Facet engineering of MOF supports regulates product selectivity in CO photoreduction by modulating electron and proton supply to COF shells.

Selective photoreduction of CO with HO to hydrocarbons is challenged by inadequate and uncontrollable electron and proton feeding. Herein, this limitation is overcome by integrating HO dissociation, CO reduction, and O evolution catalysts into a dual S-scheme heterojunction and regulating exposed facets of the heterojunction supports. In this design, H and OH species generated by HO dissociation on the NH-MIL-125 support transfer to the T-COF shell and FeO insert for CO reduction and O evolution, respectively.

circANKRD12/circTIMMDC1 synergistically regulates enteric neural crest cell migration via miR-181b-5p-PROX1-NOTCH1 axis in Hirschsprung's disease.

Background: Circular RNAs (circRNAs) are implicated in Hirschsprung's disease (HSCR), a genetic disorder caused by defective migration and proliferation of enteric neural crest cells (ENCCs).

Methods: Expression patterns of circANKRD12 and circTIMMDC1, and related molecules in the miR-181b-5p-PROX1-NOTCH1 axis were analyzed in human and mouse fetal intestines and HSCR patient tissues. Functional assays, including in vitro neural cell experiments, ex vivo ENCC explant, and in vivo zebrafish models, were conducted to assess the effects on neural cell behavior.

Rare Naegleria fowleri meningoencephalitis diagnosed via combined molecular biology and metagenomic sequencing techniques: a case report.

Background: Naegleria fowleri, a pathogenic free-living amoeba, causes primary amoebic meningoencephalitis (PAM), a rare but devastating disease with acute onset, rapid progression, and > 95% mortality. Despite its rarity, the catastrophic outcomes associated with this infection underscore the critical importance of prevention. In this report, we present a rare pediatric fatality caused by PAM in China, highlighting the challenges of diagnosis and treatment.

Overcoming Photochemical Limitations in Covalent Organic Frameworks: Low-Energy Light Driven Selective O Generation Achieved by Donor-Acceptor Strategy.

Singlet oxygen (O) plays a crucial role in various photocatalytic oxidation reactions; however, achieving high-efficiency and selective O production under low-energy light remains a challenge. Herein, we present a novel donor-acceptor (D-A) strategy in covalent organic frameworks (COFs) to regulate the localized electronic state structures for efficient and selective O generation under low-energy light. Notably, the rationally incorporation of the negatively charged carbonyl groups into the basal plane of the COF strengthens the D-A interaction, improves light harvesting in the lower-energy region, and facilitates highly selective O generation through a coupled charge-transfer mechanism.

The Hormonal Effect of Fibroblast Growth Factor 19 on the Intestinal Adaptation in Pediatric Short Bowel Syndrome: An in Vitro Study Using Patients-Derived Enteroids.

Background: Promoting intestinal adaptation is of paramount importance for restoring normal gastrointestinal function in pediatric patients with short bowel syndrome (SBS). However, the hormonal effect of fibroblast growth factor 19 (FGF19) on the intestinal adaptation of SBS patients remains unknown.

Methods: Integrated analyses using transcriptomic profiles were performed across two datasets.

A mixed-linker strategy in covalent organic frameworks for enhanced sunlight-driven photocatalytic oxidation activity and stability.

We present a simple mixed-linker strategy to enhance the photocatalytic oxidation activity and stability of covalent organic framework semiconductors. The TpTfbPa-COF, featuring an unconventional reversed AA-stacking structure with both imine and ketoamine linkages, exhibits excellent structural stability and superior photocatalytic performance compared to the fully imine-linked TfbPa-COF and the fully ketoamine-linked TpPa-COF.

Exogenous melatonin enhancing the accumulation of flavonoids and carotenoids in wolfberry fruit at cold storage.

The deterioration of fruit quality during refrigeration is a typical symptom of the storage and transportation of Lycium barbarum L. (wolfberry) fruit after harvest. This study aimed to explore the impact of melatonin (MT) treatment on the fruit quality of wolfberry stored at 4°C, using combined transcriptomics and metabolomics analyses.

Integrated transcriptomic and proteomic analyses provide insights into the biosynthesis of Lycii fructus polysaccharides from different cultivation regions.

Polysaccharides from L. fructus (LFPs) serve as important active biomacromolecules for the wide spectrum of bioactivities exhibited by Lycii fructus. However, the influence of ecological environments on the biosynthesis and structural characteristics of LFPs remains largely unexplored.

Metabolic and molecular basis of flavonoid biosynthesis in Lycii fructus: An integration of metabolomic and transcriptomic analysis.

Flavonoids serve as bioactive components and contribute to medicinal and nutritional profile of Lycii fructus. However, there is limited information regarding the influence of ecological environments on the flavonoid biosynthesis pathway. In this study, we integrated transcriptome sequencing and metabonomic techniques across three distinct cultivation regions to elucidate the processes of flavonoids biosynthesis and the associated gene expression levels in L.

A systematic review and meta-analysis exploring the bidirectional association between asthma and gastroesophageal reflux disease in children.

Asthma is the most prevalent chronic respiratory disease in children, and gastroesophageal reflux disease (GERD) is one of its extraesophageal complications of asthma. Both conditions are commonly observed in pediatric outpatient clinics, but the causality between them in children is still debated. Therefore, we conducted a systematic review and meta-analysis to evaluate the bidirectional association between asthma and GERD in children.

An ultra-dense linkage map identified quantitative trait loci corresponding to fruit quality- and size-related traits in red goji berry.

