Potential role of AhR in ischemia‑reperfusion injury and cancers: Focus on ferroptosis and lipid peroxidation signaling pathways (Review).

The aryl hydrocarbon receptor (AhR) is a pivotal ligand‑activated transcription factor that plays a crucial role in maintaining cellular redox homeostasis. The disruption of redox homeostasis in the etiology of numerous diseases primarily manifests as the accumulation of reactive species and the attenuation of the antioxidant defenses, leading to the progressive buildup of lipid peroxides. This phenomenon significantly contributes to the initiation and progression of diseases, such as atherosclerosis, cancer, diabetes and ischemia‑reperfusion injury.

Light-Induced and Strain-Releasing Reactions of Bicyclo[1.1.0]butanes with Alkenes as a Route to Spirocyclobutanes.

A photochemical approach to biologically active spirocyclobutyl oxindoles involving a cyclization/alkylation reaction sequence of bicyclo[1.1.0]butane (BCB)-containing -iodoanilides with alkenes is reported.

The impact of serum interleukin-17a as a predictive biomarker for neoadjuvant therapy response in breast cancer: a retrospective study.

Background: Breast cancer (BC) is a common and highly malignant disease. Recently, interlukin-17a (IL-17a) was found to be associated with several human malignancies. However, the role of IL-17a in predicting treatment response in BC patients undergoing neoadjuvant therapy (NAT) remains unclear, with limited data exploring its potential as a biomarker.

Reelin-LRP8 signaling mediates brain dissemination of breast cancer cells via abluminal migration.

Brain metastasis (BM) remains a significant challenge in breast cancer (BC) management. While conventional metastatic routes primarily involve hematogenous dissemination, emerging evidence suggests that BC cells can also migrate along the abluminal surface of blood vessels, bypassing the blood-brain barrier (BBB). To investigate this phenomenon, we established a zebrafish xenograft model utilizing GFP-labeled MDA-MB-231 cells, allowing real-time observation of BC cell migration along the posterior cerebral veins.

A global bibliometric and visualized analysis of the status and trends of lung metastasis in breast cancer research from 2000 to 2024.

Breast cancer remains a significant global health challenge, with lung metastasis presenting critical barriers to effective treatment and patient survival. This study conducts the first comprehensive bibliometric and visualized analysis of lung metastasis research in breast cancer from 2000 to 2024, illustrating evolving research trends and collaboration patterns in this critical area. Utilizing data from the Web of Science Core Collection, we employed bibliometric tools such as VOSviewer and CiteSpace to assess publication trends, international collaborations, influential institutions, authors, and keyword dynamics.

Application of a simple skin flap to repair large defects in a patient with radiotherapy‑induced skin squamous cell carcinoma after breast cancer surgery: A case report.

Radiotherapy is a leading treatment intervention for cancer and has been shown to improve the prognosis of patients with malignant tumors. However, there are several side effects associated with radiotherapy that require attention. The present case study describes the case of a patient who underwent breast-conserving surgery after receiving a diagnosis of right-sided breast cancer, following which they received conventional radiation therapy.

Functional Analysis of the Gene Related to Resistance Against in Maize.

In this study, the gene , associated with resistance to ear rot, was identified through transcriptome data analysis of the maize inbred line J1259. The gene was subsequently cloned and its function was investigated. The gene comprises an open reading frame of 525 base pairs, encoding a protein of 175 amino acids.

An overview of invasive micropapillary carcinoma of the breast: past, present, and future.

Invasive micropapillary carcinoma of the breast (IMPC) exhibits a unique micropapillary structure and "inside-out" growth pattern. Despite its extremely low incidence, IMPC has attracted considerable attention owing to its poor prognosis. Since Siriaunkgul and Tavassoli first proposed the term IMPC in 1993 to describe its morphological characteristics, with tumor cell clusters arranged in a pseudopapillary structure within the glandular cavity, its diagnostic rate has substantially increased.

UA influences the progression of breast cancer via the AhR/p27/cyclin E pathway.

Uric acid (UA) is the end product of purine metabolism. In recent years, UA has been found to be associated with the prognosis of clinical cancer patients. However, the intricate mechanisms by which UA affects the development and prognosis of tumor patients has not been well elucidated.

Oxidative stress in the brain-lung crosstalk: cellular and molecular perspectives.

Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the body's ability to counteract their harmful effects, playing a key role in the pathogenesis of brain and lung-related diseases. This review comprehensively examines the intricate mechanisms by which oxidative stress influences cellular and molecular pathways, contributing to neurodegenerative, cardiovascular, and respiratory disorders. Emphasizing the detrimental effects on both brain and lung health, we discuss innovative diagnostic biomarkers, such as 8-hydroxy-2'-deoxyguanosine (8-OHdG), and the potential of antioxidant therapies.

Application of a modified lateral thoracic artery perforator flap in partial breast defects.

Background: Breast cancer has become the most frequently diagnosed cancer in the world. Detection at an early stage, frequently allows women to benefit from breast conserving surgery. However, some patients are not satisfied with the breast shape after breast-conserving surgery, and autologous tissue flaps are needed to fill the defect in the resection area.

The potential of aryl hydrocarbon receptor as receptors for metabolic changes in tumors.

