Mitochondria-targeted NIR fluorescent probe for detection of hydrogen sulfide and its application in monitoring food freshness and bioimaging.

Background: The hydrogen sulfide (HS) in spoilage of raw meat poses significant food safety risks to human health. Meanwhile, as a signaling molecule, HS is crucial for maintaining human physiological homeostasis. Thus, the establishment of an efficient method for HS detection is essential for safeguarding human health.

A novel method for high-precision tungsten isotope measurements on small-size samples.

The application of Hf - W system for accurate dating and tracing of planetary events relies on highly accurate and precise tungsten isotope measurements. However, high-precision measurement of W isotopes usually requires large samples, which greatly hampers the study of low-content and/or small-size samples. In this study, a two-column W purification procedure was developed for small-size samples with the whole procedure blank of less than 40 pg and the recovery greater than 97 %.

The Tumor-Associated Neutrophils-Related Signatures Predict Prognosis and Indicate Immune Landscape in Colorectal Carcinoma.

Tumor-associated neutrophils (TANs), a major immune cell type in the tumor microenvironment (TME), are associated with antitumor or pro-tumor phenotypes. A wealth of evidence evidences demonstrated that the content of TANs has been implicated in the pathogenesis of cancer and may be ideal targets for cancer therapy. In this study, we identified TANs-related genes to construct a prognostic model and evaluated its potential as a biomarker for predicting prognosis and immunotherapeutic response in colorectal carcinoma (CRC).

High temperature and ozone co-exposure induces cardiovascular damage in mice: Insights from gut microbiome and plasma metabolomics.

Epidemiological studies have demonstrated associations between heat waves, ozone (O) pollution, and cardiovascular morbidity and mortality. High temperature (HT) and higher levels of O usually co-exist in the atmosphere. However, few studies have investigated the adverse effects of HT and O co-exposure on cardiovascular system.

A diarylethene-based probe with HSO-activated fluorescence to photochromism: Its imaging application in living cells and zebrafish.

Sulfur dioxide (SO) and its derivatives (sulfite SO and bisulfite HSO) have important applications in industrial production and food preservation, but excessive intake can be hazardous to human health. Therefore, the development of highly sensitive and selective HSO detection methods is essential to safeguard food safety and public health. Conventional HSO probes mainly rely on colorimetric or fluorescence detection, but these methods have obvious limitations in that the fluorescence signal disappears as soon as the UV irradiation is stopped, and they cannot provide long-lasting and readable detection results.

AIE-based dual-ratiometric chemosensor for detection of sulfur dioxide derivatives and viscosity and its application in food samples and biological imaging.

Background: SO is an important gas molecular messenger that participates in many physiological activities and helps maintaining the redox homeostasis in biological system. Especially, SO can effectively regulate oxidative stress and improve mitochondrial morphology. Abnormal mitochondrial viscosity can lead to a variety of diseases.

Airway microbiota dysbiosis and metabolic disorder in ozone and PM co-exposure induced lung inflammatory injury in mice.

Co-exposure to ground-level ozone (O) and fine particles (PM, ≤ 2.5 µm in diameter) has become a primary scenario for air pollution exposure of urbanites in China. Recent studies have suggested a synergistic effect of PM and O on induction of lung inflammatory injury.

Short-term exposure to air pollution on peripheral white blood cells and inflammation biomarkers: a cross-sectional study on rural residents.

Effects of short-term exposure to ambient air pollution on systemic immunological and inflammatory biomarkers in rural population have not been adequately characterized. From May to July 2021, 5816 participants in rural villages of northern Henan Province, China, participated in this cross-sectional study. Blood biomarkers of systemic inflammation were determined including peripheral white blood cells (WBC), eosinophils (EOS), basophils (BAS), monocytes (MON), lymphocytes (LYM), neutrophils (NEU), neutrophil-lymphocyte ratio (NLR), and serum high-sensitivity C-reactive protein (hs-CRP).

Rapidly responsive and highly selective NIR fluorescent probe for detecting hydrogen sulfide in food samples and living cells.

Hydrogen sulfide (HS) is a pungent gas that is one of the key mediators of signal transduction in biological systems, and its presence is related to the freshness of some protein foods. Using phenothiazine derivatives as fluorophores and 2, 4-dinitrobenzene sulfonate (DNBS) fragments as reaction groups, a near-infrared (NIR) probe WX-HS for HS identification was designed. With the addition of HS, WX-HS appeared a strong fluorescence signal at 660 nm with short reaction time (90 s) and high sensitivity, and fluorescence state change from non-fluorescent to orange-red.

Efficacy and safety of self-made WenyangJianpi-qushi Decoction combined with mometasone furoate cream in the treatment of atopic dermatitis of spleen deficiency and dampness accumulation type.

: This work was to explore the efficacy and safety of self-made WenyangJianpi-qushi Decoction plus mometasone furoate cream in atopic dermatitis (AD) of spleen deficiency and dampness accumulation type. : 120 patients with this kind of atopic dermatitis were grouped: The Observation group (disease health education + basic treatment + mometasone furoate cream + self-made Decoction) and The Control group (disease health education + basic treatment + mometasone furoate cream), 60 cases in each group. The SCORAD score, serum IgE level, peripheral blood eosinophils, adverse events, recurrence rate, and total effective rate after treatment were observed.

