Physical activity matters: prognostic impact of preoperative functioning scores in patients undergoing radical cystectomy.

Purpose: To investigate the prognostic significance of preoperative health-related quality of life (HRQOL) functioning scores, assessed by the EORTC QLQ-C30 questionnaire, in predicting survival outcomes for patients undergoing radical cystectomy (RC) for urothelial carcinoma (UC) of the bladder. While established prognostic factors include tumor stage and lymph node involvement, the role of HRQOL in survival remains underexplored.

Methods: We retrospectively analyzed patients who underwent RC for bladder cancer at a tertiary center between April 2013 and August 2024.

Efficacy of Drug-coated Balloon Dilation Versus Endoscopic Standard Treatment in Posterior Urethral Stenosis: A Real-world Comparative Study.

Objective: To evaluate recurrence rates and functional outcomes after drug-coated balloon (DCB) dilation (Optilume) compared to standard endoscopic treatment in patients with posterior urethral stenosis.

Methods: In this retrospective cohort study, we evaluated postoperative outcomes of patients who underwent either DCB dilation or standard endoscopic treatment for posterior urethral stenosis (vesicourethral anastomotic stenosis and bladder neck contracture). Recurrence-free survival (RFS) was recorded.

Prognostic impact of combined loss of RB1, p53 and p21 in muscle-invasive bladder cancer.

Introduction: Muscle-invasive bladder cancer (MIBC) represents a genetically heterogeneous disease with limited prognostic markers. This study aimed to validate the prognostic relevance of combined alterations in cell cycle regulators RB1, p53, and p21 in a broad cohort of MIBC patients undergoing radical cystectomy (RC).

Material And Methods: We analyzed formalin-fixed paraffin-embedded material from MIBC patients who underwent RC at the Department of Urology, University Hospital, Ludwig-Maximilians-University Munich.

Awareness and prevalence of testicular cancer among German firefighters.

Purpose: To investigate the awareness about their occupational elevated risk for testicular cancer, we conducted a cross-sectional study among German firefighters, as studies indicate that firefighters may be at an elevated risk for developing testicular cancer. One cause may be the exposure to carcinogenic chemicals during occupation.

Materials And Methods: A survey containing 22 questions was distributed to fire stations (including career firefighters and volunteer firefighters) in Germany.

Next-generation Solutions: Are Patients Ready for Electronic Artificial Urinary Sphincters for Male Incontinence?

Background And Objective: Urology is characterized by continuous innovation. The inception of robot-assisted radical prostatectomy (RP) marked a pivotal technological advance and further advances in digital treatment options for stress urinary incontinence (SUI) are emerging. Our aim was to assess patient willingness to receive an electronic artificial urinary sphincter (eAUS) implant and identify associated concerns.

Discrepancies between physician-assessed and patient-reported complications after cystectomy - a prospective analysis.

Purpose: Despite the high incidence of perioperative complications following cystectomy, there is a lack of evidence regarding patients' perceptions. Moreover, discrepancies between established complication grading systems and the patient's perspective remain unexplored.

Methods: We prospectively evaluated perioperative complications after cystectomy using the Clavien-Dindo Classification (CDC) and the Comprehensive Complication Index (CCI).

[Diagnostic algorithm and key differential diagnoses of hematuria].

The different causes of hematuria depend largely on age, gender and clinical context. Macrohematuria should always be investigated using cystoscopy and advanced imaging (CT/MRI with urographic phase). The most common differential diagnoses of macrohematuria include urinary tract infection, stones and urothelial carcinoma.

Radical Cystectomy with Ileal Orthotopic Neobladder after 70 Years Leads to Worse Health-Related Quality of Life.

Radical cystectomy (RC) with the formation of an ileal orthotopic neobladder (ONB) may adversely affect long-term health-related quality of life (HRQOL). An advanced age at the time of ONB construction could further exacerbate the decline in HRQOL. This study aims to establish an evidence-based age threshold at the time of RC with ONB, beyond which a significant deterioration in HRQOL is observed.

The effect of hospital caseload on perioperative mortality, morbidity and costs in bladder cancer patients undergoing radical cystectomy: results of the German nationwide inpatient data.

Objectives: To determine a data-based optimal annual radical cystectomy (RC) hospital volume threshold and evaluate its clinical significance regarding perioperative mortality, complications, length of hospital stay, and hospital revenues.

Material And Methods: We used the German Nationwide inpatient Data, provided by the Research Data Center of the Federal Bureau of Statistics (2005-2020). 95,841 patients undergoing RC were included.

Oncological impact of perioperative blood transfusion in bladder cancer patients undergoing radical cystectomy: Do we need to consider storage time of blood units, donor age, or gender matching?

Background: The oncological impact of perioperative blood transfusions (PBTs) of patients undergoing radical cystectomy (RC) because of bladder cancer (BCa) has been a controversial topic discussed in recent years. The main cause for the contradictory findings of existing studies might be the missing consideration of the storage time of red blood cell units (BUs), donor age, and gender matching.

Study Design And Methods: We retrospectively analyzed BCa patients who underwent RC in our department between 2004 and 2021.

Upstaging after Transurethral Resection of the Bladder for Non-Muscle-Invasive Cancer of the Bladder: Who Is at Highest Risk?

Introduction: Transurethral resection of the bladder (TUR-BT) is the standard initial treatment and diagnosis of bladder cancer (BC). Of note, upstaging into muscle-invasive disease (MIBC) during re-resection occurs in a significant proportion of patients. This study aimed to define risk factors at initial TUR-BT for upstaging.

Impact of bacillus Calmette-Guerin intravesical therapy on the diagnostic efficacy of The Paris System for Reporting Urinary Cytology in patients with high-grade bladder cancer.

Background: In high-grade urothelial carcinoma (UC) of the bladder, bacillus Calmette-Guerin (BCG) therapy is a therapeutic mainstay, and urinary cytology is recommended to detect recurrences. However, intravesical BCG instillations can induce morphologic changes in urothelial cells. The authors investigated the impact of BCG therapy on the efficacy of urinary cytology.