Iminoboronate chemistry enables multifunctional and reprocessable polyphenol-derived vitrimers.

Polyphenol-derived vitrimers offer compelling prospects for sustainable materials owing to their intrinsic recyclability, reprocessability and biodegradability. However, practical development remains constrained by structure degradation under harsh reprocessing conditions and the need for sophisticated modifications of the bio-sourced precursors. Herein, we reported a strategy that integrates commercially available polyphenols and low-molecular-weight PDMS through adaptable iminoboronate chemistry, obviating the need for structural modifications.

Natural Polyphenol-Functionalized Schwann Cell-Derived Exosomes as a Temporal Neuromodulation Strategy for Diabetic Periodontitis Therapy.

An interactive bidirectional relationship between periodontitis and diabetes poses great challenges for the treatment of diabetic periodontitis in clinical practice. The hyperglycemic inflammatory periodontal microenvironment is characterized by oxidative damage, chronic invasive infection, excessive inflammation, unbalanced immunomodulation, progressive neuropathy, diabetic vasculopathy, and uncoupled bone resorption and formation responses. The neuromodulation strategy holds great potential to mediate and coordinate temporally the complex microenvironment for diabetic periodontal regeneration.

Human breast milk as a bioactive material platform enabling scarless skin regeneration macrophage reprogramming and myofibroblast heterogeneity.

The regulation of the immune system and promotion of myofibroblast heterogeneity in wounds are crucial for developing scar-reducing treatments. Currently, no approved multifaceted drug exists that can fully inhibit fibrosis. In this study, we explore the beneficial effects of human breast milk (HBM), focusing on its ability to regulate the macrophage phenotype and function, and promote myofibroblast heterogeneity to inhibit skin scar formation.

Bioengineered Hydrogels for Restoring Cardiac Electronic Activity after Myocardial Infarction.

Myocardial infarction (MI) is a significant global public health challenge affecting millions of individuals every year. Cardiac tissue engineering (CTE), especially cardiac hydrogels, have emerged as a promising therapeutic strategy for MI. Formation of stiff and non-conductive fibrous scars in the infarcted area is a major cause of fatal ventricular arrhythmias and progressive heart failure.

Multifunctional Bioglues with Excellent Antibacterial Properties for Infectious Wound Healing.

Bacterial infection and wound hemorrhage remain critical determinants of mortality in traumatic injuries, necessitating the development of bioglues capable of rapid hemostasis and efficient bacterial elimination. While numerous bioglues have been reported, challenges including insufficient adhesive strength, prolonged curing time, cytotoxicity, and persistent microbial contamination limit their clinical utility. Herein, a series of multifunctional bioglues are prepared via a combination of -nitrobenzyl alcohol-modified carboxymethyl cellulose (CNC-NB), dopamine-modified carboxymethyl chitosan (CMC-DA), and antibacterial drug tobramycin (TOB).

Structural engineering of g-CN for enhanced antibacterial efficacy.

g-CN, as a novel photocatalytic antibacterial material, has been widely studied due to its broad-spectrum antibacterial properties, strong photocatalytic activity, excellent chemical and thermal stability, high versatility, and low cost. However, there is still a lack of comprehensive summaries regarding its antibacterial applications. This article reviews the preparation methods, antibacterial principles, and enhancement strategies of g-CN, and discusses its current status and prospects in antibacterial applications.

Smart polydopamine nanodot-knotted hydrogels for photodynamic tumor therapy.

Integrating nature-derived polyphenolic nanodots (PDs) with polymeric matrices presents a sustainable strategy for developing multifunctional nanocomposite hydrogels with enhanced biological performance. However, conventional PDs-knotted hydrogel fabrication methods still face significant challenges in regulating PDs properties and seamlessly incorporating them into hydrogel systems. Herein, we reported a facile and eco-friendly approach to construct polydopamine (PDA) nanodots polyethyleneimine (PEI)-mediated oxidative polymerization under mild aqueous conditions.

HH079 alleviates early-life antibiotic-exposed colon dysbiosis in mice by restoring the gut microbiota and gut barrier function.

