Targeting MET and KRAS G12C co-occurring mutation in metastatic adenoid cystic carcinoma of the trachea: a case report.

Background: MET and KRAS comutation in the same group of cells of primary tracheal adenoid cystic carcinoma is extremely rare; there is no standard of care for patient with metastatic disease.

Case Presentation: We report a 42-year-old treatment-naïve Chinese male patient with metastatic tracheal adenoid cystic carcinoma harboring a MET p.D1010Y and KRAS p.

Chemo-immunotherapy sequential with radiotherapy in advanced or metastatic esophageal squamous cell carcinoma.

Background: To evaluate the efficacy and safety of chemo-immunotherapy combined with residual lesions irradiation of advanced stage esophageal squamous cell carcinoma.

Methods: Treatment-naïve patients with radiologically and histologically confirmed advanced or metastatic squamous-cell esophageal carcinoma were enrolled. Participants received four cycles of the TP regimen combined with the PD-1 inhibitor sintilimab.

Amplification effect of side group regulation imidazolate linkages of covalent organic frameworks for efficient oxygen reduction.

Metal-free covalent organic framework (COF) materials are promising catalysts for the oxygen reduction reaction (ORR). However, it is difficult to markedly modulate their catalytic performance by only changing the side groups because their partially conjugated linkages weaken the influence of the electronic and charge transfer properties along the frameworks. Here, we demonstrated the amplification effect of micro-changes in the side units of COFs by constructing imidazole linkages for the ORR, and four different electron effect groups (H, F, OMe, and OH) were introduced.

Investigation on the fast phase transition mechanism of flow-induced oriented iPB-1.

The phase transition mechanism of isotactic polybutene-1 (iPB-1) has always been a central research topic in the fields of polymer physics and industrial application. Phase transition kinetics of the flow-induced oriented form II is significantly faster than the isotropic form II that crystallizes under quiescent condition. In this study, combining the X ray diffraction technique and a homemade extensional rheometer, the influence of amorphous region on the transformation kinetics was been investigated.

Afatinib Combined with Bevacizumab in the Treatment of Patients with Non-Small Cell Lung Cancer Harboring EGFR G719X, S768I or L861Q/P Mutations.

Purpose: To investigate the efficiency and safety of afatinib in combination with bevacizumab in patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) G719X, S768I, and L861Q mutations.

Patients And Methods: We retrospective studied treatment naïve patients with local advanced or metastatic non-small cell lung cancer harboring EGFR G719X, S768I, and L861Q mutations from January 2017 to August 2021. EGFR tyrosine kinase inhibitors (TKIs) were the first-line treatment in all patients.

Prognostic Factors and Outcomes in Advanced Stage Lung Cancer Patients with COVID-19 Omicron Variant Infection.

Background: We study the characteristics and outcomes in lung cancer patients with COVID-19 Omicron variant infection.

Methods: Hospitalized lung cancer patients with advanced-stage disease and laboratory-confirmed COVID-19 Omicron infection were included. Pneumonitis involving at least 25% of lung parenchyma on CT scans, accompanied by symptoms and oxygen saturation below 93%, were criteria for enrollment.

Osimertinib combined with bevacizumab as the first-line treatment in non-small cell lung cancer patients with brain metastasis harboring epidermal growth factor receptor mutations.

Background: The efficacy and safety of osimertinib combined with bevacizumab in non-small cell lung cancer (NSCLC) patients with brain metastasis harboring epidermal growth factor receptor (EGFR) mutations have not been fully studied.

Methods: Treatment-naïve NSCLC patients with brain metastasis harboring EGFR-activating mutations were treated with osimertinib 80 mg oral daily and bevacizumab 15 mg/kg intravenously on day 1, repeated every 21 days, until disease progression, intolerable toxicity, or death. The primary endpoint was the median progression-free survival (mPFS), and the secondary endpoints were the median overall survival (mOS), response rates, and toxicities.

Investigation of the synergistic effect of melt-extension and nanofiller on the crystal-crystal phase transition from form II to I of isotactic polybutene-1.

New questions and conjectures are raised on the crystal-crystal phase transition of isotactic polybutene-1 (iPB-1) containing nanofiller in the flow field. In this work, we investigate the phase transition from flow-induced oriented form II to I in iPB-1 blends with multi-walled carbon nanotubes (MWCNTs) with a homemade two-drum extensional rheometer combined with wide-angle X-ray diffraction (WAXD) measurements. The MWCNTs show a limited promoting effect on the phase transition kinetics under quiescent conditions, while the phase transition kinetic is highly accelerated with the impose of melt-extension.

MXene-Coated Wrinkled Fabrics for Stretchable and Multifunctional Electromagnetic Interference Shielding and Electro/Photo-Thermal Conversion Applications.

Stretchability and multifunctional heating abilities are highly desired for wearable electromagnetic interference (EMI) shielding fabrics to tackle the growing electromagnetic pollution for special crowd, such as pregnant women. Herein, we fabricated stretchable MXene-coated thermoplastic polyurethane (TPU) fabrics by simple uniaxial prestretching and spraying methods. The obtained unique wrinkled structure endowed the film with effective strain-invariant electrical conductivity and EMI shielding properties.

Development and validation of a prognostic nomogram for malignant esophageal fistula based on radiomics and clinical factors.

Background: The current study aimed to comprehensively analyze the clinical prognostic factors of malignant esophageal fistula (MEF). Furthermore, this study sought to establish and validate prognostic nomograms incorporating radiomics and clinical factors to predict overall survival and median survival after fistula for patients with MEF.

Methods: The records of 76 patients with MEF were retrospectively analyzed.

