Construction of FRET-based CDs@RBH Ratiometric Fluorescent Probe for Cu Sensing.

Excessive Cu levels pose severe threats to human health and ecosystems, necessitating sensitive and selective detection methods. A novel ratiometric fluorescent probe (CDs@RBH) based on fluorescence resonance energy transfer (FRET) was developed through electrostatic assembly. This nanoplatform employs carbon quantum dots (CDs) as the energy donor and rhodamine hydrazide (RBH) as the acceptor.

Assessment of pH-Induced Conformational Changes in Whey Protein Isolate-Dextran Conjugate Using Spectral Technology.

The functional properties of proteins are closely related to their structure and conformation. The effects of glycosylation and pH on the structural and conformational changes in whey protein isolate (WPI) were investigated using multispectral technology. More and higher-molecular-weight molecules of WPI-dextran conjugates (WDCs) with increased degrees of glycosylation (DGs) in SDS-PAGE occurred at the expense of band intensities of α-lactalbumin, β-lactoglobulin, and bovine serum albumin.

AD1 Aptamer-Engineered Fluconazole-Loaded PLGA-PEG Nanoformulations Potentiate Antifungal Efficacy through Biofilm-Penetrating Targeting against .

In this work, aptamer AD1-modified poly(lactic--glycolic acid)-poly(ethylene glycol)-fluconazole nanoparticles (AD1-PLGA-PEG-FLUCZ) were prepared, enabling the antifungal drug FLUCZ to specifically target the biofilm of , prolonging its action time on the biofilm, and enhancing its killing effect. The analytical results demonstrated that the AD1-PLGA-PEG-FLUCZ nanoparticulate system achieved a FLUCZ loading capacity of 5.89 ± 0.

Hierarchically constructed a noncovalent chitosan/hyaluronic acid hydrogel with entanglement-enhanced toughness.

Hydrogel-based artificial skin (HAS), resembling natural skin, has widespread applications. Noncovalent natural polymer-based hydrogel (NNH) with desirable biocompatibility and fast biodegradability represents an ideal candidate for HAS. However, the low toughness limited the practical applications of NNH, and presently, no effective approach has been found to boost NNH toughness without compromising biocompatibility and biodegradability.

Unique selectivity of rare-earth metal ambiphilic carbenes towards organic molecules and novel reactivity patterns with isonitriles.

Studies on the chemistry of highly active rare-earth (RE) metal ambiphilic carbenes face challenges due to the lack of appropriate model molecular platforms because the corresponding ambiphilic carbenes have empty p-orbitals. Here, the synthesis of novel multi-chelated amidate rare-earth metal pincer complexes bearing ambiphilic carbenes is realized by using indol-2-yl-based ligands. The ambiphilic carbene (indol-2-yl carbon) of these complexes is extremely active and shows unique selective reactivity towards various organic molecules including carbodiimides, imine, diphenyldiazomethane, aluminum alkyls, 9-BBN and isonitriles, which demonstrate a range of unprecedented reactivity patterns such as formal [2 + 2] cyclometallation, [3 + 3] annulation, and aza-[4 + 1] annulation, while unprecedented aza-[4 + 1 + 1] annulation products were isolated from the reactions of the rare-earth metal complexes bearing electrophilic carbenes and strongly polarized metallacyclopropanes with 2,6-dimethylphenylisonitrile.

A novel hydrazide-based fluorescent chemosensor and its application to recognize Cu and glyphosate in environmental and biological systems.

Background: Although copper ions (Cu) and glyphosate (GLY) tend to exist in the environment or living organisms at low doses, they gradually accumulate with exposure time and may eventually cause irreversible damage to living organisms. The existing detection methods are effective, but most of them lack the ability to detect multiple pollutants simultaneously or suffer from low sensitivity and poor selectivity. Therefore, it is important to develop a sensor that can efficiently and sensitively detect copper ions and glyphosate, but also has the potential for practical applications.

Laccase immobilized on electrospun polyurethane/regenerated cellulose nanofiber membranes for efficient P-Chlorophenol degradation from wastewater.

Laccase has been the focus of extensive research in the field of pollutant degradation. However, its practical application is currently severely hampered by issues such as poor stability, proneness to inactivation, and recycling challenges. In this study, numerous laccase molecules were efficiently loaded onto the electrospun polyurethane/regenerated cellulose nanofiber membrane via metal ion coordination technique.

Efficient biosynthesis of ectoine in engineered Vibrio natriegens.

The compatible solute ectoine, an amino acid derivative, was initially discovered to be a critical factor conferring high resistance to harsh environments in which the producer microbes subsist. Its diverse chemical and biomedical properties have made ectoine a star molecule, necessitating environmentally friendly and efficient preparation methods. In this study, we cloned a biosynthetic gene cluster from a strain screened from samples collected from a historic sea-salt plant.

Dynamic event-triggered H state estimation for discrete-time complex-valued memristive neural networks with mixed time delays.

