Square-Planar Tetranuclear Cluster-Based High-Symmetry Coordination Metal-Organic Polymers for Efficient Electrochemical Nitrate Reduction to Ammonia.

Metal-organic polymers (MOPs) are gaining booming attention as atomically precise single-site catalysts for electrochemical nitrate-to-ammonia conversion owing to their regular structures and tunable functionalities. However, a molecular-level understanding is still lacking for the design of more efficient MOP electrocatalysts. Here, we report the construction of high-symmetry coordination MOPs (, , and ), utilizing square-planar tetranuclear building units [M(μ-O)(CO)] (M = Mn, Fe, or Co) bridged by 2,4,6-tris(4-carboxyphenyl)-1,3,5-triazine (HTATB) ligands.

Enhancing Two-Photon Excited Fluorescence of Metal-Organic Framework Single Crystals through Modulation of Inorganic Nodes.

Regulation of the two-photon excited fluorescence (TPEF) emission intensity and wavelength of metal-organic framework (MOF) crystals with similar constitutions presents a significant challenge. In this study, two MOFs, Zn-BTPPA and Cd-BTPPA, were constructed using tetrakis(1,1'-biphenyl-4-carboxylic acid)-1,4-benzenediamine (HBTPPA) as the organic ligand and mononuclear Zn and trinuclear Cd inorganic nodes, respectively. The incorporation of HBTPPA within the MOF structures enables effective TPEF emission in both Zn-BTPPA and Cd-BTPPA.

Construction of a redox-active metal-organic framework with an octanuclear lithium one-dimensional building block.

A stable lithium metal-organic framework, constructed using a redox-active ,,','-tetrakis(4-carboxyphenyl)-1,4-phenylenediamine linker and Li cluster-based one-dimensional rod secondary building unit, exhibits good stability and reversible redox activity. The Li-MOF, which can be oxidized by AgNO, has the potential to function as an electrochromic device, thereby advancing the development of smart MOF materials.

Square-planar Tetranuclear Cluster-based Alkaline Earth Metal-organic Frameworks with Enhanced Proton Conductivity.

Alkaline earth (AE) metal complexes have garnered significant interest in various functional fields due to their nontoxicity, low density, and low cost. However, there is a lack of systematic investigation into the structural characteristics and physical properties of AE-metal-organic frameworks (MOFs). In this research, we synthesized isostructural MOFs consisting of AE(μ-Cl) clusters bridged by benzo-(1,2;3,4;5,6)-tris(thiophene-2'-carboxylic acid) (BTTC) ligands.

Development of a single-molecule biosensor with an ultra-low background for the simultaneous detection of multiple retroviral DNAs.

Human T-cell lymphotropic virus type I and type II (HTLV-I and HTLV-II) are the two most prevalent subtypes of HTLVs, and they usually infect individuals asymptomatically and may induce various diseases. Herein, we develop a single-molecule biosensor with an ultra-low background for the simultaneous detection of multiple retroviral DNAs. This biosensor is constructed by immobilizing two types of signal probes (, signal probes 1 and 2) onto the surface of magnetic beads (MBs) through specific biotin-streptavidin interactions.

A trifunctional split dumbbell probe coupled with ligation-triggered isothermal rolling circle amplification for label-free and sensitive detection of nicotinamide adenine dinucleotide.

The nicotinamide adenine dinucleotide (NAD) is an important small biomolecule that participates in a variety of physiological functions, and it has been regarded as a potential biomarker for disease diagnosis and a promising target for disease treatment. The conventional methods for NAD assay often suffer from complicated procedures, expensive labeling, poor selectivity, and unsatisfactory sensitivity. Herein, we develop a label-free and sensitive method for NAD assay based on the integration of a trifunctional split dumbbell probe with ligation-triggered isothermal rolling circle amplification (RCA).

Peptide-templated gold nanoparticle nanosensor for simultaneous detection of multiple posttranslational modification enzymes.

We developed a peptide-templated gold nanoparticle (AuNP) nanosensor for simultaneous detection of multiple posttranslational modification (PTM) enzymes with a detection limit of 28 pM for histone deacetylase (HDAC) and 0.8 pM for protein tyrosine phosphatase 1B (PTP1B), and it can be further applied for the screening of PTM enzyme inhibitors and the measurement of PTM enzymes in cancer cells.