Resource Utilization of the Electrolytic Manganese Residue in Unfired Bricks: Pretreatment, Strength Enhancement, and Microwave Absorption Properties.

The long-term accumulation of electrolytic manganese residue leads to pollution issues related to NH -N and Mn. Although various methods exist to address the pollution caused by NH -N and Mn, existing hazard-free treatment methods do not consider the subsequent utilization of the electrolytic manganese residue. Meanwhile, resource recovery methods face challenges due to the complex salt structures present in electrolytic manganese residue.

Amplified electrochemical detection of sulfadiazine based on Cu-BTC-encapsulated FeNi dual-atom catalysts with improved catalytic efficiency.

The amplification of detection signals is an important method for improving the sensitivity of electrochemical detection. This study presents an efficient strategy for preparing electrochemical catalytic materials using a simple self-assembly technique to encapsulate Fe single atoms (Fe-SAs) and Ni single atoms (Ni-SAs) in the Cu-benzene-1,3,5-tricarboxylic acid (Cu-BTC) metal-organic framework to form a Cu-BTC@FeNi-SAs catalytic system. Subsequently, Cu-BTC@FeNi-SAs was modified on the surface of a gold electrode, and sulfadiazine was used as a template to prepare a molecularly imprinted polymer (MIP) on the modified electrode.

A dansyl-quinolinium-based ratiometric fluorescent probe for detecting HSO/SO in living cells.

Background: Sulfur dioxide (SO) is recognized as a major atmospheric pollutant and its excessive emissions can pose a great threat to the environment, flora and fauna, and human health. Long-term exposure to excessive SO can cause chronic poisoning, leading to neurological disorders and cardiovascular diseases. However, there are two sides to everything.

Liquid Crystal Sensor Harnessing a Biomimetic Acetylcholinesterase Nanozyme for Detection of Trypsin in Human Serum.

Abnormal levels of trypsin in the human body can lead to various diseases, yet conventional detection methods often lack operational simplicity and real-time readout capabilities. This work presents a state-of-the-art metal organic framework (MOF) nanozyme-integrated liquid crystal (LC) sensor (MHN-LC sensor) and demonstrates the detection of trypsin as a proof of the concept. By rational engineering of the MOF-808 framework with Al and l-histidine coordination, a novel MOF nanozyme (MHis-NE) exhibiting exceptional acetylcholinesterase (AChE)-mimetic activity is successfully prepared.

Alginate oligosaccharides prevent and treat obesity by promoting brown fat thermogenesis rather than regulating gut microbiota.

Introduction: Functional oligosaccharides may provide physiological benefits through several different mechanisms. However, the specific mechanisms of alginate oligosaccharides (AOSs) for the improvement of obesity remain unclear.

Objectives: The study aimed to evaluate the effects of AOSs with degrees of polymerization (DP) 2-4 on obesity and reveal the underlying mechanism.

Porous Janus membrane for ultrasensitive detection and efficient degradation of sulfur mustard simulant.

The development of integrated systems for simultaneous chemical threat detection and decontamination is hindered by inherent sensitivity-efficiency trade-offs. We address this challenge through interfacial engineering of a Janus membrane combining D-A molecule functionalized MOFs with PDMS. A gas-liquid interfacial self-assembly strategy enables the creation of a microporous PDMS top layer for vapor preconcentration and vertically aligned MOF nanochannels (2.

-Tirucallane Triterpenoids from the Leaves of .

Thirteen new 3,4--tirucallane triterpenoids (, , ), along with one new 2,3--tirucallane triterpenoid (), one new 3,4--29-nor-tirucallane triterpenoid (), one new 3,4--28,29-dinor-tirucallane triterpenoid (), and a known tirucallane analogue () were isolated from leaves of These triterpenoids were structurally determined by spectroscopic methods, including HRESIMS, NMR spectroscopic analyses, single-crystal X-ray diffraction, and ECD data. The cytotoxicity evaluation revealed that compounds and exhibited moderate activity against HCT-116 and DLD-1 cell lines with IC values ranging from 3.7 to 4.