Cancer cells can alter their metabolism to meet energy and molecular requirements due to unfavorable environments with oxygen and nutritional deficiencies. Therefore, metabolic reprogramming is common in a tumor microenvironment (TME). Aryl hydrocarbon receptor (AhR) is a ligand-activated nuclear transcription factor, which can be activated by many exogenous and endogenous ligands.

Aryl hydrocarbon receptor: An emerging player in breast cancer pathogenesis and its potential as a drug target (Review).

Breast cancer is the most common malignancy in women. Metastatic breast cancer is incurable and is a major cause of shortened patient survival. The different molecular types of breast cancer make targeted therapy difficult and a complex challenge.

Erratum to "Single Wire Capacitive Wireless Power Transfer System for Wearable Biomedical Sensors based on Flexible Graphene Film Material".

In [1], this paper was submitted for the Special Issue on Flexible Biomedical Sensors for Healthcare Applications. The paper was instead published in Volume 16, Issue 6, 2022.

The tumor-nerve circuit in breast cancer.

It is well established that innervation is one of the updated hallmarks of cancer and that psychological stress promotes the initiation and progression of cancer. The breast tumor environment includes not only fibroblasts, adipocytes, endothelial cells, and lymphocytes but also neurons, which is increasingly discovered important in breast cancer progression. Peripheral nerves, especially sympathetic, parasympathetic, and sensory nerves, have been reported to play important but different roles in breast cancer.

Study on Rapid Detection Method for Degradation Performance of Polyolefin-Based Degradable Plastics.

In order to accurately determine the degradation performance of polyolefin-based degradable plastics, the concept of bioassimilated carbon is proposed for the first time in this paper; the bioactive and hydrophilic organic carbon in plastic degradation products is defined as bioassimilation carbon. A method for the detection of the carbonyl index and bioassimilated carbon conversion rate in polyolefin degradable plastics was developed to quickly identify its degradation performance. The measurement results show that the bioassimilated carbon conversion rate of more than 70% can be used to replace the biodegradation rate index to achieve the purpose of quickly identifying the degradation performance of plastics.

Improving yield and quality of rice under acid rain stress by regulating nitrogen assimilation with exogenous Ca.

Acid rain threatens crop yield and nutritional quality, and Ca can regulate plant responses to abiotic stresses. To improve the yield and nutritional quality of crops under acid rain stress, we applied exogenous Ca to regulate nitrogen assimilation in rice seedlings under simulated acid rain stress (pH 4.5 or 3.

Single Wire Capacitive Wireless Power Transfer System for Wearable Biomedical Sensors Based on Flexible Graphene Film Material.

This paper provides a special flexible graphene film based capacitive wireless power transfer (FGCPT) system for powering biomedical sensors of smart wearable devices. The graphene conductive material is flexible, transparent, highly conductive, and impermeable to most gases and liquids. Generally, the coupling structure of capacitive wireless power transfer (CPT) system is consisted of metal plates.

The past, present, and future of research on neuroinflammation-induced mild cognitive impairment: A bibliometric analysis.

Background: Mild cognitive impairment (MCI) is a precursor to dementia, and neuroinflammation in the brain is thought to be one of the main pathogenic mechanisms of MCI. However, the underlying neurobiological mechanisms have not been fully explored. The purpose of this study was to establish a visual model map of the articles in the field of neuroinflammation-induced MCI over the past 11 years to reveal the research hotspots and predict the future development trends in this field, which will help to promote the research and development for MCI.

Reconstruction of complex chest wall defects: A case report.

Background: Chronic radiative chest wall ulcers are common in patients undergoing radiation therapy. If not treated early, then symptoms such as erosion, bleeding and infection will appear on the skin. In severe cases, ulcers invade the ribs and pleura, presenting a mortality risk.

Markers Associated With Tumor Recurrence in Patients With Breast Cancer Achieving a Pathologic Complete Response After Neoadjuvant Chemotherapy.

Background: Patients who achieve a tumor pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) have better outcomes than patients with residual tumor. However, tumors still recur in the pCR patients. Therefore, we aim to explore factors associated with tumor recurrence in this patient population.

The efficacy of human epidermal growth factor receptor 2 (HER2) blockade switching mode in refractory patients with HER2-positive metastatic breast cancer: a phase II, multicenter, single-arm study (SYSUCC-005).

Background: Despite significant survival improvement in human epidermal growth factor receptor 2 (HER2) blockade for HER2-positive breast cancer, resistance to anti-HER2 remains inevitable. Subsequent anti-HER2 with continuing trastuzumab beyond progression is acceptable with limited efficacy when other anti-HER2 treatment is unavailable. This single-arm, phase II study (SYSUCC-005) aimed to explore the efficacy of switching mode for HER2-positive refractory metastatic breast cancer.

Noninvasively ventilated and easily operated mouse model of myocardial infarction.

The laboratory mouse is an animal model commonly used in cardiovascular research; however, it has technical challenges as a model for myocardial infarction (MI). In this study, a novel noninvasively ventilated and easily operated experimental mouse model of MI was established in Kunming mice based on a left anterior descending (LAD) coronary artery rupture. Overall, 95% of sham mice and 84% of mice with a ruptured LAD survived the surgery.