1p-Enh-regulated CYP4B1 alleviates NNK-induced heart failure and lung cancer via the STAT3 pathway.

Heart failure (HF) and lung cancer (LC) often coexist, yet their shared molecular mechanisms are unclear. We analyzed transcriptome data from the NCBI Gene Expression Omnibus (GEO) database (GSE141910, GSE57338) to identify 346 HF‑related differentially expressed genes (DEGs), then combined weighted gene co-expression network analysis (WGCNA) pinpointed 70 hub candidates. Further screening of these 70 hub candidates in TCGA lung cancer cohorts via LASSO, Random Forest, and multivariate Cox regression suggested CYP4B1 as the only independent prognostic marker.

lncRNA-miRNA/RBP-mRNA Network Involved in Human Triple-Negative Breast Cancer: An Integrated Approach.

Noncoding RNA regulatory networks play crucial roles in human breast cancer. The aim of this study was to establish a network containing multi-type RNAs and RBPs in triple-negative breast cancer (TNBC). Differential expression analyses of lncRNAs, miRNAs, and genes were performed using the GEO2R tool.

Combination of immunotherapy and whole-brain radiotherapy on prognosis of patients with multiple brain metastases: A retrospective cohort study.

Brain metastases (BMs) usually occur in the advanced stage of cancers with a poor prognosis. This study aimed to compare the clinical efficacy and effects on cognitive function of immunotherapy combined with whole brain radiotherapy (WBRT) and immunotherapy combined with WBRT plus sequential integrated boost (SEB) in the treatment of multiple BMs. A total of 57 patients diagnosed with BMs were included in Kezhou People's Hospital Affiliated to Nanjing Medical University between 2021 and 2023.

Lactate modulates the function of myeloid-derived suppressor cells via Ten-Eleven-Translocation-2-mediated demethylation of glucocorticoid-inducible kinase 1 in lung cancer model.

Background: Lactate has been shown to play an important immunosuppressive role in the tumor microenvironment (TME) and promote tumor progression through a variety of different mechanisms of action. Myeloid-derived suppressor cells (MDSCs) are important cells that play an immunosuppressive role in the TME. However, the underlying mechanism by which lactate regulates MDSCs remains unclear.

Dephosphorylation of astrocyte elevated gene-1 protein upregulates eIF4E expression to promote gastric cancer progression.

Protein phosphorylation modification plays an important role in regulating protein activity. Astrocyte elevated gene-1 (AEG-1), an adaptor protein, promotes the progression of various types of cancers by protein-protein interactions. We previously demonstrated that AEG-1 promoted the growth and metastasis of gastric cancer by upregulating the expression of oncogenic eukaryotic translation initiation factor 4E (eIF4E).

Applications of single-cell transcriptomics: updated insights in endometrial cancer.

Endometrial cancer (EC) presents a major global health challenge due to its heterogeneity and complex pathophysiology. The tumor microenvironment (TME), comprising stromal cells, immune cells, endothelial cells, and non-cellular components, critically influences EC progression. Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of EC by revealing TME cellular heterogeneity and interactions.

Targeting ARPC1B Cancer Stem Cells to Sensitise Pancreatic Cancer to Gemcitabine Treatment.

ARPC1B cancer stem cells (CSCs) in pancreatic cancer are identified as a subpopulation resistant to gemcitabine. In our study, drug repositioning, molecular docking, and surface plasmon resonance (SPR) technique jointly revealed that CK-636 can directly target ARPC1B protein with high affinity. In vitro cytotoxicity, ex vivo organoid cultures, in vivo xenograft and orthotopic gemcitabine-resistant pancreatic cancer model demonstrated that combination therapy of gemcitabine plus CK-636 showed a superior anti-tumor effect compared with gemcitabine monotherapy.

Two-year follow-up of relmacabtagene autoleucel in relapsed or refractory follicular lymphoma in RELIANCE study.

Relmacabtagene autoleucel (relma-cel) demonstrated significant clinical outcomes for ≥3 lines of treatment for relapsed or refractory (R/R) follicular lymphoma (FL) in the RELIANCE study. The primary end-point was the complete response rate (CRR) at 3 months. Key secondary end-points included the duration of response (DOR), progression-free survival (PFS), overall survival (OS) and frequency/severity of adverse events (AEs).