This paper explores the H state estimation problem for a category of discrete-time complex-valued memristive neural networks (CVMNNs). Regarding the studied CVMNNs, the phenomena of the distributed delay and time-varying delay are taken into account so as to describe the system more practically. Firstly, for further effective analysis, the examined CVMNNs are converted to an augmented system that integrates both the real and imaginary dynamics about the initial CVMNNs.

Numerical simulation study on multifield coupling of enhanced geothermal systems under different fracture characteristics.

Fractures are key geological features in hot dry rock structures and fulfill a decisive role in determining productivity and reservoir stability. Adopting the Xudong fault zone in the Songliao Basin as the research object, a multifracture heat extraction model was constructed using COMSOL software to systematically analyze productivity and various field under different numbers and locations of horizontal and vertical fractures. Moreover, the influences of vertical fracture connectivity and the characteristics of seepage and heat transfer between the upper and lower rock layers on the temperature field were evaluated.

Multi-photon AIE zinc (II) complexes for high-resolution visualization of latent fingerprints.

It is very important to achieve high contrast latent fingerprints (LFPs) imaging in the face of challenges such as imaging blur, weak anti-background interference, and third-level detail loss. We construct a series of carbazole tripyridine zinc (II) complex probes (Zn-Kt1, Zn-Kt2 and Zn-Kt3) which can specifically identify oleic acid (OA) in LFPs, thus achieving high-quality LFPs imaging performance. These complexes exhibit high brightness and long-term imaging owing to three-photon AIE properties.

Multifunctional Silk Fibroin Nanocarriers Loaded with Chlorin e6 for PDT/PTT Synergistic Elimination of Drug-Resistant Bacteria and Biofilms.

The development of drug-resistant biofilms has resulted in treatment failures for multidrug resistant (MDR) bacteria, presenting a substantial challenge to global public health. Consequently, the development of antibacterial agents has become an urgent priority. To overcome the limitations of poor penetration and inadequate efficacy of single-modal treatments for MDR bacterial biofilm infections, this study developed a Ce6/SFP nanocomposite system utilizing silk fibroin and polydopamine.

Multimodal sensing platform based on FeO/DEX/PDA@Au(Raman reporters)@Au nanocomposites for sweat biomarkers monitoring.

This paper introduces a highly sensitive and non-invasive FeO/DEX/PDA@Au(Raman reporters)@Au (FDPA(Raman reporters)A) surface-enhanced Raman scattering (SERS) and colorimetric dual mode sensor. 5,5'- dithiobis (2-nitrobenzoic acid) (DTNB) was identified as the optimized Raman reporters in the FDPAA core-shell structures. To quantitative analysis of lactate and glucose captured from human sweat, we utilized magnet to enrich the FDPA(DTNB)A-lactate/glucose composites generated by the reaction.

Hyperspectral Imaging for Rapid Detection of Common Infected Bacteria Based on Fluorescence Effect.

The rapid and accurate detection of bacterial infections in wounds is crucial for clinical diagnosis. Traditional methods, such as bacterial culture and polymerase chain reaction (PCR), are invasive and time-consuming. In this study, we propose a non-invasive detection method for common bacteria in wound infections, combining fluorescence hyperspectral imaging (FHSI) with deep learning algorithms.

Enantioselective toxicological effects of chiral profenofos and 2-Bromo-4-chlorophenol on bovine serum albumin: Molecular-cellular-biological multilevel evaluation.

As a typical chiral organophosphate insecticide, the enantiomer of profenofos exhibits significant bioselective toxicity in the environment. This study investigates the enantioselective effects of chiral profenofos and 2-Bromo-4-chlorophenol on BSA. Multispectral analysis confirmed that S/R-profenofos and 2-Bromo-4-chlorophenol alterd the microenvironment of BSA, decreasing the α-helices content from 53.

Sustainable Extraction of Kernel Oil by 2-Methyltetrahydrofuran: A Comparative Study on Physicochemical Properties and Bioactive Compounds Against Petro-Sourced Solvents.

This study aims to evaluate the effect of extraction solvent type on the physicochemical properties and bioactive compounds of Maxim. kernel oil for two successive harvest years. Oils were extracted using the bio-based solvent 2-methyltetrahydrofuran (2-MeTHF) and conventional petroleum-derived solvents (-hexane and 2-methylpentane).

Pipeline-free EHD Pump Based on Corona Discharge by Needle-Rod Electrode.

This study introduces a pipeline-free electrohydrodynamic (EHD) pump based on corona discharge and systematically examines its performance in dielectric fluid transport, flow rate modulation, directional control, and multiphase fluid separation. Experimental results demonstrate that under a high-voltage electric field, dielectric fluids can be reliably transported along both straight and curved copper rods. Furthermore, optimizing the electrode configuration─such as incorporating additional needle electrodes─significantly extends the transport distance.

Copper-catalyzed three-component radical aminoazolation of vinylarenes with -fluorobenzenesulfonimide and trimethylsilylazole derivatives.

