Protein profile of the Escherichia coli strain, BW25113, exposed to two novel iron-halide compounds: Fe(Hampy)2Cl4 and Fe(Hampy)2Br4.

The mortality rate and economic burden of infections caused by antimicrobial-resistant pathogens are increasingly higher. This frustrating scenario emphasizes the urgent need for developing new antimicrobial drugs. We have previously addressed this problem by studying the antimicrobial activity of two novel iron-halide complexes, Fe(Hampy)Cl (iron tetrachloride) and Fe(Hampy)Br (iron tetrabromide).

Health-promoting effects of GKB7 on the gastrointestinal tract in murine models.

is an anaerobic bacterium known for its ability to produce butyrate and modulate gut microbiota. This study aimed to evaluate the protective and regulatory effects of a novel strain, GKB7, isolated from a healthy Taiwanese individual, on gastrointestinal tract. Three rodent disease models were established: picrylsulfonic acid-induced colitis in rats, loperamide-induced constipation in rats, and aspirin-induced gastric ulcers in mice.

Controlled release and enhanced bioavailability of curcumin using multilayered LPSG/PVA and zein/gluten nanofibers fabricated by emulsion electrospinning.

The low stability and bioavailability, and poor aqueous solubility of curcumin (Cur) make it difficult to fully utilize its biological benefits. To overcome these limitations, emulsion electrospinning technique was used to encapsulate Cur in multilayered nanofibers made of Lepidium perfoliatum seed gum (LPSG)/polyvinyl alcohol (PVA) as the middle layer, and zein or zein/gluten nanofibers as the outer layers. Cur was first dissolved in a corn oil/Tween 80 mixture to prepare the oil phase.

Development and Validation of a QconCAT-Based LC-MS/MS Method for the Quantification of 12 Food Allergens in Foods.

Accurate detection of food allergens is crucial to ensuring food safety. This study introduces a novel LC-MS/MS method integrated with QconCAT technology for the cost-effective quantification of 12 food allergens including milk, eggs, peanuts, soybeans, wheat, sesame, and six tree nuts. Characteristic peptides were selected for specificity, stability, and resilience to heat processing using LC-HRMS, addressing inconsistencies found in prior peptide selection.

Antibacterial mechanism of ultrasound combined with oregano essential oil nano-emulsion on Escherichia coli O157:H7 and application in cherry tomatoes storage.

Escherichia coli (E. coli) O157:H7 on the surfaces of fruits and vegetables poses significant risks to human health. This study assessed the bactericidal mechanisms of ultrasound (US) and oregano essential oil nanoemulsion (OEON) against E.

GKB202 suppresses endothelin-1/ERK signaling in pancreatic cancer cells: Potential implications for circulating tumor cell regulation.

Circulating tumor cells (CTCs) play a key role in cancer metastasis. However, the complex tumor microenvironment means that targeting these cells therapeutically remains a major clinical challenge. The natural compound GKB202, derived from the mycelium of Antrodia cinnamomea, has been shown to possess anti-cancer properties.

A Comprehensive Analysis of the Fates of Pesticide Residues in Edible Agricultural Products during Food Processing.

The widespread use of pesticides in agriculture ensures crop productivity but poses significant risks to human health through residual contamination in edible products. Although food processing can mitigate pesticide residues, the efficiency of different methods varies substantially depending on pesticide physicochemical properties and commodity-specific processing steps. This review systematically evaluates the degradation patterns of pesticide residues during the processing of grains, fruits, vegetables, tea, meat, dairy, and herbal medicines.

Mushroom Bioactive Molecules as Anticancerous Agents: An Overview.

Mushrooms have long been used in Traditional Chinese medicine (TCM), where they play an important role in promoting overall health and well-being. However, the therapeutic benefits of mushrooms have made this group of macrofungi a significant part of traditional medicine, particularly in Southeast Asia and China. Across the globe, cancer is the leading cause of death.

Effect of Lactiplantibacillus plantarum MX14 and Pichia membranifaciens PY33 co-fermentation on quality characteristics of red sour soup.

Red sour soup (RSS) production faces issues with inconsistent quality, low safety and slow maturation. Fixed-input strain fermentation solves these issues by ensuring a controlled and stable process, essential for RSS modern production. This study aimed to investigate microbial adaptations, quality characteristics, and key metabolites during the fermentation of RSS by Lactiplantibacillus plantarum MX14 and Pichia membranifaciens PY33.

