Physical activity matters: prognostic impact of preoperative functioning scores in patients undergoing radical cystectomy.

Purpose: To investigate the prognostic significance of preoperative health-related quality of life (HRQOL) functioning scores, assessed by the EORTC QLQ-C30 questionnaire, in predicting survival outcomes for patients undergoing radical cystectomy (RC) for urothelial carcinoma (UC) of the bladder. While established prognostic factors include tumor stage and lymph node involvement, the role of HRQOL in survival remains underexplored.

Methods: We retrospectively analyzed patients who underwent RC for bladder cancer at a tertiary center between April 2013 and August 2024.

Adverse Pathology After Radical Prostatectomy in Low- and Intermediate-Risk Prostate Cancer: A Propensity Score-Matched Analysis of Long-Term Health-Related Quality of Life.

: Adverse pathology to high-risk prostate cancer (PCa) after radical prostatectomy (upgrading) poses a threat to risk stratification and treatment planning. The impact on sexual function, urinary continence, and health-related quality of life (HRQOL) remains unclear. : From 2004 to 2024, 4189 patients with preop low-/intermediate-risk PCa (Gleason score 6 or 7a, PSA ≤ 20 ng/mL) underwent radical prostatectomy at our department and were analyzed.

Real-World Insights: Balancing Diagnostic Benefits and Oncological Risks of Ureteroscopic Biopsy before Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma.

Introduction: The role of diagnostic ureteroscopy (URS) prior to radical nephroureterectomy (RNU) remains controversial due to concerns about an increased risk of intravesical recurrence (IVR). However, existing studies frequently exhibit two major confounders: lack of reporting on the use of mitomycin C instillation after RNU and not excluding patients with a history of bladder cancer.

Methods: We retrospectively evaluated the proportion of RNU patients for whom preoperative URS biopsy results were decisive for therapeutic decision-making.

The perioperative outcomes of retroperitoneal lymph node dissection in Germany for patients with testicular cancer: Results from the GRAND study.

We aimed to assess the current trends and outcomes of retroperitoneal lymph node dissection (RPLND) in patients with testicular cancer in Germany, as well as to provide evidence on the role of the type of surgical approach, prior chemotherapy, and annual hospital caseload. We used the GeRmAn Nationwide inpatient Data, provided by the Research Data Center of the Federal Bureau of Statistics (2005-2022). We assessed trends and perioperative outcomes (mortality, intensive care unit [ICU] admission, transfusion, acute embolism, and length of hospital stay) based on the surgical approach (robotic, laparoscopic, and open), prior chemotherapy, and annual hospital caseload (with cut-offs of three and 10 cases/year) with a multivariable regression analysis.

Perioperative complications of focal therapy for prostate cancer: results from the GeRmAn Nationwide inpatient Data (GRAND) study.

Objective: To compare the perioperative complications of the most common focal therapy (FT) modalities for prostate cancer.

Patients And Methods: We assessed the GeRmAn Nationwide inpatient Data (GRAND) from 2005 to 2023, provided by the Research Data Center of the Federal Bureau of Statistics. We compared perioperative outcomes of high-intensity focused ultrasound (HIFU), hyperthermia, irreversible electroporation of the prostate, cryotherapy, vascular photodynamic therapy of the prostate (VTP), and transurethral ultrasound ablation, as well as HIFU vs non-HIFU treatments in general.

Prognostic impact of combined loss of RB1, p53 and p21 in muscle-invasive bladder cancer.

Introduction: Muscle-invasive bladder cancer (MIBC) represents a genetically heterogeneous disease with limited prognostic markers. This study aimed to validate the prognostic relevance of combined alterations in cell cycle regulators RB1, p53, and p21 in a broad cohort of MIBC patients undergoing radical cystectomy (RC).

Material And Methods: We analyzed formalin-fixed paraffin-embedded material from MIBC patients who underwent RC at the Department of Urology, University Hospital, Ludwig-Maximilians-University Munich.

Awareness and prevalence of testicular cancer among German firefighters.

Purpose: To investigate the awareness about their occupational elevated risk for testicular cancer, we conducted a cross-sectional study among German firefighters, as studies indicate that firefighters may be at an elevated risk for developing testicular cancer. One cause may be the exposure to carcinogenic chemicals during occupation.

Materials And Methods: A survey containing 22 questions was distributed to fire stations (including career firefighters and volunteer firefighters) in Germany.

The Role of Radical Cystectomy with Orthotopic Neobladder Reconstruction in Patients Developing Bladder Cancer after Prior Radical Prostatectomy, Radiation Therapy, or BPH Surgery.

Introduction: Current evidence suggests that prior prostatic interventions, such as prostatectomy, radiation, or transurethral surgery, may increase the risk of incontinence in patients undergoing radical cystectomy (RC) with ileal orthotopic neobladder reconstruction. We aimed to evaluate the short- and long-term complications, functional outcomes of neobladder reconstruction in patients undergoing RC after prior prostatic procedures.

Methods: We analyzed patients who underwent RC after prior prostatic intervention in our department from 2013 to 2022.

