Synergistic t-to-π* Electron Transfer and Nanotube Engineering in Spinal Catalysts for Ultra-Efficient Chloride Evolution.

Facing the massive energy consumption of over 200 TWh y of chlor-alkali industry, developing high-activity and durable non-precious CER (chlorine evolution reaction) catalysts is urgently needed to address the high overpotentials and suppress the dissolution high-valance metal species. Herein, a carbon quantum dots functionalized trimetallic Fe/Co/Ni spinel oxide nanotube architecture (FCNO@CQDs) is constructed, featuring t-to-π* π-backbonding for dramatically enhanced CER activity and stability. The reverse electron flow from Co d-obritals to the vacant CQDs' π* orbitals can upshift the d-band center for enhanced intermediate adsorption, while stabilizing high-valent Co centers via increased bond order.

COX-2 targeting Ru-arene complexes from metal-ligand synergistic enhancement strategy for breast cancer therapy.

Triple-negative breast cancer (TNBC) has been a significant therapeutic challenge, due to its aggressive and metastatic characteristics. Cyclooxygenase-2 (COX-2), which is frequently overexpressed in TNBC and implicated in tumor progression, is considered as a potent therapeutic target. In this study, we reported a novel Ru-arene complex, Ru-tol, utilizing a metal-ligand synergistic enhancement (MLSE) strategy.

Bionic Design of Ni Lewis Acid Site Based on Selective Seawater Oxidation.

The side reaction caused by chloride ions and the toxicity to the active site have always been the hindrance to the electrocatalyst of the oxygen evolution reaction (OER) for seawater splitting. Herein, inspired by the early flowering of damaged plants, we designed a catalyst rich in oxygen vacancies (O) and proved that O can accelerate the formation of Ni and further oxidize it to Ni, which we named as the "ripening" mechanism of O. O reduces the hydrogen proton desorption energy by regulating local charge redistribution, thus realizing the rapid transformation of Ni→Ni→Ni.

Photothermal therapy for bacteria-infected wound healing a cation-anion inverted antiperovskite with full-spectrum solar absorption.

Clinical treatment of open wounds is challenging due to bacterial infection and biofilm protection. Antibiotics are commonly utilized as antibacterials; however, multidrug resistance (MDR) severely affects the therapeutic effect. Therefore, developing a non-antibiotic strategy for treating infections and accelerating wound healing is highly required.

Novel tryptophan 2,3-dioxygenase-targeted ruthenium(ii)-indole complex activates immunotherapy and .

Immunotherapy targeting immune checkpoints has emerged as a promising strategy in cancer treatment; however, the heterogeneous and dynamic tumor microenvironment (TME) imposes critical constraints on therapeutic outcomes. Tryptophan 2,3-dioxygenase (TDO), often dysregulated in malignant tissues, plays a pivotal role in shaping an immunosuppressive milieu by depleting tryptophan, thereby hindering anti-tumor immune response. To counteract this immune evasion mechanism, we designed a novel indole-coordinated ruthenium(ii) arene complex (In-Ru), aimed at bolstering tumor immunotherapy and thwarting immune evasion by targeting TDO expression.

A novel therapeutic strategy for osteosarcoma using anti-GD2 ADC and EZH2 inhibitor.

Osteosarcoma is the commonest malignant bone tumour in children, with a poor prognosis due to limited treatment options. Antibody-drug conjugates (ADCs) offer targeted therapeutic potential but are limited by the low expression of specific antigens like disialoganglioside (GD2) on osteosarcoma cells. This study aimed to enhance the efficacy of an anti-GD2 ADC by combining it with the enhancer of zeste homolog 2 (EZH2) inhibitor tazemetostat to upregulate GD2 expression and improve treatment outcomes.

Triple-Standard Hypochlorite Quantitative Array Enabled by Precise Stokes Shift Modulation in D-π-A Chemodosimeters.

The rational design of the D-π-A chemodosimeter with a significant Stokes shift is of great importance for enhancing the visualization of optical sensing signals. Here, three D-π-A fluorescent chemodosimeters with 2-(3-cyano-4,5,5-trimethylfuran-2(5H)-ylidene) malononitrile (TCF) as the electron-withdrawing group are synthesized by precisely modulating the electron-releasing strength. By decreasing the ability of electron release, the electrophilicity of the recognition site is increased by 1.

Small molecule interleukin (IL) 17A/A antagonists and antibodies blocking both IL17A/A and IL17A/F demonstrate equivalent degrees of efficacy in preclinical models of skin and joint inflammation.

