Racialized exposure to multiple COVID-19 deaths and their consequences for mental health.

COVID-19 unleashed a bereavement crisis on a scale unseen in over a century. While evidence suggests COVID-19 deaths are acutely damaging to well-being, it is unclear how multiple losses affect mental health, whether there are ethnoracial differences in cumulative loss, or if the association between multiple COVID-related deaths and psychological distress varies by race-ethnicity. Using national survey data (n = 1810) collected following the Omicron surge in the United States, we estimate a series of regression models to assess the association between multiple COVID-19 losses and psychological distress, racial-ethnic differences in aggregate death exposure, and differential vulnerability to multiple losses across racial-ethnic groups.

Exploring Early Perceptions and Experiences of ChatGPT in Pediatric Critical Care: A Qualitative Study Among Health Care Professionals.

To optimize the deployment of Generative Artificial Intelligence in health care, it's essential for health care professionals (HCPs) to understand these technologies' capabilities and constraints. This study explores HCPs' initial impressions and experiences using ChatGPT, a Generative Pre-trained Transformer, in Pediatric Critical Care Units (PICUs). By conducting focus groups with a diverse set of HCPs, we aimed to assess their awareness, utilization, perceived benefits, and concerns about incorporating ChatGPT into their PICUs.

Critical Assessment of the Recommended Alert Limit Curves for Occupational Heat Exposure.

Background: Occupational heat stress recommendations aim to achieve thermal equilibrium and keep core temperature (T) below 38.0°C. We assessed the recommended alert limit curves when: (1) work-rest ratios are adjusted based on wet-bulb globe temperature (WBGT) at a fixed rate of metabolic heat production (H) and (2) H is adjusted based on WBGT at a fixed work-rest ratio.

Safety of artificial intelligence-assisted optical diagnosis for leaving colorectal polyps in situ during colonoscopy (PRACTICE): a non-inferiority, randomised controlled trial.

Background: Guidelines recommend leaving in situ rectosigmoid polyps diagnosed during colonoscopy that are 5 mm or smaller if the endoscopist optically predicts them to be non-neoplastic. However, no randomised controlled trial has been done to examine the efficacy and safety of this strategy.

Methods: This open-label, multicentre, non-inferiority, randomised controlled trial enrolled adults age 18 years or older undergoing colonoscopy for screening, surveillance, or clinical indications across four Italian centres.

Incidence of long COVID among U.S. children and adults during the omicron era - Tracking Post-COVID Conditions (Track-PCC) network, 2022-2023.

Background: Long COVID, or Post-COVID Conditions (PCC), refers to new and persisting sequelae occurring in the months following an acute SARS-CoV-2 infection. Although previous studies have reported estimates of PCC incidence, few have examined trends during the Omicron variant period or have included geographically distinct regions for the same time periods.

Methods: Track PCC is a surveillance network, leveraging electronic health records and public health data to monitor incidence over time across five diverse geographic sites in the U.

Tackling microbial resistance with 4H-chromen-4-one derivatives as a novel class of penicillin binding protein 2a inhibitors.

With the continued upsurge of antibiotic resistance and reduced susceptibility to almost all frontline antibiotics, there is a pressing need for the development of new, effective, and safe alternatives. In this study, a scaffold-hopping strategy was utilized to develop a novel class of penicillin-binding protein 2a (PBP2a) inhibitors, centered around a 4H-chromen-4-one core structure. These newly designed compounds demonstrated strong antibacterial efficacy against methicillin-resistant Staphylococcus aureus (MRSA) and other drug-resistant gram-positive pathogens.

Multiple maternal occupational exposures during pregnancy and intrauterine growth: analysis of the French Longitudinal Study of Children - ELFE cohort, using data-driven approaches.

Objective: To use data-driven approaches to investigate maternal multi-occupational exposures during pregnancy and their effects on intrauterine growth.

Methods: Maternal occupational exposure to 47 factors during pregnancy was evaluated with job-exposure matrices in the French ELFE cohort. The outcomes of interest were birthweight (BW), small for gestational age (SGA) and head circumference (HC).

The Impact of Team-Based Ordering Workflows on Ambulatory Physician EHR Time, Order Volume, and Visit Volume.

Objective: To analyze national rates of team-based ordering and evaluate changes in key outcomes following adoption.

Study Setting And Design: We conducted an observational pre-post intervention-comparison study of 249,463 ambulatory physicians across 401 organizations using the Epic EHR. Our intervention was the adoption of team-based ordering, measured as the proportion of orders involving team support.

Fractures are Highly Correlated with Bone Density and Inversely Correlated with Bone Turnover Markers in Autosomal Dominant Osteopetrosis.

Autosomal Dominant Osteopetrosis (ADO) is a rare, osteosclerotic disorder usually caused by missense variants in the CLCN7 gene, resulting in impaired osteoclastic bone resorption. Penetrance is incomplete and disease severity varies widely, even among relatives within the same family. Although ADO can cause visual loss, osteonecrosis, osteomyelitis, and bone marrow failure, the most common complication of ADO is fracture.

