Combined single-cell RNA-seq and bulk RNA-seq construction of M2 TAMs signature for predicting HNSCC prognosis and immunotherapy.

Tumor associated macrophages (TAMs) in Head and neck squamous cell carcinoma (HNSCC), particularly M2-polarized subtypes, are pivotal drivers of tumorigenesis, angiogenesis, and metastasis, contributing to adverse clinical outcomes. Current prognostic markers lack precision, underscoring the need for novel biomarkers and risk stratification models. Single-cell RNA sequencing (scRNA-seq) was applied to profile the transcriptional landscape of TAMs in HNSCC at single-cell resolution.

Self-Driven, Stretchable Drug Delivery Electronics for Acne Treatment.

Acne is a common skin condition caused by the blockage of hair follicles, which is often associated with adolescents. Beyond physical discomfort and potential scarring, acne can also result in mental health issues including low self-esteem and anxiety. Among all available medical treatments, topical antibiotics are effective for acne treatment due to their rapid action, anti-inflammatory properties, minimal side effects, and accessibility.

A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage.

Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management.

Dose-response association of dietary inflammatory potential with risk of cancer: systematic review and meta-analysis of prospective cohort studies.

Observational studies indicated that the overall inflammatory potential of diets has been implicated in cancer etiology; however, the results were inconsistent. We aimed to estimate the dose-response association of dietary inflammatory potential with cancer outcomes based on prospective cohort studies. PubMed, Embase and Web of Science databases were searched up to 11 November 2023 for prospective cohort studies.

Exploring Bidirectional Causality between Obstructive Sleep Apnea and Chronic Kidney Disease via Mendelian Randomization.

Purpose: It remains unclear about the causal association between obstructive sleep apnea (OSA) and chronic kidney disease (CKD) and renal function. This study aimed to explore the bidirectional causal relationship between OSA and CKD and renal function.

Methods: We used a 2-sample bidirectional Mendelian randomization (MR) method to evaluate the causal relationship between OSA and estimated glomerular filtration rate from creatinine (eGFRcrea), eGFR from cystatin C (eGFRcys), urine albumin to creatinine ratio (UACR), blood urea nitrogen (BUN), and chronic kidney disease (CKD).

Erratum to "Integrative analysis of cuproptosis-related lncRNAs: Unveiling prognostic significance, immune microenvironment, and copper-induced mechanisms in prostate cancer" [ 3 (2025):48-59].

[This corrects the article DOI: 10.1016/j.cpt.

Detection of ppb-Level SO at Room Temperature Based on BiOSe Nanosheets.

Monitoring sulfur dioxide (SO) is crucial for protecting human health as exposure to this pollutant can cause respiratory and cardiovascular illnesses, particularly in vulnerable populations. The primary materials currently used for detecting SO are metal oxides. However, it is still a challenge to detect SO at the parts per billion (ppb) level via these materials even when operated at high temperatures.

Baicalin inhibits conjugative transfer of multidrug-resistant plasmid RP4 by regulating autoinducer-2 transporter protein LsrB.

The conjugative transfer of antibiotic resistance genes (ARGs) significantly contributes to the spread of antibiotic resistance. Quorum sensing (QS) plays a pivotal role in the regulation of this process. However, the control of conjugative transfer through quorum quenching (QQ) remains largely unexplored.

Alkane degradation mechanism of HXX308 isolated from sediment of the Mariana Trench.

The Challenger Deep of the Mariana Trench, which is the deepest site in the ocean, contains rich deposits of -alkanes in its sediments. However, the alkane metabolic processes of the bacteria in this extreme environment were not well understood. In this study, we isolated a strain HXX308 () from sediment samples of the Challenger Deep (10,816 meters below sea level).

New insights into phytochemicals via protein glycosylation focused on aging and diabetes.

Background: Protein glycosylation as a common post-translational modification that has significant impacts on protein folding, enzymatic activity, and interfering with receptor functioning. In recent years, with the rapid development of glycopeptide enrichment and analysis technology and the deepening of glycosylation research, glycosylation has gradually become a sign of disease occurrence and development. Multiple investigations suggest that protein glycosylation affect the advances of diabetes and aging.

An mRNA expression atlas for the duck with public RNA-seq datasets.

Background: Ducks are globally important poultry species and a major source of farm animal products, including meat, eggs, and feathers. A thorough understanding of the functional genomic and transcriptomic sequences is crucial for improving production efficiency.

Result: This study constructed the largest duck mRNA expression atlas among all waterfowl species to date.

Disorders of gut microbiota and fecal-serum metabolic patterns are associated with pulmonary tuberculosis and pulmonary tuberculosis comorbid type 2 diabetes mellitus.

Unlabelled: Pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are prevalent chronic diseases with substantial implications for human health. DM patients are more susceptible to PTB, which exacerbates diabetes-related complications. However, the complex molecular mechanisms underlying the enhanced susceptibility of DM patients to PTB infection remain poorly understood.

Association of environmental metallic and metalloid contaminants with cardiovascular and all-cause mortality: An umbrella review of systematic reviews and meta-analyses.

Aim: The aim was to examine the relationship between exposure to environmental metallic and metalloid pollutants and cardiovascular disease (CVD) and all-cause mortality by integrating the information currently available from systematic reviews and meta-analyses.