T-helper 17 (Th17) cells produce homodimeric IL17A/A and IL17F/F cytokines as well as the heterodimeric IL17A/F isoform, all having well known roles in defense against extracellular pathogens including fungal infection. Antibodies targeting IL17A (such as secukinumab and ixekizumab) have been approved to treat psoriasis, psoriatic arthritis, ankylosing spondylitis, and axial spondyloarthritis and are under further investigation as therapies in inflammatory disorders such as hidradenitis suppurativa and giant cell arteritis. Because many patients dislike injections with needles, orally bioavailable small molecule IL17 antagonists are desirable as next-generation drugs as long as they can replicate the degree of efficacy observed with anti-IL17A biologics.

Non-Covalent Interaction Induced Supramolecular Precipitate with Hetero-Motif Polyionic Junction for Durable Antimicrobial Activity and Infected Wound Healing.

The advent of the COVID-19 pandemic has underscored the pressing demand for antimicrobial materials that offer both durability and efficacy. Herein, the successful design and fabrication of a "water-insoluble" supramolecular precipitate is reported through the "bottom-up" assembly of polyanion sodium alginate (SA) with the antimicrobial motifs A2G and Cu. This innovative hetero-motif polyionic junction leverages a network of hydrogen bonds aligning with electrostatic interactions, and hydrophobic effects to mitigate the rapid release of active components, providing exceptional long-term antimicrobial efficacy against Staphylococcus aureus (S.

The dual carbon emission effects of digital economy: Evidence from China.

Nowadays, the digital economy has become a new engine of economic growth around the world. How to utilize the digital economy to achieve a balance between economic development and carbon emissions reduction is an imperative yet challenging endeavor for developing countries. In this paper, based on two perspectives of digital economy, the digital industrialization and industrial digitization, we use the industrial and city-level data of China from 2002 to 2017 to analyze the dual effects of digital economy on carbon emission, carbon intensity and carbon inequality.

Methyl Jasmonate Enhances the Resistance of var. Against (Coleoptera: Cerambycidae).

var. (PaP) is a very important and main planted tree species in northwestern China. However, it has been threatened by Asian longhorned beetle (ALB) infestation.

Tuning Zn Deposition Kinetics towards Deep-Reversible Zinc Metal Batteries with All-Climate Adaptability.

Uncontrollable Zn dendrites and severe hydrogen evolution reaction (HER) hamper the practical application of aqueous zinc-metal batteries, which closely related to the deposition kinetics and thermodynamic stability of Zn anode. In this work, we returned to the classic perspectives of kinetics and thermodynamics, introducing a small amount of reduced glutathione (RGSH) to reshape the kinetic behavior of Zn deposition and increasing the thermodynamic energy barrier of HER. Specifically, the steric hindrance effect of RGSH tuned the electrochemical reduction kinetics to match Zn migration and increased the proportion of Zn in the bulk phase migration, thereby inducing dendrite-free deposition behavior with ordered (002) texturing.

A bacterial methyltransferase that initiates biotin synthesis, an attractive anti-ESKAPE druggable pathway.

The covalently attached cofactor biotin plays pivotal roles in central metabolism. The top-priority ESKAPE-type pathogens, and , constitute a public health challenge of global concern. Despite the fact that the late step of biotin synthesis is a validated anti-ESKAPE drug target, the primary stage remains fragmentarily understood.

An artesunate-modified half-sandwich iridium(iii) complex inhibits colon cancer cell proliferation and metastasis through the STAT3 pathway.

Colon cancer is one of the most commonly diagnosed cancers and is recognized as the most aggressive tumor of the digestive system. Aberrant activation of signal transducer and activator of transcription 3 (STAT3) is associated with proliferation, metastasis and immunosuppression of the tumor cells. Here, to inhibit the STAT3 pathway and suppress metastasis in colon cancer cells, the half-sandwich iridium complex Ir-ART containing an artesunate-derived ligand was synthesized.

Light switchable Ir(III)-based photosensitizers: a dual-state system for non-invasive, reversible ROS control in tumor therapy.

Photodynamic therapy (PDT), a powerful anticancer approach converting oxygen to ROS for tumor ablation, encounters hurdles like limited spatio-temporal selectivity and the consequent unnecessary damage to normal tissues. Addressing these challenges, developing controllable Ir(III)-based photosensitizers (PSs) emerges as a promising solution, offering enhanced efficacy and precision in cancer therapy, while propelling the clinical progression of metal-based PSs. Herein, we proposed a series of light-controlled PSs, integrating an Ir(III)-based moiety with a light-responsive module, enabling non-invasive "off-on" control of ROS production efficient energy transfer.

