An artesunate-modified half-sandwich iridium(iii) complex inhibits colon cancer cell proliferation and metastasis through the STAT3 pathway.

Colon cancer is one of the most commonly diagnosed cancers and is recognized as the most aggressive tumor of the digestive system. Aberrant activation of signal transducer and activator of transcription 3 (STAT3) is associated with proliferation, metastasis and immunosuppression of the tumor cells. Here, to inhibit the STAT3 pathway and suppress metastasis in colon cancer cells, the half-sandwich iridium complex Ir-ART containing an artesunate-derived ligand was synthesized.

Stretchable Tb-Tb Distance Regulates the Piezofluorochromic Behavior of Chiral Tb(III)-MOF upon Compression.

Luminescent chiral microcrystals with the Tb(COO) subunit indicated strong green mechano-luminescence under compression. Furthermore, piezofluorochromic behavior in the diamond anvil cell was observed, with the intensity tendency of decreasing-increasing-decreasing and a shortened lifetime upon compression, due to the reversible stretchable Tb-Tb interactions. The Tb-Tb distance upon compression was refined through situ high-pressure X-ray absorption spectra, which was consistent with the tendency of the piezofluorochromic intensity.

Iridium(III)-Based PD-L1 Agonist Regulates p62 and ATF3 for Enhanced Cancer Immunotherapy.

Anti-PD-L1 immunotherapy, a new lung cancer treatment, is limited to a few patients due to low PD-L1 expression and tumor immunosuppression. To address these challenges, the upregulation of PD-L1 has the potential to elevate the response rate and efficiency of anti-PD-L1 and alleviate the immunosuppression of the tumor microenvironment. Herein, we developed a novel usnic acid-derived Iridium(III) complex, , that boosts PD-L1 expression and converts "cold tumors" to "hot".

Functional Upgrading of an Organo-Ir(III) Complex to an Organo-Ir(III) Prodrug as a DNA Damage-Responsive Autophagic Inducer for Hypoxic Lung Cancer Therapy.

The efficiency of nitrogen mustards (NMs), among the first chemotherapeutic agents against cancer, is limited by their monotonous mechanism of action (MoA). And tumor hypoxia is a significant obstacle in the attenuation of the chemotherapeutic efficacy. To repurpose the drug and combat hypoxia, herein, we constructed an organo-Ir(III) prodrug, , with the composition of a reactive oxygen species (ROS)-inducing moiety (Ir-arene fragment)-a hypoxic responsive moiety (azo linker)-a DNA-alkylating moiety (nitrogen mustard), and realized DNA damage response (DDR)-mediated autophagy for hypoxic lung cancer therapy for the first time.

Advantages of contrast-enhanced CT combined with DCE-MRI in identifying malignant parotid tumor.

Objective: To study the value of single and combined application of contrast-enhanced computerized tomography (CT) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in diagnosing parotid tumors.

Methods: In this retrospective study, 82 patients with parotid gland mass who received contrast-enhanced CT and DCE-MRI detection in The First People's Hospital of Huzhou from March 2018 to March 2022 were selected as study subjects. The nature of the parotid tumor was pathologically examined following the surgery.

Performance of Ir(III)-Based Anticancer Agents in the Treatment of Cisplatin-Resistant Cancer Cells.

The resistance of cancer cells to cisplatin has dramatically blocked the further application of this drug in practical treatment settings. The generation of cisplatin resistance is a complex physiological process, and several mechanisms have been reported for this. New metal-based agents with distinct anticancer mechanisms are still highly desired.

Pollution Characteristics and Spatial Distribution of Heavy Metals in Coal-Bearing Sandstone Soil: A Case Study of Coal Mine Area in Southwest China.

Soil pollution in coal mining areas is a serious environmental problem in China and elsewhere. In this study, surface and vertical profile soil samples were collected from a coal mine area in Dazhu, Southwestern China. Microscopic observation, concentrations, chemical speciation, statistical analysis, spatial distribution, and risk assessment were used to assess heavy metal pollution.

An Event-Related Potentials Study on the Syntactic Transfer Effect of Late Language Learners.

This study explored the syntactic transfer effect of the non-local subject-verb agreement structure with plural head noun after two intensive phases of input training with event-related potentials (ERP). The non-local subject-verb agreement stimuli with the plural head nouns, which never appeared in training phases, were used for the stimuli. A total of 26 late L1-Chinese L2-English learners, who began to learn English after a critical period and participated in our previous experiments, were asked back to take part in this syntactic transfer experiment.

Effect of multiple factors on the adsorption of Cd in an alluvial soil from Xiba, China.

The effects of organic matter, free Fe oxides and Mn oxides in an alluvial soil on adsorption of Cd were studied through selective chemical extraction and adsorption experiments. Compared to untreated soil, after HO treatment for removal of organic matter and NHOH·HCl treatment for removal Mn oxides, the distribution coefficient (K) decreased by a maximum of 25.2% and 64.