A copper-catalyzed three-component radical aminoazolation of vinylarenes with -fluorobenzenesulfonimide (NFSI) and trimethylsilylazole derivatives has been developed. This methodology provides an efficient and straightforward approach to generate various β-sulfoamino azoles in good to excellent yields. The protocol features exclusive chemo- and regioselectivity, and excellent functional group tolerance under mild conditions.

Superior Capacitive Energy Storage of BaTiO-Based Polymorphic Relaxor Ferroelectrics Engineered by Mesoscopically Chemical Homogeneity.

Relaxor ferroelectrics exhibit giant potentials in capacitive energy storage, however, the scales of polar nanoregions determine the critical field values where the polarization saturation occurs. In this work, a mesoscopic structure engineered ergodic relaxor state is realized by adjusting submicron-grain scaled chemical homogenity, exhibiting polymorphic polar nanoregions of various scales in different grains. This produces a relatively continuous polarization switching with increasing the applied electric field from diverse grains, thus resulting in a linear-like polarization response feature.

A Bionic Textile Sensory System for Humanoid Robots Capable of Intelligent Texture Recognition.

Artificial tactile perception systems that emulate the functions of slow adaptive (SA) and fast adaptive (FA) cutaneous mechanoreceptors are essential for developing advanced prosthetics and humanoid robots. However, constructing a high-performance sensory system within a single device capable of simultaneously perceiving both static and dynamic forces for surface-texture recognition remains a critical challenge; this contrasts with common strategies integrating individual SA- and FA-mimicking sensors in multi-layered, multi-circuit configurations. Herein, a textile pressure/tactile (PT) sensor is reported based solely on piezoresistive principle alongside high sensitivity and rapid response to both high-frequency vibrations and static forces.

Fabrication of physically multi-crosslinked sodium alginate/carboxylated-chitosan/attapulgite-base aerogel modified by polyethyleneimine for the efficient adsorption of organic dye and Cu(II) contaminants.

The simultaneous presence of heavy metal ions and organic dyes presents significant challenges for the wastewater treatment sector. In response to this pressing issue, a novel composite aerogel has been developed: polyethyleneimine-modified sodium alginate/carboxylated chitosan/attapulgite aerogels (ATP/CCS/SA-PEI), which effectively facilitates the concurrent removal of copper ions (Cu(II)), Congo red (CR), and methylene blue (MB) from aqueous solutions. Under optimal adsorption conditions, ATP/CCS/SA-PEI exhibits superior adsorption capacities for Cu(II), MB, and CR when compared to the unmodified raw materials at equivalent dosages, achieving maximum capacities of 228.

A Janus emulsions stabilized only by natural cellulose particles under the dual driving force of temperature and density.

Janus emulsions have particularly drawn researchers' attention due to their asymmetrical morphology and anisotropic characteristics. However, except for Janus emulsions with liquid-liquid structures, other types of Janus emulsions have not been studied yet. Inspired by the occasional discovery that the water film on the foam surface freezes and transforms into a hard solid interface film below freezing point, a Janus emulsion was developed by using the phase change characteristics of solid paraffin wax.

The effect of para-substituted benzaldehyde derivatives with push/pull electron groups on the conformation of bovine serum albumin and its toxicity investigation in Brachionus calyciflorus Pallas (rotifers).

As intermediates widely used in the synthesis of industrial compounds, excessive ingestion of 4-hydroxybenzaldehyde (4-HBzH) and 4-nitrobenzaldehyde (4-NBzH) may induce potentially irreversible damage in organisms. The potential toxicological of 4-HBzH and 4-NBzH were investigated through a multi-disciplinary approach involving density functional theory (DFT), multispectral techniques and molecular docking, with bovine serum albumin (BSA) employed as the model protein of the study. The interaction mechanism between 4-NBzH/4-HBzH and BSA involved static quenching, and the affinity of 4-NBzH for BSA was stronger than that of 4-HBzH as shown by the K value (4-NBzH: 6.

Research on path planning of robotic arms based on DAPF-RRT algorithm.

In response to the widely used RRT-Connect path planning algorithm in the field of robotic arms, which has problems such as long search time, random node growth, multiple and unsmooth path turns, a path planning algorithm combining dynamic step size and artificial potential field is proposed. To solve the problem of scattered sampling points in the RRT-Connect algorithm, a goal-biased strategy is introduced. To address the problem of slow expansion caused by using fixed step sizes, a dynamic step size strategy is introduced to dynamically adjust the step size.

Damping factor in magnetorheological shear stiffening gel: Fabrication and formulation of a fractional constitutive model.

A variety of magnetorheological shear stiffening gels (MRSSGs) were synthesised by incorporating varying amounts of carbonyl iron powder (CIP) into a shear stiffening gel (SSG) matrix. The dynamic damping performance of the MRSSG was initially evaluated using a rheometer. The damping factor of MRSSGs demonstrates magnetic-sensitive characteristics and can autonomously respond to external stimuli due to B-O cross-linked bonds.