Social support and adolescent mental health in Kenya: a parallel mediation analysis of perceived control and gratitude.

Introduction: Adolescent mental health is a global concern. While social support is a known protective factor, the mechanisms through which it impacts mental health, particularly in diverse settings like Kenya, require further exploration. This study aimed to investigate how perceived control and gratitude mediate the relationship between social support and mental health (symptoms of depression and anxiety) among Kenyan adolescents.

A comparative analysis of the clinical effect of multiple treatments for benign breast tumors.

PurposeThis retrospective study aimed to compare the clinical outcomes, safety profiles, and postoperative recovery characteristics of conventional open surgery, ultrasound-guided minimally invasive rotary cutting, and microwave ablation in the treatment of benign breast tumors, using historical patient data.MethodsIn total, 164 patients with benign breast tumors treated at Haidian Hospital, Beijing, from January 2020 to January 2023 were selected as study participants. Based on the treatment received by the patients, they were divided into three groups: open surgery group (87 patients treated with conventional open excision surgery), rotary cutting group (65 patients treated with Micromotion minimally invasive rotary cutting under color Doppler ultrasound guidance), and ablation group (12 patients treated with microwave ablation).

N-site-selective cross-couplings of tetrazoles with indoles.

A method for the site-selective cross-coupling of the N-position of tetrazoles with indoles is reported. The -generated N-iodotetrazole intermediates are found to be critical for both activating indoles and achieving N-selectivity. Upon reaction with indoles, heterolytic cleavage of the N-I bond in N-iodotetrazoles predominantly generates N-localized anions.

Mediating Effects of Resilience and Perceived Social Support Between Gratitude and the Adaptability to Return-To-Work in Cancer Patients.

Aims: This study aims to explore the mediating role of resilience and perceived social support in the relationship between gratitude and the work reintegration adaptability of cancer patients in China.

Design: A cross-sectional and correlational study.

Methods: A total of 402 participants were collected from July to December 2023 from a tertiary hospital in Jiangsu Province, China, using a convenience sampling method.

High-altitude effect on corneal endothelial cells and prognosis in patients with cataract surgeries: a propensity score matched analysis.

Aim: To compare analysis of the impact of high altitude on corneal endothelial cells, and the prognosis in patients with cataract surgeries.

Methods: Totally 265 plateau patients with cataract surgeries performed between January 2019 and July 2022 (average altitude=3000 m), and 524 plain patients with cataract surgeries performed between January 2020 and July 2022 were included. The propensity score matching (PSM) method was applied to match the basic information of patients in both regions on a 1:1 basis.

Ultra-high dose rate radiotherapy overcomes radioresistance in head and neck squamous cell carcinoma.

Radiotherapy (RT) resistance in head and neck squamous cell carcinoma (HNSCC) significantly hampers local control and patient prognosis. This study investigated the efficacy and molecular mechanisms of high-energy X-ray-based ultra-high dose rate radiotherapy (UHDR-RT) in overcoming RT resistance. The established RT-resistant HNSCC cell lines and animal models were subjected to UHDR-RT or conventional RT (Conv-RT) via a high-power rhodotron accelerator.

NSUN2-mediated HCV RNA m5C Methylation Facilitates Viral RNA Stability and Replication.

RNA modifications have emerged as new efficient targets against viruses. However, little is known about 5-methylcytosine (m5C) modification in the genomes of flaviviruses. Herein, we demonstrate that hepatitis C virus (HCV), dengue virus, and Zika virus exhibit high levels of viral RNA m5C modification.

N-Alkylation of 1,2,3-Triazoles with Ethers under Thermodynamical Control.

Herein, a relay strategy incorporating oxidative cross dehydrogenative coupling (CDC) and N- to N-isomerization is disclosed for the formal N-selective alkylation of triazoles with ethers under thermodynamic control conditions. By taking advantage of the different thermodynamical stabilities of N- and N-alkylated triazoles (3.65 kcal/mol), the initially formed N-isomers can be converted into their more stable N-isomers when reaching thermodynamic equilibrium.

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1.

Selective serotonin reuptake inhibitors (SSRIs) have shown promise in cancer therapy, particularly for hepatocellular carcinoma (HCC), but their molecular targets and mechanisms remain unclear. Here, we show that SSRIs exhibit significant anti-HCC effects independent of their classical target, the serotonin reuptake transporter (SERT). Using global inverse gene expression profiling, drug affinity responsive target stability assays, and in silico molecular docking, we demonstrate that citalopram targets glucose transporter 1 (GLUT1), resulting in reduced glycolytic flux.

HCV 5-Methylcytosine Enhances Viral RNA Replication through Interaction with m5C Reader YBX1.

Hepatitis C virus (HCV) is a positive-stranded RNA virus that mainly causes chronic hepatitis, cirrhosis and hepatocellular carcinoma. Recently we confirmed m5C modifications within NS5A gene of HCV RNA genome. However, the roles of the m5C modification and its interaction with host proteins in regulating HCV's life cycle, remain unexplored.