Tenuifolin Attenuates Methamphetamine-Induced Reinstatement in Mice by Regulating Hippocampal Postsynaptic BDNF Signaling.

Background: Compulsive relapse (reinstatement) behavior of methamphetamine underlies the difficulty of withdrawal and is associated with abnormal BDNF-mediated synaptic plasticity. However, how to intervene in this aberrant synaptic plasticity to prevent its reinstatement behavior in mice has not fully been studied.

Methods: The CPP was used to establish a model of methamphetamine-induced reinstatement behavior in C57BL/6 mice.

Extracellular matrix-related genes-based prognostic signature for cervical cancer: association of LAMA4 expression with prognosis and response to immunotherapy.

Background: Extracellular matrix-related genes (ERGs) are crucial in the tumorigenesis of various malignancies, including cervical cancer (CC), but their prognostic significance in CC has not been thoroughly investigated.

Methods: We interrogated RNA-seq expression profiles from the public datasets to identify differentially expressed ERGs. Cox regression analysis was utilized to evaluate their prognostic significance.

Validation of the Longitudinal Effect of an Integrated Nursing Intervention Based on the Integrated Theory of Health Behavior Change (ITHBC) on Multidimensional Health Indicators in Older Radiotherapy Patients.

Introduction: The Integrated Theory of Health Behavior Change (ITHBC) offers a structured framework for promoting sustained health behavior change through cognitive beliefs, self-regulation, and social facilitation. However, its application in geriatric oncology remains unexplored.

Methods: This quasi-experimental study enrolled 291 older adult patients who underwent radiotherapy at the Jiangsu Cancer Hospital.

Dietary Pattern of Garlic and Risk of Chronic Diseases: Evidence From Three Large-Scale Cohorts.

Background: Understanding the relationship between garlic and chronic diseases could help to improve prevention and reduce the burden of diseases. This study aimed to examine the association between garlic consumption and the risk of chronic diseases.

Methods: We included 26,524 participants from the Chinese Longitudinal Healthy Longevity Survey (CLHLS) with data of the frequency of garlic consumption, 7658 participants from the Xinjiang multiethnic cohort (XMC) study with data of garlic intake, and 141,684 participants from the UK Biobank (UKBB) with data of the preference for garlic.

Circ_CIT Promotes Nasopharyngeal Carcinoma Progression and Macrophage M2 Polarization Through miR-409-3p/ZEB1 Axis.

Purpose: Circular RNAs (circRNAs) play a crucial role in the progression of various cancers, including nasopharyngeal carcinoma (NPC). However, the mechanism of circRNA in the progression of NPC remains to be elucidated.

Patients And Methods: The expression levels of circ_CIT, microRNA-409-3p and ZEB1 in NPC tissues were detected by Real-time quantitative PCR (qRT-PCR).

Targeting LINC01711 in FAP cancer-associated fibroblasts overcomes lactate-mediated immunosuppression and enhances anti-PD-1 efficacy in lung adenocarcinoma.

The limited response rate to immune checkpoint inhibitors (ICIs) remains a significant challenge in the treatment of lung adenocarcinoma (LUAD). In our study, we identified a lactate-based chemical barrier surrounding FAP cancer-associated fibroblasts (CAFs) within the LUAD microenvironment (TME), which may hinder the infiltration and function of CD8 T cells. Further investigation revealed that FAP CAFs specifically overexpress LINC01711, which drives lactate production by promoting FGFR1-mediated phosphorylation of lactic dehydrogenase A (LDHA) at the Y10 site and facilitating the formation of active LDHA tetramers.

Persistent lineage plasticity driving lung cancer development and progression.

Background: Lung cancer, a leading cause of cancer death, displays profound histologic and molecular heterogeneity across adenocarcinoma, squamous, and small-cell types. Clinically, tumours can shift between these states, reflecting lineage plasticity-the reprogramming of differentiated cells to alternate identities. Pre-existing genomic/epigenomic diversity and microenvironmental cues supply the substrates and pressures for plasticity from disease onset.

Investigating Liquid-Liquid Phase Separation in Lung Adenocarcinoma to Improve Prognostic Accuracy and Treatment Efficacy.

Liquid-Liquid Phase Separation (LLPS) refers to the separation of biomacromolecules into separate liquid phases within the cells, plays a critical role in lung cancer pathogenesis. Using machine learning, we developed an LLPS-associated signature (LLPSAS) based on 79 key genes. The LLPSAS demonstrated superior prognostic performance compared to 140 existing lung adenocarcinoma (LUAD) prognostic models.

