Amorphous Strategy and Doping Copper on Metal-Organic Framework Surface for Enhanced Photocatalytic CO Reduction to CH.

Amorphous photocatalysts are characterized by numerous grain boundaries and abundant unsaturated sites, which enhance reaction efficiency from both kinetic and thermodynamic perspectives. However, amorphization strategies have rarely been used for photocatalytic CO reduction. Doping copper onto a metal-organic framework (MOF) surface can regulate the electronic structure of photocatalysts, promote electron transfer from the MOF to Cu, and improve the separation efficiency of electron-hole pairs.

Physiologically-based pharmacokinetic modeling predicts the drug interaction potential of GLS4 in co-administered with ritonavir.

GLS4 is a first-in-class hepatitis B virus (HBV) capsid assembly modulator (class I) that is co-administered with ritonavir to maintain the anticipated concentration required for the effective antiviral activity of GLS4. In this study, the first physiologically-based pharmacokinetic (PBPK) model for GLS4/ritonavir was successfully developed. The predictive performance of the PBPK model was verified using data from 39 clinical studies, including single-dose, multiple-dose, food effects, and drug-drug interactions (DDI).

Synergistic effect of Na doping and CoSe cocatalyst for enhanced photocatalytic hydrogen evolution performance of ZnInS.

Element doping has been demonstrated as a useful strategy to regulate the band gap and electronic structure of photocatalyst for improving photocatalytic activity. Herein, ZnInS (ZIS) nanosheets were doped with alkali metal ions (Li, Na or K) by a simple solution method. Experimental characterizations reveal that alkali metal ions doping reduce the band gap, raise the conduction band position, and improve surface hydrophilicity of ZIS.

Plasma metabolomics of immune-related adverse events for patients with lung cancer treated with PD-1/PD-L1 inhibitors.

Background: Metabolomics has the characteristics of terminal effects and reflects the physiological state of biological diseases more directly. Several current biomarkers of multiple omics were revealed to be associated with immune-related adverse events (irAEs) occurrence. However, there is a lack of reliable metabolic biomarkers to predict irAEs.

Application of physiologically based pharmacokinetic modeling of novel drugs approved by the U.S. food and drug administration.

Physiologically based pharmacokinetic (PBPK) models which can leverage preclinical data to predict the pharmacokinetic properties of drugs rapidly became an essential tool to improve the efficiency and quality of novel drug development. In this review, by searching the Application Review Files in Drugs@FDA, we analyzed the current application of PBPK models in novel drugs approved by the U.S.

Boosting Interfacial Electron Transfer and CO Enrichment on ZIF-8/ZnTe for Selective Photoelectrochemical Reduction of CO to CO.

Artificial photosynthesis is an effective way of converting CO into fuel and high value-added chemicals. However, the sluggish interfacial electron transfer and adsorption of CO at the catalyst surface strongly hamper the activity and selectivity of CO reduction. Here, we report a photocathode attaching zeolitic imidazolate framework-8 (ZIF-8) onto a ZnTe surface to mimic an aquatic leaf featuring stoma and chlorophyll for efficient photoelectrochemical conversion of CO into CO.

The Causal Effect of Gut Microbiota and Plasma Metabolome on Lung Cancer and the Heterogeneity across Subtypes: A Mendelian Randomization Study.

The causal effect and pathways of gut microbiota and plasma metabolome on lung cancer have been important topics for personalized medicine; however, the heterogeneity of lung cancer subtypes has not gained enough attention in previous studies. This study sought to employ a Mendelian randomization analysis to screen the specific gut microbiota and plasma metabolome, which may have a causal effect on lung cancer. We further extended our analysis to estimate the effects of these exposures on various pathological subtypes of lung cancer.

s valence electrons in cations of metal oxides serving as descriptors for electron and hole polarons.

In some metal oxides, an excess electron can give rise to the formation of a small polaron localized on a single site. However, there are still some metal oxides that exhibit the formation of a large polaron. The underlying mechanism behind this phenomenon remains unclear.

DPP Inhibition Enhances the Efficacy of PD-1 Blockade by Remodeling the Tumor Microenvironment in Lewis Lung Carcinoma Model.

