Covalent Organic Framework-Based Porous Anticoagulant Materials for Extracorporeal Blood Circulation.

Preventing coagulation during extracorporeal blood circulation is critical for clinical treatments. Developing anticoagulant materials for key components can reduce reliance on systemic anticoagulants and improve safety. However, such materials often show limited efficacy due to inefficient interactions with pro/anti-coagulation components, resulting from random active site distribution and orientation.

Multi-organ pathology in a small porcine model of cytokine storm syndrome characteristics.

Introduction: Cytokine Storm Syndrome (CSS) is a severe immune dysregulation characterized by excessive cytokine release and multi-organ injury. Existing murine models inadequately replicate human CSS. This study aimed to establish a D-galactosamine (D-GalN)-induced miniature pig model to investigate multi-organ pathological changes and inflammatory dynamics.

Artificial liver plasma adsorption improves survival in elderly patients with severe pneumonia: a retrospective cohort study.

Objective: To assess the therapeutic efficacy of artificial liver plasma adsorption (ALPA) in patients with severe pneumonia.

Methods: This retrospective study enrolled 151 patients meeting severe pneumonia diagnostic criteria who were admitted to the intensive care unit at Shulan Hospital, Hangzhou, China, between January 2020 and December 2024. Participants were allocated to either: (1) the ALPA intervention group ( = 56) receiving artificial liver plasma adsorption (ALPA) therapy, or (2) the control group ( = 95) receiving standard treatment.

Abscisic acid-producing bacterium Azospirillum brasilense effectively reduces heavy metals (cadmium, nickel, lead, and zinc) accumulation in pak choi across various soil types.

Heavy metal contamination of soil is a serious environmental issue that threatens agricultural products and human health. Previous studies have shown that abscisic acid (ABA)-producing bacteria can effectively decrease heavy metal accumulation in plants. However, the broader applicability of this approach across varying soil types remains undetermined, revealing significant gaps in understanding its real-world implementation under distinct edaphic conditions.

Pre-Embedded Potassium Acetate-Modified SnO Electron Transfer Layer for Efficient and Durable Perovskite Solar Cells.

Perovskite solar cells (PSCs) have garnered significant attention due to their exceptional photovoltaic performances. However, their power conversion efficiency and stability are significantly hindered by lattice defects and nonradiative recombination losses at the interface between the perovskite film and electron transport layer (ETL). Herein, we report the incorporation of multifunctional potassium acetate (KAc) into SnO ETL.

Case Report: Endoscopic lumbar interbody fusion using percutaneous unilateral biportal endoscopy and 3D printing for an andersson lesion in ankylosing spondylitis.

Background: An Andersson lesion (AL) is a late-stage lesion of ankylosing spondylitis (AS) that can be misdiagnosed. If the patient has unbearable pain or symptoms indicative of neurological damage, then posterior fusion can be considered. Compared with open surgical procedures, combining Unilateral biportal endoscopy (UBE) and 3D-printing technologies for endoscopic lumbar interbody fusion (LIF) can offer the advantages of minimal trauma and the same effect.

Comparative Efficacy of 3 Methods of Lumbar Interbody Fusion for Lumbar Degenerative Diseases in a Tertiary Public Hospital.

Objective: To evaluate the clinical efficacy of large-channel endoscope-assisted posterior lumbar interbody fusion (Endo-PLIF), minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF), and open posterior lumbar interbody fusion in treatment of degenerative diseases of the lumbar spine.

Methods: Data of 110 patients with degenerative diseases of the lumbar spine were analyzed retrospectively: 31 patients underwent Endo-PLIF, 36 patients underwent MIS-TLIF, and 43 patients underwent modified TLIF. We compared operative duration, intraoperative blood loss, latent blood loss, intraoperative radiation dose, visual analog scale score, Oswestry Disability Index, anterior protrusion angle of the intervertebral space, postoperative ambulatory time, postoperative duration of hospital stay, and complications among the 3 groups.

l-Proline Enhanced Whole Ovary Cryopreservation by Inhibiting Ice Crystal Growth and Reducing Oxidative Stress.

Cryopreservation and transplantation of ovaries are considered to be effective methods for preserving the fertility of female cancer patients. However, ice crystal and oxidative damage occur during the freeze-thaw cycle, significantly reducing the effectiveness of cryopreservation and limiting its clinical application. Thus, new technologies or agents must be explored to enhance ovarian cryopreservation.

Nanocluster-agminated amorphous cobalt nanofilms for highly selective electroreduction of nitrate to ammonia.