N7-Methylguanine-Related Gene Signature Highlights EIF4E as a Novel Therapeutic Target in HER2-Negative Breast Cancer.

Globally, breast cancer remains one of the most prevalent malignancies and a leading cause of cancer-related death in women, with over 2.3 million new cases reported annually. Despite treatment advances, one breast cancer type in particular, HER2-negative breast cancer, lacks precise therapeutic targets.

LOH12CR2 activated by sodium butyrate suppresses tumorigenesis in colorectal cancer via METTL14-mediated N6-methyladenosine modification of SPC24 mRNA.

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Epidemiological studies suggest that dietary fiber intake reduces CRC risk, with butyrate, a fermentation product of dietary fiber, showing promising anti-cancer properties. However, the underlying molecular mechanisms remain poorly understood.

Real-world first-line serplulimab therapy for advanced esophageal cancer: effectiveness, safety, and clinical implications.

Objective: The phase III ASTRUM-007 trial demonstrated significant clinical benefit in patients with PD-L1-positive esophageal squamous cell carcinoma (ESCC) treated with first-line serplulimab plus chemotherapy. This multicenter, observational cohort study aimed to evaluate the real-world outcomes, and address evidence gaps in broader patient populations.

Methods: This multicenter real-world cohort study collected the data of patients with locally advanced or metastatic esophageal cancer who received first-line serplulimab treatment, regardless of histologic type and PD-L1 expression.

Red cell indices as predictors of cancer risk: findings from a large prospective cohort study.

Background: Red blood cell disorders have been implicated in tumorigenesis. Nevertheless, the association between red cell indices (RCIs), which reflect the health status of red blood cells, and the risk of cancer has yet to be determined.

Methods: This was a prospective cohort study involving 455,897 participants who were free of cancer at baseline and had measurements of RCIs, namely mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), and hemoglobin (Hb).

SMURF2 Inhibits Autophagy and Growth in Ovarian Cancer by Regulating the RACK1/AKT/mTOR Pathway.

Background: Ovarian cancer (OC) is a common malignancy characterized by disseminated peritoneal metastases. Smad ubiquitin regulatory factor 2 (SMURF2) is involved in OC progression by stabilizing receptor for activated C kinase 1 (RACK1). However, the functions and mechanisms of action of SMURF2 in OC remain unclear.

A novel recognition of the major allergen, Hum j 1, from pollen.

Background: (HJ) is widely spread in East Asia. HJ pollen is one of the common allergens in the north of China in autumn. However, some controversy exists regarding the major allergen Hum j 1 from HJ pollen, which hamper its application in the diagnosis and treatment of HJ pollen allergy.

Prognostic Factors and Role of Pelvic Lymphadenectomy in Patients with Uterine Sarcoma: A Multi-Center Population-Based Cohort Study.

Objective: The prognostic factors and impact of pelvic lymphadenectomy in uterine sarcomas remain unclear. This study aimed to investigate the prognostic factors and role of pelvic lymphadenectomy in uterine sarcoma.

Methods: We analyzed the data of uterine sarcoma patients obtained from 17 centers through the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2021.

Impaired Meningeal Lymphatic Drainage Aggravates LPS-Induced Neuroinflammation and Depression-Like Behaviors in Mice.

The role of meningeal lymphatic vessels (mLVs) in neurodegenerative diseases has been increasingly recognized. However, their involvement in lipopolysaccharide (LPS)-induced neuroinflammation and associated depression-like behaviors remains poorly understood. Given that impaired clearance of neurotoxic substances can prolong central nervous system (CNS) inflammation, investigating the function of mLVs in this context may offer new insights into the mechanisms underlying acute neuroinflammation and provide potential therapeutic targets.

Association of cholesterol and triglyceride levels with the recurrence of early-stage lung adenocarcinoma with micropapillary pattern.

Background: Lung cancer remains the predominant cause of cancer-related mortality, with adenocarcinoma being the most prevalent histological subtype. Within our nation, lung adenocarcinoma (LUAD) exhibits the highest incidence and mortality rates among all malignant neoplasms. Specifically, the micropapillary subtype of adenocarcinoma is characterized by particularly poor prognosis and significantly reduced survival rate.