The remarkable efficacy of cancer immunotherapy has been established in several tumor types. Of the various immunotherapies, PD-1/PD-L1 inhibitors are most extensively used in the treatment of many cancers in clinics. These inhibitors restore the suppressed antitumor immune response and inhibit tumor progression by blocking the PD-1/PD-L1 signaling.

Interface Engineering of Titanium Nitride Nanotube Composites for Excellent Microwave Absorption at Elevated Temperature.

Currently, the microwave absorbers usually suffer dreadful electromagnetic wave absorption (EMWA) performance damping at elevated temperature due to impedance mismatching induced by increased conduction loss. Consequently, the development of high-performance EMWA materials with good impedance matching and strong loss ability in wide temperature spectrum has emerged as a top priority. Herein, due to the high melting point, good electrical conductivity, excellent environmental stability, EM coupling effect, and abundant interfaces of titanium nitride (TiN) nanotubes, they were designed based on the controlling kinetic diffusion procedure and Ostwald ripening process.

Application Progress of Culturomics in the Isolated Culture of Rhizobacteria: A Review.

Comprehending the structure and function of rhizobacteria components and their regulation are crucial for sustainable agricultural management. However, obtaining comprehensive species information for most bacteria in the natural environment, particularly rhizobacteria, presents a challenge using traditional culture methods. To obtain diverse and pure cultures of rhizobacteria, this study primarily reviews the evolution of rhizobacteria culturomics and associated culture methods.

Electrolyte Solvation Chemistry for Stabilizing the Zn Anode via Functionalized Organic Agents.

As a potential candidate for grid-scale energy storage technology, aqueous Zn-ion batteries (ZIBs) have attracted considerable attention due to their intrinsic safety, environmental friendliness, and ease of fabrication. Nevertheless, the road to industry for this technique is hindered by serious issues, including undesired side reactions, random growth of the Zn dendrites, electrode passivation, and anode corrosion, which are associated with the high reactivity of water molecules during the electrochemical reactions. These challenges are strongly dependent on electrolyte solvation chemistry (ESC), which subsequently determines the electrochemical behavior of the metal ions and water molecules on the electrode surface.

Hsa_circ_0092856 Promoted the Proliferation, Migration, and Invasion of NSCLC Cells by Up-Regulating the Expression of eIF3a.

Circular RNA (circRNA) plays a very important regulatory role in a variety of human malignancies such as non-small-cell lung cancer (NSCLC). In the current study, we explored the role of hsa_circ_0092856 in the progression of NSCLC. We screened CircRNA from the gene in the Circbase database.

Monodispersed, Micron-Sized Supermicroporous Silica Particles by Cetyltrimethylammonium Bromide-Mediated Preparation.

In this study, we present a novel modified Stöber method utilizing cetyltrimethylammonium bromide (CTAB) as a mediator for the preparation of monodispersed, micron-sized supermicroporous silica particles. Observed results show prepared silica particles ranging in size from 0.64 to 1.

Oxygen evolution reaction (OER) active sites in BiVO studied using density functional theory and XPS experiments.

Bismuth vanadate (BiVO/BVO) has been widely studied as a photocatalytic water splitting semiconductor material in recent years because of its many advantages, such as its ease of synthesis and suitable band gap (2.4 eV). However, BVO still has some disadvantages, one of which is the low photocatalytic water oxidation activity.

Supermolecule Polymer Derived Porous Carbon Nitride Microspheres with Controllable Energy Band Structure for Photocatalytic Hydrogen Evolution Reaction.

Porous graphitic carbon nitride microsphere with large specific surface area and controllable energy band structure is synthesized via a simple method with the supermolecule polymer of melamine-cyanuric acid (MCA) as the intermediates. The energy band structure and morphology of carbon nitride are closely correlative to the calcination time. And the CN-20 catalyst fabricated by calcination for 20 h exhibit superior photocatalytic activity of hydrogen evolution reaction (HER) under visible-light (λ ≥ 420 nm) irradiation.

Enhanced performance of BiI-incorporated CsPbBr solar cells.

