Erratum: Human endoglin-CD3 bispecific T cell engager antibody induces anti-tumor effect .

[This corrects the article DOI: 10.7150/thno.53121.

PEDV infection downregulates goblet cell differentiation through activating the Notch pathway.

Porcine epidemic diarrhoea virus (PEDV) is the most widespread porcine coronavirus worldwide, causing high mortality and a high incidence rate among piglets. The molecular mechanisms by which PEDV regulates epithelial cell function and differentiation, as well as its disruption of the intestinal mucosal barrier, are not yet fully understood. This study reveals that PEDV infection reduces the number of goblet cells and impairs the intestinal barrier integrity in newborn piglets.

[Corrigendum] Highly sensitive detection of leukemia cells based on aptamer and quantum dots.

Following the publication of the above article, the authors drew to the Editor's attention that, concerning the histological images shown in Fig. 5B on p. 890, two pairs of the data panels showed overlapping sections, such that these data were derived from the same original source where the panels were intended to show the results from differently performed experiments.

Comprehensive analysis of the clinical and biological significances of polyamine metabolism in glioma.

Polyamines, including spermidine, spermine, and putrescine, are polycationic alkylamines in mammalian cells. However, the prognostic impact of polyamine in glioma remains unclear. In the present study, we performed bioinformatic analysis to characterize the expression of polyamine metabolism family members in patients with glioma.

Advances in the treatment of malignant tumors with neurological drugs.

The nervous system governs the body's components and is essential for the physiological functions of all organ systems. The nervous system governs how the body senses, processes, and responds to its environment. Through a complex network of neurons and supporting cells, it connects sensory organs with the brain and spinal cord, and coordinates communication with target organs and tissues throughout the body.

Mechanisms and Functions of γδ T Cells in Tumor Cell Recognition.

γδ T cells are among the first line of defense in the immune system, playing a crucial role in bridging innate and adaptive immunity. Although γδ T cells are crucial for tumor immune surveillance, the complete mechanism by which γδ T cell receptors identify molecular targets in target cells remains unknown. Target cells can produce phosphoantigens (PAgs) via the mevalonate pathway or the methylerythritol phosphate pathway.

Unveiling the Ni-Fe coordination environments for enhanced 1,4-butanediol selectivity in 1,4-butynediol hydrogenation.

Biodegradable materials such as PBAT and PBS offer a promising solution to plastic pollution, which require 1,4-butanediol (BDO) as a key monomer, predominantly produced 1,4-butynediol (BYD) hydrogenation. In this study, we present an innovative approach for achieving enhanced BDO selectivity by regulating the Ni-Fe coordination environments in bimetallic catalysts for hydrogenation. The novel Fe/Ni-SiO catalyst features framework-embedded Ni species and surface-anchored Fe sites and shows a fantastic complementary interaction between Ni-FeO synergy sites; namely, Ni sites efficiently dissociate H to enable successive hydrogenation, while the coordinatively unsaturated FeO species can preferentially stabilize the terminal-OH groups in both BYD and BED intermediates during adsorption while suppressing other side reactions.

Erratum: Lentivirus-mediated shRNA Targeting CNN2 Inhibits Hepatocarcinoma and : Erratum.

[This corrects the article DOI: 10.7150/ijms.21113.

Research on Enhanced Dynamic Pig Counting Based on YOLOv8n and Deep SORT.

Pig counting is an essential activity in the administration of pig farming. Currently, manual counting is inefficient, costly, and unsuitable for systematic analysis. However, research on dynamic pig counting encounters challenges, including inadequate detection accuracy stemming from crowding, occlusion, deformation, and low-light conditions.

Correction: Wang et al. Ethynylation of Formaldehyde over CuO/SiO Catalysts Modified by Mg Species: Effects of the Existential States of Mg Species. 2019, , 1137.

In the original publication [...

Molecular characteristics of the immune escape of coronavirus PEDV under the pressure of vaccine immunity.

Coronaviruses have undergone evolutionary changes and mutations in response to the immune pressures exerted by vaccines and environmental factors, resulting in more severe consequences during breakthrough infections. Nevertheless, the specific correlation between the evolutionary mutations of coronaviruses and immune pressures remains ambiguous. Swine coronavirus-porcine epidemic diarrhea virus (PEDV)-has existed for decades.

A multi-target tracking method for UAV monitoring wildlife in Qinghai.

