Chinese Healthy Eating Index (CHEI) and risk of hypertension: A prospective cohort study in China.

The Chinese Healthy Eating Index (CHEI) is a valuable tool for assessing dietary quality. However, the relationship between CHEI and the risk of hypertension remains unclear. Therefore, a total of 1342 adults without hypertension at baseline and provided at least two survey data from 1997 to 2018 were included.

Baicalein attenuates metabolic dysfunction-associated steatohepatitis by regulating macrophage ferroptosis through nuclear factor (erythroid-derived 2)-like 2 pathway.

Ferroptosis, an iron-dependent cell death form, has recently been implicated in the development of metabolic dysfunction-associated steatohepatitis (MASH). Baicalein has demonstrated potential benefits in the prevention and treatment of liver diseases. However, the mechanisms by which baicalein ameliorates hepatic ferroptosis in MASH remain inadequately understood.

Anisotropic Magneto-Optical Raman Response Coupled with Magnetic Ordering in an A-Type Antiferromagnet.

Magneto-optical effects serve as powerful tools for probing magnetic order and spin-related couplings, yet anisotropic spin-phonon coupling in low-dimensional systems remains underexplored. Here, we uncover an anisotropic magneto-optical Raman response in the A-type van der Waals antiferromagnet CrSBr, where intrinsic lattice anisotropy and quasi-one-dimensional magnetism enable anisotropic spin-phonon interactions. Using polarization- and angle-resolved Raman spectroscopy, we identify that the ratio |/| of the mode's Raman tensor elements undergoes a dramatic change across the Néel temperature, serving as a hallmark of the paramagnetic-to-antiferromagnetic phase transition.

Associations between biological aging and the risk of endometriosis: Evidence from a large population-based prospective cohort study.

Background: Endometriosis is a common disease for women of reproductive ages. Individuals with accelerated biological aging are at a higher risk of developing various diseases, however, the effect of biological aging on the risk of endometriosis remains unclear. We aimed to explore the associations between biological aging and the risk of endometriosis.

Effect of ultrasound-assisted pH-shifting treatment on the physicochemical properties of mung bean protein/milk protein concentrate hybrid protein systems and its application in hybrid yogurt gels.

This study aimed to explore the impact of ultrasound-assisted pH-shifting on the physicochemical characteristics of a mung bean protein/milk protein concentrate (MBP/MPC) hybrid protein system and assess its applicability in hybrid yogurt gels. The results indicated that ultrasound and pH-shifting synergistically improved the physicochemical properties of hybrid protein system, increasing solubility (86.92 %-91.

Exploring the effect of milk protein concentrate on the physicochemical and digestive properties of fermentation-induced mung bean protein gels.

This study aimed to investigate the impact of introducing varying percentages (10-50 %) of milk protein concentrate (MPC) on the physicochemical characteristics and in vitro digestibility of fermentation-induced mung bean protein (MBP) gels. The results indicated that the storage modulus (G'), hardness, and chewiness of the MBP/MPC hybrid yogurt gel initially increased and then reduced with rising MPC levels. The MBP/MPC gel with a composition of 30 % MPC and 70 % MBP exhibited the highest G' and water-holding capacity (WHC) as well as the most uniform and dense network structure.

Comprehensive metabolomics based exploration of digestive characteristics of biotransformed apple polyphenols.

Apple () polyphenols possess functional properties; however, their human body absorption is impeded. To enhance their absorption, apple polyphenols were fermented using zrx01. Gastrointestinal digestion and metabolomics analyses were conducted.

Accelerated Biological Aging, Genetic Susceptibility, and Non-Alcoholic Fatty Liver Disease: Two Prospective Cohort Studies.

: Biological aging is considered a vital risk factor for age-related diseases, but its role in non-alcoholic fatty liver disease (NAFLD) remains uncertain. This study aimed to evaluate the associations of biological aging with NAFLD and the modified effect of genetic susceptibility. : This study included 329,040 participants from the UK Biobank and 6783 participants from the Dongfeng-Tongji Cohort in China.