Discrepancies between physician-assessed and patient-reported complications after cystectomy - a prospective analysis.

Purpose: Despite the high incidence of perioperative complications following cystectomy, there is a lack of evidence regarding patients' perceptions. Moreover, discrepancies between established complication grading systems and the patient's perspective remain unexplored.

Methods: We prospectively evaluated perioperative complications after cystectomy using the Clavien-Dindo Classification (CDC) and the Comprehensive Complication Index (CCI).

Radical Cystectomy with Ileal Orthotopic Neobladder after 70 Years Leads to Worse Health-Related Quality of Life.

Radical cystectomy (RC) with the formation of an ileal orthotopic neobladder (ONB) may adversely affect long-term health-related quality of life (HRQOL). An advanced age at the time of ONB construction could further exacerbate the decline in HRQOL. This study aims to establish an evidence-based age threshold at the time of RC with ONB, beyond which a significant deterioration in HRQOL is observed.

Evolution of Robotic Urology in Clinical Practice from the Beginning to Now: Results from the GRAND Study Register.

Background And Objective: Major urological guidelines do not currently recommend robot-assisted surgery compared with laparoscopic or open surgery due to the lack of high-quality evidence. We aimed to provide real-world data on the evolution of robotic urology and to compare its perioperative outcomes with those of laparoscopic and open surgeries.

Methods: We used the GeRmAn Nationwide inpatient Data (GRAND), provided by the Research Data Center of the Federal Bureau of Statistics (2005-2021), and performed multiple patient-level analyses.

The Prognostic Value of Perioperative Platelet and Leukocyte Values in Patients Undergoing Radical Cystectomy: A Prospective Long-Term Cohort Study.

Introduction: Studies assessing the impact of preoperative and first-day postoperative values of leukocytes, thrombocytes, and platelet/leukocyte ratio (PLR) after radical cystectomy (RC) are sparse. We aimed to assess the impact of these factors on long-term survival after RC.

Methods: An analysis of patients undergoing open RC from 2004 to 2023 at our center was performed.

Propensity score-matched evaluation of palliative transurethral resection and holmium laser enucleation of the prostate for bladder outlet obstruction in patients with prostate cancer.

Background: While transurethral resection of the prostate (TURP) is the standard-of-care, Holmium laser enucleation of the prostate (HoLEP) is widely accepted as a size-independent method for surgical treatment of patients with lower urinary tract symptoms (LUTS) secondary to bladder outlet obstruction (BOO). However, in an ageing society an increasing number of patients presents with BOO due to locally advanced prostate cancer. There is currently no guidelines recommendation as to the enucleation or resection technique.

The impact of perioperative risk factors on long-term survival after radical cystectomy: a prospective, high-volume cohort study.

Introduction: Radical cystectomy (RC) is the gold standard for muscle-invasive bladder cancer. Nevertheless, RC is associated with substantial perioperative morbidity and mortality. We aimed to evaluate the role of important perioperative risk factors in predicting long-term survival after RC.

The effect of hospital caseload on perioperative mortality, morbidity and costs in bladder cancer patients undergoing radical cystectomy: results of the German nationwide inpatient data.

Objectives: To determine a data-based optimal annual radical cystectomy (RC) hospital volume threshold and evaluate its clinical significance regarding perioperative mortality, complications, length of hospital stay, and hospital revenues.

Material And Methods: We used the German Nationwide inpatient Data, provided by the Research Data Center of the Federal Bureau of Statistics (2005-2020). 95,841 patients undergoing RC were included.

Oncological impact of perioperative blood transfusion in bladder cancer patients undergoing radical cystectomy: Do we need to consider storage time of blood units, donor age, or gender matching?

Background: The oncological impact of perioperative blood transfusions (PBTs) of patients undergoing radical cystectomy (RC) because of bladder cancer (BCa) has been a controversial topic discussed in recent years. The main cause for the contradictory findings of existing studies might be the missing consideration of the storage time of red blood cell units (BUs), donor age, and gender matching.

Study Design And Methods: We retrospectively analyzed BCa patients who underwent RC in our department between 2004 and 2021.

Perioperative Outcomes of Same-Session Bilateral Unilateral Ureteroscopy for Stone Removal: Results from the GRAND Study.

Same-session bilateral ureteroscopy may reduce the number of surgeries for stone removal but can lead to higher overall complication rates. We aimed to compare same-session bilateral ureteroscopy with unilateral ureteroscopy in terms of perioperative outcomes. We used the GeRmAn Nationwide inpatient Data (GRAND), provided by the Research Data Center of the Federal Bureau of Statistics (2005-2021).

Upstaging after Transurethral Resection of the Bladder for Non-Muscle-Invasive Cancer of the Bladder: Who Is at Highest Risk?

Introduction: Transurethral resection of the bladder (TUR-BT) is the standard initial treatment and diagnosis of bladder cancer (BC). Of note, upstaging into muscle-invasive disease (MIBC) during re-resection occurs in a significant proportion of patients. This study aimed to define risk factors at initial TUR-BT for upstaging.