Zanthoxylum armatum DC. Extract induced liver injury via DNA double-strand breaks-mediated cellular senescence pathway.

Aim Of The Study: To comprehensively explore the impact of Zanthoxylum armatum DC. (ZADC) on liver injury and disclose its mechanistic underpinnings, thereby laying a scientific foundation for the secure application of ZADC.

Materials And Methods: The ethyl acetate extract of ZADC (ZADC-EA) was subjected to analysis via Q-Orbitrap LC-MS/MS.

Pharmacological actions and applications of safflower flavonoids.

Safflower ( L.), also known as Honghua, blueflower, or prickly safflower, is a medicinal herb effective in promoting blood circulation, dredging meridians, eliminating blood stasis, and relieving pain. Safflower contains complex chemical components, including flavonoids, alkaloids, organic acids, pigments, etc.

Advancements in traditional Chinese medicine: Harnessing natural products for liver disease through autophagy modulation.

Globally, liver disease has emerged as a significant contributor to morbidity and mortality. The onset and progression of liver diseases are intricately linked to the modulation of autophagy, a highly conserved cellular process. Autophagy involves the systematic degradation and recycling of intracellular components, thereby maintaining cellular homeostasis.

Nonchromatin regulatory functions of the histone variant H2A.B in SWI/SNF genomic deposition.

The replacement of canonical histones with their variant forms enables the dynamic and context-dependent regulation of the mammalian genome. Histone variants also play key roles in various pathological processes including malignancies. Among these, the aberrant expression of the testis-specific histone variant H2A.

PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation.

BMP signaling acts as an instructive cue in various developmental processes such as tissue patterning, stem cell proliferation, and differentiation. However, it is not fully understood how this signaling pathway generates different cell-specific outputs. Here, we have identified PRDM16 as a key co-factor for BMP signaling in the mouse brain.

Improvement of oil-water interfacial behaviors and emulsifying properties of highland barley protein by cold plasma treatment.

The focus of this investigation is to explore the effect of cold plasma modification on the stabilization of water-in-oil (W/O) emulsions with highland barley (HB) proteins. It was notable that following cold plasma treatment, the interfacial tension of the HB protein was significantly reduced, and its rearrangement rate increased by 43 %. These changes indicate enhanced interfacial activity of the protein, suggesting improved interaction between the HB protein and the liquid interface.

hamlet mediates epithelial tissue assembly of the reproductive system.

Epithelial tissue fusion requires coordinated molecular events at the ends of two epithelial structures. Regulatory mechanisms controlling these events remain largely elusive. In the reproductive system (RS), this fusion unites the gonad and the genital disc-derived tissues, into a continuous tube.

Production Methods, Biological Activity and Potential Application Prospects of Astaxanthin.

Astaxanthin (AST), a ketocarotenoid, is prevalent in aquatic life forms. AST has a variety of health-promoting effects, such as anti-oxidation, anti-cancer, eye protection, anti-inflammatory, immune regulation, skin care, anti-diabetes, neuroprotection, etc. It holds significant potential for applications in healthcare products, food additives, pharmaceuticals, cosmetics, and aquaculture.

Associations between lipids and lung cancer subtypes.

Objective: The causative relationship between lung cancer subtypes and lipids is yet unknown. This research aims to elucidate the potential causative link connecting lipid levels to lung cancer subtypes, particularly focusing on non-small cell lung cancer (NSCLC), using the Mendelian randomization (MR) method and meta-analysis.

Methods: Summary statistics were obtained from genome-wide association study (GWAS) datasets.

Clinical Features and Outcomes of Tuberculosis after in Vitro Fertilization-Embryo Transfer Compared with Natural Pregnancy: A Retrospective Study.

We compared the clinical characteristics and outcomes of active tuberculosis (TB) during pregnancy after in vitro fertilization-embryo transfer (IVF-ET) with those in natural pregnancies. The aim was to assess the impact of the mode of pregnancy on TB and to gain a deeper understanding of the clinical characteristics of TB during pregnancy in women who conceived through IVF-ET. This study retrospectively reviewed medical records to analyze maternal and perinatal outcomes in women with active TB during pregnancy, comparing those who conceived through IVF-ET with those who conceived naturally.

Spatial transcriptomics reveals regionally altered gene expression that drives retinal degeneration.

Photoreceptor cell death is a hallmark of age-related macular degeneration. Environmental, lifestyle and genetic risk factors are known contributors to disease progression, whilst at the molecular level, oxidative stress and inflammation are central pathogenetic drivers. However, the spatial and cellular origins of these molecular mechanisms remain unclear.

Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways.