CsPbBr all-inorganic perovskite solar cells (PSCs) have been extensively investigated due to their remarkable stability. However, their limited film quality and wide bandgap result in a low photoelectric conversion efficiency (PCE). In this study, BiI was incorporated into CsPbBr films to synergistically enhance light absorption and film quality.

Roles of TRPM7 in ovarian cancer.

Ovarian cancer stands as the prevailing gynecologic malignancy, afflicting over 313,959 individuals annually worldwide, accompanied by more than 207,252 fatalities. Perturbations in calcium signaling contribute significantly to the pathogenesis of numerous cancers, including ovarian cancer, wherein alterations in calcium transporter expression have been reported. Overexpression of TRPM7, a prominent calcium transporter, has been linked to adverse prognostic outcomes in various cancer types.

Simultaneous Activation of Pyroptosis and cGAS-STING Pathway with Epigenetic/ Photodynamic Nanotheranostic for Enhanced Tumor Photoimmunotherapy.

Promoting innate immunity through pyroptosis induction or the cyclic GMP-AMP synthase-stimulator of interferon gene (cGAS-STING) pathway activation has emerged as a potent approach to counteract the immunosuppressive tumor microenvironment and elicit systemic antitumor immunity. However, current pyroptosis inducers and STING agonists often suffer from limitations including instability, unpredictable side effects, or inadequate intracellular expression of gasdermin and STING. Here, a tumor-specific nanotheranostic platform that combines photodynamic therapy (PDT) with epigenetic therapy to simultaneously activate pyroptosis and the cGAS-STING pathway in a light-controlled manner is constructed.

Multifunctional Mesoporous Silica Nanosheets for Smart Pesticide Delivery and Enhancing Pesticide Deposition.

A multifunctional nanopesticide delivery system is considered to be a novel and efficient tool for controlling pests in modern agriculture. In this study, a mesoporous silica nanosheet (H-MSN) carrier for intelligent delivery of pesticides was prepared by the sol-gel method. The prepared H-MSN carrier had obvious hexagonal flat structure, with a specific surface area of 759.

In situ synthesis of layered nickel organophosphonates for efficient aqueous nickel-zinc battery cathodes.

Aqueous nickel-zinc (Ni-Zn) batteries have received increasing research interests because of their reliable safety and economical-friendliness. However, the retarded ionic diffusion, low capacity and limited stability of traditional Ni-based cathodes greatly impedes the practical application of Ni-Zn batteries. Herein, two metal organophosphonate materials of Ni methylphosphonate (Ni-MPA) and Ni phenylphosphonate (Ni-PPA) directly grown on Ni foam are constructed successfully through one step solvothermal technique.

Simultaneous Determination of 147 Pesticide Residues in Traditional Chinese Medicines by GC-MS/MS.

Determination of pesticide residues remains a challenge in traditional Chinese medicines in which complex compounds may interfere with analysis signals. This study reports the development of a simple, effective, and high-throughput method combining gas chromatography-tandem mass spectrometry (GC-MS/MS) with either QuEChERS or solid phase extraction (SPE) to determine 147 pesticide residues in traditional Chinese medicines simultaneously. In SPE, the mixture of -hexane and ethyl acetate (1:1, v/v) was selected to extract 147 pesticides in honeysuckle, and the extracted pesticides were determined by GC-MS/MS.

Determination of Dencichine in in the Forest and Field Using High Performance Liquid Chromatography.

Dencichine is a nonprotein amino acid, an effective ingredient in with hemostatic and anti-inflammatory effects. There are few studies on the effects of regions and cultivation models on the accumulation of dencichine. In the current study, the content of dencichine in collected from its global cultivation and trading center Yunnan, China, (>640 samples) was determined using an optimized high-performance liquid chromatography method coupled with a diode array detector but without derivatization.

Fabrication of CoO@ZnInS for photocatalytic hydrogen evolution: Insights into the synergistic mechanism of photothermal effect and heterojunction.

Integration of photothermal materials and photocatalysts can effectively improve photocatalytic hydrogen production. However, the synergistic mechanism of photothermal effect and heterojunction still need to be deeply investigated. Herein, CoO@ZnInS (ZIS) core-shell heterojunction was constructed as a photothermal/ photocatalytic integrated system for photocatalytic hydrogen production.