Compensatory retinal blood flow enhancement in cognitively normal ApoE ε4 carriers.

This study aims to compare retinal vascular characteristics between ApoE ε4 carriers and non-carriers in healthy individuals. A total of 84 cognitively healthy subjects-64 non-carriers and 20 carriers of the ApoE ε4 allele-were analyzed using swept-source optical coherence tomography angiography (SS-OCTA). In the retinal vascular layer of OCTA images, parameters such as foveal avascular zone (FAZ) area, vessel perimeter, acircularity index (AI), and vascular density (FD) were quantified.

New insights into the interaction between nanocolloid of graphene oxide and dissolved organic matter: Spectroscopic methods and density functional theory calculations.

Graphene oxide (GO), due to its exceptional physicochemical properties, is widely used in industrial and agricultural fields and can exist as nanocolloid of GO (nGO) in aquatic environments. Dissolved organic matter (DOM), a major component of natural organic matter, significantly influences the environmental fate of nGO. However, their interaction mechanisms remain unclear.

Trimesic acid modified copper‑cobalt layered double hydroxide nanosheets boost electrocatalytic reduction of nitrate to ammonia.

The electrocatalytic reduction of nitrate into valuable ammonia (NH) presents an environmentally friendly and sustainable strategy for the elimination of nitrate pollution and the synthesis of ammonia. Nevertheless, the activity and selectivity for ammonia production remain unsatisfactory, particularly at low applied negative potentials. Herein, we present the synthesis of layered double hydroxide (LDH) electrocatalysts featuring adjustable Cu/Co molar ratios and organic molecule trimesic acid (TA) modification, designated as CuCo-LDH/TA (x = 0.

Ni-Bis(dithiolene) Coordination Enhanced Dual-Functional Covalent Organic Frameworks for both Cathodic Zn Storage and Anodic Zinc Deposition Control in Aqueous Zn-Ion Batteries.

In response to the increasing demand for sustainable energy storage solutions, aqueous zinc-ion batteries (AZIBs) have garnered significant attention for their high safety, low cost, and environmental friendliness. However, two major challenges to battery stability persist: developing efficient cathode materials and addressing zinc dendrite formation. Here, we report a dual-functional covalent organic framework (COF), named Ni-DAPTO, designed to improve both Zn storage on the cathode and zinc deposition kinetics on the anode.

Short-midterm outcomes of preoperative extrauterine growth restriction in premature infants with critical congenital heart disease after surgery.

Objective: To assess the factors associated with early occurrence of extrauterine growth restriction (EUGR) in preterm infants with critical congenital heart disease (CCHD) and their short-midterm outcomes.

Methods: This was a single-center retrospective study including a cohort of all premature infants (< 37weeks) undergoing surgery for CCHD at Guangdong Provincial People's Hospital from 2011 to 2022. According to the diagnostic and exclusion criteria, the subjects were divided into malnourished and un-malnourished groups.

Vimentin intermediate filaments facilitate transportation of hepatitis C virus components.

Vimentin, an intermediate filament protein, primarily contributes to intracellular organization, cell migration, and signal transduction. In recent years, the role of intermediate filaments in viral infection has garnered increasing attention. During viral infection, vimentin can regulate viral propagation by forming a vimentin cage to enclose viral replication factories, and facilitating the intracellular transport of viral components.

Bismuth oxide-loaded indium-organic framework catalysts for efficient electrochemical CO reduction.

This study investigated electrocatalytic CO reduction using bismuth oxide-loaded indium-organic framework catalysts (MIL-68(In)). Bismuth incorporation increased the density of reactive sites, reduced the energy barrier for intermediate formation, and significantly enhanced formic acid production. In an H-type cell, the Bi@MIL-68(In) catalyst achieved a Faradaic efficiency of 96.

Natural superoxide dismutase inspired Heterostructural N, S-Codoped CoFe₂O₄/MoC Electrocatalyst for highly efficient water splitting.

Current research on heterojunctions as catalysts for the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) primarily emphasizes the electron transfer processes at the heterojunction interface. However, the regulatory role of doped elements within heterostructures remains inadequately explored, despite its significant scientific implications for the advancement of efficient catalysts. Inspired by the catalytic superoxide dismutation reaction of superoxide dismutase (SOD) observed in nature, this study presents a novel heterostructural N and S co-doped CoFeO/MoC electrocatalyst.

Titanium-Polyoxometalate Crosslinked Metallo-Supramolecular Polymer as Artificial Interfacial Layer for Highly Persistent and Low-Temperature Tolerant Lithium Metal Batteries.

