Exploring the influence of path environment factors on walking behavior in urban parks with configuration attribute control.

The existing evidence regarding the influence of visual and physical environmental features of park pathways on walking behavior is limited and contentious, partly due to the lack of control over pathway configurational attributes and walking behavior measurement methods. This study addresses this gap by using space syntax and GPS to quantify the structural attributes and pedestrian counts within the pathways in Fengqing Park. Through stratified regression analysis, we examined the impact of environmental factors on walking behavior while controlling for pathway configurational attributes.

Comparing the multi-disciplinary approach utilizing cognitive behavioral therapy and sound therapy to standard audiological treatment in chronic tinnitus patients: Impact on severity reduction and quality of life improvement.

Objective: To compare the impact of a multi-disciplinary approach utilizing Cognitive Behavioral Therapy (CBT) and Sound Therapy (ST) in chronic tinnitus patients.

Methods: The clinical data of 111 adult patients with chronic tinnitus were retrospectively analyzed. Patients were divided into the CBT + ST Group (CBT + ST, n = 55) and the Standard Group (standard therapy, n = 56).

The Indirect Impact of COVID-19 Pandemic on Mortality, Complications, and Healthcare Utilization Among Patients With Chronic Respiratory Diseases in Hong Kong: An Interrupted Time Series Analysis.

Purpose: This study aimed to investigate COVID-19's indirect influence on chronic respiratory disease (CRD) patients for two years since the COVID-19 pandemic began.

Methods: Using population-based data in Hong Kong, we included CRD patients diagnosed from January 2011 to December 2021. Interrupted Time Series Analysis were applied to assess mortality, complications, and healthcare utilization rates during the "pre-COVID-19 pandemic" (January 2012-January 2020), "initial COVID-19 pandemic" (February 2020-February 2021), and "post-initial COVID-19 pandemic" (March 2021-December 2021) periods.

Assessing family influence on adolescent healthy eating: insights from knowledge, attitudes, and practices in a cross-sectional survey in Hong Kong.

Background: Poor dietary habits in adolescents contribute to the development of non-communicable diseases in adulthood. While family influence by parenting style, food parenting practice and household income on adolescent eating habits has been well-established, other family factors such as parental health conditions as well as the impact on dietary knowledge and attitudes in adolescents are underexplored. This study aimed to evaluate the relative importance of family factors on adolescent healthy eating using the knowledge, attitudes, and practices (KAP) model.

Government regulation or market mechanism? A study on the collaborative innovation pathways of the emergency industry based on evolutionary game models.

Promoting collaborative innovation within the emergency industry has become a crucial task, which is of great significance for enhancing emergency response capabilities and ensuring public safety. On the basis of considering the economic attributes of the emergency industry and the uncertainty characteristics of market returns, this study constructs an evolutionary game model for collaborative innovation among emergency enterprises, universities and research institutions (UR), and government departments, which are the main entities considered. It analyzes the evolutionary process of the strategy choices and equilibrium states of different entities, thereby revealing the key factors and intrinsic mechanisms affecting collaborative innovation pathways.

Fatigue of Li metal anode in solid-state batteries.

Solid-state lithium metal batteries (SSBs) are promising for electric vehicles because of their potential to provide high energy density and enhanced safety. However, these batteries face short-circuit challenges caused by uncontrolled lithium dendrite growth during cycling. Using operando scanning electron microscopy and phase-field simulations, we determined that failure of SSBs is closely linked to the fatigue of the lithium metal anode, which markedly contributes to interface degradation and dendrite growth in SSBs.

A hairpin reporter-driven feedback CRISPR/Cas signal amplification loop for terminal deoxynucleotidyl transferase activity detection.

The CRISPR/Cas12a system has become a powerful tool in biosensing because of its specific target recognition ability and highly efficient trans-cleavage activity. However, a problem faced by the CRISPR/Cas12a system when directly used for trace detection is the linear amplification efficiency of single-cycle digestion. Here, we present a novel hairpin reporter-driven CRISPR/Cas12a (HR-CRISPR) amplification system that establishes a positive feedback loop within the CRISPR/Cas12a platform to finish an exponential and sensitive signal amplification in a one-step reaction.

