Challenging 21-day quarantine guidelines for mumps in Beijing: Data-driven recommendations for a high-coverage MMR vaccination era (2019-2024).

Mumps is a vaccine-preventable disease. Following Beijing's implementation of a three-dose MMR vaccination strategy, incidence rates declined significantly. However, the current 21-d quarantine period lacks evidence-based support, resulting in low compliance and conflicts between healthcare providers and patients.

A biologically-based regulatory method for the lignin phenol monomers to specific components and electron transfer capacity of humic substances.

The lignin was degraded into phenol and then oxidized into quinones of chemical structure of humic substances (HS) in the polyphenol pathway, and it was considered a crucial process contributing to redox capabilities of HS. However, the microbial formation and degradation of lignin phenol monomers, and their effects on the humification process remains unclear. In this study, p-hydroxybenzoic acid, syringic acid), 4-coumaric acid, and ferulic acid were found to significantly influenced the electron transfer capacity (ETC) of HS.

Advances in F-fluorodeoxyglucose positron emission tomography/computed tomography for soft tissue sarcomas.

Soft tissue sarcomas (STS) are rare malignant tumors originating from mesodermal tissues with a poor prognosis, accounting for approximately 1% of all malignancies and comprising around 50 distinct subtypes. Conventional imaging modalities, such as computed tomography (CT) and magnetic resonance imaging (MRI), primarily provide anatomical information, whereas F-fluorodeoxyglucose positron emission tomography/CT (F-FDG PET/CT) integrates functional metabolic and anatomical imaging, serving as a critical complementary tool in the diagnosis and management of STS. This article reviews recent advances in the application of F-FDG PET/CT for STS.

Nanocatalytic-phytoremediation synergistic strategy: Functional carbon nanodots enhancing nonylphenol biodegradation in contaminated soil.

The remediation of nonylphenol (NP)-contaminated soils remains challenging due to NP's persistence and ecotoxicity. Here, we present a sustainable nano-phytoremediation strategy that integrates functional carbon nanodots (FCNs) with Tagetes patula L. to effectively enhance phytoremediation efficiency.

In vivo generation of CAR macrophages via the enucleated mesenchymal stem cell delivery system for glioblastoma therapy.

Glioblastoma multiforme (GBM) is one of the most aggressive intracranial tumors for which there is no effective treatment. Chimeric antigen receptor macrophage (CAR-M) therapies have demonstrated impressive therapeutic efficacy in solid tumors; however, the cost and rigor associated with manufacturing engineered macrophages ex vivo can be prohibitive. Here, we utilized enucleated mesenchymal stem cells (MSCs) as vehicles for the targeted delivery of CAR-encoding plasmid to reprogram glioma-associated microglia/macrophages (GAM), thereby achieving CAR-M preparation in vivo.

Inflammatory and nutritional markers predict response and prognosis of patients with locally advanced gastric cancer receiving neoadjuvant immunochemotherapy.

Background: Metabolism plays an important role in the occurrence and development of gastric cancer, including in neoadjuvant immunochemotherapy. However, whether nutrition-related indicators can predict the efficacy of neoadjuvant immunochemotherapy and the prognosis of gastric cancer patients has not been addressed. This study systematically screens various nutritional indicators to explore their efficacy in predicting responses to neoadjuvant immunochemotherapy and patients' prognosis in locally advanced gastric cancer (LAGC).

Neburon induced cardiotoxicity in embryonic and adult male zebrafish via over-activation of the Ahr-Notch1 signaling pathway.

Neburon is a phenylurea herbicide that is mainly used in the growth of crops such as wheat. It may accumulate through the food chain and harm the health of organisms and even humans. However, there are limited studies on its toxicity, especially in terms of cardiac health.

Targeting SIX2 as a novel sensitization strategy of sorafenib treatment on advanced hepatocellular carcinoma through modulating METTL9-SLC7A11 axis.

Sorafenib is the main treatment for advanced hepatocellular carcinoma (HCC), but drug resistance limits its effectiveness. Evidence increasingly indicates that, in addition to targeting tyrosine kinases, sorafenib also induces ferroptosis. However, current studies have not fully clarified the relationship between ferroptosis and sorafenib treatment sensitivity.

hijacks FABP2 to activate quorum-sensing signals and aggravate Crohn's disease by inducing gut dysbiosis.

Background: Crohn's disease (CD) is a chronic inflammatory disorder characterised by intestinal dysbiosis. While inflammation-induced leakage of host proteins is a known phenomenon in CD, how these proteins affect the gut microbiota and contribute to dysbiosis remains unclear. One hypothesis is that commensal bacteria hijack these proteins, exacerbating inflammation in CD.

