Brassinosteroid-Mediated BraSERKs Regulation and Antioxidant Defense Enhancement Confer Cd/Zn Stress Tolerance in Chinese Cabbage.

Somatic embryogenesis receptor kinases (SERKs) are pivotal regulators of plant development and stress adaptation, known to integrate multiple signaling pathways, including brassinosteroid (BR)-mediated responses to coordinately modulate stress-related gene expression. While SERKs participate in biotic/abiotic stress regulation, their roles in heavy metal (HM) stress responses and BR-mediated transcriptional control under HM exposure remain unexplored. Therefore, we systematically identified 20 BraSERK genes in Chinese cabbage (Brassica rapa subsp.

Ultraviolet-Controlled Radical Dopants: Suppressing Unpredictable Oxidation and Lithium Migration in Perovskite Solar Cells.

Perovskite solar cells (PSCs) have achieved parity in efficiency with silicon-based solar cells. This dependency introduces stability challenges and complicates device fabrication due to the traditional air-oxidation doping process, which is time-consuming, unpredictable, and requires continuous monitoring of device variability. Here, we propose two triphenyl sulfonium (TPS) salts as UV-light-triggered radical-generating dopants for 2,2',7,7'-tetrakis [N,N-di(4-methoxyphenyl) amino]-9,9'-spirobifluorene(spiro-OMeTAD).

High-density MRI coil arrays with integrated field monitoring systems for human connectome mapping.

Purpose: To develop and test two high-density MRI coil arrays with integrated field monitoring systems for enhanced diffusion imaging with strong diffusion-sensitizing gradients.

Methods: Two multichannel head coils were constructed for first- and second-generation 3T Connectome MRI scanners, incorporating 64 and 72 receive channels, respectively. The array coils were evaluated using RF bench-level metrics, including quality factor, tuning, matching, and coupling measurements.

Topologically Entangled Network Polymer Electrolyte with Ionophilic-Protonation Dual Side Chains for High-Voltage Lithium-Metal Batteries.

The development of high-voltage solid-state lithium-metal batteries (HVSSLMBs) is severely limited by unstable ion transport, insufficient oxidative stability, and poor electrode-electrolyte interface (EEI) compatibility of conventional solid electrolytes. Herein, we report a topologically entangled polymer electrolyte featuring ionophilic-protonation dual side chains. The ionophilic functional groups on these side chains provide abundant coordination sites, significantly enhancing Li transport, whereas exposed carboxyl (─COOH) groups induce protonation on the cathode surface, effectively suppressing transition metal (TM) ion migration.

The hidden network: community sense, social desirability, and their protective influence on negative emotions in aging populations.

Background: With aging populations, understanding mechanisms linking social factors to emotional well-being in the older adult is critical. This study examines how social capital, social support, community sense, and social desirability interact to influence negative emotions.

Methods: A cross-sectional survey of 904 older adult individuals in Liaoning, China, utilized standardized scales: GDS-10 (negative emotions), SSRS (social support), BSCS (community sense), and MCSDS (social desirability).

Mesenchymal stem cell-derived exosomes as a plausible immunomodulatory therapeutic tool for inflammatory diseases.

Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), especially, exosomes are considered to have diverse therapeutic effects for various significant diseases. MSC-derived exosomes (MSCex) offer substantial advantages over MSCs due to their long-term preservation, stability, absence of nuclei and fewer adverse effects such as infusion toxicity, thereby paving the way towards regenerative medicine and cell-free therapeutics. These exosomes harbor several cellular contents such as DNA, RNA, lipids, metabolites, and proteins, facilitating drug delivery and intercellular communication.

Altered Functional Connectivity Between Cortical Premotor Areas and the Spinal Cord in Chronic Stroke.

Background: Neuroscience research has contributed significantly to understanding alterations in brain structure and function after ischemic stroke. Technical limitations have excluded the spinal cord from imaging-based research. Available data are restricted to a few microstructural analyses, and functional connectivity data are absent.