Traditional Chinese Medicine formula Dai-Zong-Fang alleviating hepatic steatosis in mice via gut microbiota modulation.

Hepatic steatosis is a hepatic pathological change closely associated with metabolic disorders, commonly observed in various metabolic diseases such as metabolic syndrome (MetS), with a high global prevalence. Dai-Zong-Fang (DZF), a traditional Chinese herbal formula, is widely used in clinical treatment for MetS, exhibiting multifaceted effects in reducing obesity and regulating blood glucose and lipids. This study aims to explore the mechanism by which DZF modulates the gut microbiota and reduces hepatic steatosis based on the gut-liver axis.

An ethanolic extract of Arctium lappa L. leaves ameliorates experimental atherosclerosis by modulating lipid metabolism and inflammatory responses through PI3K/Akt and NF-κB singnaling pathways.

Ethnopharmacological Relevance: Atherosclerosis (AS), a lipid-induced inflammatory condition of the arteries, is a primary contributor to atherosclerotic cardiovascular diseases including stroke. Arctium lappa L. leaf (ALL), an edible and medicinal herb in China, has been documented and commonly used for treating stroke since the ancient times.

Evaluation of a novel deep learning based screening system for pathologic myopia.

Aim: To evaluate the clinical application value of the artificial intelligence assisted pathologic myopia (PM-AI) diagnosis model based on deep learning.

Methods: A total of 1156 readable color fundus photographs were collected and annotated based on the diagnostic criteria of Meta-pathologic myopia (PM) (2015). The PM-AI system and four eye doctors (retinal specialists 1 and 2, and ophthalmologists 1 and 2) independently evaluated the color fundus photographs to determine whether they were indicative of PM or not and the presence of myopic choroidal neovascularization (mCNV).

Synthesis and anti-parasites efficacy of coumarin derivatives against Dactylogyrus intermedius.

Dactylogyrus is one of the most common parasitic diseases in fish and causes huge losses to the aquaculture industry. With the advantages of safety, low toxicity and easy degradation, plant-derived drugs are ideal for the creation of green aquatic ingredients. The use of plant-derived drugs in aquaculture is limited by their low content and high processing costs, which is a challenge that can be solved by the chemical synthesis of plant-derived drugs.

An extracellular matrix-inspired self-healing composite hydrogel for enhanced platelet-rich plasma-mediated chronic diabetic wound treatment.

Diabetes is generally accompanied by difficult-to-heal wounds, which often lead to permanent disability and even death of patients. Because of the abundance of a variety of growth factors, platelet rich plasma (PRP) has been proven to have great clinical potential for diabetic wound treatment. However, how to suppress the explosive release of its active components while realizing adaptability to different wounds remains important for PRP therapy.

Chrysanthemum sporopollenin: A novel vaccine delivery system for nasal mucosal immunity.

Objective: Mucosal immunization was an effective defender against pathogens. Nasal vaccines could activate both systemic and mucosal immunity to trigger protective immune responses. However, due to the weak immunogenicity of nasal vaccines and the lack of appropriate antigen carriers, very few nasal vaccines have been clinically approved for human use, which was a major barrier to the development of nasal vaccines.

The Effect of Work Engagement and Perceived Organizational Support on Turnover Intention among Nurses: A Meta-Analysis Based on the Price-Mueller Model.

Aim: To elaborate on the relationship between work engagement, perceived organizational support, and the turnover intention of nurses by analysing some potential moderators.

Background: Nurses' turnover intention is negatively impacted by their level of work engagement and perceptions of organizational support. However, it is challenging to reach a consistent conclusion.

Mussel-Inspired Two-Dimensional Halide Perovskite Facilitated Dopamine Polymerization and Self-Adhesive Photoelectric Coating.

Polydopamine (PDA) is a good adhesion agent for lots of gels inspired by the mussel, whereas hybrid organic-inorganic perovskites (HOIPs) usually exhibit extraordinary optoelectronic performance. Herein, mussel-inspired chemistry has been integrated with two-dimensional HOIPs first, leading to the preparation of new crystal (HDA)PbBr () (DA = dopamine). The organic cation dopamine can be introduced into PDA resulting in a thin film of (HPDA)PbBr ().

Efficacy of femoral periarterial block in preventing thigh tourniquet pain: a randomized controlled trial.

Background: Tourniquet pain, described as a dull, tight, poorly localized aching sensation, is common in conscious patients. Although various pain-reduction methods have been implemented, none are completely effective. Femoral periarterial block (FAB) has been shown to attenuate tourniquet-induced hypertension in patients undergoing general anesthesia.

N-Selective β-Thioalkylation of Benzotriazoles with Alkenes.

Herein, N-selective β-thioalkylation of benzotriazoles with unactivated alkenes and styrenes is reported. The N-selective β-thioalkylation of benzotriazoles is highly stereospecific and works under simple and mild conditions, exhibiting excellent functional group tolerance. The high N-selectivity is a consequence of the combination of hydrogen bonding and Lewis acid/base activation, which reverses the N-position to be favored for alkylation.