Antibiotic exposure in early life disrupts gut microbiota development in infants, which could result in intestinal dysfunction. This study mimicked early-life antibiotic exposure in mice by administering antibiotic water to lactating dams, and investigated the effects of a new strain of HH079 ( HH079) on intestinal dysbiosis associated with early-life antibiotic exposure in pups. The results showed that HH079 treatment inhibited the proliferation of and after antibiotic exposure, but promoted the abundance of and and acetate production.

Two birds with one stone: natural polyphenols boosted periodontitis treatment of chlorhexidine reducing toxicity and regulating microenvironments.

Chlorhexidine (CHX) is considered the gold standard for controlling periodontal plaque and has been extensively used as a topical agent in treating periodontitis. Nevertheless, the practical clinical application of CHX is still constrained by the inherent limitations of its properties, including toxicity, inadequate biofilm scavenging capacity, and single biological effect. In this study, polyphenolic epigallocatechin gallate (EGCG) has been employed to integrate with CHX to form an EGCG-CHX nanoplatform a facile one-pot method.

Exploring the application of piezoelectric ceramics in bone regeneration.

Piezoelectric ceramics are piezoelectric materials with polycrystalline structure and have been widely used in many fields such as medical imaging and sound sensors. As knowledge about this kind of material develops, researchers find piezoelectric ceramics possess favorable piezoelectricity, biocompatibility, mechanical properties, porous structure and antibacterial effect and endeavor to apply piezoelectric ceramics to the field of bone tissue engineering. However, clinically no piezoelectric ceramics have been exercised so far.

Biogenic derived nanoparticles modulate mitochondrial function in cardiomyocytes.

Preservation of mitochondrial functionality is essential for heart hemostasis and cardiovascular diseases treatment. However, the current nanomedicines including liposomes, polymers and inorganic nanomaterials are severely hindered by poor stability, high manufacturing costs and potential biotoxicity. In this research, we present novel polyphenolic nanoparticles (NPs) derived from naturally occurring pomegranate peel (PP, labelled as PPP NPs), which exhibit potent antioxidative and anti-inflammatory properties, serving as a modulator of mitochondrial function.

ROS-responsive hydrogels: from design and additive manufacturing to biomedical applications.

Hydrogels with intricate 3D networks and high hydrophilicity have qualities resembling those of biological tissues, making them ideal candidates for use as smart biomedical materials. Reactive oxygen species (ROS) responsive hydrogels are an innovative class of smart hydrogels, and are cross-linked by ROS-responsive modules through covalent interactions, coordination interactions, or supramolecular interactions. Due to the introduction of ROS response modules, this class of hydrogels exhibits a sensitive response to the oxidative stress microenvironment existing in organisms.

Polyphenols-based intelligent oral barrier membranes for periodontal bone defect reconstruction.

Periodontitis-induced periodontal bone defects significantly impact patients' daily lives. The guided tissue regeneration and guided bone regeneration techniques, which are based on barrier membranes, have brought hope for the regeneration of periodontal bone defects. However, traditional barrier membranes lack antimicrobial properties and cannot effectively regulate the complex oxidative stress microenvironment in periodontal bone defect areas, leading to unsatisfactory outcomes in promoting periodontal bone regeneration.

Supramolecular assembly of isomeric SN-38 prodrugs regulated by conjugation sites.

Supramolecular polymers (SPs) are an emerging class of drug transporters employed to improve drug therapy. Through the rational design of self-assembling monomers, one can optimize the properties of the resulting supramolecular nanostructures, such as size, shape, surface chemistry, release, and, therefore, biological fates. This study highlights the design of isomeric SN38 prodrugs through the conjugation of hydrophilic oligo(ethylene glycol) (OEG) with hydroxyls at positions 10 and 20 on hydrophobic SN-38.

Sonochemical Synthesis of Natural Polyphenolic Nanoparticles for Modulating Oxidative Stress.