Developing highly-efficient electrocatalysts for the nitrate reduction reaction (NITRR) is a persistent challenge. Here, we present the successful synthesis of 14 amorphous/low crystallinity metal nanofilms on three-dimensional carbon fibers (M-NFs/CP), including Al, Ti, Mn, Fe, Co, Ni, Cu, Zn, Ag, In, Sn, Pb, Au, or Bi, using rapid thermal evaporation. Among these samples, our study identifies the amorphous Co nanofilm with fine agglomerated Co clusters as the optimal electrocatalyst for NITRR in a neutral medium.

-Napropamide Potentially Regulates Cadmium Accumulation in Shoots through Transport Channel Modulation.

Heavy metal contamination in soils poses a significant environmental threat to human health. This study examines the effects of the chiral herbicide napropamide (NAP) on , focusing on growth metrics and cadmium (Cd) accumulation. NAP does not adversely affect plant growth compared to the control, whereas NAP significantly reduces root length and fresh weight.

MXene/TPU Hybrid Fabrics Enable Smart Wound Management and Thermoresponsive Drug Delivery.

Thermoresponsive wound dressings with real-time monitoring and on-demand drug delivery have gained significant attention recently. However, such smart systems with stable temperature adjustment and drug release control are still lacking. Here, a novel smart fabric is designed for wound management with thermoresponsive drug delivery and simultaneously temperature monitoring.

Review on strategies for improving the added value and expanding the scope of CO electroreduction products.

The electrochemical reduction of CO into value-added chemicals has been explored as a promising solution to realize carbon neutrality and inhibit global warming. This involves utilizing the electrochemical CO reduction reaction (CORR) to produce a variety of single-carbon (C) and multi-carbon (C) products. Additionally, the electrolyte solution in the CORR system can be enriched with nitrogen sources (such as NO, NO, N, or NO) to enable the synthesis of organonitrogen compounds C-N coupling reactions.

Elevated CD169 expressing monocyte/macrophage promotes systemic inflammation and disease progression in cirrhosis.

Systemic inflammation is related to disease progression and prognosis in patients with advanced cirrhosis. However, the mechanisms underlying the initiation of inflammation are still not fully understood. The role of CD169 monocyte/macrophage in cirrhotic systemic inflammation was undetected.

Ultrafast Thermal Shock Synthesis and Porosity Engineering of 3D Hierarchical Cu-Bi Nanofoam Electrodes for Highly Selective Electrochemical CO Reduction.

Massive production of practical metal or alloy based electrocatalysts for electrocatalytic CO reduction reaction is usually limited by energy-extensive consumption, poor reproducibility, and weak adhesion on electrode substrates. Herein, we report the ultrafast thermal shock synthesis and porosity engineering of free-standing Cu-Bi bimetallic nanofoam electrocatalysts with 3D hierarchical porous structure and easily adjustable compositions. During the thermal shock process, the rapid heating and cooling steps in several seconds result in strong interaction between metal nanopowders to form multiphase nanocrystallines with abundant grain boundaries and metastable CuBi intermetallic phase.

Fluorinated Interface Engineering toward Controllable Zinc Deposition and Rapid Cation Migration of Aqueous Zn-Ion Batteries.

Metallic zinc (Zn) is a highly promising anode material for aqueous energy storage systems due to its low redox potential, high theoretical capacity, and low cost. However, rampant dendrites/by-products and torpid Zn transfer kinetics at electrode/electrolyte interface severely threaten the cycling stability, which deteriorate the electrochemical performance of Zn-ion batteries. Herein, an interfacial engineering strategy to construct alkaline earth fluoride modified metal Zn electrodes with long lifespan and high capacity retention is reported.

Review on Electrocatalytic Coreduction of Carbon Dioxide and Nitrogenous Species for Urea Synthesis.

The electrochemical coreduction of carbon dioxide (CO) and nitrogenous species (such as NO, NO, N, and NO) for urea synthesis under ambient conditions provides a promising solution to realize carbon/nitrogen neutrality and mitigate environmental pollution. Although an increasing number of studies have made some breakthroughs in electrochemical urea synthesis, the unsatisfactory Faradaic efficiency, low urea yield rate, and ambiguous C-N coupling reaction mechanisms remain the major obstacles to its large-scale applications. In this review, we present the recent progress on electrochemical urea synthesis based on CO and nitrogenous species in aqueous solutions under ambient conditions, providing useful guidance and discussion on the rational design of metal nanocatalyst, the understanding of the C-N coupling reaction mechanism, and existing challenges and prospects for electrochemical urea synthesis.

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Anti-C5a Antibody BDB-001 for Severe COVID-19: A Randomized, Double-Blind, Placebo-Controlled Phase 1 Clinical Trial in Healthy Chinese Adults.

