced JNK-BNIP3-mediated autophagy.

Background: As the main effector cells of chronic inflammation and hyperplasia of synovium, fibroblast-like synoviocytes (FLSs) show abnormal proliferation and insufficient apoptosis in the hypoxic microenvironment, which is due to the increase of BNIP3-mediated autophagy. This study aimed to explore the mechanism of geniposide (GE) on hypoxia-induced hyper-proliferative FLSs with a focus on autophagy and the JNK-BNIP3 pathway.

Methods: The dynamic changes of autophagy, apoptosis, and hypoxia-related proteins in adjuvant arthritis (AA) rats were detected by immunohistochemistry and Western blot.

Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19.

The coronavirus disease 2019 (COVID-19) pandemic is an ongoing global health concern, and effective antiviral reagents are urgently needed. Traditional Chinese medicine theory-driven natural drug research and development (TCMT-NDRD) is a feasible method to address this issue as the traditional Chinese medicine formulae have been shown effective in the treatment of COVID-19. Huashi Baidu decoction (Q-14) is a clinically approved formula for COVID-19 therapy with antiviral and anti-inflammatory effects.

Effects of different fertilization methods on Lolium multiflorum Lam. growth and bacterial community in waste slag.

Waste slag has low nutrient content, so it has insufficient nutrient cycling and transformation in the soil ecosystem. There are few studies on the application of oligotrophic phosphate-solubilizing bacteria and phosphate (P) fertilizer to improve the properties of waste slags. In this study, three oligotrophic bacterial strains with P solubilizing activity, namely, Bacillus subtilis 2C (7.

Two Facile Aniline-Based Hypercrosslinked Polymer Adsorbents for Highly Efficient Iodine Capture and Removal.

Effective capture and safe disposal of radioactive iodine (I or I) during nuclear power generation processes have always been a worldwide environmental concern. Low-cost and high-efficiency iodine removal materials are urgently needed. In this study, we synthesized two aniline-based hypercrosslinked polymers (AHCPs), AHCP-1 and AHCP-2, for iodine capture in both aqueous and gaseous phases.

Solar-Driven Evaporators with Thin-Film-Composite Architecture Inspired by Plant Roots for Treating Concentrated Nano-/Submicrometer Emulsions.

Oil/water separation by porous materials has received growing interest over the past years since the ever-increasing oily wastewater discharges seriously threaten our living environment. Purification of nano-sized and concentrated emulsions remains a big challenge because of the sharp flux decline by blocking the pores and fouling the surfaces of those porous materials. Herein, we propose a solar-driven evaporator possessing thin-film-composite architecture to deal with these two bottlenecks.

Geniposide inhibits SphK1 membrane targeting to restore macrophage polarization balance in collagen-induced arthritis mice.

Imbalance of macrophage polarization plays a critical role in the progression of rheumatoid arthritis (RA). Geniposide (GE) has been shown to exert anti-inflammatory effects. However, the effect of GE on macrophage polarization remains unclear.

Safety and protective capability of an inactivated SARS-CoV-2 vaccine on pregnancy, lactation and the growth of offspring in hACE2 mice.

The mass inoculation of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine to induce herd immunity is one of the most effective measures to fight COVID-19. The vaccination of pregnant women cannot only avoid or reduce the probability of infectious diseases, but also offers the most effective and direct protection for neonates by means of passive immunization. However, there is no randomized clinical data to ascertain whether the inactivated vaccination of pregnant women or women of childbearing age can affect conception and the fetus.