An Overview of Current Statistical Methods for Implementing Quality Tolerance Limits.

Background: In 2016, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use updated its efficacy guideline for good clinical practice and introduced predefined quality tolerance limits (QTLs) as a quality control in clinical trials. QTLs are complementary to Quality by Design (QbD) principles (ICH-E8) and are one of the components of the risk-based clinical trial quality management system.

Methods: Currently the framework for QTLs process is well established, extensively describing the operational aspects of Defining, Monitoring and Reporting, but a single source of commonly used methods to establish QTLs and secondary limits is lacking.

High-precision simultaneous measurement of Os, Os, and Os using 10 Ω amplifiers and CDDs on NTIMS.

High-precision measurements of Os/Os, Os/Os, and Os/Os ratios are significant in the fields of geochemistry and cosmochemistry. However, no high-precision measurement technique exists for simultaneously obtaining all three ratios using a static method for samples with an Os content of <1 ng or OsO and OsO ion-beam intensities of <150 mV. This greatly limits research on rare samples with small sample sizes or low Os contents, such as Lunar, Martian, or old Earth samples.

Identification and validation of SOCS1/2/3/4 as potential prognostic biomarkers and correlate with immune infiltration in glioblastoma.

Suppressor of cytokine signalling (SOCS) 1/2/3/4 are involved in the occurrence and progression of multiple malignancies; however, their prognostic and developmental value in patients with glioblastoma (GBM) remains unclear. The present study used TCGA, ONCOMINE, SangerBox3.0, UALCAN, TIMER2.

Ferroelectric Phase Transition Driven by Switchable Covalent Bonds.

The mechanism on ferroelectric phase transitions is mainly attributed to the displacive and/or order-disorder transition of internal components since the discovery of the ferroelectricity in 1920, rather than the breaking and recombination of chemical bonds. Here, we demonstrate how to utilize the chemical bond rearrangement in a diarylethene-based crystal to realize the light-driven mm2F1-type ferroelectric phase transition. Such a photoinduced phase transition is entirely driven by switchable covalent bonds with breaking and reformation, enabling the reversible light-controllable ferroelectric polarization switching, dielectric and nonlinear optical bistability.

High- Single-Component Organosilicon Ferroelectric Crystal Obtained by H/F Substitution.

Organic single-component ferroelectrics are highly desirable for their low molecular mass, light weight, low processing temperature, and excellent film-forming properties. Organosilicon materials with a strong film-forming ability, weather resistance, nontoxicity, odorlessness, and physiological inertia are very suitable for device applications related to the human body. However, the discovery of high- organic single-component ferroelectrics has been very scarce, and the organosilicon ones even less so.

Real-Time Visualization of the Antioxidative Potency of Drugs for the Prevention of Myocardium Ischemia-Reperfusion Injury by a NIR Fluorescent Nanoprobe.

The burst of the reactive oxygen species (ROS) is the culprit of myocardial ischemia-reperfusion injury. As direct ROS scavengers, antioxidants are clinically documented drugs for the prevention of reperfusion injury. However, some drugs give disappointing therapeutic performance despite their good in vitro effects.

Axial-Chiral BINOL Multiferroic Crystals with Coexistence of Ferroelectricity and Ferroelasticity.

Chirality exists everywhere from natural amino acids to particle physics. The introduction of point chirality has recently been shown to be an efficient strategy for the construction of molecular ferroelectrics. In contrast to point chirality, however, axial chirality is rarely used to design ferroelectrics so far.

Contactless Manipulation of Write-Read-Erase Data Storage in Diarylethene Ferroelectric Crystals.

The optical manipulation of polarization has gained widespread attention because it offers a promising route to new contactless memories and switches. However, the current research basically focuses on the photocontrol of data storage rather than data reading, which cannot realize the whole process of contactless write-read-erase data storage. Here, we present a pair of enantiomorphic diarylethene derivative ferroelectric crystals, showing a light-driven phase transition triggered by photoisomerization between the open and closed forms.

Domain memory effect in the organic ferroics.

Shape memory alloys have been used extensively in actuators, couplings, medical guide wires, and smart devices, because of their unique shape memory effect and superelasticity triggered by the reversible martensitic phase transformations. For ferroic materials, however, almost no memory effects have been found for their ferroic domains after reversible phase transformations. Here, we present a pair of single-component organic enantiomorphic ferroelectric/ferroelastic crystals, (R)- and (S)-N-3,5-di-tert-butylsalicylidene-1-(1-naphthyl)ethylamine SA-NPh-(R) and SA-NPh-(S).

AFF3 is a novel prognostic biomarker and a potential target for immunotherapy in gastric cancer.

Background: Gastric cancer (GC) is one of the most common cancers worldwide with a poor prognosis. The tumor microenvironment (TME) serves a pivotal role in affecting the prognosis and efficacy of immunotherapy. Given the poor prognosis of GC patients and the limitation of immunotherapy, we urged to identify new prognostic and immunotherapeutic biomarkers.