The Influence of Circadian Rhythms on DNA Damage Repair in Skin Photoaging.

Circadian rhythms, the internal timekeeping systems governing physiological processes, significantly influence skin health, particularly in response to ultraviolet radiation (UVR). Disruptions in circadian rhythms can exacerbate UVR-induced skin damage and increase the risk of skin aging and cancer. This review explores how circadian rhythms affect various aspects of skin physiology and pathology, with a special focus on DNA repair.

Ruthenium(ii)-Arene Complex Triggers Immunogenic Ferroptosis for Reversing Drug Resistance.

Chemoresistance remains an arduous challenge in oncology, but ferroptosis shows potential for overcoming it by stimulating the immune system. Herein, a novel high-performance ruthenium(II)-based arene complex [Ru(η--cym)(BTBpy)Cl] () is developed for ferroptosis-enhanced antitumor immunity and drug resistance reversal via glutathione (GSH) metabolism imbalance. shows significantly enhanced antiproliferation activity against cisplatin (CDDP)-resistant lung cancer cells (A549R), with 26.

Attract and kill trees? No simple solution for Anoplophora glabripennis (Coleoptera: Cerambycidae) control.

Anoplophora glabripennis (Motschulsky), the Asian longhorned beetle, is a serious wood-boring pest of hardwood trees. There have been records that suggest Elaeagnus angustifolia L. (Elaeagnaceae) might be an "attract and kill" tree species for A.

Impact of joint dispatch of reservoir group on water pollution incident in drinking water source area.

To reduce the harm of water contamination incidents in drinking water source areas (DWSAs) and explore feasible approaches, the research developed a hydrodynamic water quality model for DWSAs based on two dimensional water quality and quantity equations, Geographic Information System (GIS), and Digital Elevation Model (DEM). The Heshangshan Drinking Water Source Area (HDWSA) in the Three Gorges Reservoir Area (TGRA) was selected as the research area, with total phosphorus (TP) as the representative pollutant in the water. The research investigated the changes in TP content during various hydrological phase under pollution incident, compared the duration and trends of TP concentration exceeding standard value before and after joint reservoir group dispatch.

Intrinsically Decoupled Coordination Chemistries Enable Quasi-Eutectic Electrolytes with Fast Kinetics toward Enhanced Zinc-Ion Capacitors.

Eutectic electrolytes show potential beyond conventional low-concentration electrolytes (LCEs) in zinc (Zn)-ion capacitors (ZICs) yet suffer from high viscosity and sluggish kinetics. Herein, we originally propose a universal theory of intrinsically decoupling to address these issues, producing a novel electrolyte termed "quasi-eutectic" electrolyte (quasi-EE). Joint experimental and theoretical analyses confirm its unique solution coordination structure doped with near-LCE domains.

Stretchable Tb-Tb Distance Regulates the Piezofluorochromic Behavior of Chiral Tb(III)-MOF upon Compression.

Luminescent chiral microcrystals with the Tb(COO) subunit indicated strong green mechano-luminescence under compression. Furthermore, piezofluorochromic behavior in the diamond anvil cell was observed, with the intensity tendency of decreasing-increasing-decreasing and a shortened lifetime upon compression, due to the reversible stretchable Tb-Tb interactions. The Tb-Tb distance upon compression was refined through situ high-pressure X-ray absorption spectra, which was consistent with the tendency of the piezofluorochromic intensity.

Molecular probes for super-resolution imaging of drug dynamics.

Super-resolution molecular probes (SRMPs) are essential tools for visualizing drug dynamics within cells, transcending the resolution limits of conventional microscopy. In this review, we provide an overview of the principles and design strategies of SRMPs, emphasizing their role in accurately tracking drug molecules. By illuminating the intricate processes of drug distribution, diffusion, uptake, and metabolism at a subcellular and molecular level, SRMPs offer crucial insights into therapeutic interventions.

Mitochondria-Targeting Metallodrugs for Cancer Therapy: Perspectives from Cell Death Modes.

Mitochondria, recognized as the cellular powerhouses, are indispensable organelles responsible for crucial cellular processes, such as energy metabolism, material synthesis, and signaling transduction. Their intricate involvement in a broad spectrum of diseases, particularly cancer, has propelled the exploration of mitochondria-targeting treatment as a promising strategy for cancer therapy. Since the groundbreaking discovery of cisplatin, the trajectory of research on the development of metal complexes have been marked by continuous advancement, giving rise to a diverse array of metallodrugs characterized by variations in ligand types, metal center properties, and oxidation states.