Background: The tyrosine receptor kinase inhibitor (TRKi) entrectinib is used to treat neurotrophic tyrosine receptor kinase (NTRK) fusion-positive solid tumors and ROS1-positive patients. Despite its impressive efficacy against cancer, the clinical application is still limited by the central nervous system (CNS)-related toxicities. However, the precise mechanism of such CNS-related toxicities remains elusive.

Endoplasmic reticulum stress and unfolded protein response in renal lipid metabolism.

The endoplasmic reticulum (ER) is a crucial cellular organelle involved in protein synthesis, folding, modification, and transport. Exposure to internal and external stressors can induce endoplasmic reticulum stress (ERS), leading to abnormal protein folding and ER malfunction. This stress can disrupt lipid synthesis, metabolism, and transport processes.

Fabrication of soy protein isolate-konjac glucomannan emulsion gels to mimic the texture, rheological behavior and in vitro digestion of pork fat.

Fats are essential nutrients, but excessive intake can lead to obesity and certain cardiovascular diseases. In this study, an emulsion gel was prepared using alkali heat treatment with soy protein isolate (SPI) and konjac glucomannan (KGM) as a fat substitute, while pork fat was used as the control. Gel strength, rheological properties, and water holding capacity of soy protein isolate-konjac glucomannan (SPI-KGM) emulsion gel improved progressively with higher KGM content.

Clinical characteristics and pregnancy outcomes in pregnant women with TB: a retrospective cohort study.

Purpose: The influence of pregnancy on tuberculosis (TB) has not been well studied. This study aimed to investigate the demographics, clinical characteristics and outcomes of pregnant-related TB compared with the general population with TB.

Methods: We retrospectively analysed medical records of women during pregnancy or within six months postpartum with active TB who were admitted to the West China Hospital between 2011 and 2022.

SETD1B mutations confer apoptosis resistance and BCL2 independence in B cell lymphoma.

The translocation t(14;18) activates BCL2 and is considered the initiating genetic lesion in most follicular lymphomas (FL). Surprisingly, FL patients fail to respond to the BCL2 inhibitor, Venetoclax. We show that mutations and deletions affecting the histone lysine methyltransferase SETD1B (KMT2G) occur in 7% of FLs and 16% of diffuse large B cell lymphomas (DLBCL).

Pharmacological activities of L. plants and its exploitation and utilization.

The study aims to provide an up-to-date review at the advancements of the investigations on the ethnopharmacology, phytochemistry, pharmacological effect and exploitation and utilizations of L. Besides, the possible tendency and perspective for future research of this plant are discussed, as well. This article uses " L.

Effect of hydroxy-α-sanshool on lipid metabolism in liver and hepatocytes based on AMPK signaling pathway.

Background: With the increasing awareness of the safety of traditional Chinese medicine and food, as well as in-depth studies on the pharmacological activity and toxicity of Zanthoxylum armatum DC. (ZADC), it has been found that ZADC is hepatotoxic. However, the toxic substance basis and mechanism of action have not been fully elucidated.

Synthesis and characterization of ion-induced sodium alginate/soy protein isolate microgels for the controlled release.

In this study, sodium alginate/ soy protein isolate (SPI) microgels cross-linked by various divalent cations including Cu, Ba, Ca, and Zn were fabricated. Cryo-scanning electron microscopy observations revealed distinctive structural variations among the microgels. In the context of gastric pH conditions, the degree of shrinkage of the microgels followed the sequence of Ca > Ba > Cu > Zn.

A toxicological review of alkaloids.

Alkaloids are naturally occurring compounds with complex structures found in natural plants. To further improve the understanding of plant alkaloids, this review focuses on the classification, toxicity and mechanisms of action, providing insight into the occurrence of alkaloid-poisoning events and guiding the safe use of alkaloids in food, supplements and clinical applications. Based on their chemical structure, alkaloids can be divided into organic amines, diterpenoids, pyridines, isoquinolines, indoles, pyrrolidines, steroids, imidazoles and purines.

Study on SH-SY5Y autophagy inhibition and apoptosis induced by methanol extract of DC. based on mTOR signal pathway.

Background: Zanthoxylum armatum DC. (ZADC) is a novel food raw material resource, offering both edible and medicinal properties. Recent research has unveiled the toxic nature of ZADC, particularly its close association with the nervous system.

Predicting circRNA-miRNA interactions utilizing transformer-based RNA sequential learning and high-order proximity preserved embedding.

A key regulatory mechanism involves circular RNA (circRNA) acting as a sponge to modulate microRNA (miRNA), and thus, studying their interaction has significant medical implications. In this field, there are currently two pressing issues that remain unresolved. Firstly, due to the scarcity of verified interactions, we require a minimal amount of samples for training.