Recent Progress in the Diverse Synthetic Approaches to Phytosphingosine.

Phytosphingosine, a type of sphingolipids, has gained significant attention due to their diverse biological activities, including anti-inflammatory, anticancer, and immunomodulatory properties. These bioactive lipids, predominantly found in plant sources, play crucial roles in cellular signaling and membrane structure. In recent years, the chemical synthesis of phytosphingosine and other sphingolipids have become a major focus in organic chemistry due to the increasing demand for these molecules in pharmacological research and drug development.

Spatial isotope deep tracing deciphers inter-tissue metabolic crosstalk.

Organs collaborate to maintain metabolic homeostasis in mammals. Spatial metabolomics makes strides in profiling the metabolic landscape, yet can not directly inspect the metabolic crosstalk between tissues. Here, we introduce an approach to comprehensively trace the metabolic fate of C-nutrients within the body and present a robust computational tool, MSITracer, to deep-probe metabolic activity in a spatial manner.

Multi-system toxicity of lead (Pb) in Procambarus clarkii: Integrated analysis of tissue damage, immune dysfunction, oxidative stress, and microbial dysbiosis via multi-omics approaches.

The element lead (Pb) exhibits significant toxicity throughout aquatic habitats. Crustaceans sit at the top of the aquatic food chain and therefore are especially susceptible to Pb-associated toxicity. Nevertheless, there is limited information on the crustaceans exposed to Pb.

Construction of dual electric fields in carbon quantum dots-implanted g-CN piezoelectric polarized heterojunctions for sensitive photoelectrochemical detection of nitrite.

Developing rapid and accurate detection method toward nitrite (NO) in aquatic environment is crucial for human health and ecological safety. However, the accurate quantification of NO is usually hampered by challenges related to sensitivity and selectivity. Herein, a photoelectrochemical (PEC) strategy through the rational design of carbon quantum dots decorated piezoelectric graphitic phase carbon nitride (g-CN-CQDs) heterojunctions was developed for accurate quantification of NO based on the NO triggered diazotization reactions.

Crafting defects in two-dimensional organic platelets via seeded coassembly enables emergent molecular recognition.

Defect engineering plays a pivotal role in materials science, as defects significantly influence material properties. However, achieving precise control over defects in pure organic systems remains a challenge. In this study, we demonstrate the creation of controllable defects in molecular crystals through supersaturated solution-fed seeded self-assembly of two strategically designed molecules.

Real-Time Detection of Reduced Nitroreductase with a Reversible Fluorescent Probe.

Nitroreductase (NTR), a class of flavin-dependent redox enzymes, is a key biomarker for hypoxic tumors. Numerous fluorescent NTR probes have been developed to study hypoxia and associated tumors; however, they are reaction-based and provide only static information on the accumulated enzyme activity at a given time. Reversible binding probes are needed to monitor the enzyme level in real time.

Clinical characteristics and treatment analysis of pulmonary blastoma (PB): a report of 17 cases.

Introduction: To summarize the disease characteristics of pulmonary blastoma, analyze related prognostic factors, and share the diagnosis and treatment process.

Methods: This study retrospectively analyzed the clinical data of 17 patients with pulmonary blastoma admitted to Shandong Provincial Hospital from January 1994 to December 2024.

Results: The patients were predominantly middle-aged and elderly males, with clinical manifestations mainly including cough, sputum production, chest tightness, and shortness of breath.

Integrating Thiolated Mass Tags with Immuno-Mass Spectrometry Imaging to Map the Spatial Signatures of Functional Proteins in Cancer Tissues.

Cancer cells are marked by metabolic reprogramming. Mapping metabolites and their related functional proteins contributes to a comprehensive understanding of metabolic regulation during cancer progression. Mass spectrometry imaging enables the visualization of metabolites in heterogeneous cancer tissues.

MOF-based nanoagent for self-illuminating photodynamic therapy.