Ultrasound-Assisted Extraction and Microencapsulation of Polyphenols: Toward a Stable Anti-Inflammatory Ingredient for Functional Foods.

, a Chilean brown seaweed, exhibits high antioxidant activity and polyphenol content, positioning it as a promising candidate for developing bioactive food ingredients. This study evaluated the anti-inflammatory activity of an ethanolic extract of , produced via ultrasound-assisted extraction, and its subsequent microencapsulation to obtain a functional food-grade ingredient. The extract's anti-inflammatory capacity was assessed in vitro through hyaluronidase inhibition, and its cytotoxicity was evaluated using gastrointestinal cell models (HT-29 and Caco-2).

Effects of Different Highland Barley Varieties on Quality and Digestibility of Noodles.

This study comprehensively assessed the effects of ten highland barley varieties on the quality and digestibility of noodles. The characteristics of highland barley flour, including proximate composition, pasting properties, and dough mixing behavior, were analyzed. The quality of the resulting noodles was evaluated through cooking and textural property analysis.

Metabolomic analysis reveals the browning related enzymes and metabolic pattern differences in apples of different storage periods.

This study aimed to investigated metabolism and browning-related enzyme differences of Fuji apples in fresh (FC), browning pulp (BR), and browning inhibition pulp (CM) at 0, 4, 6, and 8 months of storage. Apples stored for 4-months exhibited the highest browning rate and color differences, with browning inhibition effectiveness decreasing over time. PPO and POD activity increased, while CAT and SOD decreased.

Development and application of a curcumin-cinnamon essential oil nanoemulsion agent against mycobacteria.

With the increasing prevalence of drug-resistant (), the development of novel anti-mycobacterial agents has become urgent. In this study, a curcumin-cinnamon essential oil (Cur-CEO) nanoemulsion was developed with optimized preparation parameters, including a 10% CEO volume fraction, 7.5 minutes of ultrasonic treatment, and 350 W ultrasound power, yielding a particle size of 101.

Supplementation of plant fermentation carbon sources significantly enhances the abundance of ammonia-oxidizing genes and increases nitrogen removal in a municipal wastewater treatment plant.

This paper deals with the effects of a cost-effective plant fermentation carbon source (PFCS) on nitrogen removal in a municipal wastewater treatment plant (WWTP). Carbon source and electron donor shortage remained one of the limiting factors for denitrification and nitrogen removal in the WWTPs of China. The PFCS was supplemented to increase the influent carbon/nitrogen (C/N) ratio from the original 9:1 to 82:1.

Impact of ultrasonication, ozonation, and their combination on the preservation of novel clean-label functional drink of strawberry-cantaloupe incorporated with Spirulina platensis and orange peel extracts.

Consumer demand for sustainable, nutrient-rich, and clean-label beverages is rapidly increasing, which is driving the need for innovative preservation techniques for such sensitive beverages in place of conventional chemical preservatives and thermal treatments, which have several drawbacks. These advanced methods need to be effective in maintaining quality, retaining bioactivity, ensuring safety, and extending the shelf life of these novel sensitive beverages. This study focused on the sustainable non-thermal preservation of a novel clean-label functional drink formulated from strawberry and cantaloupe juice, incorporated with Spirulina platensis and orange peel extracts.

Exploring the anti-cancer potential of daidzin in breast cancer: Integrated bioinformatics and computational insights on oncogene inhibition.

Breast cancer (BC) remains the most prevalent cancer among women, with high recurrence rates highlighting the urgent need for novel therapeutic strategies. This study evaluates the chemopreventive potential of daidzin, a dietary isoflavone, as a targeted inhibitor of key oncogenic proteins involved in BC progression. Differentially expressed genes (DEGs) between BC cells and normal samples were identified using the GSE85871 dataset.

Nutritional, Pharmacological and Industrial Applications of Mangosteen and Passion Fruit: A Review.

The stunning nutritional and medicinal attributes of tropical fruits have propelled them to international fame. Passion fruit () and mangosteen () are two examples of such fruits. This review discusses in depth their phytochemical composition, health benefits, and utility in the industrial sector.

Striking mycotoxin tolerance and zearalenone elimination capacity of the decaying wood associated yeast Sugiyamaella novakii (Trichomonascaceae).

