H3K18la Facilitates TRA2A-Mediated Alternative Splicing of STIL, Suppressing Ferroptosis and Cisplatin Treatment Sensitivity in Ovarian Cancer.

Purpose: Ovarian cancer (OC) is a common and highly lethal malignant tumor in women. Due to its hidden early symptoms, most patients are diagnosed at an advanced stage, and the tumor often develops resistance to chemotherapy, making treatment challenging. Elucidating the mechanisms of OC development and identifying new therapeutic targets, are crucial for improving treatment outcomes.

Study on the Influence of Ultrafast Laser Welding Parameters on Glass Bonding Performance.

Glass enjoys a wide range of applications thanks to its superior optical properties and chemical stability. Conventional glass bonding techniques suffer from low efficiency, limited precision, and high cost. Moreover, for multilayer glass bonding, repeated alignment is often required, further complicating the process.

Refining Prognosis and Treatment Strategies Beyond the Barcelona Clinic Liver Cancer Stage in Hepatocellular Carcinoma with Lung Metastases: A Multicenter Cohort Study.

Lung metastasis is the most common site of extrahepatic spread in hepatocellular carcinoma (HCC) and is associated with significantly poorer outcomes. Current guidelines classify these patients as Barcelona Clinic Liver Cancer (BCLC) stage C, recommending systemic therapy alone. However, this one-size-fits-all approach may overlook potential benefits in selected patients.

Three-stage dynamics of nonlinear pulse amplification in an ultrafast mid-infrared fiber amplifier with anomalous dispersion.

Nonlinear pulse amplification in optical fiber, with the capability of breaking the gain-bandwidth limitation, is a key technique for high-energy, ultrafast pulse generation. In the longer wavelength region (including 1.55 μm, 2 μm and 2.

Single-protein/RNA imaging reveals ZNF598 as a limiting factor in resolving collided ribosomes.

Ribosome-associated protein quality control (RQC) is a surveillance system that identifies and processes aberrant mRNAs with collided ribosomes. ZNF598 plays a key role by ubiquitinating the 40S subunit of collided ribosomes. However, how ZNF598 distinguishes stalled from transient ribosome collisions remains unclear.

Construction of the Veterinary DrugBank and Drug Repurposing.

AI-driven drug discovery relies on multiscale data integration. However, the veterinary drug development field currently lacks systematic integration of drug-disease-target information. To address this gap, we constructed the Veterinary DrugBank (https://ys.

Tunable VUV-to-VIS ultrafast pulses generation in hollow capillary fibers with 15.7% dispersive-wave efficiency at 320 nm.

We report a compact hollow-capillary-fiber (HCF) system that generates tunable dispersive-wave (DW) pulses spanning the vacuum ultraviolet (VUV) to visible (VIS) spectral regions. Through optimization of the HCF and gas parameters, we demonstrate continuously tunable DW generation with a wider tuning range (147-520 nm) than previously reported in similar compact systems (200-380 nm). Using a 140-μm-core, 1-m-long helium-filled HCF, we enhance deep-UV pulse generation efficiency via spectral blue-shifting of the DW at a relatively high soliton order, achieving a record 15.

Exploiting functional regions in the viral RNA genome as druggable entities.

RNA-targeting compounds or small interfering RNAs (siRNAs) offer a potent means to control viral infections. An essential prerequisite for their design depends on identifying conserved and functional viral RNA structures in cells. Techniques that probe RNA structures in situ have recently been developed including SHAPE-MaP, which has been helpful in the analysis of secondary structures of RNA.

Correlation Analysis of Sperm Cryopreservation Quality with Serum Testosterone and Sperm gDNA Methylation Levels in Xiaoshan Chickens.

Chicken semen cryopreservation is crucial for utilizing high-quality cockerel genetics, but semen is highly sensitive to cryoinjury, leading to poor preservation outcomes. This study aimed to establish a theoretical foundation for selecting cockerels for semen cryopreservation through serum testing and to improve semen quality via DNA methylation editing. Semen and serum samples were collected from 102 Xiaoshan cockerels, with semen cryopreserved and thawed following standardized protocols.