Highly Thermal Conductive Poly(vinyl alcohol) Composites with Oriented Hybrid Networks: Silver Nanowire Bridged Boron Nitride Nanoplatelets.

With the increasing demand for thermal management materials in the highly integrated electronics area, building efficient heat-transfer networks to obtain advanced thermally conductive composites is of great significance. In the present work, highly thermally conductive poly(vinyl alcohol) (PVA)/boron nitride nanoplatelets@silver nanowires (BNNS@AgNW) composites were fabricated via the combination of the electrospinning and the spraying technique, followed by a hot-pressing method. BNNS are oriented along the in-plane direction, while AgNWs with a high aspect ratio can help to construct a thermal conductive network effectively by bridging BNNS in the composites.

E2F1 Induces KIF26A Transcription and Promotes Cell Cycle Progression CDK-RB-E2Fs Feedback Loop in Breast Cancer.

Objective: The aim of this study was to investigate the role of KIF26A in breast cancer.

Method: qRT-PCR and immunohistochemistry were conducted to explore KIF26A expression and functional contribution to breast cancer development. MTS, EDU, colony formation assays, and flow cytometry analysis were conducted to assess cell proliferation characteristics and cell cycle progression.

Irinotecan combined with oxaliplatin and S-1 in patients with metastatic pancreatic adenocarcinoma: a single-arm, three-centre, prospective study.

Objective: To study the efficacy and toxicity of irinotecan combined with oxaliplatin and S-1 in patients with metastatic pancreatic adenocarcinoma.

Patients And Methods: Previously untreated patients with cytologically or histologically confirmed metastatic pancreatic adenocarcinoma underwent a treatment regimen consisting of an intravenous infusion of irinotecan 165 mg/m and oxaliplatin 85 mg/m on day 1, and oral S-1 40 mg/m twice daily on days 1-14, repeating the regimen every 21 days until one of the following occurred: disease progression, intolerable toxicity, or patient death. The primary endpoint was overall survival (OS), and the secondary endpoints were progression-free survival (PFS), response rate, toxicity, and quality of life.

Polymorph selection during melt crystallization of the isotactic polybutene-1 homopolymer depending on the melt state and crystallization pressure.

This work investigated the crystalline forms obtained from melt crystallization in the isotactic polybutene-1 (iPB-1) homopolymer via manipulation of the temperature at which samples were melted (Tmelt) and crystallization pressure (Pcry). Unlike the results under atmospheric conditions where the molten sample crystallized into the pure form II and the crystallization temperature and kinetics were affected obviously by Tmelt, the melted sample crystallized into forms II or I' under high pressure, depending on Tmelt and Pcry. The content of form I' decreases with increasing Tmelt or decreasing Pcry.

S-1 Maintenance Therapy in Extensive Stage Small-Cell Lung Cancer-A Randomized Clinical Study.

Small-cell lung cancer (SCLC) is a recalcitrant cancer for its dismal prognosis although extensive research had been done. Four to 6 cycles platinum-based chemotherapy is the mainstay treatment for the extensive-stage disease; but the role of maintenance treatment is not fully understood. This is a phase 2, open-label study.

Transparent Conductive Flexible Trilayer Films for a Deicing Window and Self-Recover Bending Sensor Based on a Single-Walled Carbon Nanotube/Polyvinyl Butyral Interlayer.

A flexible transparent conductive film (TCF) is an important component in many modern smart devices. Recent TCF is always fabricated based on indium tin oxide (ITO). However, the drawbacks of ITO (e.

A randomized clinical study to compare intrapleural infusion with intravenous infusion of bevacizumab in the management of malignant pleural effusion in patients with non-small-cell lung cancer.

Background: To compare the efficiency and toxicity of bevacizumab by intrapleural or intravenous infusion in the management of malignant pleural effusion in patients with non-small-cell lung cancer (NSCLC).

Methods: Sensitizing mutation negative NSCLC patients with malignant pleural effusion were randomized into two groups in 1:1 ratio. The pleural effusion was completely drained in 24 hours; one group received intrapleural infusion and the second group received intravenous infusion of bevacizumab at a dose of 7.

A Nomogram to Predict Distant Metastasis for Patients with Esophageal Cancer.

Background: Distant metastasis of esophageal cancer (EC) is prone to be neglected, so it is necessary to screen out the high-risk population for more sensitive and rigorous pretreatment imaging evaluations.

Objective: The aim of this study was to evaluate the risk factors for distant metastasis in patients with EC and to construct a clinical nomogram.

Methods: Eligible patients diagnosed from 2010 to 2015 were selected from the Surveillance, Epidemiology and End Results (SEER) database.

Bevacizumab Combined with Icotinib Overcomes Osimertinib Resistance in a Patient of Non-Small Cell Lung Cancer.

A 61-year-old Chinese woman was diagnosed as primary pulmonary adenocarcinoma of left superior lobe with epidermal growth factor receptor (EGFR) 19 del mutation positive. Treatment with icotinib was given, but her disease progressed after 6 months remission. CT-guide needle biopsy for the new lesion in inferior lobe of left lung demonstrated intrapulmonary metastasis, and EGFR gene panel by Amplification Refractory Mutation System Polymerase Chain Reaction (ARMS-PCR) confirmed EGFR T790M mutation.

Risk Factors for Esophageal Fistula in Esophageal Cancer Patients Treated with Radiotherapy: A Systematic Review and Meta-Analysis.

Objective: Esophageal fistula is a critical and fatal complication of esophageal cancer. The aim of this meta-analysis was to explore the risk factors for esophageal perforation in esophageal cancer patients treated with radiotherapy.

Methods: Data from the PubMed and Embase databases were retrieved for clinical research published between 1990 and 2018.