Therapeutic Vaccines for Non-Communicable Diseases: Global Progress and China's Deployment Pathways.

Background: Non-communicable diseases (NCDs) have become a major threat to global public health, with the disease burden particularly severe in developing countries, China being one of them. The preventive and control effects of traditional treatment methods on NCDs are limited, and innovative strategies are urgently needed. In recent years, vaccine technology has expanded from the field of infectious diseases to non-communicable diseases (NCDs).

Literature Review and Policy Recommendations for Single-Dose HPV Vaccination Schedule in China: Opportunities and Challenges.

Cervical cancer remains a significant global public health challenge, with human papillomavirus (HPV) as its primary cause. In response, the World Health Organization (WHO) launched a global strategy to eliminate cervical cancer by 2030 and, in its 2022 position paper, recommended a single-dose vaccination schedule. The objective of this review is to critically examine the current HPV vaccination landscape in China, including vaccination policies, immunization schedules, supply-demand dynamics, and the feasibility of transitioning to a single-dose regimen.

Molecular epidemiology and emerging genotypes of canine distemper virus in Istanbul, Türkiye.

Background: Canine distemper virus (CDV) is a highly contagious, globally distributed pathogen that remains a serious concern even with available vaccines. In Türkiye, reports of CDV outbreaks among vaccinated dogs suggest the emergence of genetically divergent strains. This study investigated CDV prevalence, clinical correlations, molecular characteristics, and phylogenetic relationships in Istanbul, Türkiye, using rectal swabs from 202 clinically ill dogs (2018–2023).

Quality of life, work status, and most challenging problems among adult burn inpatients in Wuhan Burn Center at 2 years after discharge: A prospective cohort study.

Background: There are many burn patients in China who should be concerned about their quality of life. This study aims to identify the characteristics and factors affecting quality of life among such patients.

Methods: This prospective cohort study included burn patients aged ≥ 18 who were admitted within 48 h after injury in Wuhan Burn Center of Tongren Hospital of Wuhan University (Wuhan Third Hospital) between August 2018 and March 2019.

Mapping total microbial communities and waterborne pathogens in household drinking water in China by citizen science and metabarcoding.

Introduction: Access to safe drinking water remains a critical public health priority, as waterborne diseases continue to pose global health risks. In China, microbial contamination in household water supplies is of particular concern. Traditional culture-based monitoring methods are limited in sensitivity and scope, and scaling such efforts nationwide would demand significant resources.

YlAaf1-YlAaf2, a bipartite SANT domain-containing complex of transcriptional activator, promotes filamentous growth in the dimorphic yeast .

The yeast-to-filament transition is important for dimorphic fungi to adapt to different environmental conditions. Transcriptional activators that activate downstream target genes in response to environmental stimulations are particularly important for the control of this morphological transition. However, only a limited number of key activators of filamentation have been identified.

Digital Interventions and Mental Health Outcomes in Patients With Cancer: Systematic Review and Meta-Analysis.

Background: Rising cancer rates have amplified psychiatric and psychosocial burdens, with 35%-40% of patients exhibiting diagnosable psychiatric disorders. While digital mental health interventions (DMHIs) present potential solutions for improving emotional well-being in this population, evidence remains fragmented and lacks clarity regarding optimal implementation strategies. This study evaluates the efficacy of digital interventions on mental health outcomes in patients with cancer, with particular focus on intervention duration and stakeholder involvement as moderating factors.

Global evidence on the effectiveness of task-shifting and task-sharing strategies for managing individuals with multimorbidity: systematic review and meta-analysis.

Introduction: Task-shifting and task-sharing strategies show promise for managing chronic diseases especially in low-income and middle-income countries (LMICs), though their effectiveness in multimorbidity management remains unclear. This study synthesised evidence on task-shifting and task-sharing strategies globally and assessed the impact on core health outcomes in multimorbidity management.

Methods: We conducted a systematic review and meta-analysis of global studies evaluating task-shifting and sharing interventions for individuals with multimorbidity.

Joint effects of PM components during periconception on offspring congenital heart disease risk in Chongqing, China.

Although the association between particulate matter(PM) exposure and congenital heart disease (CHD) has been widely reported, the component-specific effects, critical exposure window period, and multicomponent synergistic effects remain unknown. This study used a case-control design. In our study, we assessed PM and its components exposure concentrations during preconception and first trimester of 9152 pregnancies collected from the Chongqing Municipal Birth Defects Surveillance System.

From decentralization to re-centralization: lessons learned from Vietnam's rapid reversal in the financing of the Expanded Program on Immunization.

Ensuring sufficient financial resources for improving effective and efficient procurement of vaccines was highlighted by the Immunization Agenda 2030, which is particularly challenging for middle-income countries (MICs) that are ineligible for support from Gavi, the Vaccine Alliance. In response to the broader decentralization of the governance system and decreased international development aid, the central government of Vietnam decentralized the responsibility of financing the Expanded Program on Immunization (EPI) to provincial governments in 2023 but rapidly reversed it considering its following negative consequences, for example, severe vaccine stockouts and the largest decline in childhood immunization coverage in over 20 years. This paper analyzed the consequences closely linked to decentralization in Vietnam, the underlying reasons, and lessons for other MICs.

Canine-assisted therapy in reducing stress and anxiety levels of university students: systematic review and meta-analysis of randomized controlled trials.

Background: Due to the high prevalence of mental health issues among university students worldwide, canine-assisted therapy (CAT) has emerged as a potential intervention to reduce student stress and anxiety. This study systematically reviews and meta-analyzes the effects of CAT on reducing stress and anxiety levels among university students.

