Clinical Reasoning: A 72-Year-Old Man With Progressive Pan-Dysautonomia.

Dysautonomia is a common clinical feature among many central and peripheral neurologic disorders. Evaluation of patients with dysautonomia can be challenging in the absence of a previously established neurologic diagnosis. In this case, we discuss a 72-year-old man who presented with 9 months of progressive dysautonomia including orthostatic hypotension, urinary retention, erectile dysfunction, and constipation.

Oscillatory dynamics in isolated dystonia: five hundred hours of chronic invasive multisite motor network recordings.

Dystonia is a movement disorder characterized by involuntary muscle contractions, often treated with bilateral pallidal deep brain stimulation (DBS). However, optimizing DBS therapy remains challenging due to delayed clinical effects and a lack of objective biomarkers in dystonia. Using an investigational sensing-enabled DBS device attached to both cortical and pallidal leads, we recorded over 500 h of neural activity in a patient with cervical dystonia before and during chronic stimulation therapy while the individual went about their normal daily life.

Pharmacokinetics and Pharmacodynamics of Recombinant Human Interleukin 12 in Dog and Rabbit Models of Toxicity.

Interleukin 12 (IL-12) is a potent pro-inflammatory Th1 cytokine with transient antitumor effects when given systemically. Local administration has recently shown more promising results, particularly when lower doses are delivered directly to tumor microenvironments, promoting anti-tumor T-cell immunity. In addition, IL-12 holds promise as a mucosal adjuvant.

Assessing Supraspinatus Tendon Elasticity at Different Locations and Loading Conditions Using Ultrasound Shear-Wave Elastography in Young Healthy Population.

: This prospective study aims to investigate the feasibility of Shear-Wave Elastography (SWE) for assessing the mechanical properties of the normal supraspinatus tendon and describing the elastographic features of the supraspinatus tendon under different loading conditions and positions. : Twenty healthy volunteers (10 males and 10 females, aged 18-25 years) were examined by SWE using an 18-4 MHz linear array transducer. The elasticity of the supraspinatus tendon of the dominant hand was measured at three distinct locations: the insertion, middle, and myotendinous junction of the tendon.