The uncontrolled lithium (Li) dendrite growth and fragile native solid electrolyte interphase formation have severely hindered the practical development of Li metal batteries. Herein, a coordinatively cross-linked metallo-supramolecular polymer as anodic interfacial protective layer (MSP-IPL) is developed by utilizing titanium(IV)-polyoxometalates (Ti-POMs) as hexatopic linkers to bridge organic and inorganic moieties. The constructed MSP-IPL possesses high electrochemical stability, superior ion-transfer ability, and good air stability.

Efficient utilization of Shuanghuanglian medicine residues by microbial transformation with flavonoid glycosides-hydrolyzing strains.

Shuanghuanglian, a traditional Chinese medicine, is well-known for its bioactive compounds, such as flavonoids, which offer significant health benefits. However, the production of Shuanghuanlian generates substantial pharmaceutical residues, which are often discarded as waste, posing significant environmental and economic challenges. To date, research on repurposing these medicine residues has been limited.

Electrolyte Anion-Initiated In Situ Polymerization of Dioxolane-Derived Gel Electrolytes for Dendrite-Resistant and Separator-Free Lithium Metal Batteries.

The practicality of solid-state lithium metal batteries is limited by poor interfacial contact and low ion conductivity of solid-state electrolytes. Herein, we report a gel polymer electrolyte composed of LiN(SOF) and polymerized dioxolane prepared via in situ ring-opening polymerization triggered by radicals without the need for additional initiators and separators. Theoretical and experimental studies revealed a polymerization mechanism involving S-F bond rupture in LiN(SOF), followed by attack of a Lewis-acidic S atom in the •(SO)(FSO)N radical on a Lewis-basic O atom in dioxolane.

First-line toripalimab plus chemotherapy versus chemotherapy for advanced esophageal squamous cell carcinoma: A cost-effectiveness analysis.

Objectives: This study aims to evaluate the cost-effectiveness of toripalimab combined with chemotherapy versus chemotherapy alone as a first-line treatment for advanced esophageal squamous cell carcinoma (ESCC) from the perspective of U.S. healthcare payers.

Biomimetic fluoride-coated zinc anodes: pediatric dentistry inspires stable zinc batteries.

Zn anodes face dendrite, hydrogen evolution reaction, and corrosion issues. Inspired by the pediatric dental practice of fluoride varnish application for caries prevention, a biomimetic nano-fluoride coating was developed to isolate the Zn anode from the corrosive zinc salt solution, which significantly enhances the efficiency and lifespan of aqueous Zn-ion batteries.

Epigenetic age acceleration mediates the association between low-grade systemic inflammation and cardiovascular diseases: insight from the NHANES 1999-2002.

Background: Currently, with the global aging of the population, inflammation, recognized as a hallmark in age-related diseases, has been studied and linked to cardiovascular diseases (CVD). However, limited evidence on whether inflammation modifies epigenetic aging and affects CVD risk.

Methods: This study included 404 CVD patients and 1941 non-CVD individuals from the 1999-2002 National Health and Nutrition Examination Survey cross-sectional data.

An amphoteric and hydrogen-bond-rich artificial α-amino acid for highly durable aqueous redox flow batteries.

Aqueous organic redox flow batteries offer promising prospects for large-scale, high-safety, and cost-effective energy storage systems with no reliance on scarce mineral resources. However, challenges such as limited water solubility and poor stability hinder the practical application of organic redox molecules in aqueous organic redox flow batteries. Herein, we report the design and synthesis of an artificial redox-active α-amino acid molecule by functionalizing 1,5-dihydroxyanthraquinone with natural cysteine side group, which exhibits enhanced aqueous solubility and redox reversibility in alkaline aqueous organic redox flow batteries.

Fluorescence sensor based on layer-by-layer ligand self-assembled gold nanoclusters for on-site monitoring of chlorpyrifos.

The application of simple, sensitive, and reliable fluorescence sensors to measure trace targets still remains challenges, especially in identifying ideal fluorophores and developing innovative strategies. Herein, layer-by-layer self-assembly triple-ligand gold nanoclusters (L3-AuNCs) were developed using 6-aza-2-thiothymine, L-arginine, and trimethylphenylammonium, where the three ligands effectively suppressed the non-radiative decay of L3-AuNCs and helped achieve a high absolute quantum yield of 28.34%.

Design and synthesis of strigolactone analogues and mimics containing indolin-2-one scaffold for the Phelipanche control.

Background: The broomrapes are root-parasitic weeds widely distributed in the temperate zone area. The effective management on the Phelipanche and Orobanche parasitic weeds still remains challenging to date.