Methods: Following the PRISMA 2020 guidelines, we conducted a systematic search across multiple databases (APA PsycINFO, PubMed, Duke Libraries, CNKI, Wanfang, and Google Scholar) for randomized controlled trials published in English and Chinese.

Potassium Clearance in Optic Nerve: A Multidomain Model.

Background: Ion and water transport in the central nervous system (CNS) is governed by tightly coupled mechanisms involving electrodiffusion, osmotic pressure, and fluid convection. Disruptions to these processes are implicated in pathological conditions. Understanding the coordinated roles of glial cells and perivascular spaces in regulating ionic and fluid homeostasis is essential for interpreting neural function and dysfunction.

Influenza Vaccination and Short-Term Risk of Stroke Among Elderly Patients With Chronic Comorbidities in a Population-Based Cohort Study.

The protective effect of influenza vaccination on stroke risk has been inconclusive. In this study, we aimed to investigate the impact of influenza vaccination on the 1-year risk of stroke in individuals aged 60 years and older with COPD and hypertension or diabetes mellitus. We conducted a retrospective cohort study in four districts of Shanghai, China, from August 2017 to July 2019.

The ( ) mutation of maps to the cis-regulatory region of the Iroquois Complex (Iro-C) located in the ( gene.

The ( ) mutation first described by Morgan and Bridges in 1915 has adult visible phenotypes in wing posture and vein formation. We have mapped to a genomic region within the ( ) gene that houses the cis-regulatory elements that control expression of the Iroquois Complex genes ( ) and ( ) in the wing hinge and wing veins. Sequence analysis of the allele has identified a gtwin retrotransposon containing su(Hw) insulator binding sites within this region of .

Two Decades of Change in Childbirth Care in Cambodia (2000-2021): Disparities in Ceasarean Section Utilization Between Public and Private Facilities.

Background: Cambodia, a lower-middle-income country, confronts challenges related to childbirth safety. This study investigated the utilization of childbirth care across public and private health facilities, with a particular focus on the use of caesarean section (C-section). It also examined disparities in service utilization across urban and rural areas and among different socioeconomic statuses.

Effect of a pay-it-forward strategy on reducing HPV vaccine delay and increasing uptake among 15- to 18-year-old girls in China: A randomized controlled trial.

Background: Catch-up human papillomavirus (HPV) vaccination is challenging in many low- and middle-income countries (LMICs). Pay-it-forward offers an individual a subsidized vaccine, then an opportunity to donate to help others access vaccinations. Our randomized control trial assessed the effectiveness of pay-it-forward in improving HPV vaccination among girls aged 15-18 years in China.

Parents' learning support and school attitudes in relation to adolescent academic identity and school performance in nine countries.

An important question for parents and educators alike is how to promote adolescents' academic identity and school performance. This study investigated relations among parental education, parents' attitudes toward their adolescents' school, parental support for learning at home, and adolescents' academic identity and school performance over time and in different national contexts. Longitudinal data were collected from adolescents and their parents in nine countries (China, Colombia, Italy, Jordan, Kenya, the Philippines, Sweden, Thailand, and the United States).

Herbal Extract-Induced DNA Damage, Apoptosis, and Antioxidant Effects of : A Comparative Study of , , and .

Herbal medicine represents a rich yet complex source of bioactive compounds, offering both therapeutic potential and toxicological risks. In this study, we systematically evaluated the biological effects of three traditional herbal extracts-, , and -using as an in vivo model. All three extracts significantly reduced worm survival, induced larval arrest, and triggered a high incidence of males (HIM) phenotypes, indicative of mitotic failure and meiotic chromosome missegregation.

An automatic laryngoscopic image segmentation system based on SAM prompt engineering: from glottis annotation to vocal fold segmentation.

Introduction: Laryngeal high-speed video (HSV) is a widely used technique for diagnosing laryngeal diseases. Among various analytical approaches, segmentation of glottis regions has proven effective in evaluating vocal fold vibration patterns and detecting related disorders. However, the specific task of vocal fold segmentation remains underexplored in the literature.

Monte Carlo investigation of dosimetry in shielded region in total body irradiation treatment.

. Total body irradiation (TBI) is commonly used to treat hematological diseases requiring bone marrow transplantation. Partial transmission blocks (PTB) are utilized to shield critical organs such as the lungs and kidneys.

A Radiogenomic Deep Ensemble Learning Model for Identifying Radionecrosis Following Brain Metastases (BM) Stereotactic Radiosurgery in Patients With Non-small Cell Lung Cancer BM.

Purpose: Stereotactic radiosurgery (SRS) is widely used for brain metastases (BM), but the risk of radionecrosis poses a challenge in post-SRS management. Given the lack of noninvasive imaging methods for distinguishing radionecrosis from recurrence, we aimed to design a deep ensemble learning model that integrates patient clinical features and genomic profiles to identify radionecrosis in patients with BM with post-SRS radiographic progression.

Methods And Materials: We studied 90 BMs from 62 patients with non-small cell lung cancer, with 27 biopsy-confirmed post-SRS local recurrences.

Why the oldest old in China bypass primary care: culture, family, and health system limitations.

Purpose: This study contributes to the understanding of primary care bypassing in China by focusing on an underexplored demographic: the oldest old (individuals aged 80 years and above). While previous research has predominantly focused on health system determinants of bypassing, this study also considers social and cultural factors involved in the oldest old's health-related decision-making and health-seeking behaviour.

Methods: Data were collected through 20 in-depth interviews with participants from Shandong, Henan, and Shanghai.