Photodynamic therapy (PDT) is a minimally invasive and local light-activated treatment for annihilating tumor tissues. However, it is often limited by the tissue penetration depth of common external light sources. To address this issue, we herein report a self-illuminating ZIF-90 MOF-based composite photosensitive system prepared using a combined one-pot self-assembly and post-synthetic modification (PSM) methodology.

Synthesis, in vivo colon-targeted delivery effect and gut microbiota modulation of indole-acetylated starches derived from various native starch structures.

Indole-3-acetic acid (IAA) is a gut microbial metabolite of tryptophan that plays a crucial role in gut health. To maximize its bioactivity, colon-targeted delivery using acylated starch was developed. This study aims to investigate the interrelationships among the structural characteristics of starch and the biological functions of acylated starch in vivo.

Electrochemiluminescence immunosensor for thiamethoxam detection using NiFe-LDH-loaded Cu single-atom catalysts.

An ECL signal amplification strategy is introduced leveraging a multimetallic catalytic amplification effect. Nickel-iron bimetallic oxide compounds were synthesised and loaded with Cu SAs catalysts on their surface to create nickel-iron layered double hydroxides/copper single atoms (NiFe-LDHs/Cu-SAs) with robust catalytic properties. These NiFe-LDHs/Cu-SAs were employed as signal amplification elements to modify gold electrodes.

Guided Discovery of Antidiabetic Sesquiterpenoids From Lindera Aggregate by Activity Labeled Molecular Networking.

Introduction: The roots of Lindera aggregata (Sims) Kosterm named "Wuyao" in Chinese, showed significant antidiabetic bioactivity detected by the insulin resistance HepG2 cells. However, efficient identification of the new antidiabetic compounds has been lacking.

Objective: To develop a guided discovery strategy for new antidiabetic compounds from L.

Oxygen Vacancies on Ferrihydrite Promote Surface Polymerization of Decomposing Straw-Derived Dissolved Organic Matter: Implications for Soil Carbon Sequestration.

Soil organic matter (SOM), a key redox-active component, interacts with natural minerals at interfaces, critically influencing the transformation and sequestration of organic carbon. However, the key effects of oxygen species at iron (oxyhydr)oxide defect sites on SOM molecular activation and transformation under an anoxic environment (e.g.

CRISPR/Cas12a-Mediated Rolling Circle Amplification for the Development of Liquid Crystal-Based Sensors.

The development of high-performance liquid crystal (LC)-based sensors with remarkable sensitivity and excellent selectivity is of great importance. Herein, a CRISPR/Cas12a-based LC sensor for detecting mycotoxins in food is first reported, and the detection of aflatoxin B (AFB) is chosen as a model. AFB is added to magnetic beads (MBs) functionalized with double-stranded DNA (dsDNA) consisting of AFB aptamer and cDNA.

Cashew nut oligopeptide inhibits mast cell degranulation by suppressing activation of the NF-Κb signalling pathway.

This study aimed to isolate oligopeptides with anti-allergic properties from cashew nuts. Cashew nut protein was extracted using subcritical water extraction. Subsequently, cashew nut oligopeptides (COPs) were obtained via a two-step enzymatic hydrolysis involving alkaline proteinase and bromelain.

From biodegradation to biohazard: Polylactic acid microplastics induced rice growth inhibition in agroecosystems.

The increasing use of biodegradable plastics necessitates critical evaluation of their environmental safety. This study investigated the effects of polylactic acid microplastics (PLA-MPs, 0.1-2.

Dynamic changes in composition during processing of Lonicerae japonicae flos black tea.

Lonicerae japonicae flos (LJF) black tea is a fermented tea and it is hypothesized that microbial communities have an important role in shaping the functional and aroma components during processing. This study investigated dynamic compositional changes during LJF black tea processing using GC-IMS, LC MS, and microbiome analysis. Chemical analysis showed that processing was associated with increased content of functional components such as quinic acid, kaempferol, and luteolin, as well as aroma components such as acetic acid ethyl ester, 1-hexanol, and nonanal.