Quasi-1D NbTe for Broadband Pulse Generation from 1.0 to 3.0 μm: Bridging the Near- and Mid-Infrared.

Quasi-one-dimensional (quasi-1D) transition metal chalcogenides (TMCs), a subclass of low-dimensional materials, have attracted significant attention due to their unique optical and electronic properties, making them promising candidates for nonlinear photonics. In this work, NbTe, a quasi-1D transition metal tetrachalcogenide, was synthesized and employed for the first time as a broadband saturable absorber (SA) for pulsed laser applications. The nonlinear optical (NLO) properties of NbTe were systematically characterized at 1.

Facile Nanocomposite Hydrogel Scaffold with Sustained Drug Release and Osteo-Immunomodulatory Effects to Enhance Bone Regeneration.

High-quality repair of critical bone defects without exogenous cells remains a major clinical challenge worldwide. Herein, we fabricated a nanocomposite hydrogel scaffold (ASA/MSNs/CSH) by incorporating aspirin (ASA)-loaded mesoporous silica nanoparticles (MSNs) into genipin-cross-linked chitosan hydrochloride (CSH). The resulting scaffold was designed to provide immunomodulatory support during the process of bone regeneration.

Atrial APD prolongation caused by the upregulation of RAGE and subsequent increase in diabetic patients.

Diabetes mellitus (DM) is a risk factor for the development of atrial fibrillation (AF). The action potential duration (APD) has been demonstrated to be prolonged in the atrium of diabetic mice. In contrast, the APD is generally shortened in AF patients.

Blockade of glucagon receptor induces α-cell hypersecretion by hyperaminoacidemia in mice.

Blockade of the glucagon receptor (GCGR) has been shown to improve glycemic control. However, this therapeutic approach also brings side effects, such as α-cell hyperplasia and hyperglucagonemia, and the mechanisms underlying these side effects remain elusive. Here, we conduct single-cell transcriptomic sequencing of islets from male GCGR knockout (GCGR-KO) mice.

Disease burden and health-related quality of life among children with X-linked hypophosphataemia in China: a national cross-sectional survey.

Background: X-linked hypophosphataemia (XLH) is a rare inherited disorder often misdiagnosed and lacking sufficient aetiological treatment. Previous studies have shown that XLH is associated with worse health-related quality of life (HRQoL) and greater economic burden for children and their families compared with the general population, but evidence from China is scarce. This study aimed to comprehensively explore the burden and HRQoL of XLH children in China.

Rare disease publishing trends worldwide and in China: A CiteSpace-based bibliometric study.

This study aimed to understand research trends, determine frontier topics, and explore the developments in and the differences between research conducted in China and the rest of the world. We analyzed the research status of rare diseases in China and globally over the past decade using bibliometric methods. We focused on rare disease literature indexed in the Web of Science (WoS) and China National Knowledge Infrastructure (CNKI) databases from January 2013 to December 2023.

Automated segmentation by SCA-UNet can be directly used for radiomics diagnosis of thymic epithelial tumors.

Background: Automatic segmentation of thymic lesions in preoperative computed tomography (CT) images is crucial for accurate diagnosis but remains time-consuming. Although UNet is widely used in medical imaging, its performance is limited by the inherent drawbacks of convolutional neural networks (CNNs), such as restricted receptive fields and limited global context modeling, which affect segmentation efficiency.

Method: 712 patients with mediastinal lesions admitted to Shanghai General Hospital between October 2014 and January 2023 were included in the study.

Differential ratiometric molecularly imprinted electrochemical method for methyl-parathion and carbendazim in foods.

Non-specific adsorption of interferents on molecularly imprinted polymer (MIP) membranes bottlenecks their selective recognition to templates. Herein, we reported an improved differential MIP strategy to correct such adverse effect for determining carbendazim (CBZ) and methyl-parathion (MP) in food samples. MIP membranes of CBZ and MP were prepared using mixed functional monomers of β-cyclodextrin and thionine with synergistic recognition selectivity.

Inactivation of Notch1-TGF-β-Smads Signaling Pathway by Atorvastatin Improves Cardiac Function and Hemodynamic Performance in Acute Myocardial Infarction Rats.