Goji berries are a small-fruited shrub with industrial importance whose fruit considered beneficial in both fresh and dried forms. Current germplasms of goji berries include small fruits with a short shelf life, less sweet and bitter taste, and a lack of appropriate genetic information. This study aimed to employ whole genome resequencing to generate an ultra-dense bin linkage map and to elucidate the genetic basis of goji fruit quality and size using quantitative trait loci (QTL) mapping analysis in a cross-pollinated hybrid population.

Monitoring nonlinear large gradient subsidence in mining areas through SBAS-InSAR with PUNet and Weibull model fusion.

The subsidence of the earth's surface in mining areas is characterized by fast speed and large gradients. Conventional small baseline subset interferometric synthetic aperture radar (SBAS-InSAR) monitoring can significantly underestimate results, making it challenging to capture the surface's temporal subsidence features. In this context, this paper proposes a method for monitoring subsidence in mining areas.

Impaired intestinal FXR signaling is involved in aberrant stem cell function leading to intestinal failure-associated liver disease in pediatric patients with short bowel syndrome.

Intestinal failure-associated liver disease (IFALD) is a serious complication of long-term parenteral nutrition in patients with short bowel syndrome (SBS), and is the main cause of death in SBS patients. Prevention of IFALD is one of the major challenges in the treatment of SBS. Impairment of intestinal barrier function is a key factor in triggering IFALD, therefore promoting intestinal repair is particularly important.

The risk factors for chronic cough in children: A meta-analysis covering five continents.

Background: This study aimed to explore the risk factors for chronic cough in children and provide a reference for prevention and healthcare measures.

Methods: PubMed, Web of Science, Cochrane, and EMBASE were searched for observational studies published up to April 2024. Outcome included risk factors associated with chronic cough in children.

Epidemiologic trends and changes in humoral immunity and lymphocyte subsets levels among hospitalized children with Mycoplasma pneumoniae infection during 2019-2023.

Purpose: To understand the changes in humoral immunity and lymphocyte subsets levels among hospitalized children with Mycoplasma pneumoniae (MP) infection from 2019 to 2023.

Methods: This study retrospectively analyzed inpatients aged 0-14 years who were diagnosed with MP infection or MP pneumonia in a tertiary hospital from January 2019 to December 2023. The children were divided into three groups: before the implementation of nonpharmaceutical interventions (NPIs), during the implementation of NPIs, and after the NPIs being lifted.

New Butterfly-Shaped Naphthalimide-Based AIE Gens: Synthesis and Photophysical Properties.

Two novel naphthalimide derivatives PTZNI-Cz and PTZNI-TPA were successfully designed and synthesized, in which phenothiazine, triphenylamine and carbazole were used as electron donors and naphthalimide was used as the electron acceptor. Their photophysical, electrochemical, and thermal properties were investigated. These derivatives showed remarkable aggregation-induced emission (AIE) effect.

RNA damage compartmentalization by DHX9 stress granules.

Biomolecules incur damage during stress conditions, and damage partitioning represents a vital survival strategy for cells. Here, we identified a distinct stress granule (SG), marked by dsRNA helicase DHX9, which compartmentalizes ultraviolet (UV)-induced RNA, but not DNA, damage. Our FANCI technology revealed that DHX9 SGs are enriched in damaged intron RNA, in contrast to classical SGs that are composed of mature mRNA.

Understanding the Positive Role of Ionic Liquids in CO Capture by Poly(ethylenimine).

CO capture technology is one of the most important technical methods for significantly mitigating CO emissions in a low-carbon context. The recent invention of mixed absorbents comprising poly(ethylenimine) (PEI) and ionic liquids (ILs) provides a novel strategy for efficiently capturing CO, and this has garnered widespread attention. However, the intermolecular interactions between the IL and other constituents during the CO absorption process remain unclear.

Targeting GPX4-mediated Ferroptosis Alleviates Liver Steatosis in a Rat Model of Total Parenteral Nutrition.

Background: Parenteral nutrition-associated liver disease (PNALD) is a common hepatobiliary complication resulting from long-term parenteral nutrition (PN) that is associated with significant morbidity and mortality. Ferroptosis plays a significant role in the pathogenesis of various liver diseases. This study aims to explore the role of ferroptosis in PNALD and to uncover its underlying mechanisms.

Unveiling the Nature of Superior Sodium Storage in the CoSe/rGO Nanocomposite.

Sodium-ion batteries (SIBs) are considered the most promising alternatives to lithium-ion batteries (LIBs) due to the abundant availability of sodium and their cost-effectiveness. Transition metal selenides (TMSes) are considered promising anodes for SIBs due to their economic efficiency and high theoretical capacity. Nevertheless, overcoming the challenges of sluggish reaction kinetics and severe structural damage is crucial to improving cycle life and rate capability.

Attenuates Liver Steatosis and Bile Acid Dysregulation in Parenteral Nutrition-Fed Rats.

Parenteral nutrition (PN), a vital therapy for patients with intestinal failure, can lead to the development of parenteral nutrition-associated liver disease (PNALD). In this study, we aimed to investigate the role of () in a rat model of PNALD. Total parenteral nutrition (TPN)-fed rats were used to assess the role of in liver steatosis, bile acid metabolism, gut microbiota, and hepatocyte apoptosis.

Hollow Plasmonic P-Metal-N S-Scheme Heterojunction Photoreactor with Spatially Separated Dual Cocatalysts toward Artificial Photosynthesis.

Semiconductor-based step-scheme (S-scheme) heterojunctions possess many merits toward mimicking natural photosynthesis. However, their applications for solar-to-chemical energy conversion are hindered by inefficient charge utilization and unsatisfactory surface reactivity. Herein, two synergistic protocols are demonstrated to overcome these limitations based on the construction of a hollow plasmonic p-metal-n S-scheme heterojunction photoreactor with spatially separated dual noble-metal-free cocatalysts.