Results: Novel strigolactone (SL) analogues (X series) and mimics (O series) derived from indolin-2-one were designed and synthesized.

Square-Planar Tetranuclear Cluster-Based High-Symmetry Coordination Metal-Organic Polymers for Efficient Electrochemical Nitrate Reduction to Ammonia.

Metal-organic polymers (MOPs) are gaining booming attention as atomically precise single-site catalysts for electrochemical nitrate-to-ammonia conversion owing to their regular structures and tunable functionalities. However, a molecular-level understanding is still lacking for the design of more efficient MOP electrocatalysts. Here, we report the construction of high-symmetry coordination MOPs (, , and ), utilizing square-planar tetranuclear building units [M(μ-O)(CO)] (M = Mn, Fe, or Co) bridged by 2,4,6-tris(4-carboxyphenyl)-1,3,5-triazine (HTATB) ligands.

Alternant P-Type/N-Type Conjugated Bipolar Copolymer Cathodes for Advanced Aqueous Zinc-Ion Batteries.

To synergistically combine the features of high specific capacity of n-type organic materials with the high voltage of p-type organic materials, bipolar phenolthiazine-based cathodes with p-type/n-type structures are gaining increased attention for aqueous zinc-ion batteries (AZIBs). Nevertheless, their small molecular structure often leads to dissolution during cycling. To address the challenge, a bipolar poly(phenothiazine iodide-3,3'-diaminobenzidine), abbreviated as P(PTD-DAB), was synthesized as a cathode material.

A Dynamic Self-Healing Protective Layer Enabling Stable Zinc Ion Batteries through Strong Zn-S Affinity and Intramolecular Hydrogen Bonding.

Aqueous Zn-ion batteries (AZIBs) are promising for large-scale energy storage, yet Zn metal anodes face issues like hydrogen evolution, dendrite growth, and corrosion. Herein, we develop a self-healable, adhesive polymer layer for AZIBs by polymerizing thioctic acid (TA) on Zn surfaces. Thanks to the strong and spontaneous affinity between Zn metal surface and S atoms on polymer chains, this protective layer can firmly and dynamically adhere to the Zn surface.

Dynamical analysis of a predator-prey system with fear-induced dispersal between patches.

In this paper, a patchy model in which the migration is induced by the fear effect on the predator was investigated. By applying dynamical theory, the complete study on persistence of the system and the local/global stability of equilibria were discussed. Choosing the diffusion coefficient $ D_1 $ as the bifurcation parameter, transcritical bifurcation occurring near the trivial equilibrium was demonstrated.

Efficient Ammonia Electrosynthesis from Pure Nitrate Reduction via Tuning Bimetallic Sites in Redox-Active Covalent Organic Frameworks.

Electrocatalytic nitrate reduction reaction (NITRR) represents a promising approach for ammonia synthesis, but existing application has been constrained by the complex proton-coupled electron transfer and the sluggish kinetics induced by various intermediates. Herein, we synthesized a series of metalized covalent organic frameworks: NiTP-MTAPP MCOFs (M = 2H, Co, Cu, and Fe), based on dual redox-active centers: thiophene-substituted Ni-bis(dithiolene) ligand-Ni[CS(CHSCHO)] and metallic porphyrin. Through regulating the adsorption and desorption of species at the catalytic sites, we have identified the optimal NITRR electrocatalyst: NiTP-CoTAPP MCOF, which achieved the highest faradaic efficiency (FE) of approximately 85.

Pre-Embedded Potassium Acetate-Modified SnO Electron Transfer Layer for Efficient and Durable Perovskite Solar Cells.

Perovskite solar cells (PSCs) have garnered significant attention due to their exceptional photovoltaic performances. However, their power conversion efficiency and stability are significantly hindered by lattice defects and nonradiative recombination losses at the interface between the perovskite film and electron transport layer (ETL). Herein, we report the incorporation of multifunctional potassium acetate (KAc) into SnO ETL.

Environmentally Benign and Long Cycling Mn-Ion Full Batteries Enabled by Hydrated Eutectic Electrolytes and Polycarbonyl Conjugated Organic Anodes.

Aqueous rechargeable manganese (Mn)-ion batteries have recently emerged as a promising candidate for multivalent ion rechargeable batteries. However, challenges remain, particularly in expanding the electrolyte's voltage window and identifying compatible anode materials. Herein, we introduce a Mn-ion full battery comprising a nickel hexacyanoferrate (NiHCF) cathode, a perylene-3,4,9,10-tetracarboxylic diimide (PTCDI) anode, and a novel hydrated eutectic electrolyte formulated from Mn(ClO)·6HO and acetamide.