Impact of Population Pharmacogenomics on Cisplatin-Induced Neurotoxicities in Testicular Cancer Survivors.

Background: Cisplatin is a commonly used chemotherapeutic across numerous cancer types that can cause neurotoxicities in patients, including peripheral sensory neuropathy, tinnitus, hearing loss, and vertigo.

Objective: We aimed to evaluate, for the first time, how genetic ancestry impacts cisplatin-induced neurotoxicities and if disparities are related to population differences in allele frequency.

Methods: In a cohort of cisplatin-treated testicular cancer survivors, relationships between genetic ancestry and neurotoxicities, medications, and lifestyle factors were assessed using logistic regression and Kruskal-Wallis tests and multiple pairwise comparisons using the Wilcoxon rank-sum test (Benjamini-Hochberg adjustment).

Differential impacts of advanced age and sex in age-related trace fear memory impairment in rats.

While cognitive function remains stable for majority of the lifespan, many functions sharply decline in later life. Women have higher rates of neurodegenerative diseases that involve memory loss, including Alzheimer's disease. This sex disparity may be due to longer life expectancies when compared to men; women outlive men by roughly 5 years globally.

Benefit of coronary stenting using available intracoronary tools in high-risk patients. The OPTI-XIENCE study.

Background: The clinical benefit of using ICT for coronary stent optimization remains uncertain in randomized trials, in which a unique ICT was used in most cases.

Aim: To assess the clinical impact of intracoronary techniques (ICT) for stent optimization in high-risk patients.

Methods: The OPTI-XIENCE study is a prospective, observational, multicenter international study including high-risk patients undergoing coronary stenting, in whom any ICT was used for stent optimization at the operator's discretion.

POU6F1 promote lumbar motor circuit reorganization following spinal cord injury.

Spinal cord injury (SCI) causes irreversible motor deficits due to disrupted lumbar circuitry. However, transcriptional mechanisms in distal lumbar circuits are poorly understood. We identify POU6F1 as a critical transcriptional regulator in spinal lumbar segment (SLS, L3-L5) motor circuit regeneration.

HIV-related mortality time trends among children and young adolescents on antiretroviral therapy by age, treatment duration, and region: a systematic review and meta-regression analysis.

Background: Past cohort studies have examined mortality among children and young adolescents (aged 0-14 years) who have received antiretroviral therapy (ART), but no systematic reviews have been undertaken to synthesise these findings. Our study aims to provide the most comprehensive global estimates of paediatric mortality among children and adolescents receiving ART.

Methods: For this systematic review and meta-regression analysis, we searched PubMed and Embase from Jan 1, 1990 to July 31, 2024 for studies reporting mortality among children and young adolescents living with HIV who were on ART.

Evaluating variation in opioid prescribing for emergency general surgery patients.

Background: Although procedure-specific guidelines have been established for postoperative opioid prescribing in the elective setting, it is unknown to what extent prescriptions in the emergency setting adhere to these standards. Variation in opioid prescribing for emergency general surgery patients may represent context-appropriate deviation or an opportunity for improved stewardship.

Methods: Leveraging data from a statewide Acute Care Surgery collaborative, we identified patients undergoing 4 common procedures in the emergency setting: laparoscopic appendectomy, laparoscopic cholecystectomy, emergency hernia repair, and open colectomy.

Medical gender affirmation appears protective against problematic substance use among transgender women and transfeminine adults: Findings from The LITE Study.

Objective: To estimate the association between medical and legal gender affirmation with problematic substance use among transfeminine adults.

Methods: Data from a longitudinal cohort (The LITE Study) were analyzed (n = 1186). Participants were enrolled between March 2018 and August 2020 and followed for 2 years.

Clinical progression on CDR-SB©: Progression-free time at each 0.5 unit level in dominantly inherited and sporadic Alzheimer's disease populations.

Introduction: Clinical Dementia Rating Sum of Boxes (CDR-SB) is a reliable and clinically meaningful composite for assessing treatment effects in Alzheimer's disease (AD) clinical trials. Small CDR-SB differences at the end of a trial often lead to controversy in deriving clinically meaningful interpretations.

Methods: We estimated progression-free time (PFT) participants remained at each 0.

Quality of life in older immigrant adults on hemodialysis.

Background: In the United States (U.S.), over 34% of individuals with Chronic kidney disease (CKD) are aged 65 or older.

A digital workflow for full-arch implant fixed prosthesis: Clinical application of a 3D-printed polychromatic flangeless trial denture, anatomic bone reduction guide, and intraoral scanning for definitive prosthesis fabrication.

This clinical report presents a comprehensive digital workflow for rehabilitating a patient with maxillary terminal dentition using a full-arch, implant-supported fixed dental prosthesis (FP-1). It highlights the integration of a 3D-printed polychromatic flangeless trial denture and a customized anatomic bone reduction template, enabling prosthetically driven implant planning and optimal bone architecture modification. The workflow incorporated fully guided implant surgery using sequential templates and immediate loading with a closed-mouth pickup system.