External Electric Field-Enhanced Fenton-Like Reactivity of Multiprincipal Element Alloy.

Benefiting from high configurational entropy and tunable composition, multiprincipal element alloys (MPEAs) have emerged as promising candidates for heterogeneous catalysis. Only recently have MPEAs been explored for peroxymonosulfate (PMS)-based Fenton-like reactions. In the past, it has been known that an external electric field (EEF) can accelerate Fenton-like reactions by transferring free electrons to PMS.

Arecoline alleviates autism spectrum disorder-like behaviors and cognition disorders in a valproic acid mouse model by activating the AMPK/CREB/BDNF signaling pathway.

Studies in humans have revealed that the pathogenesis of autism spectrum disorder (ASD) is linked to white matter abnormalities involving hypomyelination and oligodendroglia dysfunction; however, effective treatments remain limited. Similarly, the valproic acid (VPA) model mice, which are widely used to study ASD, also exhibit white matter abnormalities with hypomyelination. Arecoline has been reported to enhance memory and cognition, facilitate myelination and improve neurological function.

KGSD-Net: a knowledge graph syndrome differentiation network for syndrome classification.

The integration of electronic medical records (EMRs) in modern healthcare holds significant promise; however, traditional approaches to syndrome differentiation in Traditional Chinese Medicine (TCM) often encounter limitations due to incomplete data and inconsistent frameworks. This paper addresses these challenges by introducing a novel methodology that employs large-scale language models (LLMs) to extract relevant entities from an semi-structured TCM knowledge base, facilitating the construction of a dynamic TCM knowledge graph. By applying the DeepWalk method for latent knowledge graph embedding, hidden patterns essential for accurate diagnosis are uncovered.

From single to multiple: the association of childhood trauma with frequent nightmares among youth.

Objective: Childhood trauma is a known risk factor for frequent nightmares in youth, but the effects of single and multiple traumas remain unclear. This cross-sectional study aimed to investigate the association between single and multiple childhood traumas and frequent nightmares.

Methods: Youth aged 12-25 years completed online questionnaires on childhood trauma and nightmares.

Manipulating Aromaticity to Redirect Topochemical Polymerization Pathways.

Topochemical polymerization (TCP) represents an essential route to create regio- and stereoregular polymers through solid-state transformations. Herein, we present an innovative strategy for controlling topochemical polymerization pathways by tailoring the terminal group aromaticity in the -azaquinodimethane (AQM) ring system. Substituting phenyl groups with less aromatic furyl units extends significant spin density delocalization across the conjugated core upon thermal activation, inducing significant diradicaloid characters at furyl positions and enabling unconventional reactivities in both solution and solid states.

Tunable ultraviolet dispersive-wave emission driven directly by 40-fs Ti:sapphire laser pulses in a hollow capillary fiber.

We demonstrate that by using a 1-m-long gas-filled hollow capillary fiber (HCF) with a core diameter of 100 μm, tunable ultraviolet (UV) dispersive-wave (DW) pulses can be generated in a compact, single-stage setup driven directly by 40-fs Ti:sapphire laser pulses. By adjusting the gas type and pressure inside the HCF, the central wavelength of the UV DW can be continuously tuned from 185 nm to ∼450 nm. In the experiment, we found that for ∼320-450 nm DW generation, Raman-active gas filled in the HCF can efficiently suppress the pulse fission effect of the high-order soliton due to the Raman-induced pulse energy dissipation, leading to the high-quality DW generation at these wavelengths with smooth, single-peak spectra.

Wavelength-tunable, mid-infrared ultrafast pulse generation through Raman self-frequency shift in an all-solid fluorotellurite fiber.

We report a mid-infrared (mid-IR) fiber laser system that can deliver ultrafast soliton-like pulses with a wavelength tunable from 2.8 to 4.0 μm.

Identification and functional analysis of proteins in Anabarilius grahami at different growth stages based on 4D-DIA quantitative proteomics technology.

This study compared the proteome of Anabarilius grahami at three growth stages with Carassius auratus at a single growth stage to identify and analyze protein functions in A. grahami using quantitative proteomics technology. A total of 1821 proteins were identified, among which six differentially abundant proteins (DAPs) were found as biomarkers for discriminating C.