Natural polyphenolic compounds play a vital role in nature and are widely utilized as building blocks in the fabrication of emerging functional nanomaterials. Although diverse fabrication methodologies are developed in recent years, the challenges of purification, uncontrollable reaction processes and additional additives persist. Herein, a modular and facile methodology is reported toward the fabrication of natural polyphenolic nanoparticles.

Quaternary Ammonium Assisted Synthesis of Melanin-like Poly(l-DOPA) Nanoparticles with a Boosted Photothermal Effect.

Poly(levodopa) nanoparticles (P(l-DOPA) NPs) are another kind of melanin mimetic besides well-established polydopamine nanoparticles (PDA NPs). Due to the presence of carboxyl groups, the oxidative polymerization of l-DOPA to obtain particles was not as efficient as that of dopamine. Several established methods toward P(l-DOPA) NP fabrication do not combine convenience, morphological regularity, size controllability, low cost, and adaptability to metal-free application scenarios.

Functional Polyphenol-Based Nanoparticles Boosted the Neuroprotective Effect of Riluzole for Acute Spinal Cord Injury.

Riluzole is commonly used as a neuroprotective agent for treating traumatic spinal cord injury (SCI), which works by blocking the influx of sodium and calcium ions and reducing glutamate activity. However, its clinical application is limited because of its poor solubility, short half-life, potential organ toxicity, and insufficient bioabilities toward upregulated inflammation and oxidative stress levels. To address this issue, epigallocatechin gallate (EGCG), a natural polyphenol, was employed to fabricate nanoparticles (NPs) with riluzole to enhance the neuroprotective effects.

Eumelanin-like Poly(levodopa) Nanoscavengers for Inflammation Disease Therapy.

In the current years, polydopamine nanoparticles (PDA NPs) have been extensively investigated as an eumelanin mimic. However, unlike natural eumelanin, PDA NPs contain no 5,6-dihydroxyindole-2-carboxylic acid (DHICA)-derived units and may be limited in certain intrinsic properties; superior eumelanin-like nanomaterials are still actively being sought. Levodopa (-DOPA) is a natural eumelanin precursor and expected to convert into DHICA and further remain within the final product through covalent or physical interactions.

UV absorption enhanced polydopamine coating.

Mussel-inspired polydopamine (PDA) coatings have gained significant attention in various fields, including biomedicine, energy, detection, and UV protection, owing to their versatile and promising properties. Among these properties, UV shielding stands out as a key feature of PDA coatings. Nevertheless, the current methods for tuning the UV-shielding properties of PDA coatings are quite limited, and only rely on thickness adjustment, which might involve additional issues like color and visible light transmittance to the coating layer.

Polyphenolic Platform Ameliorated Sanshool for Skin Photoprotection.

Natural evolution has nurtured a series of active molecules that play vital roles in physiological systems, but their further applications have been severely limited by rapid deactivation, short cycle time, and potential toxicity after isolation. For instance, the instability of structures and properties has greatly descended when sanshool is derived from Zanthoxylum xanthoxylum. Herein, natural polyphenols are employed to boost the key properties of sanshool by fabricating a series of nanoparticles (NPs).

Robust and Multifunctional Therapeutic Nanoparticles against Peritonitis-Induced Sepsis.

Apart from bacterial growth and endotoxin generation, the excessive production of reactive radicals linked with sepsis also has a substantial impact on triggering an inflammatory response and further treatment failure. Hence, the rational design and fabrication of robust and multifunctional nanoparticles (NPs) present a viable means of overcoming this dilemma. In this study, we used antibiotic polymyxin B (PMB) and antioxidant natural polyphenolic protocatechualdehyde (PCA) to construct robust and multifunctional NPs for sepsis treatment, leveraging the rich chemistries of PCA.

Metal-polyphenol networks-modified tantalum plate for craniomaxillofacial reconstruction.

Using three-dimensional (3D) printing technology to make the porous tantalum plate and modify its surface. The physicochemical properties, cytocompatibility, antioxidant capacity, and histocompatibility of the modified materials were evaluated to prepare for the repair of craniomaxillofacial bone defects. The porous tantalum plates were 3D printed by selective laser melting technology.