Dietary polyunsaturated fatty acid and risk of gout: a cohort study integrating genetic predisposition and metabolomics.

Objectives: Gout is the most common inflammatory arthritis and affects quality of life. Dietary polyunsaturated fatty acids (PUFAs) have protective effects against various diseases, but its role in gout remains uncertain. Our study aims to assess the association between PUFAs intake and gout risk, the role of genetic factors, and the possible impact of metabolites.

Interleukin 33 Promotes Liver Sinusoidal Endothelial Cell Dysfunction and Hepatic Fibrosis in Diabetic Mice.

Background: Interleukin 33 (IL33) drives liver fibrosis, and individuals with type 2 diabetes mellitus are more likely advanced to liver fibrosis. However, the role of IL33 in diabetic liver fibrosis remains unclear, prompting our investigation.

Methods: We developed a diabetes model in wild-type, IL33-/-, and suppression of tumorigenicity 2 (ST2-/-, IL33 receptor) mice.

Ultra-Processed Food Consumption and the Risk of Psoriasis: A Large Prospective Cohort Study.

The sales of ultra-processed food (UPF) are rapidly increasing worldwide, and there have been reports linking UPF consumption to several chronic diseases. However, there is limited prospective evidence exploring the impact of UPF on inflammatory skin diseases. This study investigates the association between UPF intake and the incidence of psoriasis using data from the UK Biobank.

Dietary Polyunsaturated Fatty Acid and the Risk of Rheumatoid Arthritis: Insights From Genetic Predisposition and Proteomics.

Objective: Our objective was to investigate the associations of polyunsaturated fatty acids (PUFAs) intake with rheumatoid arthritis (RA) risk, alongside the role of genetic predisposition and the potential mediating effects of circulating proteins.

Methods: Using data from 188,597 RA-free participants in the UK Biobank, Cox proportional hazard models assessed the association of PUFAs intake with RA risk. The polygenic risk score for RA further allowed evaluation of genetic predisposition's modifying effects.

High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models.

Accumulated senescent cells during the aging process are a key driver of functional decline and age-related disorders. Here, we identify ganoderic acid A (GAA) as a potent anti-senescent compound with low toxicity and favorable drug properties through high-content screening. GAA, a major natural component of Ganoderma lucidum, possesses broad-spectrum geroprotective activity across various species.

Association between systemic immune-inflammation index and central obesity in pediatric populations: a cross-sectional and cohort study.

Background: Central obesity in children represents a significant public health concern due to its strong association with an elevated risk of metabolic and cardiovascular disorders. The systemic immune inflammation index (SII) has been implicated in the pathophysiology of obesity-related chronic inflammation. Despite its potential relevance, the specific relationship between central obesity and SII in the pediatric population remains insufficiently explored.

The Associations of Vitamin D Status and Lifestyle Behaviors with General Obesity and Metabolically Unhealthy Obesity in Chinese Children and Adolescents.

Background: Vitamin D and lifestyle behaviors are closely related to children's health. However, current research on the combined influences of vitamin D and adherence to 24-Hour Movement Guidelines (24-HMG) on childhood obesity remains scarce. Our study aimed to examine individual and joint associations of vitamin D status and the number of recommendations for adhering to 24-HMG with obesity among Chinese children and adolescents.

Unraveling the microecological mechanisms of phosphate-solubilizing JP233 through metagenomics: insights into the roles of rhizosphere microbiota and predatory bacteria.

The effects of phosphate-solubilizing bacteria (PSB) on plant productivity are high variable under field conditions. Soil phosphorus (P) levels are proposed to impact PSB performance. Furthermore, the effect of exogenous PSB on rhizosphere microbial community and their functions are largely unexplored.

High-sensitivity hot-wire anemometer using cobalt-doped fiber-based long-period gratings.