All-microwave spectroscopy and polarization of individual nuclear spins in a solid.

Pushing the sensitivity of nuclear magnetic resonance spectroscopy to the single spin level would have a major impact in chemistry and biology and is the goal of intense research efforts. We report magnetic resonance spectroscopy measurements of individual nuclear spins in a crystal coupled to a neighboring paramagnetic center, detected using microwave fluorescence at millikelvin temperatures. We observe real-time quantum jumps of the nuclear spin state, a proof of their individual nature.

Dense convolution-based attention network for Alzheimer's disease classification.

Recently, deep learning-based medical image classification models have made substantial advancements. However, many existing models prioritize performance at the cost of efficiency, limiting their practicality in clinical use. Traditional Convolutional Neural Network (CNN)-based methods, Transformer-based methods, and hybrid approaches combining these two struggle to balance performance and model complexity.

Retiming dynamics of harmonically mode-locked laser solitons in a self-driven optomechanical lattice.

Harmonic mode-locking, realized actively or passively, is an effective technique for increasing the repetition rate of ultrafast lasers. It is critically important to understand how a harmonically mode-locked pulse train responds to external perturbations and noise, so as to make sure that it is stable and resistant to noise. Here, in a series of carefully designed experiments, we elucidate the retiming dynamics of laser pulses generated in a soliton fiber laser harmonically mode-locked at GHz frequencies to the acoustic resonance in a photonic crystal fiber (PCF) core.

A new HCM heart sound classification method based on weighted bispectrum features.

Hypertrophic cardiomyopathy (HCM), including obstructive HCM and non-obstructive HCM, can lead to sudden cardiac arrest in adolescents and athletes. Early diagnosis and treatment through auscultation of different types of HCM can prevent the occurrence of malignant events. However, it is challenging to distinguish the pathological information of HCM related to differential left ventricular outflow tract pressure gradients.

Machine learning models for predicting postoperative peritoneal metastasis after hepatocellular carcinoma rupture: a multicenter cohort study in China.

Background: Peritoneal metastasis (PM) after the rupture of hepatocellular carcinoma (HCC) is a critical issue that negatively affects patient prognosis. Machine learning models have shown great potential in predicting clinical outcomes; however, the optimal model for this specific problem remains unclear.

Methods: Clinical data were collected and analyzed from 522 patients with ruptured HCC who underwent surgery at 7 different medical centers.

Visible-Light-Induced -Quinone Methides Formation in Situ Using -Alkylarenols as Precursors for Tandem [4 + 2] Cycloaddition Reaction.

Reported herein is the generation of -quinone methides (-QMs) via metal-free visible-light-induced oxidation of -alkylarenols, as well as their subsequent reaction with olefins to afford chromans in good to excellent yields (up to 91%). The key is the selective activation of the benzylic C(sp)-H bond of -alkylarenols via single electron transfer (SET) and the formation of -QMs via hydrogen atom transfer (HAT).

Forest management impacts on soil phosphorus cycling: Insights from metagenomics in Moso bamboo plantations.

Bamboo forests are crucial ecosystems and provide essential ecological and economic services in both tropical and subtropical regions. Soil phosphorus (P), a vital nutrient for plant growth, is fundamental to the productivity and health of bamboo forests. However, the microbial mechanisms through which management practices affect soil P processes in bamboo forests remain poorly understood.

Metal-dielectric dispersive mirrors for ultraviolet lasers.

We report a broadband metal-dielectric dispersive mirror (MDDM) based on Al/SiO/HfO thin films operating in the near-ultraviolet (UV) region. Demonstrating the combined benefits of both the wide reflective bandwidth of aluminum in the UV region and the flexible dispersion control capability of HfO/SiO multilayer films, the MDDM has a wide bandwidth, low total thickness, and precise dispersion compensation ability. We propose an initial design based on a shortwave reflection enhancement structure (SWRES) to prevent shortwave light from obtaining a second time-dispersion compensation in the deep metal layer.