Intramolecular Dual Donor-Acceptor Featured Covalent Organic Frameworks Enabled by Gating Effects for Ultra-Stable Na-Metal Batteries.

Sodium metal batteries (SMBs) face severe challenges of uncontrolled sodium dendrite growth and interfacial instability. Herein, guided by theoretical predictions, a distinct locally polarized covalent organic framework (TB-Br-COF) was synthesized and employed as a Na⁺ transport accelerator to promote uniform Na deposition. TB-Br-COF excited the gating effect (a high gating ratio of 23.

Cloning and Spatiotemporal Expression Analysis of Gene cDNA in (Arctic Fox).

This study aimed to clarify the sequence characteristics and spatiotemporal expression patterns of the insulin-like growth factor 1 receptor () gene in (Arctic fox), thereby addressing the existing knowledge gap regarding -mediated growth regulation in this species. The findings establish a crucial foundation for subsequent investigations into the correlation between this gene and Arctic fox growth traits. Specific primers were designed based on the cDNA sequence of the canine gene (Accession No.

Evaluating the Effects of Neburon Exposure on Ovarian Folliculogenesis Using Zebrafish and Mouse Granulosa Cell Line.

Background: Ovarian folliculogenesis is crucial for female reproduction. This can be disrupted by various factors, including pollutants with aryl hydrocarbon receptor (AHR) agonistic activity, but the underlying mechanisms remain unclear.

Objectives: Using the herbicide neburon, a moderate AHR agonist among current pesticides, we investigated its effects on ovarian folliculogenesis in zebrafish through life-cycle exposure at environmentally relevant concentrations to elucidate the associated mechanisms.

Dumbbell-Shaped Gold Nanorod@Mesoporous Palladium Nanozymes for NIR-II-Triggered Photocatalytic Amplification and Trimodal Cancer Therapy.

While nanozyme-mediated catalytic therapy holds promise for precision oncology, achieving spatiotemporal control over enzymatic activity and synergistic therapeutic amplification in the biologically favorable second near-infrared window (NIR-II) remains an unmet challenge. In this study, we present a breakthrough in plasmonic heterojunction engineering through the rational design of asymmetric dumbbell-shaped Au nanorod@end-mesoporous Pd architectures that establish a high density of plasmonic hotspots at the mesopore sites. Unlike conventional core-shell configurations (Au@mesoPd) showing negligible NIR-II response, our heterostructure demonstrates a nearly 200% enhancement in peroxidase-like activity under 1064 nm excitation through precisely engineered hot electron dynamics.

Hydrogen-Bonded Organic Framework with Desolventization and Lithium-Rich Sites for High-Performance Lithium Metal Anodes.

Effectively managing Li migration behaviors and addressing the issues of side reactions at the electrolyte-electrode interface is crucial for advancing high-performance lithium metal batteries (LMBs). Herein, this work introduces a two-dimensional hydrogen-bonded organic framework (HOF) enriched with multi-site H-bonding and lithiophilic sites for the first time to tailor the electronic structure and solvation chemistry in lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) based electrolyte and stabilize the lithium metal anodes (LMAs) interface. Initially, the abundant lithiophilic sites (C═O, C═N) in the HOF coordinate with Li, acting as key electron donors to optimize the electronic structure while also reducing the desolvation energy barrier when Li dissociates from the solvent sheath.

Association between serum Copper-Zinc-Selenium mixture and multiple health outcomes.

Background: Metallic biomaterials have transformed modern medicine, with copper (Cu), zinc (Zn), and selenium (Se) emerging as critical components in medical applications. The study of the single and synergistic effects of serum metal concentrations on human health can provide valuable insights for future clinical transformation of biodegradable alloys.

Methods: We evaluated 2381 NHANES 2011-2016 participants to study individual and combined effects of these metals on health outcomes.

Predictive Value of Advanced Lung Cancer Inflammation Index and Development of a Nomogram for Prognosis in Patients with Cervical Cancer Treated with Radiotherapy.

Purpose: As an assessment tool of nutritional status and inflammation, the advanced lung cancer inflammation index (ALI) is associated with survival in various cancers. We aimed to investigate the association between the ALI's prognostic value and survival time in patients with the stage IIB-III cervical cancer treated with radiotherapy.

Patients And Methods: We retrospectively screened patients diagnosed with cervical cancer and underwent radiotherapy in a single institution between September 2013 to September 2015.

Navigating decisional conflict: laser peripheral iridotomy for primary angle-closure glaucoma prevention.