Introduction: The aim of this study was to determine the effects of atorvastatin on cardiac function and hemodynamics and to investigate its functional mechanism on cardiac fibrosis in acute myocardial infarction (AMI) rats.

Methods: Cardiac functions and hemodynamic changes were evaluated in each group on day 28. Quantitative reverse transcription-polymerase chain reaction, Western blot, and immunohistochemistry were performed to detect the expression of notch1, transforming growth factor-β (TGF-β), Smad2, Smad7, as well as myocardial fibrosis factors (i.

Construction of geriatric hypoalbuminemia predicting model for hypoalbuminemia patients with and without pneumonia and explainability analysis.

Background And Objectives: Pneumonia portrays a critical health concern in geriatrics. Geriatric pneumonia can lead to changes on other complications, in which hypoalbuminemia is a common complication. However, few studies have looked at the impact of pneumonia on the course of hypoalbuminemia and predicting.

Percutaneous Microwave Ablation for Aldosterone-Producing Adenoma.

Thirty-five patients diagnosed with aldosterone-producing adenomas (APAs) underwent computed tomography (CT)-guided percutaneous microwave ablation (MWA). Comparisons of aldosterone-to-renin ratio, potassium level, blood pressure (BP), and medications were performed preprocedurally, postprocedurally, and at the latest follow-up examination. The outcome assessment was based on the Primary Aldosteronism Surgical Outcome (PASO) standards.

Transsynaptic modulation of cerebellar nuclear cells: theta AC-burst stimulation.

Transcranial alternating current stimulation (tACS) and its variants are being tested in clinical trials for treatment of neurological disorders, and cerebellar tACS (ctACS) in particular has garnered much interest because of the involvement of the cerebellum in these disorders. The main objective of this study was to investigate the frequency tuning curves for the entrainment of the Purkinje cells (PCs) and the cerebellar nuclear (CN) cells by their axonal projections. In addition, we aimed to investigate the temporal and steady-state characteristics of the PC-CN transsynaptic modulation under clinically relevant stimulation waveforms.

SERS-Encoded Nanoprobes Based on Silver-Coated Gold Nanorods for Cell Sorting.

Optically-encoded probes have great potential for applications in the fields of biosensing and imaging. By employing specific encoding methods, these probes enable the detection of multiple target molecules and high-resolution imaging within the same sample. Among the various encoding methods, surface-enhanced Raman scattering (SERS) spectral encoding stands out due to its extremely narrow linewidth.

Integrating few-atom layer metal on high-entropy alloys to catalyze nitrate reduction in tandem.

While high-entropy alloy (HEA) catalysts seem to have the potential to break linear scaling relationships (LSRs) due to their structural complexity, the weighted averaging of properties among multiple principal components actually makes it challenging to diverge from the symmetry dependencies imposed by the LSRs. Herein, we develop a 'surface entropy reduction' method to induce the exsolution of a component with weak affinity for others, resulting in the formation of few-atom-layer metal (FL-M) on the surface of HEAs. These exsolved FL-M surpass the confines of the original configurational space of conventional HEAs, and collaborate with the HEA substrate, serving as geometrically separated active sites for multiple intermediates in a complex reaction.

Health service utilization, economic burden and quality of life of patients with mucopolysaccharidosis in China.

Background: Patients with mucopolysaccharidosis (MPS) often face delayed diagnoses, limited treatment options and high healthcare costs, that may significantly affect patients' quality of life. The objective of this study was to understand medical service utilization related to diagnosis and treatment, economic burden during diagnosis period, and health-related quality of life among MPS patients in China.

Methods: A series of patients diagnosed with MPS registered in the national patient organization were recruited for a cross-sectional survey from May to July 2019.

An intense cathodic electrochemiluminescence from carbon-nanosheets in situ grown on glassy carbon electrode and application in immunoanalysis via biometallization strategy.

An intense cathodic electrochemiluminescence (ECL) is reported from a polarized glassy carbon electrode (GCE) in peroxydisulfate solution. After the polarization in 1 M NaSO at the potential of - 3.7 V for 3 s, carbon nanosheets (C-NSs) were in situ grown on the surface of the GCE.