Introduction: Severe Coronavirus Disease 2019 (COVID-19) progresses with inflammation and coagulation, due to an overactive complement system. Complement component 5a (C5a) plays a key role in the complement system to trigger a powerful "cytokine and chemokine storm" in viral infection. BDB-001, a recombinant human immunoglobulin G4 (IgG4) that specially binds to C5a, has the potential to inhibit the C5a-triggered cytokine storm in treating COVID-19 patients and other inflammation diseases.

Plasma human neutrophil peptides as biomarkers of disease severity and mortality in patients with decompensated cirrhosis.

Background & Aims: Human neutrophil peptides (HNP)-1, -2 and -3 are the most abundant proteins in neutrophil azurophilic granules and are rapidly released via neutrophil degranulation upon activation. The aims of our study were to assess the role of HNP1-3 as biomarkers of disease severity in patients with decompensated cirrhosis and their value in predicting short-term mortality.

Methods: In this study, 451 patients with acutely decompensated cirrhosis (AD) were enrolled at the two medical centres.

Rapid and Green Electric-Explosion Preparation of Spherical Indium Nanocrystals with Abundant Metal Defects for Highly-Selective CO Electroreduction.

Electrochemical conversion of CO into high-value-added chemicals has been considered a promising route to achieve carbon neutrality and mitigate the global greenhouse effect. However, the lack of highly efficient electrocatalysts has limited its practical application. Herein, we propose an ultrafast and green electric explosion method to batch-scale prepare spherical indium (In) nanocrystals (NCs) with abundant metal defects toward high selective electrocatalytic CO reduction (CORR) to HCOOH.

Interfacial Reduction Nucleation of Noble Metal Nanodots on Redox-Active Metal-Organic Frameworks for High-Efficiency Electrocatalytic Conversion of Nitrate to Ammonia.

Electrochemically converting nitrate to ammonia is a promising route to realize artificial nitrogen recycling. However, developing highly efficient electrocatalysts is an ongoing challenge. Herein, we report the construction of stable and redox-active zirconium metal-organic frameworks (Zr-MOFs) based on Zr nanoclusters and redox-reversible tetrathiafulvalene (TTF) derivatives as inorganic nodes and organic linkers, respectively.

Effect of curdlan on the aggregation behavior and structure of gluten in frozen-cooked noodles during frozen storage.

Due to the crucial role of gluten network in maintaining the tensile properties of frozen-cooked noodles (FCNs), the underlying mechanism of protective effect of curdlan on FCNs quality during frozen storage was explored from the perspective of aggregation behavior and structure of gluten in this study. The results showed that curdlan weakened the depolymerization behavior of gluten proteins through inhibiting the disruption of disulfide bonds; Curdlan stabilized the secondary structure of gluten proteins by restraining the transformation of compact α-helices to other secondary structures; Atomic force microscope results implied that curdlan inhibited the aggregation of gluten chains; Confocal laser scanning microscopy observation analyzed by AngioTool software indicated that the connectivity and uniformity of gluten network were enhanced because of curdlan. This study may provide more comprehensive theories for the strengthening effect of curdlan on FCNs quality from the perspective of gluten structure and contribute to the quality improvement of FCN in the food technology field.

Safety and immunogenicity of the SARS-CoV-2 ARCoV mRNA vaccine in Chinese adults: a randomised, double-blind, placebo-controlled, phase 1 trial.

Background: Safe and effective vaccines are urgently needed to end the COVID-19 pandemic caused by SARS-CoV-2 infection. We aimed to assess the preliminary safety, tolerability, and immunogenicity of an mRNA vaccine ARCoV, which encodes the SARS-CoV-2 spike protein receptor-binding domain (RBD).

Methods: This single centre, double-blind, randomised, placebo-controlled, dose-escalation, phase 1 trial of ARCoV was conducted at Shulan (Hangzhou) hospital in Hangzhou, Zhejiang province, China.

A Polysulfides-Confined All-in-One Porous Microcapsule Lithium-Sulfur Battery Cathode.

Developing emerging materials for high energy-density lithium-sulfur (Li-S) batteries is of great significance to suppress the shuttle effect of polysulfides and to accommodate the volumetric change of sulfur. Here, a novel porous microcapsule system containing a carbon nanotubes/tin dioxide quantum dots/S (CNTs/QDs/S) composite core and a porous shell prepared through a liquid-driven coaxial microfluidic method as Li-S battery cathode is developed. The encapsulated CNTs in the microcapsules provide pathways for electron transport; SnO QDs on CNTs immobilize the polysulfides by strong adsorption, which is verified by using density functional theory calculations on binding energies.