Background: Mycotoxin-producing fungal species and their mycotoxins pose a global threat for crop production and for human and animal health. Given the increasing demand for healthier food and feed, alternative non-pesticide approaches for reducing fungal infections in crops and eliminating mycotoxin contamination in feedstock are becoming more prevalent. For such purposes, yeast species can be good candidates.

Development of postbiotic supplemented polylactic acid films for improving quality and shelf life of rainbow trout.

Bioactive metabolites derived from lactic acid bacteria (LAB), commonly referred to as postbiotics, have recently attracted increasing interest in the realm of food packaging. In the present study, biopolymeric films incorporated with postbiotics of Lactococcus lactis were produced using polylactic acid (PLA). The fabricated films were characterized in terms of physicochemical, optical, mechanical, structural, and morphological characteristics.

Improvement of oil-water interfacial behaviors and emulsifying properties of highland barley protein by cold plasma treatment.

The focus of this investigation is to explore the effect of cold plasma modification on the stabilization of water-in-oil (W/O) emulsions with highland barley (HB) proteins. It was notable that following cold plasma treatment, the interfacial tension of the HB protein was significantly reduced, and its rearrangement rate increased by 43 %. These changes indicate enhanced interfacial activity of the protein, suggesting improved interaction between the HB protein and the liquid interface.

Sustainable water reuse in food production: risks of extended-spectrum β-lactamase (ESBL)-producing and antimicrobial resistance gene release from tertiary-treated reclaimed water.

Wastewater reuse for agricultural irrigation is increasingly essential, but it carries potential public health risks due to the dissemination of antimicrobial resistance (AMR). This study evaluates the effectiveness of four tertiary wastewater treatment technologies-peracetic acid (PAA), PAA combined with low-intensity ultraviolet-C (PAA/UV Low), high-intensity UV-C (UV High), and ultrafiltration (UF)-in reducing extended-spectrum β-lactamase-producing (ESBL-) and antimicrobial resistance genes (ARGs) in reclaimed water used for irrigation. The relative abundance of the genes, normalized to the 16S RNA gene present in the water samples, was then estimated to assess whether there is an amplification of these genes during the reuse process in the wastewater treatment plant (WWTP).

Insights into the effect and mechanism of low-bitterness porcine hemoglobin hydrolysates produced by γ-glutamyl transpeptidase.

While the potential of γ-glutamyl transpeptidase from Bacillus amyloliquefaciens for reducing bitterness in porcine hemoglobin hydrolysates has been demonstrated, the underlying mechanistic basis remains unexplored. In the present study, 6 h γ-glutamyl transpeptidase treatment was demonstrated to significantly decrease bitterness intensity (P < 0.05), while enhancing umami characteristics in hemoglobin hydrolysates.

Effect of plant protein emulsifiers and carriers on the physicochemical, structural, and oxidative stability of spray-dried pomegranate seed oil emulsions.

This study compared apricot, walnut, and hazelnut kernel proteins (AKP, WKP, HKP) to whey protein concentrate (WPC) for stabilizing pomegranate seed oil-in-water emulsions before and after spray-drying. AKP demonstrated the most favorable emulsification properties, yielding an emulsion with a particle size of 262 nm, a PDI of 0.43, and a zeta potential of - 25 mV.

Characterization, antioxidant activity of banana peel carbon dots and their antibacterial mechanism against Staphylococcus aureus.

Aims: The carbon dots (CDs) used in this study are a type of carbon nanomaterial extracted from banana peels, which possess various biological activities and demonstrate significant advantages in the antimicrobial field. Staphylococcus aureus is one of the most common foodborne pathogenic bacteria, severely impacting human health and food safety, as well as causing substantial economic losses. This study investigates the properties of the CDs and their inhibition mechanism against S.

Cognitive Effect of Levetiracetam in Patients with Alzheimer's Disease or Mild Cognitive Impairment: A Systematic Review.

Background: Various therapeutic interventions have been investigated for cognitive impairment, a common problem in Alzheimer's disease (AD). Levetiracetam (LEV), an antiepileptic drug, has been shown to alleviate cognitive impairment.

Objective: The present systematic review aimed to evaluate the cognitive effects of LEV in patients with AD or mild cognitive impairment (MCI).