A high-sensitivity hot-wire anemometer is proposed for use with a cobalt-doped fiber (CDF) based long-period grating (LPG) heated optically by a 1480 nm laser. The CDF-LPG absorbs laser power and generates heat inherently, thereby eliminating the need for both metal coating and mode coupling devices that are usually required in optical fiber grating anemometers. The dip wavelength of the CDF-LPG shifts with airflow velocity due to the cooling effect of the airflow.

Genome-wide DNA methylation analysis of sorghum leaves following foreign GA3 exposure under salt stress.

Sorghum is an increasingly popular topic of research in elucidating survival and adaptation approaches to augmented salinity. Nonetheless, little is known about the outcome and modulatory networks involved in the gibberellic acid (GA3)-induced salt stress alleviation in sorghum. Here, we identified 50 mg/L GA3 as the optimal concentration for sorghum ('Jitian 3') development under salt stress.

Impact of human intervention and predator-prey dynamics on ecosystem virus transmission.

Humans and predators occupy dominant positions in ecosystems and are generally believed to play a decisive role in maintaining ecosystem stability, particularly in the context of virus transmission. However, this may not always be the case. By establishing some ecosystem virus transmission models that cover both human perspectives and predators, we have drawn the following conclusions: (1) Controlling vaccination activities from the human perspective can potentially lower the transmission rate and improve herd immunity, thereby indirectly protecting unvaccinated risk groups.

Cross-sectional and longitudinal associations between serum vitamin D and continuous metabolic syndrome score among children and adolescents: roles of levels of inflammation in peripheral blood.

Background: Serum vitamin D deficiency is intricately linked to metabolic disorders, however, evidence on its association with continuous metabolic risk in children and adolescents remains insufficient. This study aims to elucidate the relationship between serum vitamin D levels and continuous metabolic risk.

Methods: The cross-sectional analysis involved 4490 participants aged 6 ~ 18, and the longitudinal investigation included 1398 individuals aged 6 ~ 12 years.

Midwives perspectives of barriers and facilitators for the practice of promoting women's positive childbirth experience in China: A qualitative study.

Background: Women-centered care for positive childbirth experiences is currently a global trend. However, there are some barriers to promoting women's positive childbirth experiences in practice. This study explored midwives' perspectives on the barriers and facilitators to promoting women's positive childbirth experience in practice.

Genomic Analysis of SJ9: An Efficient Tetracycline-, Enrofloxacin-, and Tylosin-Degrading Fungus.

Background/objectives: Many fungi related to can degrade a wide range of pollutants and are widely distributed globally. SJ9 was enriched from fresh strawberry inter-root soil to yield fungi capable of degrading tetracycline, enrofloxacin, and tylosin.

Methods: SJ9 genome was sequenced, assembled, and annotated in this study utilizing bioinformatics software, PacBio, and the Illumina NovaSeq PE150 technology.

Mixed fermentation of lactic acid bacteria and sourdough on quality and storage characteristics of steamed bun.

The effect of mixed fermentation with sourdough and lactic acid bacteria ( and ), the physicochemical indexes, storage characteristics of dough and bun were investigated. Compared with sourdough-only dough and bun, the mixed fermentation significantly increase the total phenol, flavonoid and hydrolyzed amino acid content of the dough, the specific volume and height-diameter ratio of mixed fermentation bun increased significantly by 18.3 % and 7.

The SBP-box transcription factor PlSPL2 negatively regulates stem development in herbaceous peony.

The SBP-box transcription factor PlSPL2 silencing in herbaceous peony enhanced stem strength by regulating xylem development, whereas its overexpression in tobacco resulted in weaker stem strength and undeveloped xylem. The strength of plant stems is a critical determinant of lodging resistance of plants, which significantly affects crop yield and cut-flower quality. Squamosa promoter binding (SBP) protein-like (SPL) transcription factors (TFs), participate in multiple regulatory processes, particularly in stem development.