The role of gut microbiota and plasma metabolites in ulcerative colitis: Insights from Mendelian randomization analysis.

Emerging research suggests that alterations in gut microbiota composition may play a significant role in the pathogenesis of ulcerative colitis (UC). Plasma metabolites, which are influenced by gut microbiota, have also been implicated, but their role in UC remains unclear. This study aims to determine whether specific plasma metabolites mediate the causal relationship between gut microbiota and UC using Mendelian randomization (MR) analysis.

Quantitative Study of Reversible Nonvolatile VO Thin Films Through Plasma Driven Phase Engineering Process.

The nanoscale control of phase transition in correlated materials offers significant insight into phase transition dynamics for the advancement of future nanoelectronics devices. This study explores the phase transition phenomenon in vanadium dioxide (VO), focusing on the heterogeneous phases evolved after low-pressure plasma irradiation on VO thin films, a strong electron-correlated material. The modulation in the Argon (Ar) plasma power reveals the formation of homogeneous and heterogeneous phases with variable resistive states at room temperature.

ECM29/proteasome-mediated self-antigen generation by CNS-resident neuroglia promotes regulatory T cell activation.

Proteasomes generate antigenic peptides presented on cell surfaces-a process that, in neuroglia, is highly responsive to external stimuli. However, the function of the self-antigens presented by CNS parenchymal cells remains unclear. Here, we report that the fidelity of neuroglial self-antigens is crucial to suppress encephalitogenic T cell responses by elevating regulatory T (Treg) cell populations.

Accelerating repair of infected bone defects through post-reinforced injectable hydrogel mediated antibacterial/immunoregulatory microenvironment at bone-hydrogel interface.

Functional injectable hydrogel (IH) is promising for infected bone defects (IBDs) repair, but how to endow it with desired antibacterial/immunoregulatory functions as well as avoid mechanical failures during its manipulation has posed as main challenges. Herein, rosmarinic acid (RosA), a natural product with antibacterial/immunoregulatory activities, was utilized to develop a FCR IH through forming phenylboronic acid ester bonds with 4-formylphenyl phenylboronic acid (4-FPBA) grafted chitosan (CS) (FC). After being applied to the IBD site, the FCR IH was then injected with tobramycin (Tob) solution, another alkaline antibacterial drug, to induce in situ crystallization of the FC, endowing the resultant FCRT hydrogel with adaptively enhanced mechanical strength and structural stability.

The Influence of Remote Hearing Aid Adjustment Technology on the Current Practice of Tele-Audiology among Audiologists in Malaysia.

Objective:  Many hearing aid manufacturers have developed application programs that allow audiologists to fine-tune or adjust their patients' hearing aids remotely. This study aims to explore audiologists' experiences in using the remote hearing aid adjustment in Malaysia.

Method:  This is a qualitative research design where focus group discussions among audiologists were held.

Microscopic messengers: microbiota-derived bacterial extracellular vesicles in inflammatory bowel disease.

Inflammatory bowel disease (IBD) is a persistent and complex condition accomplished by inflammation of the gastrointestinal system, encompassing Crohn's disease (CD) and ulcerative colitis (UC). This condition is caused by the combination of genetic predispositions, environmental triggers, and dysregulated immunological responses, which complicates diagnosis and treatment. The latest developments in gastroenterology have revealed the critical significance of the gut microbiota in the pathogenesis of IBD.

Physiological and transcriptomic responses of microalgal-bacterial co-culture reveal nutrient removal and lipid production during biogas slurry treatment.

Microalgal-bacterial consortia can treat biogas slurry and produce high-value products. This study found that co-cultures of Desmodesmus sp. and Bacillus megaterium improved nutrient removal, biomass production, and lipid accumulation in Desmodesmus sp.

Cobalt (II) porphyrin nanoaggregates as sacrificial templates to improve the peroxidase-like activity of light-controlled TiO-based nanozymes for colorimetric determination of amikacin.