Aim: To investigate decisional conflict among patients diagnosed with primary angle-closure suspect (PACS) or primary angle-closure (PAC) who are considering laser peripheral iridotomy (LPI) treatment.

Methods: A total of 111 individuals diagnosed with PACS or PAC were selected through convenient sampling from March 2023 to December 2023. These participants then completed a general information questionnaire and the Decision Conflict Scale.

Enhanced emission in a supramolecular artificial light-harvesting system for a photocatalytic thiol-ene reaction.

A novel supramolecular artificial light-harvesting system (LHS) was constructed through the host-guest assembly of water-soluble phosphate-pillar[5]arene (WPP5), AIE-enhanced donor (BND), and Eosin Y (ESY) acceptor. This LHS could significantly promote the photocatalytic thiol-ene click reaction of thiophenol and styrene derivatives.

A hidden intrinsic ability of bicistronic expression based on a novel translation reinitiation mechanism in yeast.

Gene organization in operons and co-expression as polycistronic transcripts is characteristic of prokaryotes. With the evolution of the eukaryotic translation machinery, operon structure and expression of polycistrons were largely abandoned. Whether eukaryotes still possess the ability to express polycistrons, and how they functionally activate bacterial operons acquired by horizontal DNA transfer is unknown.

HPV vaccination willingness among 3,081 secondary school parents in China's capital.

Assessing knowledge of HPV and HPV vaccine and vaccine willingness among Beijing secondary school parents, and identifying decision-influencing factors. Selected via multi-stage stratified sampling, 3,081 Chaoyang secondary school students' parents participated in a June-August 2024 study. They completed a questionnaire assessing HPV knowledge, vaccine awareness, and vaccination willingness.

The interaction between central and peripheral immune systems in methamphetamine use disorder: current status and future directions.

Methamphetamine (METH) use disorder (MUD) is characterized by compulsive drug-seeking behavior and substantial neurotoxicity, posing a considerable burden on individuals and society. Traditionally perceived as a localized central nervous system disorder, recent preclinical and clinical studies have elucidated that MUD is a multifaceted disorder influenced by various biological systems, particularly the immune system. Emerging evidence suggests that both central and peripheral immune responses play a crucial role in the initiation and persistence of MUD.

Substrate-Mediated Growth of Au Nanowires Under Weak CTAB Control and Rapid Au Deposition.

The selective Au deposition at the Au-substrate interface is known to give ultrathin Au nanowires and the synthesis usually employs strong thiol-based ligands. It is shown that, by increasing the rate of Au deposition, weak cetyltrimethylammonium bromide (CTAB) can be made to behave like a strong ligand, so that it induces Active Surface Growth and gives Au nanowires. The ligand strength also depends on the packing interactions in the ligand layer, in the order of CTAB, CTAB, and CTAB.

DEK::AFF2 fusion-associated middle ear non-keratinizing squamous cell carcinoma: A case report.

Background: Primary squamous cell carcinoma (SCC) of the middle ear is rare, with non-keratinizing basaloid types being exceptionally uncommon. Distinguishing these cancers, often caused by viral factors (, human papillomavirus or Epstein-Barr virus), or specific genetic alterations (, bromodomain-containing protein 4-nuclear protein in or gene fused with FLI chromosomal rearrangement), from other cranial conditions, is difficult. The recently identified DEK::AFF2 non-keratinizing SCC (NKSCC) is a novel subtype, fitting the World Health Organization classification of head and neck neoplasms.

Terahertz scanning near-field optical microscopy for biomedical detection: Recent advances, challenges, and future perspectives.

Terahertz (THz) radiation is widely recognized as a non-destructive, label-free, and highly- sensitive tool for biomedical detections. Nevertheless, its application in precision biomedical fields faces challenges due to poor spatial resolution caused by intrinsically long wavelength characteristics. THz scanning near-field optical microscopy (THz-SNOM), which surpasses the Rayleigh criterion, offers micrometer and nanometer-scale spatial resolution, making it possible to perform precise bioinspection with THz imaging.

Phillygenin rescues impaired autophagy flux by modulating the PI3K/Akt/mToR signaling pathway in a rat model of severe acute pancreatitis.

To investigate the mechanism of pancreatic alveolar cell autophagy in rats with severe acute pancreatitis (SAP) by phillygenin (PHI) based on the PI3K/Akt/mToR pathway. Rats were randomly divided into control group (CON group), SAP model group (SAP group) and PHI treatment group (SAP+PHI group), with 10 rats in each group. 5% sodium taurocholate was injected retrogradely into the biliopancreatic duct to establish a SAP rat model, and PHI was injected intraperitoneally into the pancreas after successful establishment of the model.