Method: PubMed, Embase, and Web of Science for systematic reviews and meta-analyses were thoroughly searched up to October 9, 2024. Systematic reviews and meta-analyses of various kinds that evaluated the relationship between exposure to ambient metallic and metalloid pollutants and CVD and all-cause mortality were included.

Microplastics enhance the denitrification of glycogen-accumulating organisms by regulating electronic transport in carbon-nitrogen coupling.

The increasing presence of microplastics (MPs) in wastewater treatment systems profoundly impacts microbial metabolism and process performance. However, the effects of MPs on the denitrification process of glycogen-accumulating organisms (GAOs) remain unclear. Herein, various types and concentrations of MPs were introduced into the activate sludge of GAOs to assess their impact on denitrification processes and to investigate the underlying mechanisms.

Assessment of six surrogate insulin resistance indexes for predicting hypertension risk in rural Chinese adults.

Insulin resistance (IR) is a complex abnormality and associated with hypertension. We aimed to assess the associations of six alternate IR measures and risk of hypertension, and to compare the predictive values for hypertension. We assessed 11,223 non-hypertensive Chinese adults enrolled in The Rural Chinese Cohort Study during 2007-2008.

Algal proteins and bioactive peptides: Sustainable nutrition for human health.

Animal proteins are the primary global protein source, but their production is environmentally challenging and has low conversion efficiency. This highlights the need to diversify dietary protein sources. Algal proteins provide a sustainable alternative, outperforming traditional plant and animal proteins in protein content, quality, and digestibility.

Immunomodulatory functions of algal bioactive compounds.

Algae, a crucial constituent of marine systems, serve an indispensable function as primary producers, supporting the marine food web, contributing to carbon sequestration, and providing habitats that sustain biodiversity. This review focuses on the bioactive constituents of algae, including polysaccharides, polyphenols, polypeptides, and terpenoid compounds, and discusses their potential applications in treating immune-related diseases, as well as the mechanisms through which they modulate immune responses. The bioactive substances derived from algae, including polyphenols, bioactive peptides, terpenes, polysaccharides and other compounds, may play a preventive role by modulating allergic responses and reducing the incidence of inflammation and cancer.

Integrative analysis of cuproptosis-related lncRNAs: Unveiling prognostic significance, immune microenvironment, and copper-induced mechanisms in prostate cancer.

Background: Long non-coding ribonucleic acids (lncRNAs) regulate messenger RNA (mRNA) expression and influence cancer development and progression. Cuproptosis, a newly discovered form of cell death, plays an important role in cancer. Nonetheless, additional research investigating the association between cuproptosis-related lncRNAs and prostate cancer (PCa) prognosis is required.

The relationship between HYDIN and fallopian tubal cilia loss in patients with epithelial ovarian cancer.

Introduction: Primary cilia play an important role in the development of cancer by regulating signaling pathways. Several studies have demonstrated that women with mutations have, on average, 50% fewer ciliated cells compared with general women. However, the role of tubal cilia loss in the development of epithelial ovarian cancer (EOC) remains unclear.

The association of telomere length and coronary heart disease: A systematic review and dose-response meta-analysis.

Aims: The association of telomere length (TL) and coronary heart disease (CHD) is still debated, and there is a lack of dose-response meta-analyses on this issue. The aim is therefore to integrate existing evidence on the association between TL and CHD risk and explore the dose-response relationship between them.

Data Synthesis: PubMed, EMBASE, and Web of Science were searched for relevant studies up to September 2024.

Niche Partitioning and Intraspecific Variation of Thaumarchaeota in Deep Ocean Sediments.

Deep-sea sediments contain a large number of Thaumarchaeota that are phylogenetically distinct from their pelagic counterparts. However, their ecology and evolutionary adaptations are not well understood. Metagenomic analyses were conducted on samples from various depths of a 750-cm sediment core collected from the Mariana Trench Challenger Deep.

Notes on the genus (Lepidoptera, Zygaenidae) with description of a new species from China.

The genus Efetov & Tarmann, 1995 includes six species occurring in southwest China and Indian Sikkim. In the present paper, Li & He, , the seventh species of the genus encountered at the foot of Galongla Snow Mountain, southeast Xizang of China is described. Habitus of the adult and genitalia of the new species are illustrated, and a checklist and a key of all species are provided.

Altered intestinal microbiota and fecal metabolites in patients with latent and active pulmonary tuberculosis.

Background: Pulmonary tuberculosis (PTB) is the main cause of infection-related mortality and the most common infectious disease that develops resistance to antibiotics. Gut microbiota and their associated metabolites are assumed to induce and influence the development of PTB. However, the alterations of gut microbiota and metabolites in TB patients is currently unclear.

The Effects of Two Kinds of Gargles on Oral Mucositis in Patients After Allogeneic Stem Cell Transplantation.

Objective: The objective of this study was to compare the effects of two kinds of gargles (Koushu & Koutai) on oral mucositis (OM) in patients with agranulocytosis.

Methods: One hundred eighty patients who underwent allogeneic hematopoietic stem cell transplantation in the Peking University Institute of Hematology were enrolled from March 2018 to January 2019. The subjects were randomly divided into two groups by random number table.

Germacrone ameliorates acute lung injury induced by intestinal ischemia-reperfusion by regulating macrophage M1 polarization and mitochondrial defects.

Intestinal ischemia-reperfusion (I/R) injury severely affects the lungs. Germacrone (Ger) possesses anti-inflammatory and antioxidant properties. However, it is unclear whether it protects the lungs from I/R injury.