Although porphyrin modification can improve the peroxidase-like activity of some inorganic nanozymes, it is hardly studied that metal porphyrin self-assembled nanoaggregates as sacrificial templates to turn on the peroxidase-like activity of inorganic nanozymes under light illumination. In this work, cobalt (II) 5,10,15,20-Tetrakis (4-carboxylpheyl)porphyrin (CoTCPP) self-assembled nanoaggregates are firstly used as soft templates to prepare TiO-based nanozymes with the enhanced peroxidase-like activity. Interestingly, CoTCPP nanoaggregates can be changed into Co oxide nanoparticles dispersed into the nanosphere composites.

Hemostatic Interventions and All-Cause Mortality in Hemodynamically Unstable Pelvic Fractures: A Systematic Review and Meta-Analysis.

Objective: To conduct a systematic review and meta-analysis of the all-cause mortality associated with the most commonly used hemostatic treatments in patients with hemodynamically unstable pelvic fractures.

Methods: Up to April 30, 2023, we searched PubMed, Embase, Web of Science, and Cochrane, including the references to qualified papers. A meta-analysis was performed on studies that reported odds ratios (ORs) or the number of events needed to calculate them.

After Online Innovators Receive Performance-Contingent Material Rewards: A Study Based on an Open Innovation Platform.

In recent years, enterprises have increasingly recognized the pivotal role of external users in driving product innovation. Open innovation platforms (OIPs), which facilitate interactions between companies and external innovators, have emerged as critical conduits in this regard. However, OIP managers face the challenge of motivating innovators to sustain their contributions.

Sinomenine Alleviates Rheumatoid Arthritis by Suppressing the PI3K-Akt Signaling Pathway, as Demonstrated Through Network Pharmacology, Molecular Docking, and Experimental Validation.

Purpose: Sinomenine (SIN) is commonly used in Traditional Chinese Medicine (TCM) as a respected remedy for rheumatoid arthritis (RA). Nevertheless, the therapeutic mechanism of SIN in RA remains incompletely understood. This study aimed to delve into the molecular mechanism of SIN in the treatment of RA.

Deep learning based method for predicting DNA N6-methyladenosine sites.

DNA N6 methyladenine (6mA) plays an important role in many biological processes, and accurately identifying its sites helps one to understand its biological effects more comprehensively. Previous traditional experimental methods are very labor-intensive and traditional machine learning methods also seem to be somewhat insufficient as the database of 6mA methylation groups becomes progressively larger, so we propose a deep learning-based method called multi-scale convolutional model based on global response normalization (CG6mA) to solve the prediction problem of 6mA site. This method is tested with other methods on three different kinds of benchmark datasets, and the results show that our model can get more excellent prediction results.

MiR-4465-modified mesenchymal stem cell-derived small extracellular vesicles inhibit liver fibrosis development via targeting LOXL2 expression.

Liver fibrosis is a significant health burden, marked by the consistent deposition of collagen. Unfortunately, the currently available treatment approaches for this condition are far from optimal. Lysyl oxidase-like protein 2 (LOXL2) secreted by hepatic stellate cells (HSCs) is a crucial player in the cross-linking of matrix collagen and is a significant target for treating liver fibrosis.

Graph Convolutional Network With Self-Supervised Learning for Brain Disease Classification.

Brain functional network (BFN) analysis has become a popular method for identifying neurological diseases at their early stages and revealing sensitive biomarkers related to these diseases. Due to the fact that BFN is a graph with complex structure, graph convolutional networks (GCNs) can be naturally used in the identification of BFN, and can generally achieve an encouraging performance if given large amounts of training data. In practice, however, it is very difficult to obtain sufficient brain functional data, especially from subjects with brain disorders.

Circ_0044235 regulates the development of osteoarthritis by the modulation of miR-375/PIK3R3 axis.

Background: Circular RNAs (circRNAs) play an important role in osteoarthritis (OA). However, the role of circRNA in OA is still unclear. Here, we explored the role and mechanism of circ_0044235 in OA.