The Procapra przewalskii, plays a vital role in sustaining the ecological balance within its habitat, yet it faces significant threats from environmental degradation and illegal poaching activities. In response to this urgent conservation need, this article proposes a multi-object tracking (MOT) method for unmanned aerial vehicle (UAV). Initially, the approach utilizes a modified YOLOv7 network, which incorporates Group-Selective Convolution (GSConv) in its Neck component, effectively enhancing the network's ability to preserve detailed information while simultaneously reducing the computational load.

Erratum: Author correction to "Generation of Gal-enhanced bifunctional tumor vaccine" [Acta Pharm Sin B 12 (2022) 3177-3186].

[This corrects the article DOI: 10.1016/j.apsb.

Constructions and immunogenicity evaluations of two porcine epdemic diarrhea virus-like particle vaccines.

Porcine epidemic diarrhea virus (PEDV), a swine enteropathogenic coronavirus, causing acute diarrhea, dehydration, and up to 100 % mortality in neonatal suckling piglets, leading to huge economic losses in the global swine industry. Vaccination remains the most promising and effective way to prevent and control PEDV. In this study, we produced PEDV virus-like particles (VLPs) composed of S, M, and E proteins with a baculovirus expression system and a mammalian expression system.

An Anti-CD147 Antibody-Drug Conjugate Mehozumab-DM1 is Efficacious Against Hepatocellular Carcinoma in Cynomolgus Monkey.

Effective treatment strategies are urgently needed for hepatocellular carcinoma (HCC) patients due to frequent therapeutic resistance and recurrence. Antibody-drug conjugate (ADC) is a specific antibody-drug conjugated with small molecular compounds, which has potent killing activity against cancer cells. However, few ADC candidates for HCC are undergoing clinical evaluation.

Identification of the entosis-related prognostic signature and tumour microenvironment in hepatocellular carcinoma on the basis of bioinformatics analysis and experimental validation.

Liver cancer ranks among the deadliest cancers worldwide. Entosis, a recently uncovered method of cell death, has not yet been fully explored for its relevance to HCC. A bioinformatics analysis was performed to determine the expression and mutational landscapes of Entosis-related genes (ERGs).

Smad4 deficiency in hepatocytes attenuates NAFLD progression via inhibition of lipogenesis and macrophage polarization.

Nonalcoholic fatty liver disease (NAFLD), a major cause of chronic liver disorders, has become a serious public health issue. Although the Smad4 signaling pathway has been implicated in the progression of NAFLD, the specific role of Smad4 in hepatocytes in NAFLD pathogenesis remains unclear. Hepatocyte-specific knockout Smad4 mice (Alb) were first constructed using the Cre-Loxp recombinant system to establish a high-fat diet induced NAFLD model.

Structural basis for human NKCC1 inhibition by loop diuretic drugs.

Na-K-Cl cotransporters functions as an anion importers, regulating trans-epithelial chloride secretion, cell volume, and renal salt reabsorption. Loop diuretics, including furosemide, bumetanide, and torsemide, antagonize both NKCC1 and NKCC2, and are first-line medicines for the treatment of edema and hypertension. NKCC1 activation by the molecular crowding sensing WNK kinases is critical if cells are to combat shrinkage during hypertonic stress; however, how phosphorylation accelerates NKCC1 ion transport remains unclear.

Hyperacute rejection-engineered oncolytic virus for interventional clinical trial in refractory cancer patients.

Recently, oncolytic virus (OV) therapy has shown great promise in treating malignancies. However, intravenous safety and inherent lack of immunity are two significant limitations in clinical practice. Herein, we successfully developed a recombinant Newcastle disease virus with porcine α1,3GT gene (NDV-GT) triggering hyperacute rejection.

Moxifloxacin-Loaded Polymeric Nanoparticles for Overcoming Multidrug Resistance in Chronic Pulmonary Infections Caused by .

() infections are increasingly challenging due to their propensity to form biofilms and low outer membrane permeability, especially in chronically infected patients with thick mucus. exhibits multiple drug resistance mechanisms, making it one of the most significant global public health threats. In this study, we found that moxifloxacin (MXC) and antibacterial peptides (ε-poly-l-lysine, ε-PLL) exhibited a synergistic effect against multidrug-resistant (MDR-).

A reliable unmanned aerial vehicle multi-ship tracking method.

As the global economy expands, waterway transportation has become increasingly crucial to the logistics sector. This growth presents both significant challenges and opportunities for enhancing the accuracy of ship detection and tracking through the application of artificial intelligence. This article introduces a multi-object tracking system designed for unmanned aerial vehicles (UAVs), utilizing the YOLOv7 and Deep SORT algorithms for detection and tracking, respectively.